Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P24387 (CRHBP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Corticotropin-releasing factor-binding protein

Short name=CRF-BP
Short name=CRF-binding protein
Alternative name(s):
Corticotropin-releasing hormone-binding protein
Short name=CRH-BP
Gene names
Name:CRHBP
Synonyms:CRFBP
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length322 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.

Subcellular location

Secreted.

Sequence similarities

Belongs to the CRF-binding protein family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processbehavioral response to ethanol

Inferred from mutant phenotype PubMed 21039637. Source: UniProtKB

cellular response to cAMP

Inferred from sequence or structural similarity. Source: UniProtKB

cellular response to calcium ion

Inferred from sequence or structural similarity. Source: UniProtKB

cellular response to cocaine

Inferred from sequence or structural similarity. Source: UniProtKB

cellular response to drug

Inferred from sequence or structural similarity. Source: UniProtKB

cellular response to estradiol stimulus

Inferred from direct assay PubMed 15345745. Source: UniProtKB

cellular response to estrogen stimulus

Inferred from direct assay PubMed 15345745. Source: UniProtKB

cellular response to gonadotropin-releasing hormone

Inferred from sequence or structural similarity. Source: UniProtKB

cellular response to potassium ion

Inferred from direct assay PubMed 21624661. Source: UniProtKB

cellular response to stress

Inferred from mutant phenotype PubMed 21039637. Source: UniProtKB

cellular response to tumor necrosis factor

Inferred from direct assay PubMed 15345745. Source: UniProtKB

female pregnancy

Inferred from direct assay PubMed 18559919. Source: UniProtKB

hormone metabolic process

Inferred from electronic annotation. Source: Ensembl

hormone-mediated signaling pathway

Inferred from direct assay PubMed 18234674. Source: UniProtKB

inflammatory response

Inferred from direct assay PubMed 18559919. Source: UniProtKB

learning or memory

Traceable author statement PubMed 7477348. Source: UniProtKB

maternal aggressive behavior

Inferred from electronic annotation. Source: Ensembl

negative regulation of corticotropin secretion

Inferred from direct assay Ref.1. Source: UniProtKB

negative regulation of corticotropin-releasing hormone receptor activity

Inferred from direct assay PubMed 18234674. Source: UniProtKB

regulated secretory pathway

Inferred from direct assay PubMed 21624661. Source: UniProtKB

regulation of N-methyl-D-aspartate selective glutamate receptor activity

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of corticotropin secretion

Inferred from direct assay PubMed 13150566. Source: UniProtKB

signal transduction

Traceable author statement PubMed 7477348. Source: UniProtKB

synaptic transmission, dopaminergic

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentaxon terminus

Inferred from sequence or structural similarity. Source: UniProtKB

dendrite

Inferred from sequence or structural similarity. Source: UniProtKB

dense core granule

Inferred from sequence or structural similarity. Source: UniProtKB

extracellular space

Inferred from direct assay Ref.1PubMed 18559919. Source: UniProtKB

intracellular

Inferred from sequence or structural similarity. Source: UniProtKB

microtubule

Inferred from sequence or structural similarity. Source: UniProtKB

multivesicular body

Inferred from sequence or structural similarity. Source: UniProtKB

nucleus

Inferred from sequence or structural similarity. Source: UniProtKB

perikaryon

Inferred from sequence or structural similarity. Source: UniProtKB

secondary lysosome

Inferred from sequence or structural similarity. Source: UniProtKB

secretory granule

Inferred from direct assay PubMed 21624661. Source: UniProtKB

varicosity

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functioncorticotropin-releasing hormone binding

Inferred from direct assay Ref.1. Source: UniProtKB

peptide binding

Inferred from sequence or structural similarity. Source: UniProtKB

protein binding

Inferred from physical interaction PubMed 18234674. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424
Chain25 – 322298Corticotropin-releasing factor-binding protein
PRO_0000020994

Amino acid modifications

Glycosylation2041N-linked (GlcNAc...) Potential
Disulfide bond60 ↔ 81 Ref.2
Disulfide bond104 ↔ 141 Ref.2
Disulfide bond183 ↔ 205 Ref.2
Disulfide bond237 ↔ 264 Ref.2
Disulfide bond277 ↔ 318 Ref.2

Experimental info

Sequence conflict2791N → D in BAD97177. Ref.4

Sequences

Sequence LengthMass (Da)Tools
P24387 [UniParc].

Last modified June 1, 1994. Version 2.
Checksum: 771A894BE06039BD

FASTA32236,144
        10         20         30         40         50         60 
MSPNFKLQCH FILIFLTALR GESRYLELRE AADYDPFLLF SANLKRELAG EQPYRRALRC 

        70         80         90        100        110        120 
LDMLSLQGQF TFTADRPQLH CAAFFISEPE EFITIHYDQV SIDCQGGDFL KVFDGWILKG 

       130        140        150        160        170        180 
EKFPSSQDHP LPSAERYIDF CESGLSRRSI RSSQNVAMIF FRVHEPGNGF TLTIKTDPNL 

       190        200        210        220        230        240 
FPCNVISQTP NGKFTLVVPH QHRNCSFSII YPVVIKISDL TLGHVNGLQL KKSSAGCEGI 

       250        260        270        280        290        300 
GDFVELLGGT GLDPSKMTPL ADLCYPFHGP AQMKVGCDNT VVRMVSSGKH VNRVTFEYRQ 

       310        320 
LEPYELENPN GNSIGEFCLS GL 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of the cDNAs for human and rat corticotropin releasing factor-binding proteins."
Potter E., Behan D.P., Fischer W.H., Linton E.A., Lowry P.J., Vale W.W.
Nature 349:423-426(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
Tissue: Liver.
[2]"Assignment of disulfide bonds in corticotropin-releasing factor-binding protein."
Fischer W.H., Behan D.P., Park M., Potter E., Lowry P.J., Vale W.W.
J. Biol. Chem. 269:4313-4316(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION TO 47-48 AND 248, DISULFIDE BONDS.
[3]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Hippocampus.
[7]"Cloning and structure of the human corticotrophin releasing factor-binding protein gene (CRHBP)."
Behan D.P., Potter E., Lewis K.A., Jenkins N.A., Copeland N.G., Lowry P.J., Vale W.W.
Genomics 16:63-68(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-27.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X58022 mRNA. Translation: CAA41086.1. Sequence problems.
S60697 Genomic DNA. Translation: AAD13916.1.
CR541666 mRNA. Translation: CAG46467.1.
AK223457 mRNA. Translation: BAD97177.1.
CH471084 Genomic DNA. Translation: EAW95786.1.
BC018038 mRNA. Translation: AAH18038.1.
CCDSCCDS4034.1.
PIRS13640.
RefSeqNP_001873.2. NM_001882.3.
UniGeneHs.115617.

3D structure databases

ProteinModelPortalP24387.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107783. 1 interaction.
STRING9606.ENSP00000274368.

Chemistry

ChEMBLCHEMBL5930.

PTM databases

PhosphoSiteP24387.

Polymorphism databases

DMDM544099.

Proteomic databases

PaxDbP24387.
PeptideAtlasP24387.
PRIDEP24387.

Protocols and materials databases

DNASU1393.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000274368; ENSP00000274368; ENSG00000145708.
GeneID1393.
KEGGhsa:1393.
UCSCuc003ker.3. human.

Organism-specific databases

CTD1393.
GeneCardsGC05P076248.
HGNCHGNC:2356. CRHBP.
HPAHPA046120.
MIM122559. gene.
neXtProtNX_P24387.
PharmGKBPA26873.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG81351.
HOGENOMHOG000004819.
HOVERGENHBG051117.
InParanoidP24387.
OMAIHYDLVS.
OrthoDBEOG7TXKH2.
PhylomeDBP24387.
TreeFamTF105383.

Gene expression databases

ArrayExpressP24387.
BgeeP24387.
CleanExHS_CRHBP.
GenevestigatorP24387.

Family and domain databases

InterProIPR008435. CRF-bd.
IPR000859. CUB_dom.
[Graphical view]
PANTHERPTHR10278. PTHR10278. 1 hit.
PfamPF05428. CRF-BP. 1 hit.
[Graphical view]
PIRSFPIRSF009279. CRF_bd. 1 hit.
SUPFAMSSF49854. SSF49854. 1 hit.
ProtoNetSearch...

Other

GeneWikiCRHBP.
GenomeRNAi1393.
NextBio5699.
PROP24387.
SOURCESearch...

Entry information

Entry nameCRHBP_HUMAN
AccessionPrimary (citable) accession number: P24387
Secondary accession number(s): Q53F32, Q6FHT5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: June 1, 1994
Last modified: July 9, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM