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P24310 (CX7A1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 131. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 7A1, mitochondrial
Alternative name(s):
Cytochrome c oxidase subunit VIIa-heart
Short name=Cytochrome c oxidase subunit VIIa-H
Cytochrome c oxidase subunit VIIa-muscle
Short name=Cytochrome c oxidase subunit VIIa-M
Gene names
Name:COX7A1
Synonyms:COX7AH
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length79 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Subcellular location

Mitochondrion inner membrane.

Sequence similarities

Belongs to the cytochrome c oxidase VIIa family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2121Mitochondrion Ref.7
Chain22 – 7958Cytochrome c oxidase subunit 7A1, mitochondrial
PRO_0000006149

Regions

Topological domain22 – 4625Mitochondrial matrix By similarity
Transmembrane47 – 7529Helical; By similarity
Topological domain76 – 794Mitochondrial intermembrane By similarity

Sequences

Sequence LengthMass (Da)Tools
P24310 [UniParc].

Last modified July 1, 1993. Version 2.
Checksum: AFE9C00C53CE35C2

FASTA799,118
        10         20         30         40         50         60 
MQALRVSQAL IRSFSSTARN RFQNRVREKQ KLFQEDNDIP LYLKGGIVDN ILYRVTMTLC 

        70 
LGGTVYSLYS LGWASFPRN 

« Hide

References

« Hide 'large scale' references
[1]"Tissue-specific expression and chromosome assignment of genes specifying two isoforms of subunit VIIa of human cytochrome c oxidase."
Arnaudo E., Hirano M., Seelan R.S., Milatovich A., Hsieh C.L., Fabrizi G.M., Grossman L.I., Francke U., Schon E.A.
Gene 119:299-305(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Genomic sequence and organization of the human gene for cytochrome c oxidase subunit (COX7A1) VIIa-M."
Wolz W., Kress W., Mueller C.R.
Genomics 45:438-442(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Genomic organization and promoter regulation of human cytochrome c oxidase subunit VII heart/muscle isoform (COX7AH)."
Yu M., Jaradat S.A., Grossman L.I.
Biochim. Biophys. Acta 1574:345-353(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Heart.
[4]"Molecular evolution of the COX7A gene family in primates."
Schmidt T.R., Goodman M., Grossman L.I.
Mol. Biol. Evol. 16:619-626(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Uterus.
[7]"Subunits VIIa,b,c of human cytochrome c oxidase. Identification of both 'heart-type' and 'liver-type' isoforms of subunit VIIa in human heart."
van Kuilenburg A.B.P., van Beeumen J.J., van der Meer N.M., Muijsers A.O.
Eur. J. Biochem. 203:193-199(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 22-51.
Tissue: Heart and Skeletal muscle.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M83186 mRNA. Translation: AAA52166.1.
U81524 Genomic DNA. Translation: AAB82735.1.
AC002984 Genomic DNA. Translation: AAB81547.1.
AF037372 Genomic DNA. Translation: AAB92616.1.
AF127789 Genomic DNA. Translation: AAF72747.1.
AD001527 Genomic DNA. Translation: AAB51184.1.
BC002757 mRNA. Translation: AAH02757.1.
CCDSCCDS12490.1.
PIROSHU7A. JC1303.
RefSeqNP_001855.1. NM_001864.2.
UniGeneHs.421621.

3D structure databases

ProteinModelPortalP24310.
SMRP24310. Positions 22-77.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000292907.

Protein family/group databases

TCDB3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

PTM databases

PhosphoSiteP24310.

Proteomic databases

PaxDbP24310.
PRIDEP24310.

Protocols and materials databases

DNASU1346.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000292907; ENSP00000292907; ENSG00000161281.
GeneID1346.
KEGGhsa:1346.
UCSCuc002odm.1. human.

Organism-specific databases

CTD1346.
GeneCardsGC19M036641.
HGNCHGNC:2287. COX7A1.
MIM123995. gene.
neXtProtNX_P24310.
PharmGKBPA26805.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG70659.
HOGENOMHOG000264231.
HOVERGENHBG051095.
InParanoidP24310.
KOK02270.
OMAEASASYH.
OrthoDBEOG7BGHNV.
PhylomeDBP24310.
TreeFamTF105067.

Gene expression databases

ArrayExpressP24310.
BgeeP24310.
CleanExHS_COX7A1.
GenevestigatorP24310.

Family and domain databases

Gene3D4.10.91.10. 1 hit.
InterProIPR003177. Cyt_c_oxidase_su7a.
[Graphical view]
PANTHERPTHR10510. PTHR10510. 1 hit.
PfamPF02238. COX7a. 1 hit.
[Graphical view]
SUPFAMSSF81419. SSF81419. 1 hit.
ProtoNetSearch...

Other

ChiTaRSCOX7A1. human.
GeneWikiCOX7A1.
GenomeRNAi1346.
NextBio5457.
PROP24310.
SOURCESearch...

Entry information

Entry nameCX7A1_HUMAN
AccessionPrimary (citable) accession number: P24310
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: July 1, 1993
Last modified: July 9, 2014
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM