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P24387

- CRHBP_HUMAN

UniProt

P24387 - CRHBP_HUMAN

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Protein
Corticotropin-releasing factor-binding protein
Gene
CRHBP, CRFBP
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.

GO - Molecular functioni

  1. corticotropin-releasing hormone binding Source: UniProtKB
  2. peptide binding Source: UniProtKB
  3. protein binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. behavioral response to ethanol Source: UniProtKB
  2. cellular response to cAMP Source: UniProtKB
  3. cellular response to calcium ion Source: UniProtKB
  4. cellular response to cocaine Source: UniProtKB
  5. cellular response to drug Source: UniProtKB
  6. cellular response to estradiol stimulus Source: UniProtKB
  7. cellular response to estrogen stimulus Source: UniProtKB
  8. cellular response to gonadotropin-releasing hormone Source: UniProtKB
  9. cellular response to potassium ion Source: UniProtKB
  10. cellular response to stress Source: UniProtKB
  11. cellular response to tumor necrosis factor Source: UniProtKB
  12. female pregnancy Source: UniProtKB
  13. hormone metabolic process Source: Ensembl
  14. hormone-mediated signaling pathway Source: UniProtKB
  15. inflammatory response Source: UniProtKB
  16. learning or memory Source: UniProtKB
  17. maternal aggressive behavior Source: Ensembl
  18. negative regulation of corticotropin secretion Source: UniProtKB
  19. negative regulation of corticotropin-releasing hormone receptor activity Source: UniProtKB
  20. regulated secretory pathway Source: UniProtKB
  21. regulation of N-methyl-D-aspartate selective glutamate receptor activity Source: UniProtKB
  22. regulation of corticotropin secretion Source: UniProtKB
  23. signal transduction Source: UniProtKB
  24. synaptic transmission, dopaminergic Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Corticotropin-releasing factor-binding protein
Short name:
CRF-BP
Short name:
CRF-binding protein
Alternative name(s):
Corticotropin-releasing hormone-binding protein
Short name:
CRH-BP
Gene namesi
Name:CRHBP
Synonyms:CRFBP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:2356. CRHBP.

Subcellular locationi

GO - Cellular componenti

  1. axon terminus Source: UniProtKB
  2. dendrite Source: UniProtKB
  3. dense core granule Source: UniProtKB
  4. extracellular space Source: UniProtKB
  5. intracellular Source: UniProtKB
  6. microtubule Source: UniProtKB
  7. multivesicular body Source: UniProtKB
  8. nucleus Source: UniProtKB
  9. perikaryon Source: UniProtKB
  10. secondary lysosome Source: UniProtKB
  11. secretory granule Source: UniProtKB
  12. varicosity Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26873.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424
Add
BLAST
Chaini25 – 322298Corticotropin-releasing factor-binding protein
PRO_0000020994Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi60 ↔ 811 Publication
Disulfide bondi104 ↔ 1411 Publication
Disulfide bondi183 ↔ 2051 Publication
Glycosylationi204 – 2041N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi237 ↔ 2641 Publication
Disulfide bondi277 ↔ 3181 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP24387.
PeptideAtlasiP24387.
PRIDEiP24387.

PTM databases

PhosphoSiteiP24387.

Expressioni

Gene expression databases

ArrayExpressiP24387.
BgeeiP24387.
CleanExiHS_CRHBP.
GenevestigatoriP24387.

Organism-specific databases

HPAiHPA046120.

Interactioni

Protein-protein interaction databases

BioGridi107783. 1 interaction.
STRINGi9606.ENSP00000274368.

Structurei

3D structure databases

ProteinModelPortaliP24387.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG81351.
HOGENOMiHOG000004819.
HOVERGENiHBG051117.
InParanoidiP24387.
OMAiIHYDLVS.
OrthoDBiEOG7TXKH2.
PhylomeDBiP24387.
TreeFamiTF105383.

Family and domain databases

InterProiIPR008435. CRF-bd.
IPR000859. CUB_dom.
[Graphical view]
PANTHERiPTHR10278. PTHR10278. 1 hit.
PfamiPF05428. CRF-BP. 1 hit.
[Graphical view]
PIRSFiPIRSF009279. CRF_bd. 1 hit.
SUPFAMiSSF49854. SSF49854. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24387-1 [UniParc]FASTAAdd to Basket

« Hide

MSPNFKLQCH FILIFLTALR GESRYLELRE AADYDPFLLF SANLKRELAG    50
EQPYRRALRC LDMLSLQGQF TFTADRPQLH CAAFFISEPE EFITIHYDQV 100
SIDCQGGDFL KVFDGWILKG EKFPSSQDHP LPSAERYIDF CESGLSRRSI 150
RSSQNVAMIF FRVHEPGNGF TLTIKTDPNL FPCNVISQTP NGKFTLVVPH 200
QHRNCSFSII YPVVIKISDL TLGHVNGLQL KKSSAGCEGI GDFVELLGGT 250
GLDPSKMTPL ADLCYPFHGP AQMKVGCDNT VVRMVSSGKH VNRVTFEYRQ 300
LEPYELENPN GNSIGEFCLS GL 322
Length:322
Mass (Da):36,144
Last modified:June 1, 1994 - v2
Checksum:i771A894BE06039BD
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti279 – 2791N → D in BAD97177. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X58022 mRNA. Translation: CAA41086.1. Sequence problems.
S60697 Genomic DNA. Translation: AAD13916.1.
CR541666 mRNA. Translation: CAG46467.1.
AK223457 mRNA. Translation: BAD97177.1.
CH471084 Genomic DNA. Translation: EAW95786.1.
BC018038 mRNA. Translation: AAH18038.1.
CCDSiCCDS4034.1.
PIRiS13640.
RefSeqiNP_001873.2. NM_001882.3.
UniGeneiHs.115617.

Genome annotation databases

EnsembliENST00000274368; ENSP00000274368; ENSG00000145708.
GeneIDi1393.
KEGGihsa:1393.
UCSCiuc003ker.3. human.

Polymorphism databases

DMDMi544099.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X58022 mRNA. Translation: CAA41086.1 . Sequence problems.
S60697 Genomic DNA. Translation: AAD13916.1 .
CR541666 mRNA. Translation: CAG46467.1 .
AK223457 mRNA. Translation: BAD97177.1 .
CH471084 Genomic DNA. Translation: EAW95786.1 .
BC018038 mRNA. Translation: AAH18038.1 .
CCDSi CCDS4034.1.
PIRi S13640.
RefSeqi NP_001873.2. NM_001882.3.
UniGenei Hs.115617.

3D structure databases

ProteinModelPortali P24387.
ModBasei Search...

Protein-protein interaction databases

BioGridi 107783. 1 interaction.
STRINGi 9606.ENSP00000274368.

Chemistry

ChEMBLi CHEMBL5930.

PTM databases

PhosphoSitei P24387.

Polymorphism databases

DMDMi 544099.

Proteomic databases

PaxDbi P24387.
PeptideAtlasi P24387.
PRIDEi P24387.

Protocols and materials databases

DNASUi 1393.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000274368 ; ENSP00000274368 ; ENSG00000145708 .
GeneIDi 1393.
KEGGi hsa:1393.
UCSCi uc003ker.3. human.

Organism-specific databases

CTDi 1393.
GeneCardsi GC05P076248.
HGNCi HGNC:2356. CRHBP.
HPAi HPA046120.
MIMi 122559. gene.
neXtProti NX_P24387.
PharmGKBi PA26873.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG81351.
HOGENOMi HOG000004819.
HOVERGENi HBG051117.
InParanoidi P24387.
OMAi IHYDLVS.
OrthoDBi EOG7TXKH2.
PhylomeDBi P24387.
TreeFami TF105383.

Miscellaneous databases

GeneWikii CRHBP.
GenomeRNAii 1393.
NextBioi 5699.
PROi P24387.
SOURCEi Search...

Gene expression databases

ArrayExpressi P24387.
Bgeei P24387.
CleanExi HS_CRHBP.
Genevestigatori P24387.

Family and domain databases

InterProi IPR008435. CRF-bd.
IPR000859. CUB_dom.
[Graphical view ]
PANTHERi PTHR10278. PTHR10278. 1 hit.
Pfami PF05428. CRF-BP. 1 hit.
[Graphical view ]
PIRSFi PIRSF009279. CRF_bd. 1 hit.
SUPFAMi SSF49854. SSF49854. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of the cDNAs for human and rat corticotropin releasing factor-binding proteins."
    Potter E., Behan D.P., Fischer W.H., Linton E.A., Lowry P.J., Vale W.W.
    Nature 349:423-426(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Tissue: Liver.
  2. "Assignment of disulfide bonds in corticotropin-releasing factor-binding protein."
    Fischer W.H., Behan D.P., Park M., Potter E., Lowry P.J., Vale W.W.
    J. Biol. Chem. 269:4313-4316(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION TO 47-48 AND 248, DISULFIDE BONDS.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Hippocampus.
  7. "Cloning and structure of the human corticotrophin releasing factor-binding protein gene (CRHBP)."
    Behan D.P., Potter E., Lewis K.A., Jenkins N.A., Copeland N.G., Lowry P.J., Vale W.W.
    Genomics 16:63-68(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-27.

Entry informationi

Entry nameiCRHBP_HUMAN
AccessioniPrimary (citable) accession number: P24387
Secondary accession number(s): Q53F32, Q6FHT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: June 1, 1994
Last modified: July 9, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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