P24387 (CRHBP_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 93.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Corticotropin-releasing factor-binding protein Short name=CRF-BP Short name=CRF-binding protein Alternative name(s): Corticotropin-releasing hormone-binding protein Short name=CRH-BP | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 322 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. |
| Subcellular location | |
| Sequence similarities | Belongs to the CRF-binding protein family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Secreted |
| Domain | Signal |
| PTM | Disulfide bond Glycoprotein |
| Technical term | Complete proteome Direct protein sequencing Reference proteome |
| Gene Ontology (GO) | |
| Biological process | female pregnancy Traceable author statement. Source: ProtInc learning or memoryTraceable author statement. Source: ProtInc signal transductionTraceable author statement. Source: ProtInc |
| Cellular component | soluble fraction Traceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 24 | 24 | |||||||||
| Chain | 25 – 322 | 298 | Corticotropin-releasing factor-binding protein | PRO_0000020994 | |||||||
Amino acid modifications | |||||||||||
| Glycosylation | 204 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 60 ↔ 81 | Ref.2 | |||||||||
| Disulfide bond | 104 ↔ 141 | Ref.2 | |||||||||
| Disulfide bond | 183 ↔ 205 | Ref.2 | |||||||||
| Disulfide bond | 237 ↔ 264 | Ref.2 | |||||||||
| Disulfide bond | 277 ↔ 318 | Ref.2 | |||||||||
Experimental info | |||||||||||
| Sequence conflict | 279 | 1 | N → D in BAD97177. Ref.4 | ||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Cloning and characterization of the cDNAs for human and rat corticotropin releasing factor-binding proteins." Potter E., Behan D.P., Fischer W.H., Linton E.A., Lowry P.J., Vale W.W. Nature 349:423-426(1991) [PubMed: 1846945] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE. Tissue: Liver. |
| [2] | "Assignment of disulfide bonds in corticotropin-releasing factor-binding protein." Fischer W.H., Behan D.P., Park M., Potter E., Lowry P.J., Vale W.W. J. Biol. Chem. 269:4313-4316(1994) [PubMed: 8307998] [Abstract] Cited for: SEQUENCE REVISION TO 47-48 AND 248, DISULFIDE BONDS. |
| [3] | "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [4] | Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney. |
| [5] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [6] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Hippocampus. |
| [7] | "Cloning and structure of the human corticotrophin releasing factor-binding protein gene (CRHBP)." Behan D.P., Potter E., Lewis K.A., Jenkins N.A., Copeland N.G., Lowry P.J., Vale W.W. Genomics 16:63-68(1993) [PubMed: 8198617] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-27. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | X58022 mRNA. Translation: CAA41086.1. Sequence problems. S60697 Genomic DNA. Translation: AAD13916.1. CR541666 mRNA. Translation: CAG46467.1. AK223457 mRNA. Translation: BAD97177.1. CH471084 Genomic DNA. Translation: EAW95786.1. BC018038 mRNA. Translation: AAH18038.1. |
| IPI | IPI00306844. |
| PIR | S13640. |
| RefSeq | NP_001873.2. NM_001882.3. |
| UniGene | Hs.115617. |
3D structure databases | |
| ProteinModelPortal | P24387. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P24387. |
Polymorphism databases | |
| DMDM | 544099. |
Proteomic databases | |
| PeptideAtlas | P24387. |
| PRIDE | P24387. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000274368; ENSP00000274368; ENSG00000145708. |
| GeneID | 1393. |
| KEGG | hsa:1393. |
| UCSC | uc003ker.1. human. |
Organism-specific databases | |
| CTD | 1393. |
| GeneCards | GC05P076284. |
| H-InvDB | HIX0004962. |
| HGNC | HGNC:2356. CRHBP. |
| HPA | HPA046120. |
| MIM | 122559. gene. |
| neXtProt | NX_P24387. |
| PharmGKB | PA26873. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG07481. |
| GeneTree | ENSGT00390000001362. |
| HOGENOM | HBG713409. |
| HOVERGEN | HBG051117. |
| InParanoid | P24387. |
| OMA | QTPNGRF. |
| OrthoDB | EOG4QC15W. |
| PhylomeDB | P24387. |
Gene expression databases | |
| ArrayExpress | P24387. |
| Bgee | P24387. |
| CleanEx | HS_CRHBP. |
| Genevestigator | P24387. |
| GermOnline | ENSG00000145708. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR008435. CRF-bd. IPR000859. CUB. [Graphical view] |
| PANTHER | PTHR10278. CRF_bd. 1 hit. |
| Pfam | PF05428. CRF-BP. 1 hit. [Graphical view] |
| PIRSF | PIRSF009279. CRF_bd. 1 hit. |
| SUPFAM | SSF49854. CUB. 1 hit. |
| ProtoNet | Search... |
Other | |
| NextBio | 5699. |
| SOURCE | Search... |
Entry information
| Entry name | CRHBP_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P24387 Secondary accession number(s): Q53F32, Q6FHT5 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 5 Human chromosome 5: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with