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Protein

Kinesin-like protein cut7

Gene

cut7

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Could be a spindle pole body motor. On transition from G2 to M phase of the cell cycle, the spindle pole body duplicates; the daughter pole bodies seed microtubules which interdigitate to form a short spindle that elongates to span the nucleus at metaphase. Mutations at cut7 block spindle formation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi159 – 1668ATPPROSITE-ProRule annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ATP-dependent microtubule motor activity, plus-end-directed Source: PomBase

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • microtubule plus-end directed mitotic chromosome migration Source: PomBase
  • mitotic spindle assembly Source: PomBase
  • mitotic spindle midzone assembly Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-983189. Kinesins.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein cut7
Alternative name(s):
Cell untimely torn protein 7
Gene namesi
Name:cut7
ORF Names:SPAC25G10.07c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC25G10.07c.
PomBaseiSPAC25G10.07c. cut7.

Subcellular locationi

GO - Cellular componenti

  • condensed chromosome kinetochore Source: PomBase
  • cytoplasm Source: UniProtKB-KW
  • kinesin complex Source: GO_Central
  • meiotic spindle Source: PomBase
  • microtubule associated complex Source: PomBase
  • microtubule cytoskeleton Source: PomBase
  • mitotic spindle midzone Source: PomBase
  • mitotic spindle pole body Source: PomBase
  • nucleus Source: PomBase
  • spindle microtubule Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10851085Kinesin-like protein cut7PRO_0000125370Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1011 – 10111Phosphothreonine; by CDC2By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP24339.

Interactioni

Protein-protein interaction databases

BioGridi279182. 21 interactions.
DIPiDIP-61701N.
MINTiMINT-4687825.

Structurei

3D structure databases

ProteinModelPortaliP24339.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini72 – 421350Kinesin motorPROSITE-ProRule annotationAdd
BLAST
Repeati987 – 99812Add
BLAST
Repeati999 – 101012Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili436 – 604169Sequence analysisAdd
BLAST
Coiled coili715 – 74026Sequence analysisAdd
BLAST
Coiled coili897 – 95559Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. BimC subfamily.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

InParanoidiP24339.
KOiK10398.
OMAiHTHEESQ.
OrthoDBiEOG092C2D4G.
PhylomeDBiP24339.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 3 hits.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24339-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPRVAPGGS QQFLGKQGLK AKNPVSTPNS HFRSASNPRK RREPPTIDTG
60 70 80 90 100
YPDRSDTNSP TDHALHDENE TNINVVVRVR GRTDQEVRDN SSLAVSTSGA
110 120 130 140 150
MGAELAIQSD PSSMLVTKTY AFDKVFGPEA DQLMLFENSV APMLEQVLNG
160 170 180 190 200
YNCTIFAYGQ TGTGKTYTMS GDLSDSDGIL SEGAGLIPRA LYQLFSSLDN
210 220 230 240 250
SNQEYAVKCS YYELYNEEIR DLLVSEELRK PARVFEDTSR RGNVVITGIE
260 270 280 290 300
ESYIKNAGDG LRLLREGSHR RQVAATKCND LSSRSHSIFT ITLHRKVSSG
310 320 330 340 350
MTDETNSLTI NNNSDDLLRA SKLHMVDLAG SENIGRSGAE NKRARETGMI
360 370 380 390 400
NQSLLTLGRV INALVEKAHH IPYRESKLTR LLQDSLGGKT KTSMIVTVSS
410 420 430 440 450
TNTNLEETIS TLEYAARAKS IRNKPQNNQL VFRKVLIKDL VLDIERLKND
460 470 480 490 500
LNATRKKNGV YLAESTYKEL MDRVQNKDLL CQEQARKLEV LDLNVKSSRE
510 520 530 540 550
QLQYVSKSNQ EHKKEVEALQ LQLVNSSTEL ESVKSENEKL KNELVLEIEK
560 570 580 590 600
RKKYETNEAK ITTVATDLSQ YYRESKEYIA SLYEKLDRTE RNNKENENNF
610 620 630 640 650
WNLKFNLLTM LRSFHGSFTD ETNGYFTLLN DFNASMEELL NTHSNQLLIS
660 670 680 690 700
MTKITEHFQS LDEALQSARS SCAVPNSSLD LIVSELKDSK NSLLDALEHS
710 720 730 740 750
LQDISMSSQK LGNGISSELI ELQKDMKESY RQLVQELRSL YNLQHTHEES
760 770 780 790 800
QKELMYGVRN DIDALVKTCT TSLNDADIIL SDYISDQKSK FESKQQDLIA
810 820 830 840 850
NIGKIVSNFL QEQNESLYTK ADILHSHLND TNSNIRKANE IMNNRSEEFL
860 870 880 890 900
RNAASQAEIV GANKERIQKT VENGSQLLDS KSKAIHSNSR SMYDHCLALA
910 920 930 940 950
ESQKQGVNLE VQTLDRLLQK VKEHSEDNTK EKHQQLLDLL ESLVGNNDNL
960 970 980 990 1000
IDSIKTPHTE LQKITDHVLK GTTSLANHTN ELLGLGDESL CNLETTIEDT
1010 1020 1030 1040 1050
SLVKLETTGD TPSKRELPAT PSWTRDSSLI KETTNLNLDS DKKFVRETYT
1060 1070 1080
SSNQTNEPDV YDKPSNSSRT SLLRSSRSAY SKMKR
Length:1,085
Mass (Da):122,133
Last modified:October 1, 1996 - v3
Checksum:i5669277875559D58
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti34 – 6128SASNP…TNSPT → LRAILGNDVSLLLLTL in CAA40738 (PubMed:2145514).CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57513 Genomic DNA. Translation: CAA40738.1.
CU329670 Genomic DNA. Translation: CAA94636.1.
PIRiS14032.
T38378.
RefSeqiNP_594527.1. NM_001019956.2.

Genome annotation databases

EnsemblFungiiSPAC25G10.07c.1; SPAC25G10.07c.1:pep; SPAC25G10.07c.
GeneIDi2542732.
KEGGispo:SPAC25G10.07c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57513 Genomic DNA. Translation: CAA40738.1.
CU329670 Genomic DNA. Translation: CAA94636.1.
PIRiS14032.
T38378.
RefSeqiNP_594527.1. NM_001019956.2.

3D structure databases

ProteinModelPortaliP24339.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279182. 21 interactions.
DIPiDIP-61701N.
MINTiMINT-4687825.

Proteomic databases

MaxQBiP24339.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC25G10.07c.1; SPAC25G10.07c.1:pep; SPAC25G10.07c.
GeneIDi2542732.
KEGGispo:SPAC25G10.07c.

Organism-specific databases

EuPathDBiFungiDB:SPAC25G10.07c.
PomBaseiSPAC25G10.07c. cut7.

Phylogenomic databases

InParanoidiP24339.
KOiK10398.
OMAiHTHEESQ.
OrthoDBiEOG092C2D4G.
PhylomeDBiP24339.

Enzyme and pathway databases

ReactomeiR-SPO-983189. Kinesins.

Miscellaneous databases

PROiP24339.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 3 hits.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCUT7_SCHPO
AccessioniPrimary (citable) accession number: P24339
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: October 1, 1996
Last modified: September 7, 2016
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.