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Protein

Cytochrome c oxidase subunit 7A1, mitochondrial

Gene

COX7A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

  • cytochrome-c oxidase activity Source: ProtInc

GO - Biological processi

  • generation of precursor metabolites and energy Source: ProtInc
  • hydrogen ion transmembrane transport Source: GOC
Complete GO annotation...

Protein family/group databases

TCDBi3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 7A1, mitochondrial
Alternative name(s):
Cytochrome c oxidase subunit VIIa-heart
Short name:
Cytochrome c oxidase subunit VIIa-H
Cytochrome c oxidase subunit VIIa-muscle
Short name:
Cytochrome c oxidase subunit VIIa-M
Gene namesi
Name:COX7A1
Synonyms:COX7AH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:2287. COX7A1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 4625Mitochondrial matrixBy similarityAdd
BLAST
Transmembranei47 – 7529HelicalBy similarityAdd
BLAST
Topological domaini76 – 794Mitochondrial intermembraneBy similarity

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial respiratory chain Source: InterPro
  • mitochondrion Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26805.

Chemistry

DrugBankiDB02659. Cholic Acid.

Polymorphism and mutation databases

BioMutaiCOX7A1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2121Mitochondrion1 PublicationAdd
BLAST
Chaini22 – 7958Cytochrome c oxidase subunit 7A1, mitochondrialPRO_0000006149Add
BLAST

Proteomic databases

PaxDbiP24310.
PRIDEiP24310.

PTM databases

PhosphoSiteiP24310.

Expressioni

Gene expression databases

BgeeiP24310.
CleanExiHS_COX7A1.
ExpressionAtlasiP24310. baseline and differential.
GenevestigatoriP24310.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000292907.

Structurei

3D structure databases

ProteinModelPortaliP24310.
SMRiP24310. Positions 22-77.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIIa family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG70659.
HOGENOMiHOG000264231.
HOVERGENiHBG051095.
InParanoidiP24310.
KOiK02270.
OMAiSLYCLGW.
OrthoDBiEOG7BGHNV.
PhylomeDBiP24310.
TreeFamiTF105067.

Family and domain databases

Gene3Di4.10.91.10. 1 hit.
InterProiIPR003177. Cyt_c_oxidase_su7a.
[Graphical view]
PANTHERiPTHR10510. PTHR10510. 1 hit.
PfamiPF02238. COX7a. 1 hit.
[Graphical view]
SUPFAMiSSF81419. SSF81419. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24310-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQALRVSQAL IRSFSSTARN RFQNRVREKQ KLFQEDNDIP LYLKGGIVDN
60 70
ILYRVTMTLC LGGTVYSLYS LGWASFPRN
Length:79
Mass (Da):9,118
Last modified:July 1, 1993 - v2
Checksum:iAFE9C00C53CE35C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83186 mRNA. Translation: AAA52166.1.
U81524 Genomic DNA. Translation: AAB82735.1.
AC002984 Genomic DNA. Translation: AAB81547.1.
AF037372 Genomic DNA. Translation: AAB92616.1.
AF127789 Genomic DNA. Translation: AAF72747.1.
AD001527 Genomic DNA. Translation: AAB51184.1.
BC002757 mRNA. Translation: AAH02757.1.
CCDSiCCDS12490.1.
PIRiJC1303. OSHU7A.
RefSeqiNP_001855.1. NM_001864.3.
UniGeneiHs.421621.

Genome annotation databases

EnsembliENST00000292907; ENSP00000292907; ENSG00000161281.
GeneIDi1346.
KEGGihsa:1346.
UCSCiuc002odm.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83186 mRNA. Translation: AAA52166.1.
U81524 Genomic DNA. Translation: AAB82735.1.
AC002984 Genomic DNA. Translation: AAB81547.1.
AF037372 Genomic DNA. Translation: AAB92616.1.
AF127789 Genomic DNA. Translation: AAF72747.1.
AD001527 Genomic DNA. Translation: AAB51184.1.
BC002757 mRNA. Translation: AAH02757.1.
CCDSiCCDS12490.1.
PIRiJC1303. OSHU7A.
RefSeqiNP_001855.1. NM_001864.3.
UniGeneiHs.421621.

3D structure databases

ProteinModelPortaliP24310.
SMRiP24310. Positions 22-77.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000292907.

Chemistry

DrugBankiDB02659. Cholic Acid.

Protein family/group databases

TCDBi3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

PTM databases

PhosphoSiteiP24310.

Polymorphism and mutation databases

BioMutaiCOX7A1.

Proteomic databases

PaxDbiP24310.
PRIDEiP24310.

Protocols and materials databases

DNASUi1346.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000292907; ENSP00000292907; ENSG00000161281.
GeneIDi1346.
KEGGihsa:1346.
UCSCiuc002odm.1. human.

Organism-specific databases

CTDi1346.
GeneCardsiGC19M036641.
HGNCiHGNC:2287. COX7A1.
MIMi123995. gene.
neXtProtiNX_P24310.
PharmGKBiPA26805.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG70659.
HOGENOMiHOG000264231.
HOVERGENiHBG051095.
InParanoidiP24310.
KOiK02270.
OMAiSLYCLGW.
OrthoDBiEOG7BGHNV.
PhylomeDBiP24310.
TreeFamiTF105067.

Miscellaneous databases

ChiTaRSiCOX7A1. human.
GeneWikiiCOX7A1.
GenomeRNAii1346.
NextBioi5457.
PROiP24310.
SOURCEiSearch...

Gene expression databases

BgeeiP24310.
CleanExiHS_COX7A1.
ExpressionAtlasiP24310. baseline and differential.
GenevestigatoriP24310.

Family and domain databases

Gene3Di4.10.91.10. 1 hit.
InterProiIPR003177. Cyt_c_oxidase_su7a.
[Graphical view]
PANTHERiPTHR10510. PTHR10510. 1 hit.
PfamiPF02238. COX7a. 1 hit.
[Graphical view]
SUPFAMiSSF81419. SSF81419. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Tissue-specific expression and chromosome assignment of genes specifying two isoforms of subunit VIIa of human cytochrome c oxidase."
    Arnaudo E., Hirano M., Seelan R.S., Milatovich A., Hsieh C.L., Fabrizi G.M., Grossman L.I., Francke U., Schon E.A.
    Gene 119:299-305(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Genomic sequence and organization of the human gene for cytochrome c oxidase subunit (COX7A1) VIIa-M."
    Wolz W., Kress W., Mueller C.R.
    Genomics 45:438-442(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Genomic organization and promoter regulation of human cytochrome c oxidase subunit VII heart/muscle isoform (COX7AH)."
    Yu M., Jaradat S.A., Grossman L.I.
    Biochim. Biophys. Acta 1574:345-353(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Heart.
  4. "Molecular evolution of the COX7A gene family in primates."
    Schmidt T.R., Goodman M., Grossman L.I.
    Mol. Biol. Evol. 16:619-626(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  7. "Subunits VIIa,b,c of human cytochrome c oxidase. Identification of both 'heart-type' and 'liver-type' isoforms of subunit VIIa in human heart."
    van Kuilenburg A.B.P., van Beeumen J.J., van der Meer N.M., Muijsers A.O.
    Eur. J. Biochem. 203:193-199(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 22-51.
    Tissue: Heart and Skeletal muscle.

Entry informationi

Entry nameiCX7A1_HUMAN
AccessioniPrimary (citable) accession number: P24310
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: July 1, 1993
Last modified: May 27, 2015
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.