P24356 (F1_VACCW) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein F1

Gene names

Ordered Locus Names:	VACWR040
ORF Names:	F1L

Organism

Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) [Reference proteome]

Taxonomic identifier

10254 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Poxviridae › Chordopoxvirinae › Orthopoxvirus › Vaccinia virus

Virus host

Bos taurus (Bovine) [TaxID: 9913]

Protein attributes

Sequence length	226 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Protein with a BCL2-like fold which is essential for survival of infected cells By similarity.
Subunit structure	Homodimer. Interacts with host pro-apoptotic protein BCL2L11 (via BH3 domain) By similarity.
Sequence similarities	Belongs to the poxviridae F1 protein family.

Ontologies

Keywords
Biological process	Host-virus interaction Inhibition of host apoptosis by viral BCL2-like protein Modulation of host cell apoptosis by virus
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	modulation by virus of host apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 226	226	Protein F1		PRO_0000099476

Sequences

	Sequence		Length	Mass (Da)
	P24356 [UniParc]. Last modified December 7, 2004. Version 2. Checksum: 68DC7EB188D29ECA	FASTA	226	26,428
	10 20 30 40 50 60 MLSMFMCNNI VDYVDDIDNG IVQDIEDEAS NNVDHDYVYP LPENMVYRFD KSTNILDYLS 70 80 90 100 110 120 TERDHVMMAV RYYMSKQRLD DLYRQLPTKT RSYIDIINIY CDKVSNDYNR DMNIMYDMAS 130 140 150 160 170 180 TKSFTVYDIN NEVNTILMDN KGLGVRLATI SFITELGRRC MNPVETIKMF TLLSHTICDD 190 200 210 220 YFVDYITDIS PPDNTIPNTS TREYLKLIGI TAIMFATYKT LKYMIG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequencing of the coding region of Vaccinia-WR to an average 9-fold redundancy and an error rate of 0.16/10kb." Esposito J.J., Frace A.M., Sammons S.A., Olsen-Rasmussen M., Osborne J., Wohlhueter R. Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The vaccinia virus HindIII F fragment: nucleotide sequence of the left 6.2 kb." Roseman N.A., Slabaugh M.B. Virology 178:410-418(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-207.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY243312 Genomic DNA. Translation: AAO89319.1. M34368 mRNA. Translation: AAA48247.1.
PIR	I36213.
RefSeq	YP_232922.1. NC_006998.1.
3D structure databases
ProteinModelPortal	P24356.
SMR	P24356. Positions 38-190.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-6740435.
Protein family/group databases
MEROPS	I91.001.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3707497.
Phylogenomic databases
ProtClustDB	PHA2934.
Family and domain databases
InterPro	IPR011207. Orthopox_F1. IPR021119. Poxvirus_F1/C10. [Graphical view]
Pfam	PF11099. M11L. 1 hit. [Graphical view]
PIRSF	PIRSF015971. VAC_F1L. 1 hit.
ProtoNet	Search...

Entry information

Entry name

F1_VACCW

Accession

Primary (citable) accession number: P24356
Secondary accession number(s): Q80HY1

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
Last sequence update:	December 7, 2004
Last modified:	April 3, 2013
This is version 41 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program