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Protein

Protein Wnt-7a

Gene

Wnt7a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. Signaling by Wnt-7a allows sexually dimorphic development of the mullerian ducts.1 Publication

GO - Molecular functioni

  • cytokine activity Source: MGI
  • frizzled binding Source: MGI
  • receptor agonist activity Source: MGI
  • receptor binding Source: MGI

GO - Biological processi

  • angiogenesis Source: MGI
  • animal organ morphogenesis Source: MGI
  • asymmetric protein localization Source: MGI
  • canonical Wnt signaling pathway Source: MGI
  • cartilage condensation Source: MGI
  • cartilage development Source: BHF-UCL
  • cell-cell signaling Source: MGI
  • cell fate commitment Source: GO_Central
  • cell proliferation in forebrain Source: MGI
  • cellular response to transforming growth factor beta stimulus Source: Ensembl
  • central nervous system vasculogenesis Source: MGI
  • cerebellar granule cell differentiation Source: MGI
  • chondrocyte differentiation Source: MGI
  • dendritic spine morphogenesis Source: ParkinsonsUK-UCL
  • dorsal/ventral pattern formation Source: MGI
  • embryonic axis specification Source: MGI
  • embryonic digit morphogenesis Source: MGI
  • embryonic forelimb morphogenesis Source: MGI
  • embryonic hindlimb morphogenesis Source: MGI
  • embryonic limb morphogenesis Source: MGI
  • establishment of cell polarity Source: MGI
  • limb development Source: BHF-UCL
  • negative regulation of apoptotic process Source: MGI
  • negative regulation of neurogenesis Source: MGI
  • neurotransmitter secretion Source: MGI
  • non-canonical Wnt signaling pathway Source: MGI
  • oviduct development Source: UniProtKB
  • palate development Source: MGI
  • positive regulation of canonical Wnt signaling pathway Source: UniProtKB
  • positive regulation of endothelial cell migration Source: MGI
  • positive regulation of epithelial cell proliferation involved in wound healing Source: MGI
  • positive regulation of excitatory postsynaptic potential Source: ParkinsonsUK-UCL
  • positive regulation of excitatory synapse assembly Source: MGI
  • positive regulation of gene expression Source: MGI
  • positive regulation of JNK cascade Source: Ensembl
  • positive regulation of synapse assembly Source: MGI
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of axon diameter Source: MGI
  • regulation of axonogenesis Source: MGI
  • regulation of cell proliferation Source: MGI
  • response to estradiol Source: Ensembl
  • response to estrogen Source: MGI
  • signal transduction Source: MGI
  • skeletal muscle satellite cell activation Source: MGI
  • skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration Source: MGI
  • somatic stem cell division Source: MGI
  • somatic stem cell population maintenance Source: MGI
  • stem cell development Source: MGI
  • synapse organization Source: MGI
  • uterus development Source: MGI
  • uterus morphogenesis Source: UniProtKB
  • Wnt signaling pathway Source: ParkinsonsUK-UCL
  • Wnt signaling pathway involved in wound healing, spreading of epidermal cells Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiR-MMU-3238698. WNT ligand biogenesis and trafficking.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-7a
Gene namesi
Name:Wnt7a
Synonyms:Wnt-7a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:98961. Wnt7a.

Subcellular locationi

GO - Cellular componenti

  • cell surface Source: BHF-UCL
  • endoplasmic reticulum lumen Source: Reactome
  • extracellular space Source: GO_Central
  • presynapse Source: GOC
  • proteinaceous extracellular matrix Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Involvement in diseasei

Male mice lacking Wnt7a fail to undergo regression of the Mullerian duct as a result of the absence of the receptor for Mullerian-inhibiting substance. Wnt7a deficient females are infertile because of abnormal development of the oviduct and uterus, both of which are mullerian duct derivatives.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000004144332 – 349Protein Wnt-7aAdd BLAST318

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi73 ↔ 84By similarity
Glycosylationi83N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi123 ↔ 131By similarity
Glycosylationi127N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi133 ↔ 152By similarity
Disulfide bondi200 ↔ 214By similarity
Disulfide bondi202 ↔ 209By similarity
Lipidationi206O-palmitoleyl serine; by PORCNBy similarity1
Disulfide bondi294 ↔ 309By similarity
Glycosylationi295N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi324 ↔ 339By similarity
Disulfide bondi326 ↔ 336By similarity
Disulfide bondi331 ↔ 332By similarity

Post-translational modificationi

Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Proteomic databases

PaxDbiP24383.
PRIDEiP24383.

PTM databases

PhosphoSitePlusiP24383.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030093.
CleanExiMM_WNT7A.
GenevisibleiP24383. MM.

Interactioni

Subunit structurei

Interacts with PORCN.1 Publication

GO - Molecular functioni

  • cytokine activity Source: MGI
  • frizzled binding Source: MGI
  • receptor agonist activity Source: MGI
  • receptor binding Source: MGI

Protein-protein interaction databases

BioGridi204580. 4 interactors.
STRINGi10090.ENSMUSP00000032180.

Structurei

3D structure databases

ProteinModelPortaliP24383.
SMRiP24383.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3913. Eukaryota.
ENOG410XQZ1. LUCA.
GeneTreeiENSGT00760000118943.
HOGENOMiHOG000039528.
HOVERGENiHBG001595.
InParanoidiP24383.
KOiK00572.
OMAiYIDKSPN.
OrthoDBiEOG091G0OFF.
TreeFamiTF105310.

Family and domain databases

InterProiIPR005817. Wnt.
IPR013300. Wnt7.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01891. WNT7PROTEIN.
PR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24383-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRKARRCLG HLFLSLGIVY LRIGGFSSVV ALGASIICNK IPGLAPRQRA
60 70 80 90 100
ICQSRPDAII VIGEGSQMGL DECQFQFRNG RWNCSALGER TVFGKELKVG
110 120 130 140 150
SREAAFTYAI IAAGVAHAIT AACTQGNLSD CGCDKEKQGQ YHRDEGWKWG
160 170 180 190 200
GCSADIRYGI GFAKVFVDAR EIKQNARTLM NLHNNEAGRK ILEENMKLEC
210 220 230 240 250
KCHGVSGSCT TKTCWTTLPQ FRELGYVLKD KYNEAVHVEP VRASRNKRPT
260 270 280 290 300
FLKIKKPLSY RKPMDTDLVY IEKSPNYCEE DPVTGSVGTQ GRACNKTAPQ
310 320 330 340
ASGCDLMCCG RGYNTHQYAR VWQCNCKFHW CCYVKCNTCS ERTEMYTCK
Length:349
Mass (Da):38,974
Last modified:June 28, 2011 - v2
Checksum:iC36ACDF7930790A1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti143R → W in AAA40570 (PubMed:2279700).Curated1
Sequence conflicti273K → L in AAA40570 (PubMed:2279700).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M89801 mRNA. Translation: AAA40570.1.
AK004683 mRNA. Translation: BAB23470.1.
CH466523 Genomic DNA. Translation: EDK99298.1.
BC049093 mRNA. Translation: AAH49093.2.
BC057586 mRNA. Translation: AAH57586.1.
CCDSiCCDS39568.1.
PIRiG36470.
RefSeqiNP_033553.2. NM_009527.3.
UniGeneiMm.56964.

Genome annotation databases

EnsembliENSMUST00000032180; ENSMUSP00000032180; ENSMUSG00000030093.
GeneIDi22421.
KEGGimmu:22421.
UCSCiuc009cxz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M89801 mRNA. Translation: AAA40570.1.
AK004683 mRNA. Translation: BAB23470.1.
CH466523 Genomic DNA. Translation: EDK99298.1.
BC049093 mRNA. Translation: AAH49093.2.
BC057586 mRNA. Translation: AAH57586.1.
CCDSiCCDS39568.1.
PIRiG36470.
RefSeqiNP_033553.2. NM_009527.3.
UniGeneiMm.56964.

3D structure databases

ProteinModelPortaliP24383.
SMRiP24383.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204580. 4 interactors.
STRINGi10090.ENSMUSP00000032180.

PTM databases

PhosphoSitePlusiP24383.

Proteomic databases

PaxDbiP24383.
PRIDEiP24383.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032180; ENSMUSP00000032180; ENSMUSG00000030093.
GeneIDi22421.
KEGGimmu:22421.
UCSCiuc009cxz.1. mouse.

Organism-specific databases

CTDi7476.
MGIiMGI:98961. Wnt7a.

Phylogenomic databases

eggNOGiKOG3913. Eukaryota.
ENOG410XQZ1. LUCA.
GeneTreeiENSGT00760000118943.
HOGENOMiHOG000039528.
HOVERGENiHBG001595.
InParanoidiP24383.
KOiK00572.
OMAiYIDKSPN.
OrthoDBiEOG091G0OFF.
TreeFamiTF105310.

Enzyme and pathway databases

ReactomeiR-MMU-3238698. WNT ligand biogenesis and trafficking.

Miscellaneous databases

PROiP24383.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030093.
CleanExiMM_WNT7A.
GenevisibleiP24383. MM.

Family and domain databases

InterProiIPR005817. Wnt.
IPR013300. Wnt7.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01891. WNT7PROTEIN.
PR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWNT7A_MOUSE
AccessioniPrimary (citable) accession number: P24383
Secondary accession number(s): Q80VH3, Q9DBY3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: June 28, 2011
Last modified: November 2, 2016
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.