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P24383

- WNT7A_MOUSE

UniProt

P24383 - WNT7A_MOUSE

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Protein

Protein Wnt-7a

Gene

Wnt7a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. Signaling by Wnt-7a allows sexually dimorphic development of the mullerian ducts.1 Publication

GO - Molecular functioni

  1. frizzled binding Source: MGI
  2. receptor binding Source: MGI

GO - Biological processi

  1. angiogenesis Source: MGI
  2. asymmetric protein localization Source: MGI
  3. canonical Wnt signaling pathway Source: MGI
  4. cartilage condensation Source: Ensembl
  5. cartilage development Source: BHF-UCL
  6. cell-cell signaling Source: MGI
  7. cell fate commitment Source: RefGenome
  8. cell proliferation in forebrain Source: Ensembl
  9. cellular response to transforming growth factor beta stimulus Source: Ensembl
  10. central nervous system vasculogenesis Source: MGI
  11. cerebellar granule cell differentiation Source: MGI
  12. chondrocyte differentiation Source: Ensembl
  13. dorsal/ventral pattern formation Source: MGI
  14. embryonic axis specification Source: Ensembl
  15. embryonic digit morphogenesis Source: Ensembl
  16. embryonic forelimb morphogenesis Source: MGI
  17. embryonic hindlimb morphogenesis Source: MGI
  18. embryonic limb morphogenesis Source: MGI
  19. establishment of cell polarity Source: MGI
  20. limb development Source: BHF-UCL
  21. negative regulation of apoptotic process Source: MGI
  22. negative regulation of neurogenesis Source: Ensembl
  23. neurotransmitter secretion Source: MGI
  24. non-canonical Wnt signaling pathway Source: MGI
  25. organ morphogenesis Source: MGI
  26. oviduct development Source: UniProtKB
  27. palate development Source: Ensembl
  28. positive regulation of canonical Wnt signaling pathway Source: UniProtKB
  29. positive regulation of endothelial cell migration Source: MGI
  30. positive regulation of epithelial cell proliferation involved in wound healing Source: Ensembl
  31. positive regulation of gene expression Source: MGI
  32. positive regulation of JNK cascade Source: RefGenome
  33. positive regulation of synapse assembly Source: MGI
  34. positive regulation of transcription, DNA-templated Source: UniProtKB
  35. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  36. regulation of axon diameter Source: MGI
  37. regulation of axonogenesis Source: MGI
  38. regulation of cell proliferation Source: MGI
  39. response to estradiol Source: Ensembl
  40. response to estrogen Source: MGI
  41. signal transduction Source: MGI
  42. skeletal muscle satellite cell activation Source: MGI
  43. skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration Source: MGI
  44. somatic stem cell division Source: MGI
  45. somatic stem cell maintenance Source: MGI
  46. synapse organization Source: MGI
  47. uterus development Source: MGI
  48. uterus morphogenesis Source: UniProtKB
  49. Wnt signaling pathway involved in wound healing, spreading of epidermal cells Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_213918. WNT ligand biogenesis and trafficking.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-7a
Gene namesi
Name:Wnt7a
Synonyms:Wnt-7a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:98961. Wnt7a.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: BHF-UCL
  2. endoplasmic reticulum lumen Source: Reactome
  3. extracellular matrix Source: MGI
  4. extracellular space Source: RefGenome
  5. proteinaceous extracellular matrix Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Involvement in diseasei

Male mice lacking Wnt7a fail to undergo regression of the Mullerian duct as a result of the absence of the receptor for Mullerian-inhibiting substance. Wnt7a deficient females are infertile because of abnormal development of the oviduct and uterus, both of which are mullerian duct derivatives.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131Sequence AnalysisAdd
BLAST
Chaini32 – 349318Protein Wnt-7aPRO_0000041443Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi73 ↔ 84By similarity
Glycosylationi83 – 831N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi123 ↔ 131By similarity
Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi133 ↔ 152By similarity
Disulfide bondi200 ↔ 214By similarity
Disulfide bondi202 ↔ 209By similarity
Lipidationi206 – 2061O-palmitoyl serine; by PORCNBy similarity
Disulfide bondi294 ↔ 309By similarity
Glycosylationi295 – 2951N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi324 ↔ 339By similarity
Disulfide bondi326 ↔ 336By similarity
Disulfide bondi331 ↔ 332By similarity

Post-translational modificationi

Palmitoylation at Ser-206 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PRIDEiP24383.

PTM databases

PhosphoSiteiP24383.

Expressioni

Gene expression databases

BgeeiP24383.
CleanExiMM_WNT7A.
GenevestigatoriP24383.

Interactioni

Subunit structurei

Interacts with PORCN.1 Publication

Protein-protein interaction databases

BioGridi204580. 4 interactions.

Structurei

3D structure databases

ProteinModelPortaliP24383.
SMRiP24383. Positions 61-278.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG284879.
GeneTreeiENSGT00760000118943.
HOGENOMiHOG000039528.
HOVERGENiHBG001595.
InParanoidiP24383.
KOiK00572.
OMAiHISGCDL.
OrthoDBiEOG7C8GJ8.
TreeFamiTF105310.

Family and domain databases

InterProiIPR005817. Wnt.
IPR013300. Wnt7.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01891. WNT7PROTEIN.
PR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24383-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTRKARRCLG HLFLSLGIVY LRIGGFSSVV ALGASIICNK IPGLAPRQRA
60 70 80 90 100
ICQSRPDAII VIGEGSQMGL DECQFQFRNG RWNCSALGER TVFGKELKVG
110 120 130 140 150
SREAAFTYAI IAAGVAHAIT AACTQGNLSD CGCDKEKQGQ YHRDEGWKWG
160 170 180 190 200
GCSADIRYGI GFAKVFVDAR EIKQNARTLM NLHNNEAGRK ILEENMKLEC
210 220 230 240 250
KCHGVSGSCT TKTCWTTLPQ FRELGYVLKD KYNEAVHVEP VRASRNKRPT
260 270 280 290 300
FLKIKKPLSY RKPMDTDLVY IEKSPNYCEE DPVTGSVGTQ GRACNKTAPQ
310 320 330 340
ASGCDLMCCG RGYNTHQYAR VWQCNCKFHW CCYVKCNTCS ERTEMYTCK
Length:349
Mass (Da):38,974
Last modified:June 28, 2011 - v2
Checksum:iC36ACDF7930790A1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti143 – 1431R → W in AAA40570. (PubMed:2279700)Curated
Sequence conflicti273 – 2731K → L in AAA40570. (PubMed:2279700)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M89801 mRNA. Translation: AAA40570.1.
AK004683 mRNA. Translation: BAB23470.1.
CH466523 Genomic DNA. Translation: EDK99298.1.
BC049093 mRNA. Translation: AAH49093.2.
BC057586 mRNA. Translation: AAH57586.1.
CCDSiCCDS39568.1.
PIRiG36470.
RefSeqiNP_033553.2. NM_009527.3.
UniGeneiMm.56964.

Genome annotation databases

EnsembliENSMUST00000032180; ENSMUSP00000032180; ENSMUSG00000030093.
GeneIDi22421.
KEGGimmu:22421.
UCSCiuc009cxz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M89801 mRNA. Translation: AAA40570.1 .
AK004683 mRNA. Translation: BAB23470.1 .
CH466523 Genomic DNA. Translation: EDK99298.1 .
BC049093 mRNA. Translation: AAH49093.2 .
BC057586 mRNA. Translation: AAH57586.1 .
CCDSi CCDS39568.1.
PIRi G36470.
RefSeqi NP_033553.2. NM_009527.3.
UniGenei Mm.56964.

3D structure databases

ProteinModelPortali P24383.
SMRi P24383. Positions 61-278.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 204580. 4 interactions.

PTM databases

PhosphoSitei P24383.

Proteomic databases

PRIDEi P24383.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000032180 ; ENSMUSP00000032180 ; ENSMUSG00000030093 .
GeneIDi 22421.
KEGGi mmu:22421.
UCSCi uc009cxz.1. mouse.

Organism-specific databases

CTDi 7476.
MGIi MGI:98961. Wnt7a.

Phylogenomic databases

eggNOGi NOG284879.
GeneTreei ENSGT00760000118943.
HOGENOMi HOG000039528.
HOVERGENi HBG001595.
InParanoidi P24383.
KOi K00572.
OMAi HISGCDL.
OrthoDBi EOG7C8GJ8.
TreeFami TF105310.

Enzyme and pathway databases

Reactomei REACT_213918. WNT ligand biogenesis and trafficking.

Miscellaneous databases

NextBioi 302853.
PROi P24383.
SOURCEi Search...

Gene expression databases

Bgeei P24383.
CleanExi MM_WNT7A.
Genevestigatori P24383.

Family and domain databases

InterProi IPR005817. Wnt.
IPR013300. Wnt7.
IPR018161. Wnt_CS.
[Graphical view ]
PANTHERi PTHR12027. PTHR12027. 1 hit.
Pfami PF00110. wnt. 1 hit.
[Graphical view ]
PRINTSi PR01891. WNT7PROTEIN.
PR01349. WNTPROTEIN.
SMARTi SM00097. WNT1. 1 hit.
[Graphical view ]
PROSITEi PS00246. WNT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development."
    Gavin B.J., McMahon J.A., McMahon A.P.
    Genes Dev. 4:2319-2332(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Lung.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
  5. "Sexually dimorphic development of the mammalian reproductive tract requires Wnt-7a."
    Parr B.A., McMahon A.P.
    Nature 395:707-710(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family."
    Tanaka K., Okabayashi H., Asashima M., Perrimon N., Kadowaki T.
    Eur. J. Biochem. 267:4300-4311(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PORCN.

Entry informationi

Entry nameiWNT7A_MOUSE
AccessioniPrimary (citable) accession number: P24383
Secondary accession number(s): Q80VH3, Q9DBY3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: June 28, 2011
Last modified: October 29, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3