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P24330 (MYX_CROAD) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Myotoxin
Alternative name(s):
CAM-toxin
OrganismCrotalus adamanteus (Eastern diamondback rattlesnake)
Taxonomic identifier8729 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeCrotalinaeCrotalus

Protein attributes

Sequence length70 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cationic peptide that possess multiple functions. It acts as a cell-penetrating peptide (CPP), and as a potent voltage-gated potassium channel (Kv) inhibitor. It exhibits antimicrobial activities, hind limb paralysis, and severe muscle necrosis by a non-enzymatic mechanism By similarity.

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom gland.

Toxic dose

LD50 is 0.96 mg/kg by subcutaneous injection. Ref.3

Miscellaneous

This myotoxin is the most abundant transcript in the venom of the specimen analyzed in Ref.1.

Individuals of C.adamanteus from populations in southern and central Florida lack this toxin in their venoms (Ref.1).

Sequence similarities

Belongs to the crotamine-myotoxin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Ref.3 Ref.4
Chain23 – 7048Myotoxin
PRO_0000221562

Amino acid modifications

Disulfide bond26 ↔ 58 By similarity
Disulfide bond33 ↔ 52 By similarity
Disulfide bond40 ↔ 59 By similarity

Experimental info

Sequence conflict631S → V in AEJ31978. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P24330 [UniParc].

Last modified November 13, 2013. Version 2.
Checksum: 21432AE06B0989EE

FASTA708,017
        10         20         30         40         50         60 
MKILYLLFAF LFLAFLSEPG NAYKRCHKKG GHCFPKTVIC LPPSSDFGKM DCRWRWKCCK 

        70 
KGSVNNAISI 

« Hide

References

[1]"The venom-gland transcriptome of the eastern diamondback rattlesnake (Crotalus adamanteus)."
Rokyta D.R., Lemmon A.R., Margres M.J., Aronow K.
BMC Genomics 13:312-312(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Venom gland.
[2]"A high-throughput venom-gland transcriptome for the eastern diamondback rattlesnake (Crotalus adamanteus) and evidence for pervasive positive selection across toxin classes."
Rokyta D.R., Wray K.P., Lemmon A.R., Lemmon E.M., Caudle S.B.
Toxicon 57:657-671(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-63.
[3]"Amino acid sequence of a myotoxin from venom of the eastern diamondback rattlesnake (Crotalus adamanteus)."
Samejima Y., Aoki Y., Mebs D.
Toxicon 29:461-468(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 23-67, LETHAL DOSE.
Tissue: Venom.
[4]"Linking the transcriptome and proteome to characterize the venom of the eastern diamondback rattlesnake (Crotalus adamanteus)."
Margres M.J., McGivern J.J., Wray K.P., Seavy M., Calvin K., Rokyta D.R.
J. Proteomics 96:145-158(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 23-34, IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: Venom.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
HQ414100 mRNA. Translation: AEJ31978.1.
JU173668 mRNA. Translation: AFJ49194.1.
PIRA37909.

3D structure databases

ProteinModelPortalP24330.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG006434.

Family and domain databases

Gene3D2.20.20.10. 1 hit.
InterProIPR023355. Myo_neuro_toxin.
IPR000881. Rattlesnake_Myotoxin.
[Graphical view]
PfamPF00819. Myotoxins. 1 hit.
[Graphical view]
PRINTSPR00283. MYOTOXIN.
ProDomPD005972. Myotoxin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEPS00459. MYOTOXINS_1. 1 hit.
PS51345. MYOTOXINS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMYX_CROAD
AccessionPrimary (citable) accession number: P24330
Secondary accession number(s): F8S0Z6, J3RY57
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: November 13, 2013
Last modified: March 19, 2014
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families