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P24387

- CRHBP_HUMAN

UniProt

P24387 - CRHBP_HUMAN

Protein

Corticotropin-releasing factor-binding protein

Gene

CRHBP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 2 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.

    GO - Molecular functioni

    1. corticotropin-releasing hormone binding Source: UniProtKB
    2. peptide binding Source: UniProtKB
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. behavioral response to ethanol Source: UniProtKB
    2. cellular response to calcium ion Source: UniProtKB
    3. cellular response to cAMP Source: UniProtKB
    4. cellular response to cocaine Source: UniProtKB
    5. cellular response to drug Source: UniProtKB
    6. cellular response to estradiol stimulus Source: UniProtKB
    7. cellular response to estrogen stimulus Source: UniProtKB
    8. cellular response to gonadotropin-releasing hormone Source: UniProtKB
    9. cellular response to potassium ion Source: UniProtKB
    10. cellular response to stress Source: UniProtKB
    11. cellular response to tumor necrosis factor Source: UniProtKB
    12. female pregnancy Source: UniProtKB
    13. hormone-mediated signaling pathway Source: UniProtKB
    14. hormone metabolic process Source: Ensembl
    15. inflammatory response Source: UniProtKB
    16. learning or memory Source: UniProtKB
    17. maternal aggressive behavior Source: Ensembl
    18. negative regulation of corticotropin-releasing hormone receptor activity Source: UniProtKB
    19. negative regulation of corticotropin secretion Source: UniProtKB
    20. regulated secretory pathway Source: UniProtKB
    21. regulation of corticotropin secretion Source: UniProtKB
    22. regulation of N-methyl-D-aspartate selective glutamate receptor activity Source: UniProtKB
    23. signal transduction Source: UniProtKB
    24. synaptic transmission, dopaminergic Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Corticotropin-releasing factor-binding protein
    Short name:
    CRF-BP
    Short name:
    CRF-binding protein
    Alternative name(s):
    Corticotropin-releasing hormone-binding protein
    Short name:
    CRH-BP
    Gene namesi
    Name:CRHBP
    Synonyms:CRFBP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:2356. CRHBP.

    Subcellular locationi

    GO - Cellular componenti

    1. axon terminus Source: UniProtKB
    2. dendrite Source: UniProtKB
    3. dense core granule Source: UniProtKB
    4. extracellular space Source: UniProtKB
    5. intracellular Source: UniProtKB
    6. microtubule Source: UniProtKB
    7. multivesicular body Source: UniProtKB
    8. nucleus Source: UniProtKB
    9. perikaryon Source: UniProtKB
    10. secondary lysosome Source: UniProtKB
    11. secretory granule Source: UniProtKB
    12. varicosity Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26873.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Add
    BLAST
    Chaini25 – 322298Corticotropin-releasing factor-binding proteinPRO_0000020994Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi60 ↔ 811 Publication
    Disulfide bondi104 ↔ 1411 Publication
    Disulfide bondi183 ↔ 2051 Publication
    Glycosylationi204 – 2041N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi237 ↔ 2641 Publication
    Disulfide bondi277 ↔ 3181 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP24387.
    PeptideAtlasiP24387.
    PRIDEiP24387.

    PTM databases

    PhosphoSiteiP24387.

    Expressioni

    Gene expression databases

    ArrayExpressiP24387.
    BgeeiP24387.
    CleanExiHS_CRHBP.
    GenevestigatoriP24387.

    Organism-specific databases

    HPAiHPA046120.

    Interactioni

    Protein-protein interaction databases

    BioGridi107783. 1 interaction.
    STRINGi9606.ENSP00000274368.

    Structurei

    3D structure databases

    ProteinModelPortaliP24387.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CRF-binding protein family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG81351.
    HOGENOMiHOG000004819.
    HOVERGENiHBG051117.
    InParanoidiP24387.
    OMAiIHYDLVS.
    OrthoDBiEOG7TXKH2.
    PhylomeDBiP24387.
    TreeFamiTF105383.

    Family and domain databases

    InterProiIPR008435. CRF-bd.
    IPR000859. CUB_dom.
    [Graphical view]
    PANTHERiPTHR10278. PTHR10278. 1 hit.
    PfamiPF05428. CRF-BP. 1 hit.
    [Graphical view]
    PIRSFiPIRSF009279. CRF_bd. 1 hit.
    SUPFAMiSSF49854. SSF49854. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P24387-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSPNFKLQCH FILIFLTALR GESRYLELRE AADYDPFLLF SANLKRELAG    50
    EQPYRRALRC LDMLSLQGQF TFTADRPQLH CAAFFISEPE EFITIHYDQV 100
    SIDCQGGDFL KVFDGWILKG EKFPSSQDHP LPSAERYIDF CESGLSRRSI 150
    RSSQNVAMIF FRVHEPGNGF TLTIKTDPNL FPCNVISQTP NGKFTLVVPH 200
    QHRNCSFSII YPVVIKISDL TLGHVNGLQL KKSSAGCEGI GDFVELLGGT 250
    GLDPSKMTPL ADLCYPFHGP AQMKVGCDNT VVRMVSSGKH VNRVTFEYRQ 300
    LEPYELENPN GNSIGEFCLS GL 322
    Length:322
    Mass (Da):36,144
    Last modified:June 1, 1994 - v2
    Checksum:i771A894BE06039BD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti279 – 2791N → D in BAD97177. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X58022 mRNA. Translation: CAA41086.1. Sequence problems.
    S60697 Genomic DNA. Translation: AAD13916.1.
    CR541666 mRNA. Translation: CAG46467.1.
    AK223457 mRNA. Translation: BAD97177.1.
    CH471084 Genomic DNA. Translation: EAW95786.1.
    BC018038 mRNA. Translation: AAH18038.1.
    CCDSiCCDS4034.1.
    PIRiS13640.
    RefSeqiNP_001873.2. NM_001882.3.
    UniGeneiHs.115617.

    Genome annotation databases

    EnsembliENST00000274368; ENSP00000274368; ENSG00000145708.
    GeneIDi1393.
    KEGGihsa:1393.
    UCSCiuc003ker.3. human.

    Polymorphism databases

    DMDMi544099.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X58022 mRNA. Translation: CAA41086.1 . Sequence problems.
    S60697 Genomic DNA. Translation: AAD13916.1 .
    CR541666 mRNA. Translation: CAG46467.1 .
    AK223457 mRNA. Translation: BAD97177.1 .
    CH471084 Genomic DNA. Translation: EAW95786.1 .
    BC018038 mRNA. Translation: AAH18038.1 .
    CCDSi CCDS4034.1.
    PIRi S13640.
    RefSeqi NP_001873.2. NM_001882.3.
    UniGenei Hs.115617.

    3D structure databases

    ProteinModelPortali P24387.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107783. 1 interaction.
    STRINGi 9606.ENSP00000274368.

    Chemistry

    ChEMBLi CHEMBL5930.

    PTM databases

    PhosphoSitei P24387.

    Polymorphism databases

    DMDMi 544099.

    Proteomic databases

    PaxDbi P24387.
    PeptideAtlasi P24387.
    PRIDEi P24387.

    Protocols and materials databases

    DNASUi 1393.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000274368 ; ENSP00000274368 ; ENSG00000145708 .
    GeneIDi 1393.
    KEGGi hsa:1393.
    UCSCi uc003ker.3. human.

    Organism-specific databases

    CTDi 1393.
    GeneCardsi GC05P076248.
    HGNCi HGNC:2356. CRHBP.
    HPAi HPA046120.
    MIMi 122559. gene.
    neXtProti NX_P24387.
    PharmGKBi PA26873.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG81351.
    HOGENOMi HOG000004819.
    HOVERGENi HBG051117.
    InParanoidi P24387.
    OMAi IHYDLVS.
    OrthoDBi EOG7TXKH2.
    PhylomeDBi P24387.
    TreeFami TF105383.

    Miscellaneous databases

    GeneWikii CRHBP.
    GenomeRNAii 1393.
    NextBioi 5699.
    PROi P24387.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P24387.
    Bgeei P24387.
    CleanExi HS_CRHBP.
    Genevestigatori P24387.

    Family and domain databases

    InterProi IPR008435. CRF-bd.
    IPR000859. CUB_dom.
    [Graphical view ]
    PANTHERi PTHR10278. PTHR10278. 1 hit.
    Pfami PF05428. CRF-BP. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF009279. CRF_bd. 1 hit.
    SUPFAMi SSF49854. SSF49854. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of the cDNAs for human and rat corticotropin releasing factor-binding proteins."
      Potter E., Behan D.P., Fischer W.H., Linton E.A., Lowry P.J., Vale W.W.
      Nature 349:423-426(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
      Tissue: Liver.
    2. "Assignment of disulfide bonds in corticotropin-releasing factor-binding protein."
      Fischer W.H., Behan D.P., Park M., Potter E., Lowry P.J., Vale W.W.
      J. Biol. Chem. 269:4313-4316(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION TO 47-48 AND 248, DISULFIDE BONDS.
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Hippocampus.
    7. "Cloning and structure of the human corticotrophin releasing factor-binding protein gene (CRHBP)."
      Behan D.P., Potter E., Lewis K.A., Jenkins N.A., Copeland N.G., Lowry P.J., Vale W.W.
      Genomics 16:63-68(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-27.

    Entry informationi

    Entry nameiCRHBP_HUMAN
    AccessioniPrimary (citable) accession number: P24387
    Secondary accession number(s): Q53F32, Q6FHT5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 117 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3