ID   CX7A1_HUMAN             Reviewed;          79 AA.
AC   P24310;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 2.
DT   24-JAN-2024, entry version 185.
DE   RecName: Full=Cytochrome c oxidase subunit 7A1, mitochondrial;
DE   AltName: Full=Cytochrome c oxidase subunit VIIa-heart;
DE            Short=Cytochrome c oxidase subunit VIIa-H;
DE   AltName: Full=Cytochrome c oxidase subunit VIIa-muscle;
DE            Short=Cytochrome c oxidase subunit VIIa-M;
DE   Flags: Precursor;
GN   Name=COX7A1; Synonyms=COX7AH;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1327965; DOI=10.1016/0378-1119(92)90287-y;
RA   Arnaudo E., Hirano M., Seelan R.S., Milatovich A., Hsieh C.L.,
RA   Fabrizi G.M., Grossman L.I., Francke U., Schon E.A.;
RT   "Tissue-specific expression and chromosome assignment of genes specifying
RT   two isoforms of subunit VIIa of human cytochrome c oxidase.";
RL   Gene 119:299-305(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9344674; DOI=10.1006/geno.1997.4937;
RA   Wolz W., Kress W., Mueller C.R.;
RT   "Genomic sequence and organization of the human gene for cytochrome c
RT   oxidase subunit (COX7A1) VIIa-M.";
RL   Genomics 45:438-442(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Heart;
RX   PubMed=11997101; DOI=10.1016/s0167-4781(02)00228-2;
RA   Yu M., Jaradat S.A., Grossman L.I.;
RT   "Genomic organization and promoter regulation of human cytochrome c oxidase
RT   subunit VII heart/muscle isoform (COX7AH).";
RL   Biochim. Biophys. Acta 1574:345-353(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10335655; DOI=10.1093/oxfordjournals.molbev.a026144;
RA   Schmidt T.R., Goodman M., Grossman L.I.;
RT   "Molecular evolution of the COX7A gene family in primates.";
RL   Mol. Biol. Evol. 16:619-626(1999).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Uterus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [7]
RP   PROTEIN SEQUENCE OF 22-51.
RC   TISSUE=Heart, and Skeletal muscle;
RX   PubMed=1309697; DOI=10.1111/j.1432-1033.1992.tb19847.x;
RA   van Kuilenburg A.B.P., van Beeumen J.J., van der Meer N.M., Muijsers A.O.;
RT   "Subunits VIIa,b,c of human cytochrome c oxidase. Identification of both
RT   'heart-type' and 'liver-type' isoforms of subunit VIIa in human heart.";
RL   Eur. J. Biochem. 203:193-199(1992).
CC   -!- FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the
CC       mitochondrial electron transport chain which drives oxidative
CC       phosphorylation. The respiratory chain contains 3 multisubunit
CC       complexes succinate dehydrogenase (complex II, CII), ubiquinol-
CC       cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III,
CC       CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to
CC       transfer electrons derived from NADH and succinate to molecular oxygen,
CC       creating an electrochemical gradient over the inner membrane that
CC       drives transmembrane transport and the ATP synthase. Cytochrome c
CC       oxidase is the component of the respiratory chain that catalyzes the
CC       reduction of oxygen to water. Electrons originating from reduced
CC       cytochrome c in the intermembrane space (IMS) are transferred via the
CC       dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1
CC       to the active site in subunit 1, a binuclear center (BNC) formed by
CC       heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2
CC       water molecules using 4 electrons from cytochrome c in the IMS and 4
CC       protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P10174}.
CC   -!- PATHWAY: Energy metabolism; oxidative phosphorylation.
CC       {ECO:0000250|UniProtKB:P10174}.
CC   -!- SUBUNIT: Component of the cytochrome c oxidase (complex IV, CIV), a
CC       multisubunit enzyme composed of 14 subunits. The complex is composed of
CC       a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in
CC       the mitochondrial DNA, and 11 supernumerary subunits COX4I1 (or
CC       COX4I2), COX5A, COX5B, COX6A1 (or COX6A2), COX6B1 (or COX6B2), COX6C,
CC       COX7A2 (or COX7A1), COX7B, COX7C, COX8A and NDUFA4, which are encoded
CC       in the nuclear genome (By similarity). The complex exists as a monomer
CC       or a dimer and forms supercomplexes (SCs) in the inner mitochondrial
CC       membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and
CC       ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex
CC       III, CIII), resulting in different assemblies (supercomplex
CC       SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity).
CC       {ECO:0000250|UniProtKB:P07470}.
CC   -!- INTERACTION:
CC       P24310; O75190-2: DNAJB6; NbExp=3; IntAct=EBI-25876196, EBI-12593112;
CC       P24310; O14901: KLF11; NbExp=3; IntAct=EBI-25876196, EBI-948266;
CC       P24310; P28331-2: NDUFS1; NbExp=3; IntAct=EBI-25876196, EBI-6190702;
CC       P24310; Q9BVL2: NUP58; NbExp=3; IntAct=EBI-25876196, EBI-2811583;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:P07470}; Single-pass membrane protein
CC       {ECO:0000250|UniProtKB:P07470}.
CC   -!- SIMILARITY: Belongs to the cytochrome c oxidase VIIa family.
CC       {ECO:0000305}.
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DR   EMBL; M83186; AAA52166.1; -; mRNA.
DR   EMBL; U81524; AAB82735.1; -; Genomic_DNA.
DR   EMBL; AC002984; AAB81547.1; -; Genomic_DNA.
DR   EMBL; AF037372; AAB92616.1; -; Genomic_DNA.
DR   EMBL; AF127789; AAF72747.1; -; Genomic_DNA.
DR   EMBL; AD001527; AAB51184.1; -; Genomic_DNA.
DR   EMBL; BC002757; AAH02757.1; -; mRNA.
DR   CCDS; CCDS12490.1; -.
DR   PIR; JC1303; OSHU7A.
DR   RefSeq; NP_001855.1; NM_001864.3.
DR   AlphaFoldDB; P24310; -.
DR   SMR; P24310; -.
DR   BioGRID; 107739; 11.
DR   IntAct; P24310; 4.
DR   STRING; 9606.ENSP00000292907; -.
DR   DrugBank; DB02659; Cholic Acid.
DR   DrugBank; DB04464; N-Formylmethionine.
DR   TCDB; 3.D.4.11.1; the proton-translocating cytochrome oxidase (cox) superfamily.
DR   iPTMnet; P24310; -.
DR   PhosphoSitePlus; P24310; -.
DR   SwissPalm; P24310; -.
DR   BioMuta; COX7A1; -.
DR   jPOST; P24310; -.
DR   MassIVE; P24310; -.
DR   PaxDb; 9606-ENSP00000292907; -.
DR   PeptideAtlas; P24310; -.
DR   ProteomicsDB; 54195; -.
DR   Antibodypedia; 44654; 123 antibodies from 22 providers.
DR   DNASU; 1346; -.
DR   Ensembl; ENST00000292907.8; ENSP00000292907.3; ENSG00000161281.11.
DR   GeneID; 1346; -.
DR   KEGG; hsa:1346; -.
DR   MANE-Select; ENST00000292907.8; ENSP00000292907.3; NM_001864.4; NP_001855.1.
DR   AGR; HGNC:2287; -.
DR   CTD; 1346; -.
DR   DisGeNET; 1346; -.
DR   GeneCards; COX7A1; -.
DR   HGNC; HGNC:2287; COX7A1.
DR   HPA; ENSG00000161281; Group enriched (heart muscle, skeletal muscle, tongue).
DR   MIM; 123995; gene.
DR   neXtProt; NX_P24310; -.
DR   OpenTargets; ENSG00000161281; -.
DR   PharmGKB; PA26805; -.
DR   VEuPathDB; HostDB:ENSG00000161281; -.
DR   eggNOG; ENOG502SBK9; Eukaryota.
DR   GeneTree; ENSGT00940000162305; -.
DR   HOGENOM; CLU_173437_1_0_1; -.
DR   InParanoid; P24310; -.
DR   OMA; IAGTCYS; -.
DR   OrthoDB; 5352834at2759; -.
DR   PhylomeDB; P24310; -.
DR   TreeFam; TF105067; -.
DR   PathwayCommons; P24310; -.
DR   SignaLink; P24310; -.
DR   UniPathway; UPA00705; -.
DR   BioGRID-ORCS; 1346; 16 hits in 1158 CRISPR screens.
DR   ChiTaRS; COX7A1; human.
DR   GeneWiki; COX7A1; -.
DR   GenomeRNAi; 1346; -.
DR   Pharos; P24310; Tbio.
DR   PRO; PR:P24310; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; P24310; Protein.
DR   Bgee; ENSG00000161281; Expressed in heart right ventricle and 196 other cell types or tissues.
DR   ExpressionAtlas; P24310; baseline and differential.
DR   GO; GO:0005746; C:mitochondrial respirasome; IBA:GO_Central.
DR   GO; GO:0005751; C:mitochondrial respiratory chain complex IV; IEA:InterPro.
DR   GO; GO:0005739; C:mitochondrion; TAS:ProtInc.
DR   GO; GO:0004129; F:cytochrome-c oxidase activity; TAS:ProtInc.
DR   GO; GO:0006091; P:generation of precursor metabolites and energy; TAS:ProtInc.
DR   GO; GO:0006123; P:mitochondrial electron transport, cytochrome c to oxygen; IEA:InterPro.
DR   GO; GO:0097250; P:mitochondrial respirasome assembly; IBA:GO_Central.
DR   GO; GO:0002082; P:regulation of oxidative phosphorylation; IBA:GO_Central.
DR   CDD; cd00928; Cyt_c_Oxidase_VIIa; 1.
DR   Gene3D; 4.10.91.10; Cytochrome c oxidase, subunit VIIa; 1.
DR   InterPro; IPR039297; COX7a.
DR   InterPro; IPR036539; Cyt_c_oxidase_su7a_sf.
DR   InterPro; IPR003177; Cytc_oxidase_su7a_met.
DR   PANTHER; PTHR10510; CYTOCHROME C OXIDASE POLYPEPTIDE 7A; 1.
DR   PANTHER; PTHR10510:SF5; CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL; 1.
DR   Pfam; PF02238; COX7a; 1.
DR   SUPFAM; SSF81419; Mitochondrial cytochrome c oxidase subunit VIIa; 1.
DR   Genevisible; P24310; HS.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Oxidoreductase; Reference proteome;
KW   Transit peptide; Transmembrane; Transmembrane helix.
FT   TRANSIT         1..21
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000269|PubMed:1309697"
FT   CHAIN           22..79
FT                   /note="Cytochrome c oxidase subunit 7A1, mitochondrial"
FT                   /id="PRO_0000006149"
FT   TOPO_DOM        22..46
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000250|UniProtKB:P07470"
FT   TRANSMEM        47..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000250|UniProtKB:P07470"
FT   TOPO_DOM        76..79
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000250|UniProtKB:P07470"
SQ   SEQUENCE   79 AA;  9118 MW;  AFE9C00C53CE35C2 CRC64;
     MQALRVSQAL IRSFSSTARN RFQNRVREKQ KLFQEDNDIP LYLKGGIVDN ILYRVTMTLC
     LGGTVYSLYS LGWASFPRN
//