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Protein

10 kDa chaperonin

Gene

groS

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Names & Taxonomyi

Protein namesi
Recommended name:
10 kDa chaperonin
Alternative name(s):
10 kDa antigen
GroES protein
Protein Cpn10
Gene namesi
Name:groS
Synonyms:chpA, groES, mopB
Ordered Locus Names:ML0380
ORF Names:B1620_C3_227, B229_C3_247
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML0380.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 1009910 kDa chaperoninPRO_0000174786Add
BLAST

Interactioni

Subunit structurei

Heptamer of 7 subunits arranged in a ring.

Protein-protein interaction databases

STRINGi272631.ML0380.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1LEPX-ray3.50A/B/C/D/E/F/G2-100[»]
ProteinModelPortaliP24301.
SMRiP24301. Positions 2-100.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP24301.

Family & Domainsi

Sequence similaritiesi

Belongs to the GroES chaperonin family.Curated

Phylogenomic databases

eggNOGiENOG4105K5Y. Bacteria.
COG0234. LUCA.
HOGENOMiHOG000133897.
KOiK04078.
OMAiDTGKEKP.
OrthoDBiPOG091H004B.

Family and domain databases

CDDicd00320. cpn10. 1 hit.
Gene3Di2.30.33.40. 1 hit.
HAMAPiMF_00580. CH10. 1 hit.
InterProiIPR020818. Chaperonin_GroES.
IPR018369. Chaprnonin_Cpn10_CS.
IPR011032. GroES-like.
[Graphical view]
PANTHERiPTHR10772. PTHR10772. 1 hit.
PfamiPF00166. Cpn10. 1 hit.
[Graphical view]
PRINTSiPR00297. CHAPERONIN10.
SMARTiSM00883. Cpn10. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
PROSITEiPS00681. CHAPERONINS_CPN10. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24301-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKVKIKPLE DKILVQAGEA ETMTPSGLVI PENAKEKPQE GTVVAVGPGR
60 70 80 90 100
WDEDGAKRIP VDVSEGDIVI YSKYGGTEIK YNGEEYLILS ARDVLAVVSK
Length:100
Mass (Da):10,800
Last modified:January 23, 2007 - v2
Checksum:iA3BE12F8CA6764E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59413 Genomic DNA. No translation available.
Z11665 Genomic DNA. Translation: CAB63917.1.
U00015 Genomic DNA. Translation: AAC43227.1.
U00020 Genomic DNA. Translation: AAA17311.1.
AL583918 Genomic DNA. Translation: CAC29888.1.
PIRiS25180.
S72818.
RefSeqiNP_301372.1. NC_002677.1.
WP_010907696.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC29888; CAC29888; CAC29888.
GeneIDi909076.
KEGGimle:ML0380.
PATRICi18051386. VBIMycLep78757_0642.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59413 Genomic DNA. No translation available.
Z11665 Genomic DNA. Translation: CAB63917.1.
U00015 Genomic DNA. Translation: AAC43227.1.
U00020 Genomic DNA. Translation: AAA17311.1.
AL583918 Genomic DNA. Translation: CAC29888.1.
PIRiS25180.
S72818.
RefSeqiNP_301372.1. NC_002677.1.
WP_010907696.1. NC_002677.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1LEPX-ray3.50A/B/C/D/E/F/G2-100[»]
ProteinModelPortaliP24301.
SMRiP24301. Positions 2-100.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML0380.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC29888; CAC29888; CAC29888.
GeneIDi909076.
KEGGimle:ML0380.
PATRICi18051386. VBIMycLep78757_0642.

Organism-specific databases

LepromaiML0380.

Phylogenomic databases

eggNOGiENOG4105K5Y. Bacteria.
COG0234. LUCA.
HOGENOMiHOG000133897.
KOiK04078.
OMAiDTGKEKP.
OrthoDBiPOG091H004B.

Miscellaneous databases

EvolutionaryTraceiP24301.

Family and domain databases

CDDicd00320. cpn10. 1 hit.
Gene3Di2.30.33.40. 1 hit.
HAMAPiMF_00580. CH10. 1 hit.
InterProiIPR020818. Chaperonin_GroES.
IPR018369. Chaprnonin_Cpn10_CS.
IPR011032. GroES-like.
[Graphical view]
PANTHERiPTHR10772. PTHR10772. 1 hit.
PfamiPF00166. Cpn10. 1 hit.
[Graphical view]
PRINTSiPR00297. CHAPERONIN10.
SMARTiSM00883. Cpn10. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
PROSITEiPS00681. CHAPERONINS_CPN10. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCH10_MYCLE
AccessioniPrimary (citable) accession number: P24301
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.