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P24385

- CCND1_HUMAN

UniProt

P24385 - CCND1_HUMAN

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Protein

G1/S-specific cyclin-D1

Gene

CCND1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner.4 Publications

GO - Molecular functioni

  1. cyclin-dependent protein serine/threonine kinase regulator activity Source: Ensembl
  2. enzyme binding Source: UniProtKB
  3. histone deacetylase binding Source: UniProtKB
  4. proline-rich region binding Source: UniProtKB
  5. protein kinase activity Source: Ensembl
  6. protein kinase binding Source: UniProtKB
  7. transcription corepressor activity Source: UniProtKB
  8. transcription factor binding Source: UniProtKB

GO - Biological processi

  1. canonical Wnt signaling pathway Source: Ensembl
  2. cell division Source: UniProtKB-KW
  3. cellular response to DNA damage stimulus Source: UniProtKB
  4. endoplasmic reticulum unfolded protein response Source: Ensembl
  5. fat cell differentiation Source: Ensembl
  6. G1/S transition of mitotic cell cycle Source: UniProtKB
  7. lactation Source: Ensembl
  8. Leydig cell differentiation Source: Ensembl
  9. liver development Source: Ensembl
  10. mammary gland alveolus development Source: Ensembl
  11. mammary gland epithelial cell proliferation Source: Ensembl
  12. mitotic cell cycle Source: Reactome
  13. mitotic G1 DNA damage checkpoint Source: UniProtKB
  14. negative regulation of cell cycle arrest Source: UniProtKB
  15. negative regulation of epithelial cell differentiation Source: Ensembl
  16. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  17. negative regulation of Wnt signaling pathway Source: Ensembl
  18. Notch signaling pathway Source: Reactome
  19. organ regeneration Source: Ensembl
  20. positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: BHF-UCL
  21. positive regulation of G2/M transition of mitotic cell cycle Source: UniProtKB
  22. positive regulation of mammary gland epithelial cell proliferation Source: Ensembl
  23. positive regulation of protein phosphorylation Source: BHF-UCL
  24. re-entry into mitotic cell cycle Source: Ensembl
  25. response to calcium ion Source: Ensembl
  26. response to corticosterone Source: Ensembl
  27. response to drug Source: UniProtKB
  28. response to estrogen Source: Ensembl
  29. response to ethanol Source: Ensembl
  30. response to iron ion Source: Ensembl
  31. response to magnesium ion Source: Ensembl
  32. response to organonitrogen compound Source: Ensembl
  33. response to UV-A Source: BHF-UCL
  34. response to vitamin E Source: Ensembl
  35. response to X-ray Source: Ensembl
  36. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Cyclin, Repressor

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiREACT_118568. Pre-NOTCH Transcription and Translation.
REACT_4. Ubiquitin-dependent degradation of Cyclin D1.
REACT_821. Cyclin D associated events in G1.
SignaLinkiP24385.

Names & Taxonomyi

Protein namesi
Recommended name:
G1/S-specific cyclin-D1
Alternative name(s):
B-cell lymphoma 1 protein
Short name:
BCL-1
BCL-1 oncogene
PRAD1 oncogene
Gene namesi
Name:CCND1
Synonyms:BCL1, PRAD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:1582. CCND1.

Subcellular locationi

Nucleus 1 Publication. Cytoplasm 1 Publication. Membrane 1 Publication
Note: Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members.By similarity

GO - Cellular componenti

  1. cyclin-dependent protein kinase holoenzyme complex Source: BHF-UCL
  2. cytosol Source: Reactome
  3. intracellular Source: LIFEdb
  4. membrane Source: UniProtKB-KW
  5. nucleoplasm Source: Reactome
  6. nucleus Source: UniProtKB
  7. tight junction Source: Ensembl
  8. transcriptional repressor complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving CCND1 may be a cause of B-lymphocytic malignancy, particularly mantle-cell lymphoma (MCL). Translocation t(11;14)(q13;q32) with immunoglobulin gene regions. Activation of CCND1 may be oncogenic by directly altering progression through the cell cycle.
A chromosomal aberration involving CCND1 may be a cause of parathyroid adenomas. Translocation t(11;11)(q13;p15) with the parathyroid hormone (PTH) enhancer.
Multiple myeloma (MM) [MIM:254500]: A malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia.1 Publication
Note: The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving CCND1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus.

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi286 – 2861T → A: Reduces ubiquitination and subsequent degradation by the proteasome; when associated with A-288. Abolishes ubiquitination and subsequent degradation following DNA damage. 2 Publications
Mutagenesisi288 – 2881T → A: Reduces ubiquitination and subsequent degradation by the proteasome; when associated with A-286. 1 Publication

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

MIMi254500. phenotype.
Orphaneti67038. B-cell chronic lymphocytic leukemia.
52416. Mantle cell lymphoma.
29073. Multiple myeloma.
PharmGKBiPA75.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 295295G1/S-specific cyclin-D1PRO_0000080430Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki269 – 269Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei286 – 2861Phosphothreonine1 Publication

Post-translational modificationi

Phosphorylation at Thr-286 by MAP kinases is required for ubiquitination and degradation following DNA damage. It probably plays an essential role for recognition by the FBXO31 component of SCF (SKP1-cullin-F-box) protein ligase complex.2 Publications
Ubiquitinated, primarily as 'Lys-48'-linked polyubiquitination. Ubiquitinated by a SCF (SKP1-CUL1-F-box protein) ubiquitin-protein ligase complex containing FBXO4 and CRYAB. Following DNA damage it is ubiquitinated by some SCF (SKP1-cullin-F-box) protein ligase complex containing FBXO31. SCF-type ubiquitination is dependent on Thr-286 phosphorylation (By similarity). Ubiquitinated also by UHRF2 apparently in a phosphorylation-independent manner. Ubiquitination leads to its degradation and G1 arrest. Deubiquitinated by USP2; leading to its stabilization.By similarity2 Publications

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP24385.
PaxDbiP24385.
PRIDEiP24385.

PTM databases

PhosphoSiteiP24385.

Expressioni

Gene expression databases

BgeeiP24385.
CleanExiHS_CCND1.
ExpressionAtlasiP24385. baseline and differential.
GenevestigatoriP24385.

Organism-specific databases

HPAiCAB000024.
HPA027801.

Interactioni

Subunit structurei

Interacts with FBXO4 (By similarity). Interacts with either CDK4 or CDK6 protein kinase to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Component of the ternary complex CCND1/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase activity. Interacts directly with CDKN1B. Interacts with UHRF2; the interaction ubiquitinates CCND1 and appears to occur independently of phosphorylation. Can form similar complexes with either CDKN1A or CDKN2A. Interacts with USP2. Interacts (via cyclin N-terminal domain) with INSM1 (via N-terminal region); the interaction competes with the binding of CCND1 to CDK4 during cell cycle progression and inhibits CDK4 activity. Interacts with CDK4; the interaction is prevented with the binding of CCND1 to INSM1 during cell cycle progression.By similarity8 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BRCA1P383983EBI-375001,EBI-349905
CDK4P1180211EBI-375001,EBI-295644
Cdk4P302852EBI-375001,EBI-847225From a different organism.
CDK6Q005342EBI-375001,EBI-295663
CDKN1AP389366EBI-375001,EBI-375077
CDKN1BP465272EBI-375001,EBI-519280
Ralbp1Q627962EBI-375001,EBI-3956409From a different organism.
UHRF2Q96PU44EBI-375001,EBI-625304

Protein-protein interaction databases

BioGridi107067. 77 interactions.
DIPiDIP-123N.
IntActiP24385. 28 interactions.
MINTiMINT-135422.
STRINGi9606.ENSP00000227507.

Structurei

Secondary structure

1
295
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi9 – 113
Helixi26 – 3712
Helixi44 – 474
Helixi54 – 7017
Helixi77 – 8913
Turni96 – 983
Helixi99 – 11416
Helixi121 – 1277
Turni128 – 1303
Helixi134 – 14714
Turni148 – 1503
Helixi157 – 16610
Helixi172 – 19019
Helixi194 – 1974
Helixi200 – 21819
Turni220 – 2223
Helixi224 – 2263
Helixi229 – 2379
Helixi241 – 25515
Turni256 – 2605
Beta strandi261 – 2633

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2W96X-ray2.30A1-271[»]
2W99X-ray2.80A1-271[»]
2W9FX-ray2.85A1-271[»]
2W9ZX-ray2.45A16-271[»]
ProteinModelPortaliP24385.
SMRiP24385. Positions 22-267.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP24385.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 152125Cyclin N-terminalAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi272 – 2809Poly-Glu

Sequence similaritiesi

Belongs to the cyclin family. Cyclin D subfamily.Curated
Contains 1 cyclin N-terminal domain.Curated

Phylogenomic databases

eggNOGiCOG5024.
HOGENOMiHOG000008182.
HOVERGENiHBG050837.
InParanoidiP24385.
KOiK04503.
OMAiMKETVPL.
OrthoDBiEOG7J447H.
PhylomeDBiP24385.
TreeFamiTF101004.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR014400. Cyclin_A/B/D/E/F.
IPR004367. Cyclin_C-dom.
IPR015451. Cyclin_D.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERiPTHR10177:SF67. PTHR10177:SF67. 1 hit.
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFiPIRSF001771. Cyclin_A_B_D_E. 1 hit.
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24385-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEHQLLCCEV ETIRRAYPDA NLLNDRVLRA MLKAEETCAP SVSYFKCVQK
60 70 80 90 100
EVLPSMRKIV ATWMLEVCEE QKCEEEVFPL AMNYLDRFLS LEPVKKSRLQ
110 120 130 140 150
LLGATCMFVA SKMKETIPLT AEKLCIYTDN SIRPEELLQM ELLLVNKLKW
160 170 180 190 200
NLAAMTPHDF IEHFLSKMPE AEENKQIIRK HAQTFVALCA TDVKFISNPP
210 220 230 240 250
SMVAAGSVVA AVQGLNLRSP NNFLSYYRLT RFLSRVIKCD PDCLRACQEQ
260 270 280 290
IEALLESSLR QAQQNMDPKA AEEEEEEEEE VDLACTPTDV RDVDI
Length:295
Mass (Da):33,729
Last modified:March 1, 1992 - v1
Checksum:i3CC00C9905F58D3A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti130 – 1301N → G in AAA52136. (PubMed:1827756)Curated
Sequence conflicti168 – 1692MP → IA in M74092. (PubMed:1833066)Curated
Sequence conflicti188 – 1881L → S in AAA52136. (PubMed:1827756)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59798 mRNA. Translation: CAA42470.1.
M74092 mRNA. No translation available.
M64349 mRNA. Translation: AAA52136.1.
M73554 mRNA. Translation: AAA58392.1.
Z23022 mRNA. Translation: CAA80558.1.
BT019845 mRNA. Translation: AAV38648.1.
AF511593 Genomic DNA. Translation: AAM34300.2.
BC000076 mRNA. Translation: AAH00076.1.
BC001501 mRNA. Translation: AAH01501.1.
BC014078 mRNA. Translation: AAH14078.1.
BC023620 mRNA. Translation: AAH23620.1.
BC025302 mRNA. Translation: AAH25302.1.
L09054 Genomic DNA. Translation: AAA36481.1.
CCDSiCCDS8191.1.
PIRiA38977.
RefSeqiNP_444284.1. NM_053056.2.
UniGeneiHs.523852.

Genome annotation databases

EnsembliENST00000227507; ENSP00000227507; ENSG00000110092.
GeneIDi595.
KEGGihsa:595.
UCSCiuc001opa.3. human.

Polymorphism databases

DMDMi116152.

Keywords - Coding sequence diversityi

Chromosomal rearrangement

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs
SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59798 mRNA. Translation: CAA42470.1 .
M74092 mRNA. No translation available.
M64349 mRNA. Translation: AAA52136.1 .
M73554 mRNA. Translation: AAA58392.1 .
Z23022 mRNA. Translation: CAA80558.1 .
BT019845 mRNA. Translation: AAV38648.1 .
AF511593 Genomic DNA. Translation: AAM34300.2 .
BC000076 mRNA. Translation: AAH00076.1 .
BC001501 mRNA. Translation: AAH01501.1 .
BC014078 mRNA. Translation: AAH14078.1 .
BC023620 mRNA. Translation: AAH23620.1 .
BC025302 mRNA. Translation: AAH25302.1 .
L09054 Genomic DNA. Translation: AAA36481.1 .
CCDSi CCDS8191.1.
PIRi A38977.
RefSeqi NP_444284.1. NM_053056.2.
UniGenei Hs.523852.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2W96 X-ray 2.30 A 1-271 [» ]
2W99 X-ray 2.80 A 1-271 [» ]
2W9F X-ray 2.85 A 1-271 [» ]
2W9Z X-ray 2.45 A 16-271 [» ]
ProteinModelPortali P24385.
SMRi P24385. Positions 22-267.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107067. 77 interactions.
DIPi DIP-123N.
IntActi P24385. 28 interactions.
MINTi MINT-135422.
STRINGi 9606.ENSP00000227507.

Chemistry

BindingDBi P24385.
ChEMBLi CHEMBL1907601.
DrugBanki DB01169. Arsenic trioxide.

PTM databases

PhosphoSitei P24385.

Polymorphism databases

DMDMi 116152.

Proteomic databases

MaxQBi P24385.
PaxDbi P24385.
PRIDEi P24385.

Protocols and materials databases

DNASUi 595.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000227507 ; ENSP00000227507 ; ENSG00000110092 .
GeneIDi 595.
KEGGi hsa:595.
UCSCi uc001opa.3. human.

Organism-specific databases

CTDi 595.
GeneCardsi GC11P069455.
HGNCi HGNC:1582. CCND1.
HPAi CAB000024.
HPA027801.
MIMi 168461. gene.
254500. phenotype.
neXtProti NX_P24385.
Orphaneti 67038. B-cell chronic lymphocytic leukemia.
52416. Mantle cell lymphoma.
29073. Multiple myeloma.
PharmGKBi PA75.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5024.
HOGENOMi HOG000008182.
HOVERGENi HBG050837.
InParanoidi P24385.
KOi K04503.
OMAi MKETVPL.
OrthoDBi EOG7J447H.
PhylomeDBi P24385.
TreeFami TF101004.

Enzyme and pathway databases

Reactomei REACT_118568. Pre-NOTCH Transcription and Translation.
REACT_4. Ubiquitin-dependent degradation of Cyclin D1.
REACT_821. Cyclin D associated events in G1.
SignaLinki P24385.

Miscellaneous databases

ChiTaRSi CCND1. human.
EvolutionaryTracei P24385.
GeneWikii Cyclin_D1.
GenomeRNAii 595.
NextBioi 2419.
PROi P24385.
SOURCEi Search...

Gene expression databases

Bgeei P24385.
CleanExi HS_CCND1.
ExpressionAtlasi P24385. baseline and differential.
Genevestigatori P24385.

Family and domain databases

Gene3Di 1.10.472.10. 2 hits.
InterProi IPR013763. Cyclin-like.
IPR014400. Cyclin_A/B/D/E/F.
IPR004367. Cyclin_C-dom.
IPR015451. Cyclin_D.
IPR006671. Cyclin_N.
[Graphical view ]
PANTHERi PTHR10177:SF67. PTHR10177:SF67. 1 hit.
Pfami PF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF001771. Cyclin_A_B_D_E. 1 hit.
SMARTi SM00385. CYCLIN. 1 hit.
[Graphical view ]
SUPFAMi SSF47954. SSF47954. 2 hits.
PROSITEi PS00292. CYCLINS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel cyclin encoded by a bcl1-linked candidate oncogene."
    Motokura T., Bloom T., Kim H.G., Jueppner H., Ruderman J.V., Kronenberg H.M., Arnold A.
    Nature 350:512-515(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast."
    Lew D.J., Dulic V., Reed S.I.
    Cell 66:1197-1206(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Characterization of a candidate bcl-1 gene."
    Withers D.A., Harvey R.C., Faust J.B., Melnyk O., Carey K., Meeker T.C.
    Mol. Cell. Biol. 11:4846-4853(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "Rearrangement of CCND1 (BCL1/PRAD1) 3' untranslated region in mantle-cell lymphomas and t(11q13)-associated leukemias."
    Rimokh R., Berger F., Bastard C., Klein B., French M., Archimbaud E., Rouault J.-P., Santa Lucia B., Duret L., Vuillaume M.
    Blood 83:3689-3696(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  6. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. NIEHS SNPs program
    Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Placenta.
  9. "The PRAD1/cyclin D1 proto-oncogene: genomic organization, 5' DNA sequence, and sequence of a tumor-specific rearrangement breakpoint."
    Motokura T., Arnold A.
    Genes Chromosomes Cancer 7:89-95(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-66.
    Tissue: Placenta.
  10. "CDK6 (PLSTIRE) and CDK4 (PSK-J3) are a distinct subset of the cyclin-dependent kinases that associate with cyclin D1."
    Bates S., Bonetta L., McAllan D., Parry D., Holder A., Dickson C., Peters G.
    Oncogene 9:71-79(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CDK4 AND CDK6.
  11. "Dysregulation of cyclin D1 by translocation into an IgH gamma switch region in two multiple myeloma cell lines."
    Chesi M., Bergsagel P.L., Brents L.A., Smith C.M., Gerhard D.S., Kuehl W.M.
    Blood 88:674-681(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN MULTIPLE MYELOMA.
  12. Cited for: INTERACTION WITH CDK4 IN THE CCND1-CDK4-CDKN COMPLEX, SUBCELLULAR LOCATION, FUNCTION.
  13. "Ubiquitination of free cyclin D1 is independent of phosphorylation on threonine 286."
    Germain D., Russell A., Thompson A., Hendley J.
    J. Biol. Chem. 275:12074-12079(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION, MUTAGENESIS OF THR-286 AND THR-288.
  14. "Cyclin-dependent kinases regulate the antiproliferative function of Smads."
    Matsuura I., Denissova N.G., Wang G., He D., Long J., Liu F.
    Nature 430:226-231(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF CCND1-CDK4 COMPLEX IN SMAD PHOSPHORYLATION.
  15. "INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases."
    Liu W.D., Wang H.W., Muguira M., Breslin M.B., Lan M.S.
    Biochem. J. 397:169-177(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH INSM1.
  16. "Identification of an INSM1-binding site in the insulin promoter: negative regulation of the insulin gene transcription."
    Wang H.W., Muguira M., Liu W.D., Zhang T., Chen C., Aucoin R., Breslin M.B., Lan M.S.
    J. Endocrinol. 198:29-39(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH INSM1.
  17. "Zinc finger transcription factor INSM1 interrupts cyclin D1 and CDK4 binding and induces cell cycle arrest."
    Zhang T., Liu W.D., Saunee N.A., Breslin M.B., Lan M.S.
    J. Biol. Chem. 284:5574-5581(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH INSM1 AND CDK4.
  18. "Suppression of cancer cell growth by promoting cyclin D1 degradation."
    Shan J., Zhao W., Gu W.
    Mol. Cell 36:469-476(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH USP2, UBIQUITINATION, DEUBIQUITINATION BY USP2.
  19. "F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage."
    Santra M.K., Wajapeyee N., Green M.R.
    Nature 459:722-725(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT THR-286, UBIQUITINATION, MUTAGENESIS OF THR-286.
  20. "NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor."
    Mori T., Ikeda D.D., Fukushima T., Takenoshita S., Kochi H.
    Cell Cycle 10:3284-3299(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION, INTERACTION WITH UHRF2.
  21. Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 1-271 IN COMPLEX WITH WILD TYPE AND MUTANTS ALA-172; PHE-172 AND ASP-172 CDK4.

Entry informationi

Entry nameiCCND1_HUMAN
AccessioniPrimary (citable) accession number: P24385
Secondary accession number(s): Q6LEF0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: October 29, 2014
This is version 164 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3