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P24343

- HXD12_CHICK

UniProt

P24343 - HXD12_CHICK

Protein

Homeobox protein Hox-D12

Gene

HOXD12

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 2 (01 Jul 1993)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi198 – 25760HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. embryonic digit morphogenesis Source: Ensembl
    2. pattern specification process Source: Ensembl
    3. skeletal system development Source: Ensembl
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-D12
    Alternative name(s):
    Homeobox protein Hox-4.7
    Short name:
    Chox-4.7
    Short name:
    Ghox-4.7
    Homeobox protein Hox-4F
    Short name:
    Chox-4F
    Gene namesi
    Name:HOXD12
    Synonyms:CHOX-4.7
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Chromosome 7

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    2. transcription factor complex Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 266266Homeobox protein Hox-D12PRO_0000200240Add
    BLAST

    Expressioni

    Tissue specificityi

    Expressed primarily in limb buds.

    Developmental stagei

    Coordinately expressed in partially overlapping domains during wing development.

    Interactioni

    Subunit structurei

    Interacts with MAF and MAFB.1 Publication

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000015070.

    Structurei

    3D structure databases

    ProteinModelPortaliP24343.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Abd-B homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG241833.
    GeneTreeiENSGT00750000117432.
    HOGENOMiHOG000231177.
    HOVERGENiHBG052050.
    InParanoidiP24343.
    KOiK09297.
    OMAiQAKFYAP.
    OrthoDBiEOG73FQNH.
    PhylomeDBiP24343.
    TreeFamiTF351604.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P24343-1 [UniParc]FASTAAdd to Basket

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    MCDRSLYRSG YVGSLLNLQS PDSFYFPNLR ANGSQLAALP TISYPRSSIP    50
    WTCPSPCAAQ PQGHAFGGAA QPYLPGSVPI SISSNSNKEC LEENSKYYAH 100
    DASSKQEERC RQRQSFANDP TITHAANLKP AKYDHSSLPR SLHGSAALFE 150
    VNSCTSSLKE DIKNSVNLNL TVQPAAVQSC LRPSVQDGLP WCPTQGRSRK 200
    KRKPYTKQQI AELENEFLLN EFINRQKRKE LSNRLNLSDQ QVKIWFQNRR 250
    MKKKRVVMRE QALSMY 266
    Length:266
    Mass (Da):30,014
    Last modified:July 1, 1993 - v2
    Checksum:iAD2D45FD24AC6D73
    GO

    Sequence cautioni

    The sequence BAA01134.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti198 – 1981S → R(PubMed:1673231)Curated
    Sequence conflicti219 – 2191L → V(PubMed:1673231)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X62019 mRNA. Translation: CAA43974.1.
    D10289 Genomic DNA. Translation: BAA01134.1. Different initiation.
    PIRiA45186.
    C37914.
    S14800.
    RefSeqiNP_990580.1. NM_205249.1.
    UniGeneiGga.695.

    Genome annotation databases

    EnsembliENSGALT00000015086; ENSGALP00000015070; ENSGALG00000009274.
    GeneIDi396178.
    KEGGigga:396178.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X62019 mRNA. Translation: CAA43974.1 .
    D10289 Genomic DNA. Translation: BAA01134.1 . Different initiation.
    PIRi A45186.
    C37914.
    S14800.
    RefSeqi NP_990580.1. NM_205249.1.
    UniGenei Gga.695.

    3D structure databases

    ProteinModelPortali P24343.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000015070.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGALT00000015086 ; ENSGALP00000015070 ; ENSGALG00000009274 .
    GeneIDi 396178.
    KEGGi gga:396178.

    Organism-specific databases

    CTDi 3238.

    Phylogenomic databases

    eggNOGi NOG241833.
    GeneTreei ENSGT00750000117432.
    HOGENOMi HOG000231177.
    HOVERGENi HBG052050.
    InParanoidi P24343.
    KOi K09297.
    OMAi QAKFYAP.
    OrthoDBi EOG73FQNH.
    PhylomeDBi P24343.
    TreeFami TF351604.

    Miscellaneous databases

    NextBioi 20816232.
    PROi P24343.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Ghox 4.7: a chick homeobox gene expressed primarily in limb buds with limb-type differences in expression."
      Mackem S., Mahon K.A.
      Development 112:791-806(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Involvement of the Chox-4 chicken homeobox genes in determination of anteroposterior axial polarity during limb development."
      Nohno T., Noji S., Koyama E., Ohyama K., Myokai F., Kuroiwa A., Saito T., Taniguchi S.
      Cell 64:1197-1205(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 196-258.
    3. "Expression of the homeobox Hox-4 genes and the specification of position in chick wing development."
      Izpisua-Belmonte J.-C., Tickle C., Dolle P., Wolpert L., Duboule D.
      Nature 350:585-589(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 198-257.
    4. "A set of Hox proteins interact with the Maf oncoprotein to inhibit its DNA binding, transactivation, and transforming activities."
      Kataoka K., Yoshitomo-Nakagawa K., Shioda S., Nishizawa M.
      J. Biol. Chem. 276:819-826(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MAF AND MAFB.

    Entry informationi

    Entry nameiHXD12_CHICK
    AccessioniPrimary (citable) accession number: P24343
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 117 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3