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Protein

Homeobox protein Hox-D12

Gene

HOXD12

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi198 – 25760HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. embryonic digit morphogenesis Source: Ensembl
  2. pattern specification process Source: Ensembl
  3. regulation of transcription, DNA-templated Source: UniProtKB-KW
  4. skeletal system development Source: Ensembl
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-D12
Alternative name(s):
Homeobox protein Hox-4.7
Short name:
Chox-4.7
Short name:
Ghox-4.7
Homeobox protein Hox-4F
Short name:
Chox-4F
Gene namesi
Name:HOXD12
Synonyms:CHOX-4.7
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 7

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
  2. transcription factor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 266266Homeobox protein Hox-D12PRO_0000200240Add
BLAST

Expressioni

Tissue specificityi

Expressed primarily in limb buds.

Developmental stagei

Coordinately expressed in partially overlapping domains during wing development.

Interactioni

Subunit structurei

Interacts with MAF and MAFB.1 Publication

Protein-protein interaction databases

STRINGi9031.ENSGALP00000015070.

Structurei

3D structure databases

ProteinModelPortaliP24343.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG241833.
GeneTreeiENSGT00760000118834.
HOGENOMiHOG000231177.
HOVERGENiHBG052050.
InParanoidiP24343.
KOiK09297.
OMAiQAKFYAP.
OrthoDBiEOG73FQNH.
PhylomeDBiP24343.
TreeFamiTF351604.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24343-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCDRSLYRSG YVGSLLNLQS PDSFYFPNLR ANGSQLAALP TISYPRSSIP
60 70 80 90 100
WTCPSPCAAQ PQGHAFGGAA QPYLPGSVPI SISSNSNKEC LEENSKYYAH
110 120 130 140 150
DASSKQEERC RQRQSFANDP TITHAANLKP AKYDHSSLPR SLHGSAALFE
160 170 180 190 200
VNSCTSSLKE DIKNSVNLNL TVQPAAVQSC LRPSVQDGLP WCPTQGRSRK
210 220 230 240 250
KRKPYTKQQI AELENEFLLN EFINRQKRKE LSNRLNLSDQ QVKIWFQNRR
260
MKKKRVVMRE QALSMY
Length:266
Mass (Da):30,014
Last modified:July 1, 1993 - v2
Checksum:iAD2D45FD24AC6D73
GO

Sequence cautioni

The sequence BAA01134.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti198 – 1981S → R(PubMed:1673231)Curated
Sequence conflicti219 – 2191L → V(PubMed:1673231)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62019 mRNA. Translation: CAA43974.1.
D10289 Genomic DNA. Translation: BAA01134.1. Different initiation.
PIRiA45186.
C37914.
S14800.
RefSeqiNP_990580.1. NM_205249.1.
UniGeneiGga.695.

Genome annotation databases

EnsembliENSGALT00000015086; ENSGALP00000015070; ENSGALG00000009274.
GeneIDi396178.
KEGGigga:396178.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62019 mRNA. Translation: CAA43974.1.
D10289 Genomic DNA. Translation: BAA01134.1. Different initiation.
PIRiA45186.
C37914.
S14800.
RefSeqiNP_990580.1. NM_205249.1.
UniGeneiGga.695.

3D structure databases

ProteinModelPortaliP24343.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000015070.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000015086; ENSGALP00000015070; ENSGALG00000009274.
GeneIDi396178.
KEGGigga:396178.

Organism-specific databases

CTDi3238.

Phylogenomic databases

eggNOGiNOG241833.
GeneTreeiENSGT00760000118834.
HOGENOMiHOG000231177.
HOVERGENiHBG052050.
InParanoidiP24343.
KOiK09297.
OMAiQAKFYAP.
OrthoDBiEOG73FQNH.
PhylomeDBiP24343.
TreeFamiTF351604.

Miscellaneous databases

NextBioi20816232.
PROiP24343.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Ghox 4.7: a chick homeobox gene expressed primarily in limb buds with limb-type differences in expression."
    Mackem S., Mahon K.A.
    Development 112:791-806(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Involvement of the Chox-4 chicken homeobox genes in determination of anteroposterior axial polarity during limb development."
    Nohno T., Noji S., Koyama E., Ohyama K., Myokai F., Kuroiwa A., Saito T., Taniguchi S.
    Cell 64:1197-1205(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 196-258.
  3. "Expression of the homeobox Hox-4 genes and the specification of position in chick wing development."
    Izpisua-Belmonte J.-C., Tickle C., Dolle P., Wolpert L., Duboule D.
    Nature 350:585-589(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 198-257.
  4. "A set of Hox proteins interact with the Maf oncoprotein to inhibit its DNA binding, transactivation, and transforming activities."
    Kataoka K., Yoshitomo-Nakagawa K., Shioda S., Nishizawa M.
    J. Biol. Chem. 276:819-826(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MAF AND MAFB.

Entry informationi

Entry nameiHXD12_CHICK
AccessioniPrimary (citable) accession number: P24343
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: July 1, 1993
Last modified: February 4, 2015
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.