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P24344

- HXD13_CHICK

UniProt

P24344 - HXD13_CHICK

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Protein

Homeobox protein Hox-D13

Gene
HOXD13, CHOX-4.8
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi234 – 29360HomeoboxAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-D13
Alternative name(s):
Homeobox protein Hox-4.8
Short name:
Chox-4.8
Homeobox protein Hox-4G
Short name:
Chox-4G
Gene namesi
Name:HOXD13
Synonyms:CHOX-4.8
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 301301Homeobox protein Hox-D13PRO_0000200246Add
BLAST

Expressioni

Developmental stagei

Coordinately expressed in partially overlapping domains during wing development.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000015076.

Structurei

3D structure databases

ProteinModelPortaliP24344.
SMRiP24344. Positions 234-291.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi10 – 167Poly-Gly
Compositional biasi38 – 469Poly-Ala

Sequence similaritiesi

Belongs to the Abd-B homeobox family.

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG251666.
HOGENOMiHOG000231176.
HOVERGENiHBG106958.
InParanoidiP24344.
KOiK09298.
PhylomeDBiP24344.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR022067. HoxA13_N.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF12284. HoxA13_N. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24344-1 [UniParc]FASTAAdd to Basket

« Hide

MDGLRGDSSG GGGGGGTPGQ CRNFLSSPVF GAAHTGRAAA AAAAAASGFA    50
YAGGGERSGA AARPDPPAKD CPGSGAPPAA PALGYGYHFG NGYYSCRMSN 100
GVGIQQNALK SPPHASIGGF PVEKYMDVSS LTSTSVPANE VSTRAKEVSS 150
YQGYTNPYQH VPGYIDMVST FGSGEPRHET YISMEGYQSW TLANGWNGQV 200
YCAKDQTQSS HFWKSSFPGD VALNQPEMCV YRRGRKKRVP YTKLQLKELE 250
NEYAINKFIN KDKRRRISAA TNLSERQVTI WFQNRRVKDK KIVSKLKDNV 300
S 301
Length:301
Mass (Da):32,373
Last modified:November 1, 1995 - v3
Checksum:iE598FD4E14AA6BCA
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti208 – 21811QSSHFWKSSFP → NSNFSRRVFSL1 PublicationAdd
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L09550 mRNA. Translation: AAA48824.1.
D10290 Genomic DNA. Translation: BAA01135.1.
PIRiS35526.
RefSeqiNP_990765.1. NM_205434.1.
UniGeneiGga.4131.

Genome annotation databases

GeneIDi396415.
KEGGigga:396415.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L09550 mRNA. Translation: AAA48824.1 .
D10290 Genomic DNA. Translation: BAA01135.1 .
PIRi S35526.
RefSeqi NP_990765.1. NM_205434.1.
UniGenei Gga.4131.

3D structure databases

ProteinModelPortali P24344.
SMRi P24344. Positions 234-291.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000015076.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396415.
KEGGi gga:396415.

Organism-specific databases

CTDi 3239.

Phylogenomic databases

eggNOGi NOG251666.
HOGENOMi HOG000231176.
HOVERGENi HBG106958.
InParanoidi P24344.
KOi K09298.
PhylomeDBi P24344.

Miscellaneous databases

NextBioi 20816456.
PROi P24344.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR022067. HoxA13_N.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF12284. HoxA13_N. 1 hit.
[Graphical view ]
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning of full coding chicken cDNAs for the homeobox-containing gene Hoxd-13."
    Rogina B., Upholt W.B.
    Nucleic Acids Res. 21:1316-1316(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Nohno T.
    Submitted (FEB-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE OF 208-301.
  3. "Involvement of the Chox-4 chicken homeobox genes in determination of anteroposterior axial polarity during limb development."
    Nohno T., Noji S., Koyama E., Ohyama K., Myokai F., Kuroiwa A., Saito T., Taniguchi S.
    Cell 64:1197-1205(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 234-301.
  4. "Expression of the homeobox Hox-4 genes and the specification of position in chick wing development."
    Izpisua-Belmonte J.-C., Tickle C., Dolle P., Wolpert L., Duboule D.
    Nature 350:585-589(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 234-293.

Entry informationi

Entry nameiHXD13_CHICK
AccessioniPrimary (citable) accession number: P24344
Secondary accession number(s): Q90781
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 97 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi