Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P24343 (HXD12_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-D12
Alternative name(s):
Homeobox protein Hox-4.7
Short name=Chox-4.7
Short name=Ghox-4.7
Homeobox protein Hox-4F
Short name=Chox-4F
Gene names
Name:HOXD12
Synonyms:CHOX-4.7
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length266 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subunit structure

Interacts with MAF and MAFB. Ref.4

Subcellular location

Nucleus.

Tissue specificity

Expressed primarily in limb buds.

Developmental stage

Coordinately expressed in partially overlapping domains during wing development.

Sequence similarities

Belongs to the Abd-B homeobox family.

Contains 1 homeobox DNA-binding domain.

Sequence caution

The sequence BAA01134.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 266266Homeobox protein Hox-D12
PRO_0000200240

Regions

DNA binding198 – 25760Homeobox

Experimental info

Sequence conflict1981S → R Ref.3
Sequence conflict2191L → V Ref.3

Sequences

Sequence LengthMass (Da)Tools
P24343 [UniParc].

Last modified July 1, 1993. Version 2.
Checksum: AD2D45FD24AC6D73

FASTA26630,014
        10         20         30         40         50         60 
MCDRSLYRSG YVGSLLNLQS PDSFYFPNLR ANGSQLAALP TISYPRSSIP WTCPSPCAAQ 

        70         80         90        100        110        120 
PQGHAFGGAA QPYLPGSVPI SISSNSNKEC LEENSKYYAH DASSKQEERC RQRQSFANDP 

       130        140        150        160        170        180 
TITHAANLKP AKYDHSSLPR SLHGSAALFE VNSCTSSLKE DIKNSVNLNL TVQPAAVQSC 

       190        200        210        220        230        240 
LRPSVQDGLP WCPTQGRSRK KRKPYTKQQI AELENEFLLN EFINRQKRKE LSNRLNLSDQ 

       250        260 
QVKIWFQNRR MKKKRVVMRE QALSMY 

« Hide

References

[1]"Ghox 4.7: a chick homeobox gene expressed primarily in limb buds with limb-type differences in expression."
Mackem S., Mahon K.A.
Development 112:791-806(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Involvement of the Chox-4 chicken homeobox genes in determination of anteroposterior axial polarity during limb development."
Nohno T., Noji S., Koyama E., Ohyama K., Myokai F., Kuroiwa A., Saito T., Taniguchi S.
Cell 64:1197-1205(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 196-258.
[3]"Expression of the homeobox Hox-4 genes and the specification of position in chick wing development."
Izpisua-Belmonte J.-C., Tickle C., Dolle P., Wolpert L., Duboule D.
Nature 350:585-589(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 198-257.
[4]"A set of Hox proteins interact with the Maf oncoprotein to inhibit its DNA binding, transactivation, and transforming activities."
Kataoka K., Yoshitomo-Nakagawa K., Shioda S., Nishizawa M.
J. Biol. Chem. 276:819-826(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH MAF AND MAFB.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X62019 mRNA. Translation: CAA43974.1.
D10289 Genomic DNA. Translation: BAA01134.1. Different initiation.
PIRA45186.
C37914.
S14800.
RefSeqNP_990580.1. NM_205249.1.
UniGeneGga.695.

3D structure databases

ProteinModelPortalP24343.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000015070.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGALT00000015086; ENSGALP00000015070; ENSGALG00000009274.
GeneID396178.
KEGGgga:396178.

Organism-specific databases

CTD3238.

Phylogenomic databases

eggNOGNOG241833.
GeneTreeENSGT00750000117432.
HOGENOMHOG000231177.
HOVERGENHBG052050.
InParanoidP24343.
KOK09297.
OMALQGAPCA.
OrthoDBEOG73FQNH.
PhylomeDBP24343.
TreeFamTF351604.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20816232.
PROP24343.

Entry information

Entry nameHXD12_CHICK
AccessionPrimary (citable) accession number: P24343
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: July 1, 1993
Last modified: April 16, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries