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Protein

Homeobox protein Hox-D12

Gene

HOXD12

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi198 – 257HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-D12
Alternative name(s):
Homeobox protein Hox-4.7
Short name:
Chox-4.7
Short name:
Ghox-4.7
Homeobox protein Hox-4F
Short name:
Chox-4F
Gene namesi
Name:HOXD12
Synonyms:CHOX-4.7
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002002401 – 266Homeobox protein Hox-D12Add BLAST266

Proteomic databases

PaxDbiP24343

Expressioni

Tissue specificityi

Expressed primarily in limb buds.

Developmental stagei

Coordinately expressed in partially overlapping domains during wing development.

Gene expression databases

BgeeiENSGALG00000009274

Interactioni

Subunit structurei

Interacts with MAF and MAFB.1 Publication

Protein-protein interaction databases

MINTiP24343
STRINGi9031.ENSGALP00000015070

Structurei

3D structure databases

ProteinModelPortaliP24343
SMRiP24343
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0487 Eukaryota
ENOG4111FJP LUCA
GeneTreeiENSGT00910000143984
HOGENOMiHOG000231177
HOVERGENiHBG052050
InParanoidiP24343
KOiK09297
OMAiKFYAPEA
OrthoDBiEOG091G0P35
PhylomeDBiP24343
TreeFamiTF351604

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P24343-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCDRSLYRSG YVGSLLNLQS PDSFYFPNLR ANGSQLAALP TISYPRSSIP
60 70 80 90 100
WTCPSPCAAQ PQGHAFGGAA QPYLPGSVPI SISSNSNKEC LEENSKYYAH
110 120 130 140 150
DASSKQEERC RQRQSFANDP TITHAANLKP AKYDHSSLPR SLHGSAALFE
160 170 180 190 200
VNSCTSSLKE DIKNSVNLNL TVQPAAVQSC LRPSVQDGLP WCPTQGRSRK
210 220 230 240 250
KRKPYTKQQI AELENEFLLN EFINRQKRKE LSNRLNLSDQ QVKIWFQNRR
260
MKKKRVVMRE QALSMY
Length:266
Mass (Da):30,014
Last modified:July 1, 1993 - v2
Checksum:iAD2D45FD24AC6D73
GO

Sequence cautioni

The sequence BAA01134 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti198S → R (PubMed:1673231).Curated1
Sequence conflicti219L → V (PubMed:1673231).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62019 mRNA Translation: CAA43974.1
D10289 Genomic DNA Translation: BAA01134.1 Different initiation.
PIRiA45186
C37914
S14800
RefSeqiNP_990580.1, NM_205249.1
UniGeneiGga.695

Genome annotation databases

EnsembliENSGALT00000015086; ENSGALP00000015070; ENSGALG00000009274
GeneIDi396178
KEGGigga:396178

Similar proteinsi

Entry informationi

Entry nameiHXD12_CHICK
AccessioniPrimary (citable) accession number: P24343
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: July 1, 1993
Last modified: May 23, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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