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Protein

Homeobox protein Hox-D12

Gene

HOXD12

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi198 – 257HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-D12
Alternative name(s):
Homeobox protein Hox-4.7
Short name:
Chox-4.7
Short name:
Ghox-4.7
Homeobox protein Hox-4F
Short name:
Chox-4F
Gene namesi
Name:HOXD12
Synonyms:CHOX-4.7
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 7

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002002401 – 266Homeobox protein Hox-D12Add BLAST266

Proteomic databases

PaxDbiP24343.

Expressioni

Tissue specificityi

Expressed primarily in limb buds.

Developmental stagei

Coordinately expressed in partially overlapping domains during wing development.

Gene expression databases

BgeeiENSGALG00000009274.

Interactioni

Subunit structurei

Interacts with MAF and MAFB.1 Publication

Protein-protein interaction databases

STRINGi9031.ENSGALP00000015070.

Structurei

3D structure databases

ProteinModelPortaliP24343.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0487. Eukaryota.
ENOG4111FJP. LUCA.
GeneTreeiENSGT00760000118834.
HOGENOMiHOG000231177.
HOVERGENiHBG052050.
InParanoidiP24343.
KOiK09297.
OMAiQAKFYAP.
OrthoDBiEOG091G0P35.
PhylomeDBiP24343.
TreeFamiTF351604.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24343-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCDRSLYRSG YVGSLLNLQS PDSFYFPNLR ANGSQLAALP TISYPRSSIP
60 70 80 90 100
WTCPSPCAAQ PQGHAFGGAA QPYLPGSVPI SISSNSNKEC LEENSKYYAH
110 120 130 140 150
DASSKQEERC RQRQSFANDP TITHAANLKP AKYDHSSLPR SLHGSAALFE
160 170 180 190 200
VNSCTSSLKE DIKNSVNLNL TVQPAAVQSC LRPSVQDGLP WCPTQGRSRK
210 220 230 240 250
KRKPYTKQQI AELENEFLLN EFINRQKRKE LSNRLNLSDQ QVKIWFQNRR
260
MKKKRVVMRE QALSMY
Length:266
Mass (Da):30,014
Last modified:July 1, 1993 - v2
Checksum:iAD2D45FD24AC6D73
GO

Sequence cautioni

The sequence BAA01134 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti198S → R (PubMed:1673231).Curated1
Sequence conflicti219L → V (PubMed:1673231).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62019 mRNA. Translation: CAA43974.1.
D10289 Genomic DNA. Translation: BAA01134.1. Different initiation.
PIRiA45186.
C37914.
S14800.
RefSeqiNP_990580.1. NM_205249.1.
UniGeneiGga.695.

Genome annotation databases

EnsembliENSGALT00000015086; ENSGALP00000015070; ENSGALG00000009274.
GeneIDi396178.
KEGGigga:396178.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62019 mRNA. Translation: CAA43974.1.
D10289 Genomic DNA. Translation: BAA01134.1. Different initiation.
PIRiA45186.
C37914.
S14800.
RefSeqiNP_990580.1. NM_205249.1.
UniGeneiGga.695.

3D structure databases

ProteinModelPortaliP24343.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000015070.

Proteomic databases

PaxDbiP24343.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000015086; ENSGALP00000015070; ENSGALG00000009274.
GeneIDi396178.
KEGGigga:396178.

Organism-specific databases

CTDi3238.

Phylogenomic databases

eggNOGiKOG0487. Eukaryota.
ENOG4111FJP. LUCA.
GeneTreeiENSGT00760000118834.
HOGENOMiHOG000231177.
HOVERGENiHBG052050.
InParanoidiP24343.
KOiK09297.
OMAiQAKFYAP.
OrthoDBiEOG091G0P35.
PhylomeDBiP24343.
TreeFamiTF351604.

Miscellaneous databases

PROiP24343.

Gene expression databases

BgeeiENSGALG00000009274.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHXD12_CHICK
AccessioniPrimary (citable) accession number: P24343
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: July 1, 1993
Last modified: September 7, 2016
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.