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Protein

Stromelysin-3

Gene

MMP11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play an important role in the progression of epithelial malignancies.

Cofactori

Protein has several cofactor binding sites:
  • Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity
  • Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi80Zinc 2; in inhibited formBy similarity1
Metal bindingi166Zinc 1By similarity1
Metal bindingi171CalciumBy similarity1
Metal bindingi172Calcium; via carbonyl oxygenBy similarity1
Metal bindingi174Calcium; via carbonyl oxygenBy similarity1
Metal bindingi176Calcium; via carbonyl oxygenBy similarity1
Metal bindingi179Zinc 1By similarity1
Metal bindingi192Zinc 1By similarity1
Metal bindingi215Zinc 2; catalyticBy similarity1
Active sitei216PROSITE-ProRule annotation1
Metal bindingi219Zinc 2; catalyticBy similarity1
Metal bindingi225Zinc 2; catalyticBy similarity1

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • metalloendopeptidase activity Source: ProtInc
  • serine-type endopeptidase activity Source: Reactome
  • zinc ion binding Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Biological processi

Collagen degradation

Keywords - Ligandi

Calcium, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000099953-MONOMER.
BRENDAi3.4.24.B3. 2681.
ReactomeiR-HSA-1442490. Collagen degradation.
R-HSA-1474228. Degradation of the extracellular matrix.
R-HSA-1592389. Activation of Matrix Metalloproteinases.

Protein family/group databases

MEROPSiM10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Stromelysin-3 (EC:3.4.24.-)
Short name:
SL-3
Short name:
ST3
Alternative name(s):
Matrix metalloproteinase-11
Short name:
MMP-11
Gene namesi
Name:MMP11
Synonyms:STMY3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:7157. MMP11.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: Reactome
  • Golgi lumen Source: Reactome
  • proteinaceous extracellular matrix Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi4320.
OpenTargetsiENSG00000099953.
ENSG00000275365.
PharmGKBiPA30869.

Chemistry databases

ChEMBLiCHEMBL2867.
DrugBankiDB00786. Marimastat.
GuidetoPHARMACOLOGYi1635.

Polymorphism and mutation databases

BioMutaiMMP11.
DMDMi317373418.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
PropeptideiPRO_000002877032 – 97Activation peptideBy similarityAdd BLAST66
ChainiPRO_000002877198 – 488Stromelysin-3Add BLAST391

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi294 ↔ 480By similarity

Post-translational modificationi

The precursor is cleaved by a furin endopeptidase.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Zymogen

Proteomic databases

PaxDbiP24347.
PeptideAtlasiP24347.
PRIDEiP24347.

PTM databases

iPTMnetiP24347.
PhosphoSitePlusiP24347.

Expressioni

Tissue specificityi

Specifically expressed in stromal cells of breast carcinomas.

Gene expression databases

BgeeiENSG00000099953.
CleanExiHS_MMP11.
ExpressionAtlasiP24347. baseline and differential.
GenevisibleiP24347. HS.

Organism-specific databases

HPAiCAB002593.
HPA068864.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000215743.

Chemistry databases

BindingDBiP24347.

Structurei

3D structure databases

ProteinModelPortaliP24347.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati291 – 339Hemopexin 1Add BLAST49
Repeati340 – 382Hemopexin 2Add BLAST43
Repeati384 – 432Hemopexin 3Add BLAST49
Repeati433 – 480Hemopexin 4Add BLAST48

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi78 – 85Cysteine switchBy similarity8

Domaini

The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

Sequence similaritiesi

Belongs to the peptidase M10A family.Curated
Contains 4 hemopexin repeats.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1565. Eukaryota.
ENOG410XQ5D. LUCA.
GeneTreeiENSGT00760000118870.
HOGENOMiHOG000217927.
HOVERGENiHBG052484.
InParanoidiP24347.
KOiK07993.
OMAiFFQGAQY.
OrthoDBiEOG091G03DP.
PhylomeDBiP24347.
TreeFamiTF315428.

Family and domain databases

CDDicd00094. HX. 1 hit.
cd04278. ZnMc_MMP. 1 hit.
Gene3Di2.110.10.10. 1 hit.
3.40.390.10. 1 hit.
InterProiIPR000585. Hemopexin-like_dom.
IPR018487. Hemopexin-like_repeat.
IPR018486. Hemopexin_CS.
IPR033739. M10A_MMP.
IPR024079. MetalloPept_cat_dom.
IPR001818. Pept_M10_metallopeptidase.
IPR021190. Pept_M10A.
IPR016293. Pept_M10A_stromelysin-type.
IPR021158. Pept_M10A_Zn_BS.
IPR006026. Peptidase_Metallo.
IPR028705. Stromelysin-3.
[Graphical view]
PANTHERiPTHR10201:SF20. PTHR10201:SF20. 1 hit.
PfamiPF00045. Hemopexin. 4 hits.
PF00413. Peptidase_M10. 1 hit.
[Graphical view]
PIRSFiPIRSF001191. Peptidase_M10A_matrix. 1 hit.
PRINTSiPR00138. MATRIXIN.
SMARTiSM00120. HX. 4 hits.
SM00235. ZnMc. 1 hit.
[Graphical view]
SUPFAMiSSF50923. SSF50923. 1 hit.
PROSITEiPS00546. CYSTEINE_SWITCH. 1 hit.
PS00024. HEMOPEXIN. 1 hit.
PS51642. HEMOPEXIN_2. 4 hits.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24347-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPAAWLRSA AARALLPPML LLLLQPPPLL ARALPPDAHH LHAERRGPQP
60 70 80 90 100
WHAALPSSPA PAPATQEAPR PASSLRPPRC GVPDPSDGLS ARNRQKRFVL
110 120 130 140 150
SGGRWEKTDL TYRILRFPWQ LVQEQVRQTM AEALKVWSDV TPLTFTEVHE
160 170 180 190 200
GRADIMIDFA RYWHGDDLPF DGPGGILAHA FFPKTHREGD VHFDYDETWT
210 220 230 240 250
IGDDQGTDLL QVAAHEFGHV LGLQHTTAAK ALMSAFYTFR YPLSLSPDDC
260 270 280 290 300
RGVQHLYGQP WPTVTSRTPA LGPQAGIDTN EIAPLEPDAP PDACEASFDA
310 320 330 340 350
VSTIRGELFF FKAGFVWRLR GGQLQPGYPA LASRHWQGLP SPVDAAFEDA
360 370 380 390 400
QGHIWFFQGA QYWVYDGEKP VLGPAPLTEL GLVRFPVHAA LVWGPEKNKI
410 420 430 440 450
YFFRGRDYWR FHPSTRRVDS PVPRRATDWR GVPSEIDAAF QDADGYAYFL
460 470 480
RGRLYWKFDP VKVKALEGFP RLVGPDFFGC AEPANTFL
Length:488
Mass (Da):54,590
Last modified:January 11, 2011 - v3
Checksum:iF03C537EE76706A9
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02218138A → V.2 PublicationsCorresponds to variant rs738792dbSNPEnsembl.1
Natural variantiVAR_02218244E → K.1 PublicationCorresponds to variant rs28363646dbSNPEnsembl.1
Natural variantiVAR_02218361P → L.1 PublicationCorresponds to variant rs28363647dbSNPEnsembl.1
Natural variantiVAR_02218486S → P.1 PublicationCorresponds to variant rs28363648dbSNPEnsembl.1
Natural variantiVAR_036140166D → N in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_029659182F → S.1 PublicationCorresponds to variant rs17854940dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57766 mRNA. Translation: CAA40918.1.
AY899208 Genomic DNA. Translation: AAW65373.1.
AP000349 Genomic DNA. No translation available.
BC057788 mRNA. Translation: AAH57788.1.
X84664 Genomic DNA. Translation: CAA59150.1.
CCDSiCCDS13816.1.
PIRiS13423.
RefSeqiNP_005931.2. NM_005940.4.
UniGeneiHs.143751.

Genome annotation databases

EnsembliENST00000215743; ENSP00000215743; ENSG00000099953.
ENST00000612388; ENSP00000483349; ENSG00000275365.
GeneIDi4320.
KEGGihsa:4320.
UCSCiuc002zxx.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57766 mRNA. Translation: CAA40918.1.
AY899208 Genomic DNA. Translation: AAW65373.1.
AP000349 Genomic DNA. No translation available.
BC057788 mRNA. Translation: AAH57788.1.
X84664 Genomic DNA. Translation: CAA59150.1.
CCDSiCCDS13816.1.
PIRiS13423.
RefSeqiNP_005931.2. NM_005940.4.
UniGeneiHs.143751.

3D structure databases

ProteinModelPortaliP24347.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000215743.

Chemistry databases

BindingDBiP24347.
ChEMBLiCHEMBL2867.
DrugBankiDB00786. Marimastat.
GuidetoPHARMACOLOGYi1635.

Protein family/group databases

MEROPSiM10.007.

PTM databases

iPTMnetiP24347.
PhosphoSitePlusiP24347.

Polymorphism and mutation databases

BioMutaiMMP11.
DMDMi317373418.

Proteomic databases

PaxDbiP24347.
PeptideAtlasiP24347.
PRIDEiP24347.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000215743; ENSP00000215743; ENSG00000099953.
ENST00000612388; ENSP00000483349; ENSG00000275365.
GeneIDi4320.
KEGGihsa:4320.
UCSCiuc002zxx.4. human.

Organism-specific databases

CTDi4320.
DisGeNETi4320.
GeneCardsiMMP11.
H-InvDBHIX0203187.
HGNCiHGNC:7157. MMP11.
HPAiCAB002593.
HPA068864.
MIMi185261. gene.
neXtProtiNX_P24347.
OpenTargetsiENSG00000099953.
ENSG00000275365.
PharmGKBiPA30869.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1565. Eukaryota.
ENOG410XQ5D. LUCA.
GeneTreeiENSGT00760000118870.
HOGENOMiHOG000217927.
HOVERGENiHBG052484.
InParanoidiP24347.
KOiK07993.
OMAiFFQGAQY.
OrthoDBiEOG091G03DP.
PhylomeDBiP24347.
TreeFamiTF315428.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000099953-MONOMER.
BRENDAi3.4.24.B3. 2681.
ReactomeiR-HSA-1442490. Collagen degradation.
R-HSA-1474228. Degradation of the extracellular matrix.
R-HSA-1592389. Activation of Matrix Metalloproteinases.

Miscellaneous databases

ChiTaRSiMMP11. human.
GeneWikiiMMP11.
GenomeRNAii4320.
PROiP24347.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000099953.
CleanExiHS_MMP11.
ExpressionAtlasiP24347. baseline and differential.
GenevisibleiP24347. HS.

Family and domain databases

CDDicd00094. HX. 1 hit.
cd04278. ZnMc_MMP. 1 hit.
Gene3Di2.110.10.10. 1 hit.
3.40.390.10. 1 hit.
InterProiIPR000585. Hemopexin-like_dom.
IPR018487. Hemopexin-like_repeat.
IPR018486. Hemopexin_CS.
IPR033739. M10A_MMP.
IPR024079. MetalloPept_cat_dom.
IPR001818. Pept_M10_metallopeptidase.
IPR021190. Pept_M10A.
IPR016293. Pept_M10A_stromelysin-type.
IPR021158. Pept_M10A_Zn_BS.
IPR006026. Peptidase_Metallo.
IPR028705. Stromelysin-3.
[Graphical view]
PANTHERiPTHR10201:SF20. PTHR10201:SF20. 1 hit.
PfamiPF00045. Hemopexin. 4 hits.
PF00413. Peptidase_M10. 1 hit.
[Graphical view]
PIRSFiPIRSF001191. Peptidase_M10A_matrix. 1 hit.
PRINTSiPR00138. MATRIXIN.
SMARTiSM00120. HX. 4 hits.
SM00235. ZnMc. 1 hit.
[Graphical view]
SUPFAMiSSF50923. SSF50923. 1 hit.
PROSITEiPS00546. CYSTEINE_SWITCH. 1 hit.
PS00024. HEMOPEXIN. 1 hit.
PS51642. HEMOPEXIN_2. 4 hits.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMMP11_HUMAN
AccessioniPrimary (citable) accession number: P24347
Secondary accession number(s): Q5FX24, Q6PEZ6, Q9UC26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: January 11, 2011
Last modified: November 30, 2016
This is version 173 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.