##gff-version 3
P24389	UniProtKB	Chain	1	257	.	.	.	ID=PRO_0000154313;Note=Type I iodothyronine deiodinase	
P24389	UniProtKB	Transmembrane	13	33	.	.	.	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P24389	UniProtKB	Active site	126	126	.	.	.	.	
P24389	UniProtKB	Non-standard residue	126	126	.	.	.	Note=Selenocysteine	
P24389	UniProtKB	Mutagenesis	158	158	.	.	.	Note=Loss of enzyme activity. H->F%2CQ%2CN;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1517238;Dbxref=PMID:1517238	
P24389	UniProtKB	Mutagenesis	174	174	.	.	.	Note=100-fold increase in KM. H->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1517238;Dbxref=PMID:1517238	
P24389	UniProtKB	Mutagenesis	174	174	.	.	.	Note=20-fold increase in KM. H->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1517238;Dbxref=PMID:1517238	
P24389	UniProtKB	Mutagenesis	185	185	.	.	.	Note=No effect on enzyme activity. H->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1517238;Dbxref=PMID:1517238