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Protein

Myotoxin

Gene
N/A
Organism
Crotalus adamanteus (Eastern diamondback rattlesnake)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cationic peptide that possesses multiple functions. It acts as a cell-penetrating peptide (CPP), and as a potent voltage-gated potassium channel (Kv) inhibitor. It exhibits antimicrobial activities, hind limb paralysis, and severe muscle necrosis by a non-enzymatic mechanism (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Ion channel impairing toxin, Myotoxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Myotoxin
Alternative name(s):
CAM-toxin
OrganismiCrotalus adamanteus (Eastern diamondback rattlesnake)
Taxonomic identifieri8729 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeCrotalinaeCrotalus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Toxic dosei

LD50 is 0.96 mg/kg by subcutaneous injection.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 222 PublicationsAdd BLAST22
ChainiPRO_000022156223 – 70MyotoxinAdd BLAST48

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26 ↔ 58PROSITE-ProRule annotation
Disulfide bondi33 ↔ 52PROSITE-ProRule annotation
Disulfide bondi40 ↔ 59PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Family & Domainsi

Sequence similaritiesi

Belongs to the crotamine-myotoxin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG006434.

Family and domain databases

Gene3Di2.20.20.10. 1 hit.
InterProiIPR023355. Myo_neuro_toxin.
IPR000881. Myotoxin.
[Graphical view]
PfamiPF00819. Myotoxins. 1 hit.
[Graphical view]
PRINTSiPR00283. MYOTOXIN.
ProDomiPD005972. Myotoxin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00459. MYOTOXINS_1. 1 hit.
PS51345. MYOTOXINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24330-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKILYLLFAF LFLAFLSEPG NAYKRCHKKG GHCFPKTVIC LPPSSDFGKM
60 70
DCRWRWKCCK KGSVNNAISI
Length:70
Mass (Da):8,017
Last modified:November 13, 2013 - v2
Checksum:i21432AE06B0989EE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti63S → V in AEJ31978 (PubMed:21255598).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ414100 mRNA. Translation: AEJ31978.1.
JU173668 mRNA. Translation: AFJ49194.1.
PIRiA37909.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ414100 mRNA. Translation: AEJ31978.1.
JU173668 mRNA. Translation: AFJ49194.1.
PIRiA37909.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG006434.

Family and domain databases

Gene3Di2.20.20.10. 1 hit.
InterProiIPR023355. Myo_neuro_toxin.
IPR000881. Myotoxin.
[Graphical view]
PfamiPF00819. Myotoxins. 1 hit.
[Graphical view]
PRINTSiPR00283. MYOTOXIN.
ProDomiPD005972. Myotoxin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00459. MYOTOXINS_1. 1 hit.
PS51345. MYOTOXINS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYX_CROAD
AccessioniPrimary (citable) accession number: P24330
Secondary accession number(s): F8S0Z6, J3RY57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: November 13, 2013
Last modified: October 14, 2015
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Miscellaneous

This myotoxin is the most abundant transcript in the venom of the specimen analyzed in PubMed:23025625.
Individuals of C.adamanteus from populations in southern and central Florida lack this toxin in their venoms.1 Publication

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.