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P24383

- WNT7A_MOUSE

UniProt

P24383 - WNT7A_MOUSE

Protein

Protein Wnt-7a

Gene

Wnt7a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 2 (28 Jun 2011)
      Previous versions | rss
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    Functioni

    Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. Signaling by Wnt-7a allows sexually dimorphic development of the mullerian ducts.1 Publication

    GO - Molecular functioni

    1. frizzled binding Source: MGI
    2. receptor binding Source: MGI

    GO - Biological processi

    1. asymmetric protein localization Source: MGI
    2. canonical Wnt signaling pathway Source: MGI
    3. cartilage condensation Source: Ensembl
    4. cartilage development Source: BHF-UCL
    5. cell-cell signaling Source: MGI
    6. cell fate commitment Source: RefGenome
    7. cell proliferation in forebrain Source: Ensembl
    8. cellular response to transforming growth factor beta stimulus Source: Ensembl
    9. central nervous system vasculogenesis Source: MGI
    10. cerebellar granule cell differentiation Source: MGI
    11. chondrocyte differentiation Source: Ensembl
    12. dorsal/ventral pattern formation Source: MGI
    13. embryonic axis specification Source: Ensembl
    14. embryonic digit morphogenesis Source: Ensembl
    15. embryonic forelimb morphogenesis Source: MGI
    16. embryonic hindlimb morphogenesis Source: MGI
    17. embryonic limb morphogenesis Source: MGI
    18. establishment of cell polarity Source: MGI
    19. limb development Source: BHF-UCL
    20. negative regulation of apoptotic process Source: MGI
    21. negative regulation of neurogenesis Source: Ensembl
    22. neurotransmitter secretion Source: MGI
    23. non-canonical Wnt signaling pathway Source: MGI
    24. organ morphogenesis Source: MGI
    25. oviduct development Source: UniProtKB
    26. palate development Source: Ensembl
    27. positive regulation of canonical Wnt signaling pathway Source: UniProtKB
    28. positive regulation of epithelial cell proliferation involved in wound healing Source: Ensembl
    29. positive regulation of JNK cascade Source: RefGenome
    30. positive regulation of synapse assembly Source: MGI
    31. positive regulation of transcription, DNA-templated Source: UniProtKB
    32. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    33. regulation of axon diameter Source: MGI
    34. regulation of axonogenesis Source: MGI
    35. regulation of cell proliferation Source: MGI
    36. response to estradiol Source: Ensembl
    37. response to estrogen Source: MGI
    38. signal transduction Source: MGI
    39. skeletal muscle satellite cell activation Source: MGI
    40. skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration Source: MGI
    41. somatic stem cell division Source: MGI
    42. somatic stem cell maintenance Source: MGI
    43. synapse organization Source: MGI
    44. uterus development Source: MGI
    45. uterus morphogenesis Source: UniProtKB
    46. Wnt signaling pathway involved in wound healing, spreading of epidermal cells Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Wnt signaling pathway

    Enzyme and pathway databases

    ReactomeiREACT_213918. WNT ligand biogenesis and trafficking.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein Wnt-7a
    Gene namesi
    Name:Wnt7a
    Synonyms:Wnt-7a
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:98961. Wnt7a.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: BHF-UCL
    2. endoplasmic reticulum lumen Source: Reactome
    3. extracellular matrix Source: MGI
    4. extracellular space Source: RefGenome
    5. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Male mice lacking Wnt7a fail to undergo regression of the Mullerian duct as a result of the absence of the receptor for Mullerian-inhibiting substance. Wnt7a deficient females are infertile because of abnormal development of the oviduct and uterus, both of which are mullerian duct derivatives.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3131Sequence AnalysisAdd
    BLAST
    Chaini32 – 349318Protein Wnt-7aPRO_0000041443Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi73 ↔ 84By similarity
    Glycosylationi83 – 831N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi123 ↔ 131By similarity
    Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi133 ↔ 152By similarity
    Disulfide bondi200 ↔ 214By similarity
    Disulfide bondi202 ↔ 209By similarity
    Lipidationi206 – 2061O-palmitoyl serine; by PORCNBy similarity
    Disulfide bondi294 ↔ 309By similarity
    Glycosylationi295 – 2951N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi324 ↔ 339By similarity
    Disulfide bondi326 ↔ 336By similarity
    Disulfide bondi331 ↔ 332By similarity

    Post-translational modificationi

    Palmitoylation at Ser-206 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PRIDEiP24383.

    PTM databases

    PhosphoSiteiP24383.

    Expressioni

    Gene expression databases

    BgeeiP24383.
    CleanExiMM_WNT7A.
    GenevestigatoriP24383.

    Interactioni

    Subunit structurei

    Interacts with PORCN.1 Publication

    Protein-protein interaction databases

    BioGridi204580. 4 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP24383.
    SMRiP24383. Positions 61-278.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Wnt family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG284879.
    GeneTreeiENSGT00740000115016.
    HOGENOMiHOG000039528.
    HOVERGENiHBG001595.
    InParanoidiQ9DBY3.
    KOiK00572.
    OMAiHISGCDL.
    OrthoDBiEOG7C8GJ8.
    TreeFamiTF105310.

    Family and domain databases

    InterProiIPR005817. Wnt.
    IPR013300. Wnt7.
    IPR018161. Wnt_CS.
    [Graphical view]
    PANTHERiPTHR12027. PTHR12027. 1 hit.
    PfamiPF00110. wnt. 1 hit.
    [Graphical view]
    PRINTSiPR01891. WNT7PROTEIN.
    PR01349. WNTPROTEIN.
    SMARTiSM00097. WNT1. 1 hit.
    [Graphical view]
    PROSITEiPS00246. WNT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P24383-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTRKARRCLG HLFLSLGIVY LRIGGFSSVV ALGASIICNK IPGLAPRQRA    50
    ICQSRPDAII VIGEGSQMGL DECQFQFRNG RWNCSALGER TVFGKELKVG 100
    SREAAFTYAI IAAGVAHAIT AACTQGNLSD CGCDKEKQGQ YHRDEGWKWG 150
    GCSADIRYGI GFAKVFVDAR EIKQNARTLM NLHNNEAGRK ILEENMKLEC 200
    KCHGVSGSCT TKTCWTTLPQ FRELGYVLKD KYNEAVHVEP VRASRNKRPT 250
    FLKIKKPLSY RKPMDTDLVY IEKSPNYCEE DPVTGSVGTQ GRACNKTAPQ 300
    ASGCDLMCCG RGYNTHQYAR VWQCNCKFHW CCYVKCNTCS ERTEMYTCK 349
    Length:349
    Mass (Da):38,974
    Last modified:June 28, 2011 - v2
    Checksum:iC36ACDF7930790A1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti143 – 1431R → W in AAA40570. (PubMed:2279700)Curated
    Sequence conflicti273 – 2731K → L in AAA40570. (PubMed:2279700)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M89801 mRNA. Translation: AAA40570.1.
    AK004683 mRNA. Translation: BAB23470.1.
    CH466523 Genomic DNA. Translation: EDK99298.1.
    BC049093 mRNA. Translation: AAH49093.2.
    BC057586 mRNA. Translation: AAH57586.1.
    CCDSiCCDS39568.1.
    PIRiG36470.
    RefSeqiNP_033553.2. NM_009527.3.
    UniGeneiMm.56964.

    Genome annotation databases

    EnsembliENSMUST00000032180; ENSMUSP00000032180; ENSMUSG00000030093.
    GeneIDi22421.
    KEGGimmu:22421.
    UCSCiuc009cxz.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M89801 mRNA. Translation: AAA40570.1 .
    AK004683 mRNA. Translation: BAB23470.1 .
    CH466523 Genomic DNA. Translation: EDK99298.1 .
    BC049093 mRNA. Translation: AAH49093.2 .
    BC057586 mRNA. Translation: AAH57586.1 .
    CCDSi CCDS39568.1.
    PIRi G36470.
    RefSeqi NP_033553.2. NM_009527.3.
    UniGenei Mm.56964.

    3D structure databases

    ProteinModelPortali P24383.
    SMRi P24383. Positions 61-278.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204580. 4 interactions.

    PTM databases

    PhosphoSitei P24383.

    Proteomic databases

    PRIDEi P24383.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000032180 ; ENSMUSP00000032180 ; ENSMUSG00000030093 .
    GeneIDi 22421.
    KEGGi mmu:22421.
    UCSCi uc009cxz.1. mouse.

    Organism-specific databases

    CTDi 7476.
    MGIi MGI:98961. Wnt7a.

    Phylogenomic databases

    eggNOGi NOG284879.
    GeneTreei ENSGT00740000115016.
    HOGENOMi HOG000039528.
    HOVERGENi HBG001595.
    InParanoidi Q9DBY3.
    KOi K00572.
    OMAi HISGCDL.
    OrthoDBi EOG7C8GJ8.
    TreeFami TF105310.

    Enzyme and pathway databases

    Reactomei REACT_213918. WNT ligand biogenesis and trafficking.

    Miscellaneous databases

    NextBioi 302853.
    PROi P24383.
    SOURCEi Search...

    Gene expression databases

    Bgeei P24383.
    CleanExi MM_WNT7A.
    Genevestigatori P24383.

    Family and domain databases

    InterProi IPR005817. Wnt.
    IPR013300. Wnt7.
    IPR018161. Wnt_CS.
    [Graphical view ]
    PANTHERi PTHR12027. PTHR12027. 1 hit.
    Pfami PF00110. wnt. 1 hit.
    [Graphical view ]
    PRINTSi PR01891. WNT7PROTEIN.
    PR01349. WNTPROTEIN.
    SMARTi SM00097. WNT1. 1 hit.
    [Graphical view ]
    PROSITEi PS00246. WNT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development."
      Gavin B.J., McMahon J.A., McMahon A.P.
      Genes Dev. 4:2319-2332(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Lung.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
    5. "Sexually dimorphic development of the mammalian reproductive tract requires Wnt-7a."
      Parr B.A., McMahon A.P.
      Nature 395:707-710(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. "The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family."
      Tanaka K., Okabayashi H., Asashima M., Perrimon N., Kadowaki T.
      Eur. J. Biochem. 267:4300-4311(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PORCN.

    Entry informationi

    Entry nameiWNT7A_MOUSE
    AccessioniPrimary (citable) accession number: P24383
    Secondary accession number(s): Q80VH3, Q9DBY3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3