ID CRHBP_HUMAN Reviewed; 322 AA. AC P24387; Q53F32; Q6FHT5; DT 01-MAR-1992, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-1994, sequence version 2. DT 25-JAN-2012, entry version 93. DE RecName: Full=Corticotropin-releasing factor-binding protein; DE Short=CRF-BP; DE Short=CRF-binding protein; DE AltName: Full=Corticotropin-releasing hormone-binding protein; DE Short=CRH-BP; DE Flags: Precursor; GN Name=CRHBP; Synonyms=CRFBP; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE. RC TISSUE=Liver; RX MEDLINE=91125460; PubMed=1846945; DOI=10.1038/349423a0; RA Potter E., Behan D.P., Fischer W.H., Linton E.A., Lowry P.J., RA Vale W.W.; RT "Cloning and characterization of the cDNAs for human and rat RT corticotropin releasing factor-binding proteins."; RL Nature 349:423-426(1991). RN [2] RP SEQUENCE REVISION TO 47-48 AND 248, AND DISULFIDE BONDS. RX MEDLINE=94140858; PubMed=8307998; RA Fischer W.H., Behan D.P., Park M., Potter E., Lowry P.J., Vale W.W.; RT "Assignment of disulfide bonds in corticotropin-releasing factor- RT binding protein."; RL J. Biol. Chem. 269:4313-4316(1994). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.; RT "Cloning of human full open reading frames in Gateway(TM) system entry RT vector (pDONR201)."; RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Kidney; RA Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.; RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Hippocampus; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [7] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-27. RX MEDLINE=93252414; PubMed=8198617; DOI=10.1006/geno.1993.1141; RA Behan D.P., Potter E., Lewis K.A., Jenkins N.A., Copeland N.G., RA Lowry P.J., Vale W.W.; RT "Cloning and structure of the human corticotrophin releasing factor- RT binding protein gene (CRHBP)."; RL Genomics 16:63-68(1993). CC -!- FUNCTION: Binds CRF and inactivates it. May prevent inappropriate CC pituitary-adrenal stimulation in pregnancy. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- SIMILARITY: Belongs to the CRF-binding protein family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; X58022; CAA41086.1; ALT_SEQ; mRNA. DR EMBL; S60697; AAD13916.1; -; Genomic_DNA. DR EMBL; CR541666; CAG46467.1; -; mRNA. DR EMBL; AK223457; BAD97177.1; -; mRNA. DR EMBL; CH471084; EAW95786.1; -; Genomic_DNA. DR EMBL; BC018038; AAH18038.1; -; mRNA. DR IPI; IPI00306844; -. DR PIR; S13640; S13640. DR RefSeq; NP_001873.2; NM_001882.3. DR UniGene; Hs.115617; -. DR ProteinModelPortal; P24387; -. DR STRING; P24387; -. DR DMDM; 544099; -. DR PeptideAtlas; P24387; -. DR PRIDE; P24387; -. DR Ensembl; ENST00000274368; ENSP00000274368; ENSG00000145708. DR GeneID; 1393; -. DR KEGG; hsa:1393; -. DR UCSC; uc003ker.1; human. DR CTD; 1393; -. DR GeneCards; GC05P076284; -. DR H-InvDB; HIX0004962; -. DR HGNC; HGNC:2356; CRHBP. DR HPA; HPA046120; -. DR MIM; 122559; gene. DR neXtProt; NX_P24387; -. DR PharmGKB; PA26873; -. DR eggNOG; prNOG07481; -. DR GeneTree; ENSGT00390000001362; -. DR HOGENOM; HBG713409; -. DR HOVERGEN; HBG051117; -. DR InParanoid; P24387; -. DR OMA; QTPNGRF; -. DR OrthoDB; EOG4QC15W; -. DR PhylomeDB; P24387; -. DR NextBio; 5699; -. DR ArrayExpress; P24387; -. DR Bgee; P24387; -. DR CleanEx; HS_CRHBP; -. DR Genevestigator; P24387; -. DR GermOnline; ENSG00000145708; Homo sapiens. DR GO; GO:0005625; C:soluble fraction; TAS:ProtInc. DR GO; GO:0007565; P:female pregnancy; TAS:ProtInc. DR GO; GO:0007611; P:learning or memory; TAS:ProtInc. DR GO; GO:0007165; P:signal transduction; TAS:ProtInc. DR InterPro; IPR008435; CRF-bd. DR InterPro; IPR000859; CUB. DR PANTHER; PTHR10278; CRF_bd; 1. DR Pfam; PF05428; CRF-BP; 1. DR PIRSF; PIRSF009279; CRF_bd; 1. DR SUPFAM; SSF49854; CUB; 1. PE 1: Evidence at protein level; KW Complete proteome; Direct protein sequencing; Disulfide bond; KW Glycoprotein; Reference proteome; Secreted; Signal. FT SIGNAL 1 24 FT CHAIN 25 322 Corticotropin-releasing factor-binding FT protein. FT /FTId=PRO_0000020994. FT CARBOHYD 204 204 N-linked (GlcNAc...) (Potential). FT DISULFID 60 81 FT DISULFID 104 141 FT DISULFID 183 205 FT DISULFID 237 264 FT DISULFID 277 318 FT CONFLICT 279 279 N -> D (in Ref. 4; BAD97177). SQ SEQUENCE 322 AA; 36144 MW; 771A894BE06039BD CRC64; MSPNFKLQCH FILIFLTALR GESRYLELRE AADYDPFLLF SANLKRELAG EQPYRRALRC LDMLSLQGQF TFTADRPQLH CAAFFISEPE EFITIHYDQV SIDCQGGDFL KVFDGWILKG EKFPSSQDHP LPSAERYIDF CESGLSRRSI RSSQNVAMIF FRVHEPGNGF TLTIKTDPNL FPCNVISQTP NGKFTLVVPH QHRNCSFSII YPVVIKISDL TLGHVNGLQL KKSSAGCEGI GDFVELLGGT GLDPSKMTPL ADLCYPFHGP AQMKVGCDNT VVRMVSSGKH VNRVTFEYRQ LEPYELENPN GNSIGEFCLS GL //