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Protein

Amphiregulin

Gene

Areg

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.

GO - Molecular functioni

  • epidermal growth factor receptor binding Source: RGD
  • growth factor activity Source: RGD

GO - Biological processi

  • central nervous system development Source: RGD
  • dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis Source: Ensembl
  • epidermal growth factor receptor signaling pathway Source: RGD
  • epithelial cell proliferation involved in mammary gland duct elongation Source: Ensembl
  • glial cell proliferation Source: RGD
  • G-protein coupled receptor signaling pathway Source: Ensembl
  • mammary gland alveolus development Source: Ensembl
  • mammary gland branching involved in thelarche Source: Ensembl
  • negative regulation of osteoblast differentiation Source: RGD
  • neuron projection development Source: RGD
  • positive regulation of cell proliferation Source: RGD
  • positive regulation of DNA replication Source: Ensembl
  • positive regulation of phosphorylation Source: RGD
  • response to cAMP Source: RGD
  • response to estradiol Source: Ensembl
  • response to glucocorticoid Source: RGD
  • response to hydrogen peroxide Source: RGD
  • response to organic cyclic compound Source: RGD
  • response to peptide hormone Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Enzyme and pathway databases

ReactomeiR-RNO-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-RNO-5694530. Cargo concentration in the ER.

Names & Taxonomyi

Protein namesi
Recommended name:
Amphiregulin
Short name:
AR
Alternative name(s):
Schwannoma-derived growth factor
Short name:
SDGF
Gene namesi
Name:Areg
Synonyms:Sdgf
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi2149. Areg.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei190 – 21324HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell surface Source: Ensembl
  • cytoplasm Source: Ensembl
  • extracellular space Source: RGD
  • integral component of membrane Source: UniProtKB-KW
  • nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Propeptidei25 – 9672PRO_0000007478Add
BLAST
Chaini97 – 243147AmphiregulinPRO_0000007479Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi30 – 301N-linked (GlcNAc...)Sequence analysis
Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence analysis
Disulfide bondi137 ↔ 150PROSITE-ProRule annotation
Disulfide bondi145 ↔ 161PROSITE-ProRule annotation
Disulfide bondi163 ↔ 172PROSITE-ProRule annotation
Glycosylationi236 – 2361N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP24338.
PRIDEiP24338.

Expressioni

Gene expression databases

BgeeiENSRNOG00000002754.
GenevisibleiP24338. RN.

Interactioni

Subunit structurei

The immature precursor interacts with CNIH.By similarity

GO - Molecular functioni

  • epidermal growth factor receptor binding Source: RGD
  • growth factor activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003703.

Structurei

3D structure databases

ProteinModelPortaliP24338.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini133 – 17341EGF-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the amphiregulin family.Curated
Contains 1 EGF-like domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXZG. Eukaryota.
ENOG4112CXY. LUCA.
GeneTreeiENSGT00530000063708.
HOGENOMiHOG000034038.
HOVERGENiHBG060279.
InParanoidiP24338.
KOiK09782.
OMAiCKCHQDY.
OrthoDBiEOG091G0XMN.
PhylomeDBiP24338.
TreeFamiTF332773.

Family and domain databases

InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR015497. EGF_rcpt_ligand.
[Graphical view]
PANTHERiPTHR10740. PTHR10740. 1 hit.
PROSITEiPS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24338-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTPSLSLAL SVLSLLVLGS GHYAAGLELN GTSSGKGEPS SGDHSAGGLV
60 70 80 90 100
VSEVSTISEM PSGSELSTGD YDYSEEYDNE PQISGYIVDD SVRVEQVIKP
110 120 130 140 150
KENKTEGEKS SEKPKRKKKG GKGGKGRRNR KKKKNPCAAK FQNFCIHGEC
160 170 180 190 200
RYIENLEVVT CHCHQDYFGE RCGEKTMKTQ KKDDSDLSKI ALAAIIVFVS
210 220 230 240
AVSVAAIGII TAVLLRKRFF REYEEAEERR RLRQENGTAH AIA
Length:243
Mass (Da):26,633
Last modified:March 1, 1992 - v1
Checksum:iF59A8173D4921599
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55183 mRNA. Translation: CAA38967.1.
PIRiS13296.
RefSeqiNP_058819.1. NM_017123.1.
UniGeneiRn.10568.

Genome annotation databases

EnsembliENSRNOT00000003703; ENSRNOP00000003703; ENSRNOG00000002754.
GeneIDi29183.
KEGGirno:29183.
UCSCiRGD:2149. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55183 mRNA. Translation: CAA38967.1.
PIRiS13296.
RefSeqiNP_058819.1. NM_017123.1.
UniGeneiRn.10568.

3D structure databases

ProteinModelPortaliP24338.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003703.

Proteomic databases

PaxDbiP24338.
PRIDEiP24338.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000003703; ENSRNOP00000003703; ENSRNOG00000002754.
GeneIDi29183.
KEGGirno:29183.
UCSCiRGD:2149. rat.

Organism-specific databases

CTDi374.
RGDi2149. Areg.

Phylogenomic databases

eggNOGiENOG410IXZG. Eukaryota.
ENOG4112CXY. LUCA.
GeneTreeiENSGT00530000063708.
HOGENOMiHOG000034038.
HOVERGENiHBG060279.
InParanoidiP24338.
KOiK09782.
OMAiCKCHQDY.
OrthoDBiEOG091G0XMN.
PhylomeDBiP24338.
TreeFamiTF332773.

Enzyme and pathway databases

ReactomeiR-RNO-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-RNO-5694530. Cargo concentration in the ER.

Miscellaneous databases

PROiP24338.

Gene expression databases

BgeeiENSRNOG00000002754.
GenevisibleiP24338. RN.

Family and domain databases

InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR015497. EGF_rcpt_ligand.
[Graphical view]
PANTHERiPTHR10740. PTHR10740. 1 hit.
PROSITEiPS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAREG_RAT
AccessioniPrimary (citable) accession number: P24338
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: September 7, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.