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Protein

Putative ATP-dependent RNA helicase an3

Gene

an3

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Putative ATP-dependent RNA helicase.

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi241 – 248ATPPROSITE-ProRule annotation8
Nucleotide bindingi265 – 272ATPPROSITE-ProRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHelicase, Hydrolase, RNA-binding
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

SABIO-RKiP24346.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative ATP-dependent RNA helicase an3 (EC:3.6.4.13)
Gene namesi
Name:an3
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-17330554. ddx3x.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000550151 – 697Putative ATP-dependent RNA helicase an3Add BLAST697

Proteomic databases

PRIDEiP24346.

Interactioni

Protein-protein interaction databases

DIPiDIP-59067N.

Structurei

3D structure databases

ProteinModelPortaliP24346.
SMRiP24346.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini252 – 444Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST193
Domaini455 – 616Helicase C-terminalPROSITE-ProRule annotationAdd BLAST162

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi221 – 249Q motifAdd BLAST29
Motifi388 – 391DEAD box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi623 – 697Gly/Ser-richAdd BLAST75

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG015893.
KOiK11594.

Family and domain databases

InterProiView protein in InterPro
IPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
PfamiView protein in Pfam
PF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
SMARTiView protein in SMART
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.

Sequencei

Sequence statusi: Complete.

P24346-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHVAVENVL NLDQQFAGLD LNSADAESGV AGTKGRYIPP HLRNKEASRN
60 70 80 90 100
DSNWDSGRGG NGYINGMQDD RDGRMNGYDR GGYGSRGTGR SDRGFYDREN
110 120 130 140 150
SGWNSGRDKD AYSSFGSRGD RGKGSLFNER GSGSRRTDDR RQDGFDGMGN
160 170 180 190 200
RSDKSGFGRF DRGNSRWSDD RNDEDDWSKP LAPNDRVEQE LFSGSNTGIN
210 220 230 240 250
FEKYDDIPVE ATGSNCPPHI ESFHDVTMGE IIMGNIQLTR YTRPTPVQKH
260 270 280 290 300
AIPIIIEKRD LMACAQTGSG KTAAFLLPIL SQIYADGPGD AMKHLQENGR
310 320 330 340 350
YGRRKQFPLS LVLAPTRELA VQIYEEARKF AYRSRVRPCV VYGGADIGQQ
360 370 380 390 400
IRDLERGCHL LVATPGRLVD MMERGKIGLD FCKYLVLDEA DRMLDMGFEP
410 420 430 440 450
QIRRIVEQDT MPPKGVRQTM MFSATFPKEI QILARDFLDE YIFLAVGRVG
460 470 480 490 500
STSENITQKV VWVEEMDKRS FLLDLLNATG KDSLTLVFVE TKKGADALED
510 520 530 540 550
FLYHEGYACT SIHGDRSQRD REEALHQFRS GKSPILVATA VAARGLDISN
560 570 580 590 600
VKHVINFDLP SDIEEYVHRI GRTGRVGNLG LATSFFNEKN INITKDLLDL
610 620 630 640 650
LVEAKQEVPS WLENMAYEQH HKSSSRGRSK SRFSGGFGAK DYRQSSGAGS
660 670 680 690
SFGSSRGGRS SGHGGSRGFG GGYGGFYNSD GYGGNYGGSS QVDWWGN
Length:697
Mass (Da):77,303
Last modified:March 1, 1992 - v1
Checksum:iF3DD23EB60B2E2EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57328 mRNA. Translation: CAA40605.1.
PIRiS13654.
RefSeqiNP_001095245.1. NM_001101775.1.
UniGeneiXl.21985.

Genome annotation databases

GeneIDi397935.
KEGGixla:397935.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57328 mRNA. Translation: CAA40605.1.
PIRiS13654.
RefSeqiNP_001095245.1. NM_001101775.1.
UniGeneiXl.21985.

3D structure databases

ProteinModelPortaliP24346.
SMRiP24346.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59067N.

Proteomic databases

PRIDEiP24346.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi397935.
KEGGixla:397935.

Organism-specific databases

CTDi397935.
XenbaseiXB-GENE-17330554. ddx3x.

Phylogenomic databases

HOVERGENiHBG015893.
KOiK11594.

Enzyme and pathway databases

SABIO-RKiP24346.

Family and domain databases

InterProiView protein in InterPro
IPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
PfamiView protein in Pfam
PF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
SMARTiView protein in SMART
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDDX3_XENLA
AccessioniPrimary (citable) accession number: P24346
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: April 12, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.