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Protein

Peptidyl-prolyl cis-trans isomerase B

Gene

Ppib

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationi

Cyclosporin A (CsA) inhibits CYPB.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Keywords - Ligandi

Cyclosporin

Enzyme and pathway databases

ReactomeiR-RNO-1650814. Collagen biosynthesis and modifying enzymes.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase B (EC:5.2.1.8)
Short name:
PPIase B
Alternative name(s):
CYP-S1
Cyclophilin B
Rotamase B
S-cyclophilin
Short name:
SCYLP
Gene namesi
Name:Ppib
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi620312. Ppib.

Subcellular locationi

  • Endoplasmic reticulum lumen By similarity
  • Melanosome By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333By similarityAdd
BLAST
Chaini34 – 216183Peptidyl-prolyl cis-trans isomerase BPRO_0000025481Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei209 – 2091N6-acetyllysine; alternateBy similarity
Modified residuei209 – 2091N6-succinyllysine; alternateBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP24368.
PRIDEiP24368.

PTM databases

iPTMnetiP24368.
PhosphoSiteiP24368.
SwissPalmiP24368.

Expressioni

Tissue specificityi

Widely expressed with highest levels in kidney.1 Publication

Gene expression databases

BgeeiENSRNOG00000016781.
GenevisibleiP24368. RN.

Interactioni

Subunit structurei

Interacts with DYM. Interacts with CALR, CANX and CLGN (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Pdia4P386592EBI-916926,EBI-917435

GO - Molecular functioni

Protein-protein interaction databases

BioGridi249051. 1 interaction.
IntActiP24368. 4 interactions.
MINTiMINT-4566333.
STRINGi10116.ENSRNOP00000022828.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini47 – 204158PPIase cyclophilin-typePROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi213 – 2164Prevents secretion from ERBy similarity

Sequence similaritiesi

Contains 1 PPIase cyclophilin-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0880. Eukaryota.
ENOG410Z0G4. LUCA.
GeneTreeiENSGT00760000119072.
HOGENOMiHOG000065981.
HOVERGENiHBG001065.
InParanoidiP24368.
KOiK03768.
OMAiPSVANDK.
OrthoDBiEOG091G0BGL.
PhylomeDBiP24368.
TreeFamiTF354259.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24368-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRLSERNMK VLFAAALIVG SVVFLLLPGP SVANDKKKGP KVTVKVYFDF
60 70 80 90 100
QIGDEPVGRV TFGLFGKTVP KTVDNFVALA TGEKGFGYKN SKFHRVIKDF
110 120 130 140 150
MIQGGDFTRG DGTGGKSIYG ERFPDENFKL KHYGPGWVSM ANAGKDTNGS
160 170 180 190 200
QFFITTVKTS WLDGKHVVFG KVLEGMDVVR KVENTKTDSR DKPLKDVIIV
210
DCGKIEVEKP FAIAKE
Length:216
Mass (Da):23,803
Last modified:November 25, 2008 - v3
Checksum:i8750D541754380D5
GO

Sequence cautioni

The sequence AAC25590 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti54 – 7017DEPVG…GKTVP → GRTCRTSDLWTLWKDCS (PubMed:2194066).CuratedAdd
BLAST
Sequence conflicti95 – 962RV → HM (PubMed:2194066).Curated

Polymorphismi

Higher levels occur in the proximal convoluted tubule of strain SHR than strain Wistar Kyoto.1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071225 mRNA. Translation: AAC25590.1. Different initiation.
BC061971 mRNA. Translation: AAH61971.1.
PIRiS71547.
RefSeqiNP_071981.1. NM_022536.2.
UniGeneiRn.1893.

Genome annotation databases

EnsembliENSRNOT00000022828; ENSRNOP00000022828; ENSRNOG00000016781.
GeneIDi64367.
KEGGirno:64367.
UCSCiRGD:620312. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071225 mRNA. Translation: AAC25590.1. Different initiation.
BC061971 mRNA. Translation: AAH61971.1.
PIRiS71547.
RefSeqiNP_071981.1. NM_022536.2.
UniGeneiRn.1893.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249051. 1 interaction.
IntActiP24368. 4 interactions.
MINTiMINT-4566333.
STRINGi10116.ENSRNOP00000022828.

PTM databases

iPTMnetiP24368.
PhosphoSiteiP24368.
SwissPalmiP24368.

Proteomic databases

PaxDbiP24368.
PRIDEiP24368.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000022828; ENSRNOP00000022828; ENSRNOG00000016781.
GeneIDi64367.
KEGGirno:64367.
UCSCiRGD:620312. rat.

Organism-specific databases

CTDi5479.
RGDi620312. Ppib.

Phylogenomic databases

eggNOGiKOG0880. Eukaryota.
ENOG410Z0G4. LUCA.
GeneTreeiENSGT00760000119072.
HOGENOMiHOG000065981.
HOVERGENiHBG001065.
InParanoidiP24368.
KOiK03768.
OMAiPSVANDK.
OrthoDBiEOG091G0BGL.
PhylomeDBiP24368.
TreeFamiTF354259.

Enzyme and pathway databases

ReactomeiR-RNO-1650814. Collagen biosynthesis and modifying enzymes.

Miscellaneous databases

PROiP24368.

Gene expression databases

BgeeiENSRNOG00000016781.
GenevisibleiP24368. RN.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPPIB_RAT
AccessioniPrimary (citable) accession number: P24368
Secondary accession number(s): O88541
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: November 25, 2008
Last modified: September 7, 2016
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-9 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.