Homeobox protein Hox-D12 - Gallus gallus (Chicken)

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P24343 (HXD12_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 107. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Homeobox protein Hox-D12

Alternative name(s):
Homeobox protein Hox-4.7
Short name=Chox-4.7
Short name=Ghox-4.7
Homeobox protein Hox-4F
Short name=Chox-4F

Gene names

Name:	HOXD12
Synonyms:	CHOX-4.7

Organism

Gallus gallus (Chicken) [Reference proteome]

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	266 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subunit structure	Interacts with MAF and MAFB. Ref.4
Subcellular location	Nucleus.
Tissue specificity	Expressed primarily in limb buds.
Developmental stage	Coordinately expressed in partially overlapping domains during wing development.
Sequence similarities	Belongs to the Abd-B homeobox family. Contains 1 homeobox DNA-binding domain.
Sequence caution	The sequence BAA01134.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	embryonic digit morphogenesis Inferred from electronic annotation. Source: Compara pattern specification process Inferred from electronic annotation. Source: Compara skeletal system development Inferred from electronic annotation. Source: Compara transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	transcription factor complex Inferred from electronic annotation. Source: Compara
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
MAF	Q789F3	2	EBI-445651,EBI-445622

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 266

266

Homeobox protein Hox-D12

PRO_0000200240

Regions

DNA binding

198 – 257

Homeobox

Experimental info

Sequence conflict

198

S → R Ref.3

Sequence conflict

219

L → V Ref.3

Sequences

Sequence

Length

Mass (Da)

Tools

P24343 [UniParc].

Last modified July 1, 1993. Version 2.
Checksum: AD2D45FD24AC6D73
Show »

FASTA

266

30,014

        10         20         30         40         50         60 
MCDRSLYRSG YVGSLLNLQS PDSFYFPNLR ANGSQLAALP TISYPRSSIP WTCPSPCAAQ 

        70         80         90        100        110        120 
PQGHAFGGAA QPYLPGSVPI SISSNSNKEC LEENSKYYAH DASSKQEERC RQRQSFANDP 

       130        140        150        160        170        180 
TITHAANLKP AKYDHSSLPR SLHGSAALFE VNSCTSSLKE DIKNSVNLNL TVQPAAVQSC 

       190        200        210        220        230        240 
LRPSVQDGLP WCPTQGRSRK KRKPYTKQQI AELENEFLLN EFINRQKRKE LSNRLNLSDQ 

       250        260 
QVKIWFQNRR MKKKRVVMRE QALSMY

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References

[1]	"Ghox 4.7: a chick homeobox gene expressed primarily in limb buds with limb-type differences in expression." Mackem S., Mahon K.A. Development 112:791-806(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Involvement of the Chox-4 chicken homeobox genes in determination of anteroposterior axial polarity during limb development." Nohno T., Noji S., Koyama E., Ohyama K., Myokai F., Kuroiwa A., Saito T., Taniguchi S. Cell 64:1197-1205(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 196-258.
[3]	"Expression of the homeobox Hox-4 genes and the specification of position in chick wing development." Izpisua-Belmonte J.-C., Tickle C., Dolle P., Wolpert L., Duboule D. Nature 350:585-589(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 198-257.
[4]	"A set of Hox proteins interact with the Maf oncoprotein to inhibit its DNA binding, transactivation, and transforming activities." Kataoka K., Yoshitomo-Nakagawa K., Shioda S., Nishizawa M. J. Biol. Chem. 276:819-826(2001) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH MAF AND MAFB.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X62019 mRNA. Translation: CAA43974.1. D10289 Genomic DNA. Translation: BAA01134.1. Different initiation.
IPI	IPI00598647.
PIR	A45186. C37914. S14800.
RefSeq	NP_990580.1. NM_205249.1.
UniGene	Gga.695.
3D structure databases
ProteinModelPortal	P24343.
ModBase	Search...
Protein-protein interaction databases
IntAct	P24343. 7 interactions.
STRING	9031.ENSGALP00000015070.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSGALT00000015086; ENSGALP00000015070; ENSGALG00000009274.
GeneID	396178.
KEGG	gga:396178.
Organism-specific databases
CTD	3238.
Phylogenomic databases
eggNOG	NOG241833.
GeneTree	ENSGT00700000104263.
HOGENOM	HOG000231177.
HOVERGEN	HBG052050.
InParanoid	P24343.
KO	K09297.
OMA	PDGLPWG.
OrthoDB	EOG43N7DG.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20816232.

Entry information

Entry name

HXD12_CHICK

Accession

Primary (citable) accession number: P24343

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
Last sequence update:	July 1, 1993
Last modified:	April 3, 2013
This is version 107 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Other

Entry information

Relevant documents