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Protein

UDP-glucose 4-epimerase

Gene

galE

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD. By controlling the internal galactose concentration, it may be linked to the biosynthesis of lipopolysaccharide surface molecules, which are important for the pathogenesis of H.influenzae.1 Publication

Catalytic activityi

UDP-alpha-D-glucose = UDP-alpha-D-galactose.

Cofactori

NAD+By similarity

Pathwayi: galactose metabolism

This protein is involved in the pathway galactose metabolism, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway galactose metabolism and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei99NADBy similarity1
Binding sitei124NADBy similarity1
Binding sitei124SubstrateBy similarity1
Active sitei149Proton acceptorBy similarity1
Binding sitei149NADBy similarity1
Binding sitei149SubstrateBy similarity1
Binding sitei153NADBy similarity1
Binding sitei178NAD; via carbonyl oxygenBy similarity1
Binding sitei179SubstrateBy similarity1
Binding sitei231SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 12NADBy similarity2
Nucleotide bindingi31 – 36NADBy similarity6
Nucleotide bindingi58 – 59NADBy similarity2
Nucleotide bindingi80 – 84NADBy similarity5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processCarbohydrate metabolism, Galactose metabolism
LigandNAD

Enzyme and pathway databases

BioCyciHINF71421:G1GJ1-367-MONOMER
UniPathwayiUPA00214

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucose 4-epimerase (EC:5.1.3.2)
Alternative name(s):
Galactowaldenase
UDP-galactose 4-epimerase
Gene namesi
Name:galE
Ordered Locus Names:HI_0351
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001832051 – 338UDP-glucose 4-epimeraseAdd BLAST338

Proteomic databases

PRIDEiP24325

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi71421.HI0351

Structurei

3D structure databases

ProteinModelPortaliP24325
SMRiP24325
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni199 – 200Substrate bindingBy similarity2
Regioni216 – 218Substrate bindingBy similarity3
Regioni292 – 295Substrate bindingBy similarity4

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CMR Bacteria
COG1087 LUCA
KOiK01784
OMAiHQPETHA
PhylomeDBiP24325

Family and domain databases

CDDicd05247 UDP_G4E_1_SDR_e, 1 hit
InterProiView protein in InterPro
IPR001509 Epimerase_deHydtase
IPR036291 NAD(P)-bd_dom_sf
IPR005886 UDP_G4E
PfamiView protein in Pfam
PF01370 Epimerase, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR01179 galE, 1 hit

Sequencei

Sequence statusi: Complete.

P24325-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAILVTGGAG YIGSHTVVEL LNVGKEVVVL DNLCNSSPKS LERVKQITGK
60 70 80 90 100
EAKFYEGDIL DRALLQKIFA ENEINSVIHF AGLKAVGESV QKPTEYYMNN
110 120 130 140 150
VAGTLVLIQE MKKAGVWNFV FSSSATVYGD PKIIPITEDC EVGGTTNPYG
160 170 180 190 200
TSKYMVEQIL RDTAKAEPKF SMTILRYFNP VGAHESGLIG EDPNGIPNNL
210 220 230 240 250
LPYISQVAIG KLAQLSVFGS DYDTHDGTGV RDYIHVVDLA VGHLKALQRH
260 270 280 290 300
ENDAGLHIYN LGTGHGYSVL DMVKAFEKAN NITIAYKLVE RRSGDIATCY
310 320 330
SDPSLAAKEL GWVAERGLEK MMQDTWNWQK NNPKGYRD
Length:338
Mass (Da):37,165
Last modified:November 1, 1995 - v2
Checksum:i449934B0E21C8A56
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti285A → P in strain: RM 7004. 1
Natural varianti333P → S in strain: RM 7004. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57315 Genomic DNA Translation: CAA40568.1
L42023 Genomic DNA Translation: AAC22012.1
PIRiA64063
RefSeqiNP_438515.1, NC_000907.1
WP_005694325.1, NC_000907.1

Genome annotation databases

EnsemblBacteriaiAAC22012; AAC22012; HI_0351
GeneIDi949642
KEGGihin:HI0351
PATRICifig|71421.8.peg.370

Similar proteinsi

Entry informationi

Entry nameiGALE_HAEIN
AccessioniPrimary (citable) accession number: P24325
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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