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Protein

ER lumen protein-retaining receptor 1

Gene

KDELR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for the retention of luminal endoplasmic reticulum resident proteins via vesicular recycling. This receptor recognizes the C-terminal K-D-E-L motif. COPI-coated transport intermediates, either in the form of round vesicles or as tubular processes, mediate retrograde traffic of the KDEL receptor-ligand complexes. Also required for normal vesicular traffic through the Golgi.1 Publication

GO - Molecular functioni

  • KDEL sequence binding Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000105438-MONOMER.
ReactomeiR-HSA-6807878. COPI-mediated anterograde transport.
R-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
SIGNORiP24390.

Protein family/group databases

TCDBi9.B.191.1.5. the endoplasmic reticulum retention receptor (kdelr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
ER lumen protein-retaining receptor 1
Alternative name(s):
KDEL endoplasmic reticulum protein retention receptor 1
Short name:
KDEL receptor 1
Putative MAPK-activating protein PM23
Gene namesi
Name:KDELR1
Synonyms:ERD2.1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:6304. KDELR1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 2LumenalSequence analysis2
Transmembranei3 – 21HelicalSequence analysisAdd BLAST19
Topological domaini22 – 35CytoplasmicSequence analysisAdd BLAST14
Transmembranei36 – 53HelicalSequence analysisAdd BLAST18
Topological domaini54 – 61LumenalSequence analysis8
Transmembranei62 – 80HelicalSequence analysisAdd BLAST19
Topological domaini81 – 96CytoplasmicSequence analysisAdd BLAST16
Transmembranei97 – 110HelicalSequence analysisAdd BLAST14
Topological domaini111 – 117LumenalSequence analysis7
Transmembranei118 – 137HelicalSequence analysisAdd BLAST20
Topological domaini138 – 149CytoplasmicSequence analysisAdd BLAST12
Transmembranei150 – 168HelicalSequence analysisAdd BLAST19
Topological domaini169 – 178LumenalSequence analysis10
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Topological domaini200 – 212CytoplasmicSequence analysisAdd BLAST13

GO - Cellular componenti

  • cis-Golgi network Source: Ensembl
  • COPI-coated vesicle membrane Source: UniProtKB-SubCell
  • endoplasmic reticulum-Golgi intermediate compartment Source: UniProtKB
  • endoplasmic reticulum-Golgi intermediate compartment membrane Source: Reactome
  • endoplasmic reticulum membrane Source: Reactome
  • Golgi membrane Source: Reactome
  • integral component of membrane Source: ProtInc
  • membrane Source: ProtInc
  • transport vesicle Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi209S → A: Inhibits coatomer/ARF-GAP recruitment, receptor redistribution, and intracellular retention of KDEL ligands. 1 Publication1
Mutagenesisi209S → D: Redistribution to the ER is not affected upon PKA inactivation. 1 Publication1

Organism-specific databases

DisGeNETi10945.
OpenTargetsiENSG00000105438.
PharmGKBiPA30083.

Polymorphism and mutation databases

BioMutaiKDELR1.
DMDMi119543.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001941531 – 212ER lumen protein-retaining receptor 1Add BLAST212

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei209Phosphoserine; by PKA1 Publication1

Post-translational modificationi

Phosphorylation by PKA at Ser-209 is required for endoplasmic reticulum retention function.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP24390.
MaxQBiP24390.
PaxDbiP24390.
PeptideAtlasiP24390.
PRIDEiP24390.
TopDownProteomicsiP24390-1. [P24390-1]

PTM databases

iPTMnetiP24390.
PhosphoSitePlusiP24390.

Expressioni

Gene expression databases

BgeeiENSG00000105438.
CleanExiHS_KDELR1.
ExpressionAtlasiP24390. baseline and differential.
GenevisibleiP24390. HS.

Organism-specific databases

HPAiCAB017455.
HPA047440.

Interactioni

Subunit structurei

Upon ligand binding the receptor oligomerizes and interacts with components of the transport machinery such as ARFGAP1 and ARF1.1 Publication

Protein-protein interaction databases

BioGridi116145. 26 interactors.
DIPiDIP-48668N.
IntActiP24390. 9 interactors.
MINTiMINT-3010262.
STRINGi9606.ENSP00000329471.

Structurei

3D structure databases

ProteinModelPortaliP24390.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ERD2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3106. Eukaryota.
COG5196. LUCA.
GeneTreeiENSGT00390000004010.
HOGENOMiHOG000231400.
HOVERGENiHBG001398.
InParanoidiP24390.
KOiK10949.
PhylomeDBiP24390.
TreeFamiTF314792.

Family and domain databases

InterProiIPR000133. ER_ret_rcpt.
[Graphical view]
PANTHERiPTHR10585. PTHR10585. 1 hit.
PfamiPF00810. ER_lumen_recept. 1 hit.
[Graphical view]
PRINTSiPR00660. ERLUMENR.
PROSITEiPS00951. ER_LUMEN_RECEPTOR_1. 1 hit.
PS00952. ER_LUMEN_RECEPTOR_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P24390-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNLFRFLGDL SHLLAIILLL LKIWKSRSCA GISGKSQVLF AVVFTARYLD
60 70 80 90 100
LFTNYISLYN TCMKVVYIAC SFTTVWLIYS KFKATYDGNH DTFRVEFLVV
110 120 130 140 150
PTAILAFLVN HDFTPLEILW TFSIYLESVA ILPQLFMVSK TGEAETITSH
160 170 180 190 200
YLFALGVYRT LYLFNWIWRY HFEGFFDLIA IVAGLVQTVL YCDFFYLYIT
210
KVLKGKKLSL PA
Length:212
Mass (Da):24,542
Last modified:March 1, 1992 - v1
Checksum:iB863C0F09CFC0551
GO
Isoform 2 (identifier: P24390-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-62: Missing.

Note: No experimental confirmation available.
Show »
Length:150
Mass (Da):17,487
Checksum:iE2A47258FC75BC7E
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0554841 – 62Missing in isoform 2. 1 PublicationAdd BLAST62

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55885 mRNA. Translation: CAA39371.1.
AB097047 mRNA. Translation: BAC77400.1.
AK075185 mRNA. Translation: BAC11457.1.
AK312647 mRNA. Translation: BAG35531.1.
AC011514 Genomic DNA. No translation available.
CH471177 Genomic DNA. Translation: EAW52340.1.
CH471177 Genomic DNA. Translation: EAW52343.1.
CH471177 Genomic DNA. Translation: EAW52345.1.
BC018778 mRNA. Translation: AAH18778.1.
CCDSiCCDS12718.1. [P24390-1]
PIRiS13293.
RefSeqiNP_006792.1. NM_006801.2. [P24390-1]
UniGeneiHs.515515.

Genome annotation databases

EnsembliENST00000330720; ENSP00000329471; ENSG00000105438. [P24390-1]
ENST00000597017; ENSP00000470841; ENSG00000105438. [P24390-2]
GeneIDi10945.
KEGGihsa:10945.
UCSCiuc002pja.2. human. [P24390-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55885 mRNA. Translation: CAA39371.1.
AB097047 mRNA. Translation: BAC77400.1.
AK075185 mRNA. Translation: BAC11457.1.
AK312647 mRNA. Translation: BAG35531.1.
AC011514 Genomic DNA. No translation available.
CH471177 Genomic DNA. Translation: EAW52340.1.
CH471177 Genomic DNA. Translation: EAW52343.1.
CH471177 Genomic DNA. Translation: EAW52345.1.
BC018778 mRNA. Translation: AAH18778.1.
CCDSiCCDS12718.1. [P24390-1]
PIRiS13293.
RefSeqiNP_006792.1. NM_006801.2. [P24390-1]
UniGeneiHs.515515.

3D structure databases

ProteinModelPortaliP24390.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116145. 26 interactors.
DIPiDIP-48668N.
IntActiP24390. 9 interactors.
MINTiMINT-3010262.
STRINGi9606.ENSP00000329471.

Protein family/group databases

TCDBi9.B.191.1.5. the endoplasmic reticulum retention receptor (kdelr) family.

PTM databases

iPTMnetiP24390.
PhosphoSitePlusiP24390.

Polymorphism and mutation databases

BioMutaiKDELR1.
DMDMi119543.

Proteomic databases

EPDiP24390.
MaxQBiP24390.
PaxDbiP24390.
PeptideAtlasiP24390.
PRIDEiP24390.
TopDownProteomicsiP24390-1. [P24390-1]

Protocols and materials databases

DNASUi10945.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330720; ENSP00000329471; ENSG00000105438. [P24390-1]
ENST00000597017; ENSP00000470841; ENSG00000105438. [P24390-2]
GeneIDi10945.
KEGGihsa:10945.
UCSCiuc002pja.2. human. [P24390-1]

Organism-specific databases

CTDi10945.
DisGeNETi10945.
GeneCardsiKDELR1.
HGNCiHGNC:6304. KDELR1.
HPAiCAB017455.
HPA047440.
MIMi131235. gene.
neXtProtiNX_P24390.
OpenTargetsiENSG00000105438.
PharmGKBiPA30083.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3106. Eukaryota.
COG5196. LUCA.
GeneTreeiENSGT00390000004010.
HOGENOMiHOG000231400.
HOVERGENiHBG001398.
InParanoidiP24390.
KOiK10949.
PhylomeDBiP24390.
TreeFamiTF314792.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000105438-MONOMER.
ReactomeiR-HSA-6807878. COPI-mediated anterograde transport.
R-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
SIGNORiP24390.

Miscellaneous databases

ChiTaRSiKDELR1. human.
GeneWikiiKDELR1.
GenomeRNAii10945.
PROiP24390.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105438.
CleanExiHS_KDELR1.
ExpressionAtlasiP24390. baseline and differential.
GenevisibleiP24390. HS.

Family and domain databases

InterProiIPR000133. ER_ret_rcpt.
[Graphical view]
PANTHERiPTHR10585. PTHR10585. 1 hit.
PfamiPF00810. ER_lumen_recept. 1 hit.
[Graphical view]
PRINTSiPR00660. ERLUMENR.
PROSITEiPS00951. ER_LUMEN_RECEPTOR_1. 1 hit.
PS00952. ER_LUMEN_RECEPTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiERD21_HUMAN
AccessioniPrimary (citable) accession number: P24390
Secondary accession number(s): B2R6N4, Q54A39, Q8NBW7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: November 30, 2016
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.