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Protein

Nucleoprotein

Gene

N

Organism
Human parainfluenza 1 virus (strain C39) (HPIV-1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Encapsidates the genome in a ratio of 1 N per 6 ribonucleotides, protecting it from nucleases. The nucleocapsid (NC) has a helical structure. The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication. During replication, encapsidation by N is coupled to RNA synthesis and all replicative products are resistant to nucleases (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding, Viral nucleoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoprotein
Alternative name(s):
Nucleocapsid protein
Short name:
NP
Short name:
Protein N
Gene namesi
Name:N
Synonyms:NP
OrganismiHuman parainfluenza 1 virus (strain C39) (HPIV-1)
Taxonomic identifieri11210 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeRespirovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Capsid protein, Helical capsid protein, Host cytoplasm, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001426721 – 524NucleoproteinAdd BLAST524

Interactioni

Subunit structurei

Homomultimerizes to form the nucleocapsid. Binds to viral genomic RNA. In nucleocapsid, binds the P protein and thereby positions the polymerase on the template.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 400NcoreBy similarityAdd BLAST400
Regioni401 – 524NtailBy similarityAdd BLAST124

Domaini

Ncore is globular and carries regions required for N self-assembly and RNA-binding. Ntail is an intrinsically disordered monomeric domain (By similarity).By similarity

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR002021. Paramyx_ncap.
PfamiView protein in Pfam
PF00973. Paramyxo_ncap. 1 hit.

Sequencei

Sequence statusi: Complete.

P24304-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGLLSTFDT FSSRRSESIN KSGGGAIIPG QRSTVSVFIL GPSVTDDADK
60 70 80 90 100
LLIATTFLAH SLDTDKQHSQ RGGFLVSLLA MAYSSPELYL TTNGVNADVK
110 120 130 140 150
YVIYNIERDP KRTKTDGFIV KTRDMEYERT TEWLFGPMIN KNPLFQGQRE
160 170 180 190 200
NADLEALLQT YGYPACLGAI IVQVWIVLVK AITSSSGLRK GFFNRLEAFR
210 220 230 240 250
QDGTVKSALV FTGDTVEGIG AVMRSQQSLV SLMVETLVTM NTSRSDLTTL
260 270 280 290 300
EKNIQIVGNY IRESGLASFM NTIKYGVETK MAALTLSNLR PDINKLRSLV
310 320 330 340 350
DIYLSKGARA PFTCILRDPV HGEFAPGNYP ALWSYAMGVA VVQNKAMQQY
360 370 380 390 400
VTGRTYLDME MFLLGQAVAK DADSKISSAL EEELGVTDTA KERLRHHLTN
410 420 430 440 450
LSGGDGAYHK PTGGGAIEVA IDHTDITFGA EDTADRDNKN WTNNSNERWM
460 470 480 490 500
NHSINNHTIT ISGAEELEEE TNDEDITDIE NKIARRLADR KQRLSQANNR
510 520
QDASSDADHE NDDDATAAAG IGGI
Length:524
Mass (Da):57,551
Last modified:March 1, 1992 - v1
Checksum:i7C4B734BD226590A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62850 mRNA. Translation: AAA46828.1.

Similar proteinsi

Entry informationi

Entry nameiNCAP_PI1HC
AccessioniPrimary (citable) accession number: P24304
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: November 30, 2016
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families