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Protein

Corticotropin-releasing factor-binding protein

Gene

CRHBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.

GO - Molecular functioni

  • corticotropin-releasing hormone binding Source: UniProtKB
  • peptide binding Source: UniProtKB

GO - Biological processi

  • behavioral response to ethanol Source: UniProtKB
  • cellular response to calcium ion Source: UniProtKB
  • cellular response to cAMP Source: UniProtKB
  • cellular response to cocaine Source: UniProtKB
  • cellular response to drug Source: UniProtKB
  • cellular response to estradiol stimulus Source: UniProtKB
  • cellular response to estrogen stimulus Source: UniProtKB
  • cellular response to gonadotropin-releasing hormone Source: UniProtKB
  • cellular response to potassium ion Source: UniProtKB
  • cellular response to stress Source: UniProtKB
  • cellular response to tumor necrosis factor Source: UniProtKB
  • female pregnancy Source: UniProtKB
  • hormone-mediated signaling pathway Source: UniProtKB
  • hormone metabolic process Source: Ensembl
  • inflammatory response Source: UniProtKB
  • learning or memory Source: UniProtKB
  • maternal aggressive behavior Source: Ensembl
  • negative regulation of corticotropin-releasing hormone receptor activity Source: UniProtKB
  • negative regulation of corticotropin secretion Source: UniProtKB
  • regulated exocytosis Source: UniProtKB
  • regulation of corticotropin secretion Source: UniProtKB
  • regulation of N-methyl-D-aspartate selective glutamate receptor activity Source: UniProtKB
  • signal transduction Source: UniProtKB
  • synaptic transmission, dopaminergic Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000145708-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Corticotropin-releasing factor-binding protein
Short name:
CRF-BP
Short name:
CRF-binding protein
Alternative name(s):
Corticotropin-releasing hormone-binding protein
Short name:
CRH-BP
Gene namesi
Name:CRHBP
Synonyms:CRFBP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:2356. CRHBP.

Subcellular locationi

GO - Cellular componenti

  • axon terminus Source: UniProtKB
  • dendrite Source: UniProtKB
  • dense core granule Source: UniProtKB
  • extracellular space Source: UniProtKB
  • intracellular Source: UniProtKB
  • microtubule Source: UniProtKB
  • multivesicular body Source: UniProtKB
  • nucleus Source: UniProtKB
  • perikaryon Source: UniProtKB
  • secondary lysosome Source: UniProtKB
  • secretory granule Source: UniProtKB
  • varicosity Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi1393.
OpenTargetsiENSG00000145708.
PharmGKBiPA26873.

Chemistry databases

ChEMBLiCHEMBL5930.

Polymorphism and mutation databases

BioMutaiCRHBP.
DMDMi544099.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Add BLAST24
ChainiPRO_000002099425 – 322Corticotropin-releasing factor-binding proteinAdd BLAST298

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi60 ↔ 811 Publication
Disulfide bondi104 ↔ 1411 Publication
Disulfide bondi183 ↔ 2051 Publication
Glycosylationi204N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi237 ↔ 2641 Publication
Disulfide bondi277 ↔ 3181 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP24387.
PeptideAtlasiP24387.
PRIDEiP24387.

PTM databases

iPTMnetiP24387.
PhosphoSitePlusiP24387.

Expressioni

Gene expression databases

BgeeiENSG00000145708.
CleanExiHS_CRHBP.
ExpressionAtlasiP24387. baseline and differential.
GenevisibleiP24387. HS.

Organism-specific databases

HPAiHPA046120.

Interactioni

Protein-protein interaction databases

BioGridi107783. 12 interactors.
STRINGi9606.ENSP00000274368.

Chemistry databases

BindingDBiP24387.

Structurei

3D structure databases

ProteinModelPortaliP24387.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CRF-binding protein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410II3D. Eukaryota.
ENOG4111JUQ. LUCA.
GeneTreeiENSGT00390000001362.
HOGENOMiHOG000004819.
HOVERGENiHBG051117.
InParanoidiP24387.
OMAiIHYDLVS.
OrthoDBiEOG091G094Q.
PhylomeDBiP24387.
TreeFamiTF105383.

Family and domain databases

Gene3Di2.60.120.290. 1 hit.
InterProiIPR008435. CRF-bd.
IPR000859. CUB_dom.
[Graphical view]
PANTHERiPTHR10278:SF0. PTHR10278:SF0. 1 hit.
PfamiPF05428. CRF-BP. 1 hit.
[Graphical view]
PIRSFiPIRSF009279. CRF_bd. 1 hit.
SUPFAMiSSF49854. SSF49854. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24387-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPNFKLQCH FILIFLTALR GESRYLELRE AADYDPFLLF SANLKRELAG
60 70 80 90 100
EQPYRRALRC LDMLSLQGQF TFTADRPQLH CAAFFISEPE EFITIHYDQV
110 120 130 140 150
SIDCQGGDFL KVFDGWILKG EKFPSSQDHP LPSAERYIDF CESGLSRRSI
160 170 180 190 200
RSSQNVAMIF FRVHEPGNGF TLTIKTDPNL FPCNVISQTP NGKFTLVVPH
210 220 230 240 250
QHRNCSFSII YPVVIKISDL TLGHVNGLQL KKSSAGCEGI GDFVELLGGT
260 270 280 290 300
GLDPSKMTPL ADLCYPFHGP AQMKVGCDNT VVRMVSSGKH VNRVTFEYRQ
310 320
LEPYELENPN GNSIGEFCLS GL
Length:322
Mass (Da):36,144
Last modified:June 1, 1994 - v2
Checksum:i771A894BE06039BD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti279N → D in BAD97177 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58022 mRNA. Translation: CAA41086.1. Sequence problems.
S60697 Genomic DNA. Translation: AAD13916.1.
CR541666 mRNA. Translation: CAG46467.1.
AK223457 mRNA. Translation: BAD97177.1.
CH471084 Genomic DNA. Translation: EAW95786.1.
BC018038 mRNA. Translation: AAH18038.1.
CCDSiCCDS4034.1.
PIRiS13640.
RefSeqiNP_001873.2. NM_001882.3.
UniGeneiHs.115617.

Genome annotation databases

EnsembliENST00000274368; ENSP00000274368; ENSG00000145708.
GeneIDi1393.
KEGGihsa:1393.
UCSCiuc003ker.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58022 mRNA. Translation: CAA41086.1. Sequence problems.
S60697 Genomic DNA. Translation: AAD13916.1.
CR541666 mRNA. Translation: CAG46467.1.
AK223457 mRNA. Translation: BAD97177.1.
CH471084 Genomic DNA. Translation: EAW95786.1.
BC018038 mRNA. Translation: AAH18038.1.
CCDSiCCDS4034.1.
PIRiS13640.
RefSeqiNP_001873.2. NM_001882.3.
UniGeneiHs.115617.

3D structure databases

ProteinModelPortaliP24387.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107783. 12 interactors.
STRINGi9606.ENSP00000274368.

Chemistry databases

BindingDBiP24387.
ChEMBLiCHEMBL5930.

PTM databases

iPTMnetiP24387.
PhosphoSitePlusiP24387.

Polymorphism and mutation databases

BioMutaiCRHBP.
DMDMi544099.

Proteomic databases

PaxDbiP24387.
PeptideAtlasiP24387.
PRIDEiP24387.

Protocols and materials databases

DNASUi1393.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000274368; ENSP00000274368; ENSG00000145708.
GeneIDi1393.
KEGGihsa:1393.
UCSCiuc003ker.4. human.

Organism-specific databases

CTDi1393.
DisGeNETi1393.
GeneCardsiCRHBP.
HGNCiHGNC:2356. CRHBP.
HPAiHPA046120.
MIMi122559. gene.
neXtProtiNX_P24387.
OpenTargetsiENSG00000145708.
PharmGKBiPA26873.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II3D. Eukaryota.
ENOG4111JUQ. LUCA.
GeneTreeiENSGT00390000001362.
HOGENOMiHOG000004819.
HOVERGENiHBG051117.
InParanoidiP24387.
OMAiIHYDLVS.
OrthoDBiEOG091G094Q.
PhylomeDBiP24387.
TreeFamiTF105383.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000145708-MONOMER.

Miscellaneous databases

GeneWikiiCRHBP.
GenomeRNAii1393.
PROiP24387.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000145708.
CleanExiHS_CRHBP.
ExpressionAtlasiP24387. baseline and differential.
GenevisibleiP24387. HS.

Family and domain databases

Gene3Di2.60.120.290. 1 hit.
InterProiIPR008435. CRF-bd.
IPR000859. CUB_dom.
[Graphical view]
PANTHERiPTHR10278:SF0. PTHR10278:SF0. 1 hit.
PfamiPF05428. CRF-BP. 1 hit.
[Graphical view]
PIRSFiPIRSF009279. CRF_bd. 1 hit.
SUPFAMiSSF49854. SSF49854. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCRHBP_HUMAN
AccessioniPrimary (citable) accession number: P24387
Secondary accession number(s): Q53F32, Q6FHT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: June 1, 1994
Last modified: November 30, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.