Reviewed, UniProtKB/Swiss-Prot P24391 (TOM40_NEUCR)

Names and origin

Protein names

Recommended name:
    Mitochondrial import receptor subunit tom-40
Alternative name(s):
    Translocase of outer membrane 40 kDa subunit
    Protein MOM38

Gene names

Name:	tom-40
Synonyms:	mom38, tom40
ORF Names:	B10H4.150, NCU01179

Organism

Neurospora crassa [Complete proteome]

Taxonomic identifier

5141 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Sordariales › Sordariaceae › Neurospora

Protein attributes

Sequence length	349 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Channel-forming protein essential for import of protein precursors into mitochondria. Ref.4
Subunit structure	Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 8 different proteins (tom-5, tom-6, tom-7, tom-20, tom-22, tom-37, tom-40 and tom-70). Interacts with mitochondrial targeting sequences. Ref.4
Subcellular location	Mitochondrion outer membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the Tom40 family.

Ontologies

Keywords
Biological process	Ion transport Protein transport Transport
Cellular component	Membrane Mitochondrion Mitochondrion outer membrane
Domain	Transmembrane
Molecular function	Porin
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	anion transport Inferred from electronic annotation. Source: InterPro intracellular protein transport Inferred from electronic annotation. Source: InterPro transmembrane transport Inferred from electronic annotation. Source: InterPro
Cellular component	mitochondrial outer membrane Inferred from electronic annotation. Source: UniProtKB-KW pore complex Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	P-P-bond-hydrolysis-driven protein transmembrane transporter activity Inferred from electronic annotation. Source: InterPro voltage-gated anion channel activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
BAX	Q07812	1	EBI-1791540,EBI-516580	From a different organism.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 349	349	Mitochondrial import receptor subunit tom-40		PRO_0000051533

Sequences

	Sequence		Length	Mass (Da)
	P24391-1 [UniParc]. Last modified March 1, 1992. Version 1. Checksum: C17F11B576B36427	FASTA	349	38,151
	10 20 30 40 50 60 MASFSTESPL AMLRDNAIYS SLSDAFNAFQ ERRKQFGLSN PGTIETIARE VQRDTLLTNY 70 80 90 100 110 120 MFSGLRADVT KAFSLAPLFQ VSHQFAMGER LNPYAFAALY GTNQIFAQGN LDNEGALSTR 130 140 150 160 170 180 FNYRWGDRTI TKTQFSIGGG QDMAQFEHEH LGDDFSASLK AINPSFLDGG LTGIFVGDYL 190 200 210 220 230 240 QAVTPRLGLG LQAVWQRQGL TQGPDTAISY FARYKAGDWV ASAQLQAQGA LNTSFWKKLT 250 260 270 280 290 300 DRVQAGVDMT LSVAPSQSMM GGLTKEGITT FGAKYDFRMS TFRAQIDSKG KLSCLLEKRL 310 320 330 340 GAAPVTLTFA ADVDHVTQQA KLGMSVSIEA SDVDLQEQQE GAQSLNIPF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a mitochondrial receptor complex required for recognition and membrane insertion of precursor proteins." Kiebler M., Pfaller R., Soellner T., Griffiths G., Horstmann H., Pfanner N., Neupert W. Nature 348:610-616(1990) [PubMed: 2174514] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence." Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U. Nucleic Acids Res. 31:1944-1954(2003) [PubMed: 12655011] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
[3]	"The genome sequence of the filamentous fungus Neurospora crassa." Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D. , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W. Nature 422:859-868(2003) [PubMed: 12712197] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
[4]	"Tom40, the pore-forming component of the protein-conducting TOM channel in the outer membrane of mitochondria." Ahting U., Thieffry M., Engelhardt H., Hegerl R., Neupert W., Nussberger S. J. Cell Biol. 153:1151-1160(2001) [PubMed: 11402060] [Abstract] Cited for: FUNCTION, SUBUNIT.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X56883 mRNA. Translation: CAA40205.1. AL670010 Genomic DNA. Translation: CAD21402.1. AABX02000015 Genomic DNA. Translation: EAA32309.1.
PIR	S13418.
RefSeq	XP_961545.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P24391. 1 interaction.
STRING	P24391.
Genome annotation databases
GeneID	3877741.
KEGG	ncr:NCU01179.
NMPDR	fig|5141.1.peg.4605.
Phylogenomic databases
eggNOG	fuNOG04556.
OrthoDB	EOG918D4V.
PhylomeDB	P24391.
Enzyme and pathway databases
BioCyc	NCRA-XX3-01:NCRA-XX3-01-004889-MONOMER.
Family and domain databases
InterPro	IPR001925. Porin_Euk. IPR005686. Tom40. [Graphical view]
Pfam	PF01459. Porin_3. 1 hit. [Graphical view]
TIGRFAMs	TIGR00989. 3a0801s07tom40. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TOM40_NEUCR

Accession

Primary (citable) accession number: P24391
Secondary accession number(s): Q7RVE2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
Last sequence update:	March 1, 1992
Last modified:	February 9, 2010
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)