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Protein

Homeobox protein Hox-D13

Gene

HOXD13

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor that binds gene promoters and activates their transcription (By similarity). Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (PubMed:1672266).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi234 – 293HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-D13
Alternative name(s):
Homeobox protein Hox-4.8
Short name:
Chox-4.8
Homeobox protein Hox-4G
Short name:
Chox-4G
Gene namesi
Name:HOXD13
Synonyms:CHOX-4.8
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

  • Nucleus By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002002461 – 301Homeobox protein Hox-D13Add BLAST301

Proteomic databases

PaxDbiP24344.

Expressioni

Developmental stagei

Coordinately expressed in partially overlapping domains during wing development.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000015076.

Structurei

3D structure databases

ProteinModelPortaliP24344.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi10 – 16Poly-Gly7
Compositional biasi38 – 46Poly-Ala9

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0487. Eukaryota.
ENOG4111FJP. LUCA.
HOGENOMiHOG000231176.
HOVERGENiHBG106958.
InParanoidiP24344.
KOiK09298.
PhylomeDBiP24344.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR022067. HoxA13_N.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF12284. HoxA13_N. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24344-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGLRGDSSG GGGGGGTPGQ CRNFLSSPVF GAAHTGRAAA AAAAAASGFA
60 70 80 90 100
YAGGGERSGA AARPDPPAKD CPGSGAPPAA PALGYGYHFG NGYYSCRMSN
110 120 130 140 150
GVGIQQNALK SPPHASIGGF PVEKYMDVSS LTSTSVPANE VSTRAKEVSS
160 170 180 190 200
YQGYTNPYQH VPGYIDMVST FGSGEPRHET YISMEGYQSW TLANGWNGQV
210 220 230 240 250
YCAKDQTQSS HFWKSSFPGD VALNQPEMCV YRRGRKKRVP YTKLQLKELE
260 270 280 290 300
NEYAINKFIN KDKRRRISAA TNLSERQVTI WFQNRRVKDK KIVSKLKDNV

S
Length:301
Mass (Da):32,373
Last modified:November 1, 1995 - v3
Checksum:iE598FD4E14AA6BCA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti208 – 218QSSHFWKSSFP → NSNFSRRVFSL (Ref. 2) CuratedAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L09550 mRNA. Translation: AAA48824.1.
D10290 Genomic DNA. Translation: BAA01135.1.
PIRiS35526.
RefSeqiNP_990765.1. NM_205434.1.
UniGeneiGga.4131.

Genome annotation databases

GeneIDi396415.
KEGGigga:396415.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L09550 mRNA. Translation: AAA48824.1.
D10290 Genomic DNA. Translation: BAA01135.1.
PIRiS35526.
RefSeqiNP_990765.1. NM_205434.1.
UniGeneiGga.4131.

3D structure databases

ProteinModelPortaliP24344.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000015076.

Proteomic databases

PaxDbiP24344.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396415.
KEGGigga:396415.

Organism-specific databases

CTDi3239.

Phylogenomic databases

eggNOGiKOG0487. Eukaryota.
ENOG4111FJP. LUCA.
HOGENOMiHOG000231176.
HOVERGENiHBG106958.
InParanoidiP24344.
KOiK09298.
PhylomeDBiP24344.

Miscellaneous databases

PROiP24344.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR022067. HoxA13_N.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF12284. HoxA13_N. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHXD13_CHICK
AccessioniPrimary (citable) accession number: P24344
Secondary accession number(s): Q90781
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 109 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.