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P24391 (TOM40_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Mitochondrial import receptor subunit tom-40
Alternative name(s):
Protein MOM38
Translocase of outer membrane 40 kDa subunit
Gene names
Name:tom-40
Synonyms:mom38, tom40
ORF Names:B10H4.150, NCU01179
OrganismNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifier367110 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Sordariales › Sordariaceae › Neurospora

Protein attributes

Sequence length349 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Channel-forming protein essential for import of protein precursors into mitochondria. Ref.4

Subunit structure

Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 8 different proteins (tom-5, tom-6, tom-7, tom-20, tom-22, tom-37, tom-40 and tom-70). Interacts with mitochondrial targeting sequences. Ref.4

Subcellular location

Mitochondrion outer membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the Tom40 family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

BAXQ078122EBI-1791540,EBI-516580From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 349349Mitochondrial import receptor subunit tom-40
PRO_0000051533

Sequences

Sequence LengthMass (Da)Tools
P24391 [UniParc].

Last modified March 1, 1992. Version 1.
Checksum: C17F11B576B36427

FASTA34938,151
        10         20         30         40         50         60 
MASFSTESPL AMLRDNAIYS SLSDAFNAFQ ERRKQFGLSN PGTIETIARE VQRDTLLTNY 

        70         80         90        100        110        120 
MFSGLRADVT KAFSLAPLFQ VSHQFAMGER LNPYAFAALY GTNQIFAQGN LDNEGALSTR 

       130        140        150        160        170        180 
FNYRWGDRTI TKTQFSIGGG QDMAQFEHEH LGDDFSASLK AINPSFLDGG LTGIFVGDYL 

       190        200        210        220        230        240 
QAVTPRLGLG LQAVWQRQGL TQGPDTAISY FARYKAGDWV ASAQLQAQGA LNTSFWKKLT 

       250        260        270        280        290        300 
DRVQAGVDMT LSVAPSQSMM GGLTKEGITT FGAKYDFRMS TFRAQIDSKG KLSCLLEKRL 

       310        320        330        340 
GAAPVTLTFA ADVDHVTQQA KLGMSVSIEA SDVDLQEQQE GAQSLNIPF

« Hide

References

« Hide 'large scale' references
[1]"Identification of a mitochondrial receptor complex required for recognition and membrane insertion of precursor proteins."
Kiebler M., Pfaller R., Soellner T., Griffiths G., Horstmann H., Pfanner N., Neupert W.
Nature 348:610-616(1990) [PubMed: 2174514] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence."
Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.
Nucleic Acids Res. 31:1944-1954(2003) [PubMed: 12655011] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
[3]"The genome sequence of the filamentous fungus Neurospora crassa."
Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D. expand/collapse author list , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
Nature 422:859-868(2003) [PubMed: 12712197] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
[4]"Tom40, the pore-forming component of the protein-conducting TOM channel in the outer membrane of mitochondria."
Ahting U., Thieffry M., Engelhardt H., Hegerl R., Neupert W., Nussberger S.
J. Cell Biol. 153:1151-1160(2001) [PubMed: 11402060] [Abstract]
Cited for: FUNCTION, SUBUNIT.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X56883 mRNA. Translation: CAA40205.1.
AL670010 Genomic DNA. Translation: CAD21402.1.
AABX02000015 Genomic DNA. Translation: EAA32309.1.
PIRS13418.
RefSeqXP_961545.1. XM_956452.2.
UniGeneNcr.25002.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActP24391. 1 interaction.
STRINGP24391.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiEFNCRT00000004357; EFNCRP00000004357; EFNCRG00000004351.
GeneID3877741.
KEGGncr:NCU01179.
NMPDRfig|5141.1.peg.4605.

Phylogenomic databases

eggNOGfuNOG04556.
GeneTreeEFGT00050000006164.
OMAGRVMTDG.
OrthoDBEOG4QRMCQ.

Enzyme and pathway databases

BioCycNCRA-XX3-01:NCRA-XX3-01-004889-MONOMER.

Family and domain databases

InterProIPR001925. Porin_Euk.
IPR005686. Tom40.
[Graphical view]
KOK11518.
PfamPF01459. Porin_3. 1 hit.
[Graphical view]
TIGRFAMsTIGR00989. 3a0801s07tom40. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTOM40_NEUCR
AccessionPrimary (citable) accession number: P24391
Secondary accession number(s): Q7RVE2
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: December 14, 2011
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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