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P24344 (HXD13_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-D13
Alternative name(s):
Homeobox protein Hox-4.8
Short name=Chox-4.8
Homeobox protein Hox-4G
Short name=Chox-4G
Gene names
Name:HOXD13
Synonyms:CHOX-4.8
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length301 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular location

Nucleus.

Developmental stage

Coordinately expressed in partially overlapping domains during wing development.

Sequence similarities

Belongs to the Abd-B homeobox family.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmulticellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 301301Homeobox protein Hox-D13
PRO_0000200246

Regions

DNA binding234 – 29360Homeobox
Compositional bias10 – 167Poly-Gly
Compositional bias38 – 469Poly-Ala

Experimental info

Sequence conflict208 – 21811QSSHFWKSSFP → NSNFSRRVFSL Ref.2

Sequences

Sequence LengthMass (Da)Tools
P24344 [UniParc].

Last modified November 1, 1995. Version 3.
Checksum: E598FD4E14AA6BCA

FASTA30132,373
        10         20         30         40         50         60 
MDGLRGDSSG GGGGGGTPGQ CRNFLSSPVF GAAHTGRAAA AAAAAASGFA YAGGGERSGA 

        70         80         90        100        110        120 
AARPDPPAKD CPGSGAPPAA PALGYGYHFG NGYYSCRMSN GVGIQQNALK SPPHASIGGF 

       130        140        150        160        170        180 
PVEKYMDVSS LTSTSVPANE VSTRAKEVSS YQGYTNPYQH VPGYIDMVST FGSGEPRHET 

       190        200        210        220        230        240 
YISMEGYQSW TLANGWNGQV YCAKDQTQSS HFWKSSFPGD VALNQPEMCV YRRGRKKRVP 

       250        260        270        280        290        300 
YTKLQLKELE NEYAINKFIN KDKRRRISAA TNLSERQVTI WFQNRRVKDK KIVSKLKDNV 


S 

« Hide

References

[1]"Cloning of full coding chicken cDNAs for the homeobox-containing gene Hoxd-13."
Rogina B., Upholt W.B.
Nucleic Acids Res. 21:1316-1316(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]Nohno T.
Submitted (FEB-1992) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE OF 208-301.
[3]"Involvement of the Chox-4 chicken homeobox genes in determination of anteroposterior axial polarity during limb development."
Nohno T., Noji S., Koyama E., Ohyama K., Myokai F., Kuroiwa A., Saito T., Taniguchi S.
Cell 64:1197-1205(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 234-301.
[4]"Expression of the homeobox Hox-4 genes and the specification of position in chick wing development."
Izpisua-Belmonte J.-C., Tickle C., Dolle P., Wolpert L., Duboule D.
Nature 350:585-589(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 234-293.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L09550 mRNA. Translation: AAA48824.1.
D10290 Genomic DNA. Translation: BAA01135.1.
PIRS35526.
RefSeqNP_990765.1. NM_205434.1.
UniGeneGga.4131.

3D structure databases

ProteinModelPortalP24344.
SMRP24344. Positions 234-291.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000015076.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID396415.
KEGGgga:396415.

Organism-specific databases

CTD3239.

Phylogenomic databases

eggNOGNOG251666.
HOGENOMHOG000231176.
HOVERGENHBG106958.
InParanoidP24344.
KOK09298.
PhylomeDBP24344.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR022067. HoxA13_N.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF12284. HoxA13_N. 1 hit.
[Graphical view]
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20816456.
PROP24344.

Entry information

Entry nameHXD13_CHICK
AccessionPrimary (citable) accession number: P24344
Secondary accession number(s): Q90781
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 97 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries