10 kDa chaperonin - Mycobacterium leprae

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P24301 (CH10_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 94. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
10 kDa chaperonin

Alternative name(s):
10 kDa antigen
GroES protein
Protein Cpn10

Gene names

Name:	groS
Synonyms:	chpA, groES, mopB
Ordered Locus Names:	ML0380
ORF Names:	B1620_C3_227, B229_C3_247

Organism

Mycobacterium leprae [Complete proteome] [HAMAP]

Taxonomic identifier

1769 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	100 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. HAMAP MF_00580
Subunit structure	Heptamer of 7 subunits arranged in a ring.
Subcellular location	Cytoplasm HAMAP MF_00580.
Sequence similarities	Belongs to the GroES chaperonin family.

Ontologies

Keywords
Biological process	Stress response
Cellular component	Cytoplasm
Molecular function	Chaperone
Technical term	3D-structure Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	protein folding Inferred from electronic annotation. Source: InterPro response to stress Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

Removed Ref.1

Chain

2 – 100

10 kDa chaperonin HAMAP MF_00580

PRO_0000174786

Sequences

Sequence

Length

Mass (Da)

Tools

P24301 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: A3BE12F8CA6764E2
Show »

FASTA

100

10,800

        10         20         30         40         50         60 
MAKVKIKPLE DKILVQAGEA ETMTPSGLVI PENAKEKPQE GTVVAVGPGR WDEDGAKRIP 

        70         80         90        100 
VDVSEGDIVI YSKYGGTEIK YNGEEYLILS ARDVLAVVSK

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A major T cell antigen of Mycobacterium leprae is a 10-kD heat-shock cognate protein." Mehra V.L., Bloom B.R., Bajardi A.C., Grisso A.C., Sieling P.A., Alland D., Convit J., Fan X., Hunter S.W., Brennan P.J., Rea T.H., Modlin R.L. J. Exp. Med. 175:275-284(1992) [PubMed: 1730920] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-25.
[2]	"Mycobacteria contain two groEL genes: the second Mycobacterium leprae groEL gene is arranged in an operon with groES." de Wit T.F.R., Bekelie S., Osland A., Miko T.L., Hermans P.W.M., van Soolingen D., Drijfhout J., Schoeningh R., Janson A.A.M., Thole J.E.R. Mol. Microbiol. 6:1995-2007(1992) [PubMed: 1354834] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	Smith D.R., Robison K. Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Massive gene decay in the leprosy bacillus." Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R., Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E., Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Duthoy S. Barrell B.G. Nature 409:1007-1011(2001) [PubMed: 11234002] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TN.
[5]	"Structure of the heat shock protein chaperonin-10 of Mycobacterium leprae." Mande S.C., Mehra V., Bloom B.R., Hol W.G.J. Science 271:203-207(1996) [PubMed: 8539620] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS).
[6]	Erratum Mande S.C., Mehra V., Bloom B.R., Hol W.G.J. Science 271:1655-1655(1996)
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X59413 Genomic DNA. No translation available.
Z11665 Genomic DNA. Translation: CAB63917.1.
U00015 Genomic DNA. Translation: AAC43227.1.
U00020 Genomic DNA. Translation: AAA17311.1.
AL583918 Genomic DNA. Translation: CAC29888.1.

PIR

S25180.
S72818.

RefSeq

NP_301372.1. NC_002677.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1LEP	X-ray	3.50	A/B/C/D/E/F/G	2-100	[»]

ProteinModelPortal

P24301.

SMR

P24301. Positions 2-100.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

EBMYCT00000028933; EBMYCP00000028539; EBMYCG00000028928.

GeneID

909076.

GenomeReviews

Gene locus ML0380 in contig AL450380_GR.

KEGG

mle:ML0380.

NMPDR

fig|272631.1.peg.244.

PATRIC

18051386. VBIMycLep78757_0642.

Organism-specific databases

Leproma

ML0380.

CMR

Search...

Phylogenomic databases

GeneTree

EBGT00050000017607.

HOGENOM

HBG703377.

OMA

GQLLEMQ.

ProtClustDB

PRK00364.

Enzyme and pathway databases

BioCyc

MLEP272631:ML0380-MONOMER.

Family and domain databases

HAMAP

MF_00580. CH10.
[Tree]

InterPro

IPR020818. Chaperonin_Cpn10.
IPR018369. Chaprnonin_Cpn10_CS.
IPR011032. GroES-like.
[Graphical view]

Gene3D

G3DSA:2.30.33.40. Chaprnin_Cpn10. 1 hit.

K04078.

PANTHER

PTHR10772. Chaprnin_Cpn10. 1 hit.

Pfam

PF00166. Cpn10. 1 hit.
[Graphical view]

PRINTS

PR00297. CHAPERONIN10.

SMART

SM00883. Cpn10. 1 hit.
[Graphical view]

SUPFAM

SSF50129. GroES_like. 1 hit.

PROSITE

PS00681. CHAPERONINS_CPN10. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

CH10_MYCLE

Accession

Primary (citable) accession number: P24301

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
Last sequence update:	January 23, 2007
Last modified:	January 25, 2012
This is version 94 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents