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P24383 (WNT7A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein Wnt-7a
Gene names
Name:Wnt7a
Synonyms:Wnt-7a
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length349 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. Signaling by Wnt-7a allows sexually dimorphic development of the mullerian ducts. Ref.5

Subunit structure

Interacts with PORCN. Ref.6

Subcellular location

Secretedextracellular spaceextracellular matrix.

Post-translational modification

Palmitoylation at Ser-206 is required for efficient binding to frizzled receptors. It is also required for subsequent palmitoylation at Cys-73. Palmitoylation is necessary for proper trafficking to cell surface By similarity.

Involvement in disease

Male mice lacking Wnt7a fail to undergo regression of the Mullerian duct as a result of the absence of the receptor for Mullerian-inhibiting substance. Wnt7a deficient females are infertile because of abnormal development of the oviduct and uterus, both of which are mullerian duct derivatives.

Sequence similarities

Belongs to the Wnt family.

Ontologies

Keywords
   Biological processWnt signaling pathway
   Cellular componentExtracellular matrix
Secreted
   DomainSignal
   Molecular functionDevelopmental protein
   PTMGlycoprotein
Lipoprotein
Palmitate
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processWnt signaling pathway involved in wound healing, spreading of epidermal cells

Inferred from electronic annotation. Source: Ensembl

asymmetric protein localization

Inferred from direct assay PubMed 19497282. Source: MGI

canonical Wnt signaling pathway

Inferred from genetic interaction PubMed 19023080. Source: MGI

cartilage condensation

Inferred from electronic annotation. Source: Ensembl

cartilage development

Inferred from direct assay PubMed 16826533. Source: BHF-UCL

cell fate commitment

Inferred from Biological aspect of Ancestor. Source: RefGenome

cell proliferation in forebrain

Inferred from electronic annotation. Source: Ensembl

cell-cell signaling

Traceable author statement PubMed 9889131. Source: MGI

cellular response to transforming growth factor beta stimulus

Inferred from electronic annotation. Source: Ensembl

central nervous system vasculogenesis

Inferred from genetic interaction PubMed 19023080. Source: MGI

cerebellar granule cell differentiation

Inferred from direct assay PubMed 9405095. Source: MGI

chondrocyte differentiation

Inferred from electronic annotation. Source: Ensembl

dorsal/ventral pattern formation

Inferred from mutant phenotype PubMed 7885472PubMed 9362463. Source: MGI

embryonic axis specification

Inferred from electronic annotation. Source: Ensembl

embryonic digit morphogenesis

Inferred from electronic annotation. Source: Ensembl

embryonic forelimb morphogenesis

Inferred from genetic interaction PubMed 15880584PubMed 9362463. Source: MGI

embryonic hindlimb morphogenesis

Inferred from genetic interaction PubMed 15880584. Source: MGI

embryonic limb morphogenesis

Inferred from genetic interaction PubMed 15242796. Source: MGI

establishment of cell polarity

Inferred from direct assay PubMed 19497282. Source: MGI

limb development

Inferred from direct assay PubMed 16826533. Source: BHF-UCL

negative regulation of apoptotic process

Inferred from mutant phenotype PubMed 15070830. Source: MGI

negative regulation of neurogenesis

Inferred from electronic annotation. Source: Ensembl

neurotransmitter secretion

Inferred from genetic interaction PubMed 16818724. Source: MGI

non-canonical Wnt signaling pathway

Inferred from genetic interaction PubMed 19497282. Source: MGI

organ morphogenesis

Traceable author statement PubMed 9889131. Source: MGI

oviduct development

Inferred from mutant phenotype PubMed 14695376. Source: UniProtKB

palate development

Inferred from electronic annotation. Source: Ensembl

positive regulation of JNK cascade

Inferred from Biological aspect of Ancestor. Source: RefGenome

positive regulation of canonical Wnt signaling pathway

Inferred from direct assay PubMed 12937339. Source: UniProtKB

positive regulation of epithelial cell proliferation involved in wound healing

Inferred from electronic annotation. Source: Ensembl

positive regulation of synapse assembly

Inferred from direct assay PubMed 9405095. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription, DNA-templated

Inferred from direct assay PubMed 12937339. Source: UniProtKB

regulation of axon diameter

Inferred from direct assay PubMed 9405095. Source: MGI

regulation of axonogenesis

Inferred from direct assay PubMed 9405095. Source: MGI

regulation of cell proliferation

Inferred from mutant phenotype PubMed 15070830. Source: MGI

response to estradiol

Inferred from electronic annotation. Source: Ensembl

response to estrogen

Inferred from mutant phenotype PubMed 15070830. Source: MGI

satellite cell activation

Inferred from direct assay PubMed 19497282. Source: MGI

satellite cell maintenance involved in skeletal muscle regeneration

Inferred from direct assay PubMed 19497282. Source: MGI

signal transduction

Traceable author statement PubMed 9889131. Source: MGI

somatic stem cell division

Inferred from direct assay PubMed 19497282. Source: MGI

somatic stem cell maintenance

Inferred from mutant phenotype PubMed 19497282. Source: MGI

synapse organization

Inferred from mutant phenotype PubMed 16818724. Source: MGI

uterus development

Inferred from mutant phenotype PubMed 15070830PubMed 15073149. Source: MGI

uterus morphogenesis

Inferred from mutant phenotype PubMed 14695376. Source: UniProtKB

   Cellular_componentcell surface

Inferred from direct assay PubMed 8167409. Source: BHF-UCL

endoplasmic reticulum lumen

Traceable author statement. Source: Reactome

extracellular matrix

Inferred from direct assay PubMed 8167409. Source: MGI

extracellular space

Inferred from Biological aspect of Ancestor. Source: RefGenome

proteinaceous extracellular matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionfrizzled binding

Inferred from physical interaction PubMed 19497282. Source: MGI

receptor binding

Traceable author statement PubMed 9889131. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3131 Potential
Chain32 – 349318Protein Wnt-7a
PRO_0000041443

Amino acid modifications

Lipidation731S-palmitoyl cysteine By similarity
Lipidation2061O-palmitoyl serine; by PORCN By similarity
Glycosylation831N-linked (GlcNAc...) Potential
Glycosylation1271N-linked (GlcNAc...) Potential
Glycosylation2951N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict1431R → W in AAA40570. Ref.1
Sequence conflict2731K → L in AAA40570. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P24383 [UniParc].

Last modified June 28, 2011. Version 2.
Checksum: C36ACDF7930790A1

FASTA34938,974
        10         20         30         40         50         60 
MTRKARRCLG HLFLSLGIVY LRIGGFSSVV ALGASIICNK IPGLAPRQRA ICQSRPDAII 

        70         80         90        100        110        120 
VIGEGSQMGL DECQFQFRNG RWNCSALGER TVFGKELKVG SREAAFTYAI IAAGVAHAIT 

       130        140        150        160        170        180 
AACTQGNLSD CGCDKEKQGQ YHRDEGWKWG GCSADIRYGI GFAKVFVDAR EIKQNARTLM 

       190        200        210        220        230        240 
NLHNNEAGRK ILEENMKLEC KCHGVSGSCT TKTCWTTLPQ FRELGYVLKD KYNEAVHVEP 

       250        260        270        280        290        300 
VRASRNKRPT FLKIKKPLSY RKPMDTDLVY IEKSPNYCEE DPVTGSVGTQ GRACNKTAPQ 

       310        320        330        340 
ASGCDLMCCG RGYNTHQYAR VWQCNCKFHW CCYVKCNTCS ERTEMYTCK 

« Hide

References

« Hide 'large scale' references
[1]"Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development."
Gavin B.J., McMahon J.A., McMahon A.P.
Genes Dev. 4:2319-2332(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Lung.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
[5]"Sexually dimorphic development of the mammalian reproductive tract requires Wnt-7a."
Parr B.A., McMahon A.P.
Nature 395:707-710(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[6]"The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family."
Tanaka K., Okabayashi H., Asashima M., Perrimon N., Kadowaki T.
Eur. J. Biochem. 267:4300-4311(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH PORCN.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M89801 mRNA. Translation: AAA40570.1.
AK004683 mRNA. Translation: BAB23470.1.
CH466523 Genomic DNA. Translation: EDK99298.1.
BC049093 mRNA. Translation: AAH49093.2.
BC057586 mRNA. Translation: AAH57586.1.
CCDSCCDS39568.1.
PIRG36470.
RefSeqNP_033553.2. NM_009527.3.
UniGeneMm.56964.

3D structure databases

ProteinModelPortalP24383.
SMRP24383. Positions 61-278.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid204580. 4 interactions.

PTM databases

PhosphoSiteP24383.

Proteomic databases

PRIDEP24383.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000032180; ENSMUSP00000032180; ENSMUSG00000030093.
GeneID22421.
KEGGmmu:22421.
UCSCuc009cxz.1. mouse.

Organism-specific databases

CTD7476.
MGIMGI:98961. Wnt7a.

Phylogenomic databases

eggNOGNOG284879.
GeneTreeENSGT00740000115016.
HOGENOMHOG000039528.
HOVERGENHBG001595.
InParanoidQ9DBY3.
KOK00572.
OMAHISGCDL.
OrthoDBEOG7C8GJ8.
TreeFamTF105310.

Enzyme and pathway databases

ReactomeREACT_188257. Signal Transduction.

Gene expression databases

BgeeP24383.
CleanExMM_WNT7A.
GenevestigatorP24383.

Family and domain databases

InterProIPR005817. Wnt.
IPR013300. Wnt7.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERPTHR12027. PTHR12027. 1 hit.
PfamPF00110. wnt. 1 hit.
[Graphical view]
PRINTSPR01891. WNT7PROTEIN.
PR01349. WNTPROTEIN.
SMARTSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio302853.
PROP24383.
SOURCESearch...

Entry information

Entry nameWNT7A_MOUSE
AccessionPrimary (citable) accession number: P24383
Secondary accession number(s): Q80VH3, Q9DBY3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: June 28, 2011
Last modified: July 9, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot