P24390 (ERD21_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ER lumen protein retaining receptor 1

Alternative name(s):
KDEL endoplasmic reticulum protein retention receptor 1
Short name=KDEL receptor 1
Putative MAPK-activating protein PM23

Gene names

Name:	KDELR1
Synonyms:	ERD2.1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	212 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L.
Subunit structure	Interacts with ARFGAP1 By similarity.
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the ERD2 family.

Ontologies

Keywords
Biological process	ER-Golgi transport Protein transport Transport
Cellular component	Endoplasmic reticulum Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Receptor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	intracellular protein transport Traceable author statement. Source: ProtInc protein retention in ER lumen Inferred from electronic annotation. Source: InterPro vesicle-mediated transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell endoplasmic reticulum-Golgi intermediate compartment Inferred from direct assay. Source: UniProtKB integral to membrane Traceable author statement. Source: ProtInc membrane fraction Traceable author statement. Source: ProtInc
Molecular function	KDEL sequence binding Traceable author statement. Source: ProtInc receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
BZW1	Q7L1Q6	1	EBI-1043076,EBI-1046727
NEK6	Q9HC98	1	EBI-1043076,EBI-740364
SERINC3	Q13530	1	EBI-1043076,EBI-1045571
WBP5	Q9UHQ7	1	EBI-1043076,EBI-1051372

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 212	212	ER lumen protein retaining receptor 1		PRO_0000194153
Regions
	Topological domain	1 – 2	2	Lumenal Potential
	Transmembrane	3 – 21	19	Helical; Potential
	Topological domain	22 – 35	14	Cytoplasmic Potential
	Transmembrane	36 – 53	18	Helical; Potential
	Topological domain	54 – 61	8	Lumenal Potential
	Transmembrane	62 – 80	19	Helical; Potential
	Topological domain	81 – 96	16	Cytoplasmic Potential
	Transmembrane	97 – 110	14	Helical; Potential
	Topological domain	111 – 117	7	Lumenal Potential
	Transmembrane	118 – 137	20	Helical; Potential
	Topological domain	138 – 149	12	Cytoplasmic Potential
	Transmembrane	150 – 168	19	Helical; Potential
	Topological domain	169 – 178	10	Lumenal Potential
	Transmembrane	179 – 199	21	Helical; Potential
	Topological domain	200 – 212	13	Cytoplasmic Potential

Sequences

	Sequence		Length	Mass (Da)
	P24390 [UniParc]. Last modified March 1, 1992. Version 1. Checksum: B863C0F09CFC0551	FASTA	212	24,542
	10 20 30 40 50 60 MNLFRFLGDL SHLLAIILLL LKIWKSRSCA GISGKSQVLF AVVFTARYLD LFTNYISLYN 70 80 90 100 110 120 TCMKVVYIAC SFTTVWLIYS KFKATYDGNH DTFRVEFLVV PTAILAFLVN HDFTPLEILW 130 140 150 160 170 180 TFSIYLESVA ILPQLFMVSK TGEAETITSH YLFALGVYRT LYLFNWIWRY HFEGFFDLIA 190 200 210 IVAGLVQTVL YCDFFYLYIT KVLKGKKLSL PA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A human homologue of the yeast HDEL receptor." Lewis M.J., Pelham H.R.B. Nature 348:162-163(1990) [PubMed: 2172835] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta.
[2]	"Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways." Matsuda A., Suzuki Y., Honda G., Muramatsu S., Matsuzaki O., Nagano Y., Doi T., Shimotohno K., Harada T., Nishida E., Hayashi H., Sugano S. Oncogene 22:3307-3318(2003) [PubMed: 12761501] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung fibroblast.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin.
[6]	"Mutational analysis of the human KDEL receptor: distinct structural requirements for Golgi retention, ligand binding and retrograde transport." Townsley F.M., Wilson D.W., Pelham H.R.B. EMBO J. 12:2821-2829(1993) [PubMed: 8392934] [Abstract] Cited for: MUTAGENESIS.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X55885 mRNA. Translation: CAA39371.1. AB097047 mRNA. Translation: BAC77400.1. AK312647 mRNA. Translation: BAG35531.1. CH471177 Genomic DNA. Translation: EAW52340.1. BC018778 mRNA. Translation: AAH18778.1.
IPI	IPI00028116.
PIR	S13293.
RefSeq	NP_006792.1. NM_006801.2.
UniGene	Hs.515515.
3D structure databases
ProteinModelPortal	P24390.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-48668N.
IntAct	P24390. 7 interactions.
STRING	P24390.
PTM databases
PhosphoSite	P24390.
Polymorphism databases
DMDM	119543.
Proteomic databases
PRIDE	P24390.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000330720; ENSP00000329471; ENSG00000105438.
GeneID	10945.
KEGG	hsa:10945.
UCSC	uc002pjb.1. human.
Organism-specific databases
CTD	10945.
GeneCards	GC19M048885.
H-InvDB	HIX0015291.
HGNC	HGNC:6304. KDELR1.
HPA	CAB017455.
MIM	131235. gene.
neXtProt	NX_P24390.
PharmGKB	PA30083.
GenAtlas	Search...
Phylogenomic databases
eggNOG	maNOG18830.
HOGENOM	HBG332839.
HOVERGEN	HBG001398.
InParanoid	P24390.
OMA	TYDHNHD.
OrthoDB	EOG4BCDNV.
PhylomeDB	P24390.
Gene expression databases
ArrayExpress	P24390.
Bgee	P24390.
CleanEx	HS_KDELR1.
Genevestigator	P24390.
GermOnline	ENSG00000105438. Homo sapiens.
Family and domain databases
InterPro	IPR000133. ER_ret_rcpt. [Graphical view]
KO	K10949.
PANTHER	PTHR10585. ER_ret_rcpt. 1 hit.
Pfam	PF00810. ER_lumen_recept. 1 hit. [Graphical view]
PRINTS	PR00660. ERLUMENR.
PROSITE	PS00951. ER_LUMEN_RECEPTOR_1. 1 hit. PS00952. ER_LUMEN_RECEPTOR_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	41585.
SOURCE	Search...

Entry information

Entry name

ERD21_HUMAN

Accession

Primary (citable) accession number: P24390
Secondary accession number(s): B2R6N4, Q54A39

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
Last sequence update:	March 1, 1992
Last modified:	January 25, 2012
This is version 100 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.