P24387 (CRHBP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Corticotropin-releasing factor-binding protein
Short name=CRF-BP
Short name=CRF-binding protein

Alternative name(s):
Corticotropin-releasing hormone-binding protein
Short name=CRH-BP

Gene names

Name:	CRHBP
Synonyms:	CRFBP

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	322 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.
Subcellular location	Secreted.
Sequence similarities	Belongs to the CRF-binding protein family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	behavioral response to ethanol Inferred from mutant phenotype PubMed 21039637. Source: UniProtKB cellular response to cAMP Inferred from sequence or structural similarity. Source: UniProtKB cellular response to calcium ion Inferred from sequence or structural similarity. Source: UniProtKB cellular response to cocaine Inferred from sequence or structural similarity. Source: UniProtKB cellular response to drug Inferred from sequence or structural similarity. Source: UniProtKB cellular response to estradiol stimulus Inferred from direct assay PubMed 15345745. Source: UniProtKB cellular response to gonadotropin-releasing hormone Inferred from sequence or structural similarity. Source: UniProtKB cellular response to potassium ion Inferred from direct assay PubMed 21624661. Source: UniProtKB cellular response to stress Inferred from mutant phenotype PubMed 21039637. Source: UniProtKB cellular response to tumor necrosis factor Inferred from direct assay PubMed 15345745. Source: UniProtKB female pregnancy Inferred from direct assay PubMed 18559919. Source: UniProtKB hormone metabolic process Inferred from electronic annotation. Source: Compara hormone-mediated signaling pathway Inferred from direct assay PubMed 18234674. Source: UniProtKB inflammatory response Inferred from direct assay PubMed 18559919. Source: UniProtKB learning or memory Traceable author statement PubMed 7477348. Source: UniProtKB maternal aggressive behavior Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of corticotropin secretion Inferred from direct assay Ref.1. Source: UniProtKB negative regulation of corticotropin-releasing hormone receptor activity Inferred from direct assay PubMed 18234674. Source: UniProtKB regulated secretory pathway Inferred from direct assay PubMed 21624661. Source: UniProtKB regulation of N-methyl-D-aspartate selective glutamate receptor activity Inferred from sequence or structural similarity. Source: UniProtKB regulation of behavior Inferred from mutant phenotype PubMed 17599466PubMed 17728670PubMed 21039637. Source: UniProtKB synaptic transmission, dopaminergic Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	axon terminus Inferred from sequence or structural similarity. Source: UniProtKB dendrite Inferred from sequence or structural similarity. Source: UniProtKB dense core granule Inferred from sequence or structural similarity. Source: UniProtKB extracellular space Inferred from direct assay Ref.1PubMed 18559919. Source: UniProtKB microtubule Inferred from sequence or structural similarity. Source: UniProtKB multivesicular body Inferred from sequence or structural similarity. Source: UniProtKB nucleus Inferred from sequence or structural similarity. Source: UniProtKB perikaryon Inferred from sequence or structural similarity. Source: UniProtKB secondary lysosome Inferred from sequence or structural similarity. Source: UniProtKB varicosity Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	corticotropin-releasing hormone binding Inferred from direct assay Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24
	Chain	25 – 322	298	Corticotropin-releasing factor-binding protein		PRO_0000020994
Amino acid modifications
	Glycosylation	204	1	N-linked (GlcNAc...) Potential
	Disulfide bond	60 ↔ 81		Ref.2
	Disulfide bond	104 ↔ 141		Ref.2
	Disulfide bond	183 ↔ 205		Ref.2
	Disulfide bond	237 ↔ 264		Ref.2
	Disulfide bond	277 ↔ 318		Ref.2
Experimental info
	Sequence conflict	279	1	N → D in BAD97177. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	P24387 [UniParc]. Last modified June 1, 1994. Version 2. Checksum: 771A894BE06039BD	FASTA	322	36,144
	10 20 30 40 50 60 MSPNFKLQCH FILIFLTALR GESRYLELRE AADYDPFLLF SANLKRELAG EQPYRRALRC 70 80 90 100 110 120 LDMLSLQGQF TFTADRPQLH CAAFFISEPE EFITIHYDQV SIDCQGGDFL KVFDGWILKG 130 140 150 160 170 180 EKFPSSQDHP LPSAERYIDF CESGLSRRSI RSSQNVAMIF FRVHEPGNGF TLTIKTDPNL 190 200 210 220 230 240 FPCNVISQTP NGKFTLVVPH QHRNCSFSII YPVVIKISDL TLGHVNGLQL KKSSAGCEGI 250 260 270 280 290 300 GDFVELLGGT GLDPSKMTPL ADLCYPFHGP AQMKVGCDNT VVRMVSSGKH VNRVTFEYRQ 310 320 LEPYELENPN GNSIGEFCLS GL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of the cDNAs for human and rat corticotropin releasing factor-binding proteins." Potter E., Behan D.P., Fischer W.H., Linton E.A., Lowry P.J., Vale W.W. Nature 349:423-426(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE. Tissue: Liver.
[2]	"Assignment of disulfide bonds in corticotropin-releasing factor-binding protein." Fischer W.H., Behan D.P., Park M., Potter E., Lowry P.J., Vale W.W. J. Biol. Chem. 269:4313-4316(1994) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION TO 47-48 AND 248, DISULFIDE BONDS.
[3]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Hippocampus.
[7]	"Cloning and structure of the human corticotrophin releasing factor-binding protein gene (CRHBP)." Behan D.P., Potter E., Lewis K.A., Jenkins N.A., Copeland N.G., Lowry P.J., Vale W.W. Genomics 16:63-68(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-27.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X58022 mRNA. Translation: CAA41086.1. Sequence problems. S60697 Genomic DNA. Translation: AAD13916.1. CR541666 mRNA. Translation: CAG46467.1. AK223457 mRNA. Translation: BAD97177.1. CH471084 Genomic DNA. Translation: EAW95786.1. BC018038 mRNA. Translation: AAH18038.1.
IPI	IPI00306844.
PIR	S13640.
RefSeq	NP_001873.2. NM_001882.3.
UniGene	Hs.115617.
3D structure databases
ProteinModelPortal	P24387.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000274368.
PTM databases
PhosphoSite	P24387.
Polymorphism databases
DMDM	544099.
Proteomic databases
PaxDb	P24387.
PeptideAtlas	P24387.
PRIDE	P24387.
Protocols and materials databases
DNASU	1393.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000274368; ENSP00000274368; ENSG00000145708.
GeneID	1393.
KEGG	hsa:1393.
UCSC	uc003ker.3. human.
Organism-specific databases
CTD	1393.
GeneCards	GC05P076248.
HGNC	HGNC:2356. CRHBP.
HPA	HPA046120.
MIM	122559. gene.
neXtProt	NX_P24387.
PharmGKB	PA26873.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG81351.
HOGENOM	HOG000004819.
HOVERGEN	HBG051117.
InParanoid	P24387.
OMA	QTPNGRF.
OrthoDB	EOG4QC15W.
PhylomeDB	P24387.
Gene expression databases
ArrayExpress	P24387.
Bgee	P24387.
CleanEx	HS_CRHBP.
Genevestigator	P24387.
GermOnline	ENSG00000145708. Homo sapiens.
Family and domain databases
InterPro	IPR008435. CRF-bd. IPR000859. CUB_dom. [Graphical view]
PANTHER	PTHR10278. PTHR10278. 1 hit.
Pfam	PF05428. CRF-BP. 1 hit. [Graphical view]
PIRSF	PIRSF009279. CRF_bd. 1 hit.
SUPFAM	SSF49854. CUB. 1 hit.
ProtoNet	Search...
Other
ChEMBL	CHEMBL5930.
GenomeRNAi	1393.
NextBio	5699.
SOURCE	Search...

Entry information

Entry name

CRHBP_HUMAN

Accession

Primary (citable) accession number: P24387
Secondary accession number(s): Q53F32, Q6FHT5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
Last sequence update:	June 1, 1994
Last modified:	April 3, 2013
This is version 106 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.