Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P24344

- HXD13_CHICK

UniProt

P24344 - HXD13_CHICK

Protein

Homeobox protein Hox-D13

Gene

HOXD13

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 3 (01 Nov 1995)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi234 – 29360HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-D13
    Alternative name(s):
    Homeobox protein Hox-4.8
    Short name:
    Chox-4.8
    Homeobox protein Hox-4G
    Short name:
    Chox-4G
    Gene namesi
    Name:HOXD13
    Synonyms:CHOX-4.8
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 301301Homeobox protein Hox-D13PRO_0000200246Add
    BLAST

    Expressioni

    Developmental stagei

    Coordinately expressed in partially overlapping domains during wing development.

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000015076.

    Structurei

    3D structure databases

    ProteinModelPortaliP24344.
    SMRiP24344. Positions 234-291.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi10 – 167Poly-Gly
    Compositional biasi38 – 469Poly-Ala

    Sequence similaritiesi

    Belongs to the Abd-B homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG251666.
    HOGENOMiHOG000231176.
    HOVERGENiHBG106958.
    InParanoidiP24344.
    KOiK09298.
    PhylomeDBiP24344.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR022067. HoxA13_N.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF12284. HoxA13_N. 1 hit.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P24344-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDGLRGDSSG GGGGGGTPGQ CRNFLSSPVF GAAHTGRAAA AAAAAASGFA    50
    YAGGGERSGA AARPDPPAKD CPGSGAPPAA PALGYGYHFG NGYYSCRMSN 100
    GVGIQQNALK SPPHASIGGF PVEKYMDVSS LTSTSVPANE VSTRAKEVSS 150
    YQGYTNPYQH VPGYIDMVST FGSGEPRHET YISMEGYQSW TLANGWNGQV 200
    YCAKDQTQSS HFWKSSFPGD VALNQPEMCV YRRGRKKRVP YTKLQLKELE 250
    NEYAINKFIN KDKRRRISAA TNLSERQVTI WFQNRRVKDK KIVSKLKDNV 300
    S 301
    Length:301
    Mass (Da):32,373
    Last modified:November 1, 1995 - v3
    Checksum:iE598FD4E14AA6BCA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti208 – 21811QSSHFWKSSFP → NSNFSRRVFSL1 PublicationCuratedAdd
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L09550 mRNA. Translation: AAA48824.1.
    D10290 Genomic DNA. Translation: BAA01135.1.
    PIRiS35526.
    RefSeqiNP_990765.1. NM_205434.1.
    UniGeneiGga.4131.

    Genome annotation databases

    GeneIDi396415.
    KEGGigga:396415.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L09550 mRNA. Translation: AAA48824.1 .
    D10290 Genomic DNA. Translation: BAA01135.1 .
    PIRi S35526.
    RefSeqi NP_990765.1. NM_205434.1.
    UniGenei Gga.4131.

    3D structure databases

    ProteinModelPortali P24344.
    SMRi P24344. Positions 234-291.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000015076.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 396415.
    KEGGi gga:396415.

    Organism-specific databases

    CTDi 3239.

    Phylogenomic databases

    eggNOGi NOG251666.
    HOGENOMi HOG000231176.
    HOVERGENi HBG106958.
    InParanoidi P24344.
    KOi K09298.
    PhylomeDBi P24344.

    Miscellaneous databases

    NextBioi 20816456.
    PROi P24344.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR022067. HoxA13_N.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF12284. HoxA13_N. 1 hit.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of full coding chicken cDNAs for the homeobox-containing gene Hoxd-13."
      Rogina B., Upholt W.B.
      Nucleic Acids Res. 21:1316-1316(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Nohno T.
      Submitted (FEB-1992) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE OF 208-301.
    3. "Involvement of the Chox-4 chicken homeobox genes in determination of anteroposterior axial polarity during limb development."
      Nohno T., Noji S., Koyama E., Ohyama K., Myokai F., Kuroiwa A., Saito T., Taniguchi S.
      Cell 64:1197-1205(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 234-301.
    4. "Expression of the homeobox Hox-4 genes and the specification of position in chick wing development."
      Izpisua-Belmonte J.-C., Tickle C., Dolle P., Wolpert L., Duboule D.
      Nature 350:585-589(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 234-293.

    Entry informationi

    Entry nameiHXD13_CHICK
    AccessioniPrimary (citable) accession number: P24344
    Secondary accession number(s): Q90781
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 98 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3