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P24310

- CX7A1_HUMAN

UniProt

P24310 - CX7A1_HUMAN

Protein

Cytochrome c oxidase subunit 7A1, mitochondrial

Gene

COX7A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: ProtInc

    GO - Biological processi

    1. generation of precursor metabolites and energy Source: ProtInc
    2. hydrogen ion transmembrane transport Source: GOC

    Protein family/group databases

    TCDBi3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 7A1, mitochondrial
    Alternative name(s):
    Cytochrome c oxidase subunit VIIa-heart
    Short name:
    Cytochrome c oxidase subunit VIIa-H
    Cytochrome c oxidase subunit VIIa-muscle
    Short name:
    Cytochrome c oxidase subunit VIIa-M
    Gene namesi
    Name:COX7A1
    Synonyms:COX7AH
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:2287. COX7A1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial respiratory chain Source: InterPro
    3. mitochondrion Source: ProtInc

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26805.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2121Mitochondrion1 PublicationAdd
    BLAST
    Chaini22 – 7958Cytochrome c oxidase subunit 7A1, mitochondrialPRO_0000006149Add
    BLAST

    Proteomic databases

    PaxDbiP24310.
    PRIDEiP24310.

    PTM databases

    PhosphoSiteiP24310.

    Expressioni

    Gene expression databases

    ArrayExpressiP24310.
    BgeeiP24310.
    CleanExiHS_COX7A1.
    GenevestigatoriP24310.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000292907.

    Structurei

    3D structure databases

    ProteinModelPortaliP24310.
    SMRiP24310. Positions 22-77.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 4625Mitochondrial matrixBy similarityAdd
    BLAST
    Topological domaini76 – 794Mitochondrial intermembraneBy similarity

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei47 – 7529HelicalBy similarityAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome c oxidase VIIa family.Curated

    Keywords - Domaini

    Transit peptide, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG70659.
    HOGENOMiHOG000264231.
    HOVERGENiHBG051095.
    InParanoidiP24310.
    KOiK02270.
    OMAiEASASYH.
    OrthoDBiEOG7BGHNV.
    PhylomeDBiP24310.
    TreeFamiTF105067.

    Family and domain databases

    Gene3Di4.10.91.10. 1 hit.
    InterProiIPR003177. Cyt_c_oxidase_su7a.
    [Graphical view]
    PANTHERiPTHR10510. PTHR10510. 1 hit.
    PfamiPF02238. COX7a. 1 hit.
    [Graphical view]
    SUPFAMiSSF81419. SSF81419. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P24310-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQALRVSQAL IRSFSSTARN RFQNRVREKQ KLFQEDNDIP LYLKGGIVDN   50
    ILYRVTMTLC LGGTVYSLYS LGWASFPRN 79
    Length:79
    Mass (Da):9,118
    Last modified:July 1, 1993 - v2
    Checksum:iAFE9C00C53CE35C2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M83186 mRNA. Translation: AAA52166.1.
    U81524 Genomic DNA. Translation: AAB82735.1.
    AC002984 Genomic DNA. Translation: AAB81547.1.
    AF037372 Genomic DNA. Translation: AAB92616.1.
    AF127789 Genomic DNA. Translation: AAF72747.1.
    AD001527 Genomic DNA. Translation: AAB51184.1.
    BC002757 mRNA. Translation: AAH02757.1.
    CCDSiCCDS12490.1.
    PIRiJC1303. OSHU7A.
    RefSeqiNP_001855.1. NM_001864.2.
    UniGeneiHs.421621.

    Genome annotation databases

    EnsembliENST00000292907; ENSP00000292907; ENSG00000161281.
    GeneIDi1346.
    KEGGihsa:1346.
    UCSCiuc002odm.1. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M83186 mRNA. Translation: AAA52166.1 .
    U81524 Genomic DNA. Translation: AAB82735.1 .
    AC002984 Genomic DNA. Translation: AAB81547.1 .
    AF037372 Genomic DNA. Translation: AAB92616.1 .
    AF127789 Genomic DNA. Translation: AAF72747.1 .
    AD001527 Genomic DNA. Translation: AAB51184.1 .
    BC002757 mRNA. Translation: AAH02757.1 .
    CCDSi CCDS12490.1.
    PIRi JC1303. OSHU7A.
    RefSeqi NP_001855.1. NM_001864.2.
    UniGenei Hs.421621.

    3D structure databases

    ProteinModelPortali P24310.
    SMRi P24310. Positions 22-77.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000292907.

    Protein family/group databases

    TCDBi 3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

    PTM databases

    PhosphoSitei P24310.

    Proteomic databases

    PaxDbi P24310.
    PRIDEi P24310.

    Protocols and materials databases

    DNASUi 1346.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000292907 ; ENSP00000292907 ; ENSG00000161281 .
    GeneIDi 1346.
    KEGGi hsa:1346.
    UCSCi uc002odm.1. human.

    Organism-specific databases

    CTDi 1346.
    GeneCardsi GC19M036641.
    HGNCi HGNC:2287. COX7A1.
    MIMi 123995. gene.
    neXtProti NX_P24310.
    PharmGKBi PA26805.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG70659.
    HOGENOMi HOG000264231.
    HOVERGENi HBG051095.
    InParanoidi P24310.
    KOi K02270.
    OMAi EASASYH.
    OrthoDBi EOG7BGHNV.
    PhylomeDBi P24310.
    TreeFami TF105067.

    Miscellaneous databases

    ChiTaRSi COX7A1. human.
    GeneWikii COX7A1.
    GenomeRNAii 1346.
    NextBioi 5457.
    PROi P24310.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P24310.
    Bgeei P24310.
    CleanExi HS_COX7A1.
    Genevestigatori P24310.

    Family and domain databases

    Gene3Di 4.10.91.10. 1 hit.
    InterProi IPR003177. Cyt_c_oxidase_su7a.
    [Graphical view ]
    PANTHERi PTHR10510. PTHR10510. 1 hit.
    Pfami PF02238. COX7a. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81419. SSF81419. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Tissue-specific expression and chromosome assignment of genes specifying two isoforms of subunit VIIa of human cytochrome c oxidase."
      Arnaudo E., Hirano M., Seelan R.S., Milatovich A., Hsieh C.L., Fabrizi G.M., Grossman L.I., Francke U., Schon E.A.
      Gene 119:299-305(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Genomic sequence and organization of the human gene for cytochrome c oxidase subunit (COX7A1) VIIa-M."
      Wolz W., Kress W., Mueller C.R.
      Genomics 45:438-442(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Genomic organization and promoter regulation of human cytochrome c oxidase subunit VII heart/muscle isoform (COX7AH)."
      Yu M., Jaradat S.A., Grossman L.I.
      Biochim. Biophys. Acta 1574:345-353(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Heart.
    4. "Molecular evolution of the COX7A gene family in primates."
      Schmidt T.R., Goodman M., Grossman L.I.
      Mol. Biol. Evol. 16:619-626(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Uterus.
    7. "Subunits VIIa,b,c of human cytochrome c oxidase. Identification of both 'heart-type' and 'liver-type' isoforms of subunit VIIa in human heart."
      van Kuilenburg A.B.P., van Beeumen J.J., van der Meer N.M., Muijsers A.O.
      Eur. J. Biochem. 203:193-199(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 22-51.
      Tissue: Heart and Skeletal muscle.

    Entry informationi

    Entry nameiCX7A1_HUMAN
    AccessioniPrimary (citable) accession number: P24310
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 132 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3