UniProtKB - P24383 (WNT7A_MOUSE)
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Protein
Protein Wnt-7a
Gene
Wnt7a
Organism
Mus musculus (Mouse)
Status
Functioni
Ligand for members of the frizzled family of seven transmembrane receptors (PubMed:18230341, PubMed:20530549). Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:18230341, PubMed:23629626). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development (PubMed:7885472, PubMed:9790192, PubMed:9769174). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes (PubMed:9790192). Required for normal neural stem cell proliferation in the hippocampus dentate gyrus (PubMed:23629626). Required for normal progress through the cell cycle in neural progenitor cells, for self-renewal of neural stem cells, and for normal neuronal differentiation and maturation (PubMed:23629626). Promotes formation of synapses via its interaction with FZD5 (PubMed:20530549).6 Publications
Miscellaneous
Male mice lacking Wnt7a fail to undergo regression of the Mullerian duct as a result of the absence of the receptor for Mullerian-inhibiting substance. In males, mature sperm fills the vas deferens, but sperm exit is blocked due to the persistence of the Mullerian duct, causing male sterility. Wnt7a deficient females are infertile because of abnormal development of the oviduct and uterus, both of which are Mullerian duct derivatives.1 Publication
GO - Molecular functioni
- cytokine activity Source: MGI
- frizzled binding Source: MGI
- receptor binding Source: MGI
- receptor ligand activity Source: MGI
GO - Biological processi
- angiogenesis Source: MGI
- animal organ morphogenesis Source: MGI
- asymmetric protein localization involved in cell fate determination Source: MGI
- canonical Wnt signaling pathway Source: MGI
- cartilage condensation Source: MGI
- cartilage development Source: BHF-UCL
- cell-cell signaling Source: MGI
- cell fate commitment Source: GO_Central
- cell proliferation in forebrain Source: MGI
- cellular response to transforming growth factor beta stimulus Source: Ensembl
- central nervous system vasculogenesis Source: MGI
- cerebellar granule cell differentiation Source: MGI
- chondrocyte differentiation Source: MGI
- dendritic spine morphogenesis Source: ParkinsonsUK-UCL
- dorsal/ventral pattern formation Source: MGI
- embryonic axis specification Source: MGI
- embryonic digit morphogenesis Source: MGI
- embryonic forelimb morphogenesis Source: MGI
- embryonic hindlimb morphogenesis Source: MGI
- embryonic limb morphogenesis Source: MGI
- establishment of cell polarity Source: MGI
- limb development Source: BHF-UCL
- negative regulation of apoptotic process Source: MGI
- negative regulation of neurogenesis Source: MGI
- neurotransmitter secretion Source: MGI
- non-canonical Wnt signaling pathway Source: MGI
- oviduct development Source: UniProtKB
- palate development Source: MGI
- positive regulation of canonical Wnt signaling pathway Source: UniProtKB
- positive regulation of cellular protein metabolic process Source: MGI
- positive regulation of endothelial cell migration Source: MGI
- positive regulation of epithelial cell proliferation involved in wound healing Source: MGI
- positive regulation of excitatory postsynaptic potential Source: ParkinsonsUK-UCL
- positive regulation of excitatory synapse assembly Source: MGI
- positive regulation of gene expression Source: MGI
- positive regulation of JNK cascade Source: Ensembl
- positive regulation of synapse assembly Source: MGI
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: MGI
- regulation of axon diameter Source: MGI
- regulation of axonogenesis Source: MGI
- regulation of cell proliferation Source: MGI
- response to estradiol Source: Ensembl
- response to estrogen Source: MGI
- signal transduction Source: MGI
- skeletal muscle satellite cell activation Source: MGI
- skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration Source: MGI
- somatic stem cell division Source: MGI
- somatic stem cell population maintenance Source: MGI
- stem cell development Source: MGI
- synapse organization Source: MGI
- uterus development Source: MGI
- uterus morphogenesis Source: UniProtKB
- Wnt signaling pathway Source: ParkinsonsUK-UCL
- Wnt signaling pathway involved in wound healing, spreading of epidermal cells Source: MGI
Keywordsi
Molecular function | Developmental protein |
Biological process | Wnt signaling pathway |
Enzyme and pathway databases
Reactomei | R-MMU-3238698. WNT ligand biogenesis and trafficking. |
Names & Taxonomyi
Protein namesi | Recommended name: Protein Wnt-7a |
Gene namesi | Name:Wnt7a Synonyms:Wnt-7a |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:98961. Wnt7a. |
Pathology & Biotechi
Involvement in diseasei
Defects in Wnt7a cause the postaxial hemimelia (px) phenotype that is characterized by limb patterning defects accompanied by Mullerian duct-associated sterility in both sexes.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 31 | Sequence analysisAdd BLAST | 31 | |
ChainiPRO_0000041443 | 32 – 349 | Protein Wnt-7aAdd BLAST | 318 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 73 ↔ 84 | By similarity | ||
Glycosylationi | 83 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 123 ↔ 131 | By similarity | ||
Glycosylationi | 127 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 133 ↔ 152 | By similarity | ||
Disulfide bondi | 200 ↔ 214 | By similarity | ||
Disulfide bondi | 202 ↔ 209 | By similarity | ||
Lipidationi | 206 | O-palmitoleoyl serine; by PORCNBy similarity | 1 | |
Disulfide bondi | 294 ↔ 309 | By similarity | ||
Glycosylationi | 295 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 324 ↔ 339 | By similarity | ||
Disulfide bondi | 326 ↔ 336 | By similarity | ||
Disulfide bondi | 331 ↔ 332 | By similarity |
Post-translational modificationi
Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.By similarity
Keywords - PTMi
Disulfide bond, Glycoprotein, LipoproteinProteomic databases
PaxDbi | P24383. |
PRIDEi | P24383. |
PTM databases
PhosphoSitePlusi | P24383. |
Expressioni
Developmental stagei
Detected in the flanking ectoderm of the trunk prior to limb outgrowth. First detected in the presumptive forelimb region at 8.75 dpc, and in the presumptive hindlimb region at 9.25 dpc. Uniformly distributed throughout the dorsal limb ectoderm during the initial stages of limb-bud outgrowth (9.25 dpc for the forelimbs, 9.75 dpc for the hindlimbs).1 Publication
Gene expression databases
Bgeei | ENSMUSG00000030093. |
CleanExi | MM_WNT7A. |
Genevisiblei | P24383. MM. |
Interactioni
Subunit structurei
Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity. The complex with AFM may represent the physiological form in body fluids (By similarity). Interacts with FZD5 (PubMed:18230341, PubMed:20530549). Interacts with PORCN (PubMed:10866835).By similarity3 Publications
GO - Molecular functioni
- cytokine activity Source: MGI
- frizzled binding Source: MGI
- receptor binding Source: MGI
- receptor ligand activity Source: MGI
Protein-protein interaction databases
BioGridi | 204580. 4 interactors. |
STRINGi | 10090.ENSMUSP00000032180. |
Structurei
3D structure databases
ProteinModelPortali | P24383. |
SMRi | P24383. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the Wnt family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3913. Eukaryota. ENOG410XQZ1. LUCA. |
GeneTreei | ENSGT00760000118943. |
HOGENOMi | HOG000039528. |
HOVERGENi | HBG001595. |
InParanoidi | P24383. |
KOi | K00572. |
OMAi | YIDKSPN. |
OrthoDBi | EOG091G0OFF. |
TreeFami | TF105310. |
Family and domain databases
InterProi | View protein in InterPro IPR005817. Wnt. IPR013300. Wnt7. IPR018161. Wnt_CS. |
PANTHERi | PTHR12027. PTHR12027. 1 hit. |
Pfami | View protein in Pfam PF00110. wnt. 1 hit. |
PRINTSi | PR01891. WNT7PROTEIN. PR01349. WNTPROTEIN. |
SMARTi | View protein in SMART SM00097. WNT1. 1 hit. |
PROSITEi | View protein in PROSITE PS00246. WNT1. 1 hit. |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P24383-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTRKARRCLG HLFLSLGIVY LRIGGFSSVV ALGASIICNK IPGLAPRQRA
60 70 80 90 100
ICQSRPDAII VIGEGSQMGL DECQFQFRNG RWNCSALGER TVFGKELKVG
110 120 130 140 150
SREAAFTYAI IAAGVAHAIT AACTQGNLSD CGCDKEKQGQ YHRDEGWKWG
160 170 180 190 200
GCSADIRYGI GFAKVFVDAR EIKQNARTLM NLHNNEAGRK ILEENMKLEC
210 220 230 240 250
KCHGVSGSCT TKTCWTTLPQ FRELGYVLKD KYNEAVHVEP VRASRNKRPT
260 270 280 290 300
FLKIKKPLSY RKPMDTDLVY IEKSPNYCEE DPVTGSVGTQ GRACNKTAPQ
310 320 330 340
ASGCDLMCCG RGYNTHQYAR VWQCNCKFHW CCYVKCNTCS ERTEMYTCK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 143 | R → W in AAA40570 (PubMed:2279700).Curated | 1 | |
Sequence conflicti | 273 | K → L in AAA40570 (PubMed:2279700).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M89801 mRNA. Translation: AAA40570.1. AK004683 mRNA. Translation: BAB23470.1. CH466523 Genomic DNA. Translation: EDK99298.1. BC049093 mRNA. Translation: AAH49093.2. BC057586 mRNA. Translation: AAH57586.1. |
CCDSi | CCDS39568.1. |
PIRi | G36470. |
RefSeqi | NP_033553.2. NM_009527.3. |
UniGenei | Mm.56964. |
Genome annotation databases
Ensembli | ENSMUST00000032180; ENSMUSP00000032180; ENSMUSG00000030093. |
GeneIDi | 22421. |
KEGGi | mmu:22421. |
UCSCi | uc009cxz.1. mouse. |
Similar proteinsi
Entry informationi
Entry namei | WNT7A_MOUSE | |
Accessioni | P24383Primary (citable) accession number: P24383 Secondary accession number(s): Q80VH3, Q9DBY3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 1992 |
Last sequence update: | June 28, 2011 | |
Last modified: | March 28, 2018 | |
This is version 145 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |