P24310 (CX7A1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 7A1, mitochondrial

Alternative name(s):
Cytochrome c oxidase subunit VIIa-heart
Short name=Cytochrome c oxidase subunit VIIa-H
Cytochrome c oxidase subunit VIIa-muscle
Short name=Cytochrome c oxidase subunit VIIa-M

Gene names

Name:	COX7A1
Synonyms:	COX7AH

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	79 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Subcellular location	Mitochondrion inner membrane.
Sequence similarities	Belongs to the cytochrome c oxidase VIIa family.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transit peptide Transmembrane Transmembrane helix
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	generation of precursor metabolites and energy Traceable author statement. Source: ProtInc
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial respiratory chain Inferred from electronic annotation. Source: InterPro
Molecular function	cytochrome-c oxidase activity Traceable author statement. Source: ProtInc electron carrier activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 21	21	Mitochondrion Ref.7
	Chain	22 – 79	58	Cytochrome c oxidase subunit 7A1, mitochondrial		PRO_0000006149
Regions
	Topological domain	22 – 46	25	Mitochondrial matrix By similarity
	Transmembrane	47 – 75	29	Helical; By similarity
	Topological domain	76 – 79	4	Mitochondrial intermembrane By similarity

Sequences

	Sequence		Length	Mass (Da)
	P24310 [UniParc]. Last modified July 1, 1993. Version 2. Checksum: AFE9C00C53CE35C2	FASTA	79	9,118
	10 20 30 40 50 60 MQALRVSQAL IRSFSSTARN RFQNRVREKQ KLFQEDNDIP LYLKGGIVDN ILYRVTMTLC 70 LGGTVYSLYS LGWASFPRN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Tissue-specific expression and chromosome assignment of genes specifying two isoforms of subunit VIIa of human cytochrome c oxidase." Arnaudo E., Hirano M., Seelan R.S., Milatovich A., Hsieh C.L., Fabrizi G.M., Grossman L.I., Francke U., Schon E.A. Gene 119:299-305(1992) [PubMed: 1327965] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Genomic sequence and organization of the human gene for cytochrome c oxidase subunit (COX7A1) VIIa-M." Wolz W., Kress W., Mueller C.R. Genomics 45:438-442(1997) [PubMed: 9344674] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Genomic organization and promoter regulation of human cytochrome c oxidase subunit VII heart/muscle isoform (COX7AH)." Yu M., Jaradat S.A., Grossman L.I. Biochim. Biophys. Acta 1574:345-353(2002) [PubMed: 11997101] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Heart.
[4]	"Molecular evolution of the COX7A gene family in primates." Schmidt T.R., Goodman M., Grossman L.I. Mol. Biol. Evol. 16:619-626(1999) [PubMed: 10335655] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed: 15057824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus.
[7]	"Subunits VIIa,b,c of human cytochrome c oxidase. Identification of both 'heart-type' and 'liver-type' isoforms of subunit VIIa in human heart." van Kuilenburg A.B.P., van Beeumen J.J., van der Meer N.M., Muijsers A.O. Eur. J. Biochem. 203:193-199(1992) [PubMed: 1309697] [Abstract] Cited for: PROTEIN SEQUENCE OF 22-51. Tissue: Heart and Skeletal muscle.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M83186 mRNA. Translation: AAA52166.1. U81524 Genomic DNA. Translation: AAB82735.1. AC002984 Genomic DNA. Translation: AAB81547.1. AF037372 Genomic DNA. Translation: AAB92616.1. AF127789 Genomic DNA. Translation: AAF72747.1. AD001527 Genomic DNA. Translation: AAB51184.1. BC002757 mRNA. Translation: AAH02757.1.
IPI	IPI00306720.
PIR	OSHU7A. JC1303.
RefSeq	NP_001855.1. NM_001864.2.
UniGene	Hs.421621.
3D structure databases
ProteinModelPortal	P24310.
SMR	P24310. Positions 22-77.
ModBase	Search...
Protein-protein interaction databases
STRING	P24310.
Protein family/group databases
TCDB	3.D.4.11.1. proton-translocating cytochrome oxidase (COX) superfamily.
Polymorphism databases
DMDM	399287.
Proteomic databases
PRIDE	P24310.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000292907; ENSP00000292907; ENSG00000161281.
GeneID	1346.
KEGG	hsa:1346.
UCSC	uc002odm.1. human.
Organism-specific databases
CTD	1346.
GeneCards	GC19M036641.
H-InvDB	HIX0015057.
HGNC	HGNC:2287. COX7A1.
MIM	123995. gene.
neXtProt	NX_P24310.
PharmGKB	PA26805.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG21377.
HOVERGEN	HBG051095.
InParanoid	P24310.
OrthoDB	EOG4WQ147.
PhylomeDB	P24310.
Gene expression databases
ArrayExpress	P24310.
Bgee	P24310.
CleanEx	HS_COX7A1.
Genevestigator	P24310.
GermOnline	ENSG00000161281. Homo sapiens.
Family and domain databases
InterPro	IPR003177. Cyt_c_oxidase_su7a. [Graphical view]
Gene3D	G3DSA:4.10.91.10. Cyt_c_oxidase_7a_su. 1 hit.
KO	K02270.
PANTHER	PTHR10510. COX7a. 1 hit.
Pfam	PF02238. COX7a. 1 hit. [Graphical view]
SUPFAM	SSF81419. Cyt_c_oxidase_7a_su. 1 hit.
ProtoNet	Search...
Other
NextBio	5457.
SOURCE	Search...

Entry information

Entry name

CX7A1_HUMAN

Accession

Primary (citable) accession number: P24310

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
Last sequence update:	July 1, 1993
Last modified:	January 25, 2012
This is version 110 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.