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Protein

Rubredoxin

Gene

rub

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

Cofactori

Fe3+Note: Binds 1 Fe3+ ion per subunit.

Temperature dependencei

Extremely thermostable, being unaffected after incubation for 24 hours at 95 degrees Celsius.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi6Iron1
Metal bindingi9Iron1
Metal bindingi39Iron1
Metal bindingi42Iron1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Rubredoxin
Short name:
Rd
Gene namesi
Name:rub
Ordered Locus Names:PF1282
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000001013 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001350632 – 54RubredoxinAdd BLAST53

Proteomic databases

PRIDEiP24297.

Interactioni

Protein-protein interaction databases

STRINGi186497.PF1282.

Structurei

Secondary structure

154
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 6Combined sources4
Turni7 – 9Combined sources3
Beta strandi12 – 14Combined sources3
Turni15 – 17Combined sources3
Helixi20 – 22Combined sources3
Helixi30 – 32Combined sources3
Turni40 – 42Combined sources3
Helixi46 – 48Combined sources3
Beta strandi49 – 52Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BQ8X-ray1.10A1-54[»]
1BQ9X-ray1.20A1-54[»]
1BRFX-ray0.95A2-54[»]
1CAAX-ray1.80A2-54[»]
1CADX-ray1.80A2-54[»]
1IU5X-ray1.50A2-54[»]
1IU6neutron diffraction1.60A2-54[»]
1QCVNMR-A2-54[»]
1RWDNMR-A2-54[»]
1VCXneutron diffraction1.50A2-54[»]
1ZRPNMR-A2-54[»]
2PVXX-ray1.04A/B/C/D/E/F/G/H1-54[»]
3KYUX-ray1.10A1-54[»]
3KYVX-ray1.10A1-54[»]
3KYWX-ray1.10A1-54[»]
3KYXOther1.68A1-54[»]
3KYYX-ray1.10A1-54[»]
3RYGneutron diffraction1.75A1-54[»]
3RZ6neutron diffraction1.75A1-54[»]
3RZTneutron diffraction1.75A1-54[»]
3SS2neutron diffraction1.75A1-54[»]
4AR3neutron diffraction1.05A1-54[»]
4AR4neutron diffraction1.38A1-54[»]
4AR5X-ray1.00A1-54[»]
4AR6X-ray0.92A1-54[»]
4K9Fneutron diffraction1.75A1-54[»]
5AI2neutron diffraction1.75A1-54[»]
5AI3X-ray1.02A1-54[»]
ProteinModelPortaliP24297.
SMRiP24297.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP24297.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 52Rubredoxin-likePROSITE-ProRule annotationAdd BLAST51

Sequence similaritiesi

Belongs to the rubredoxin family.Curated
Contains 1 rubredoxin-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiarCOG04391. Archaea.
COG1773. LUCA.
HOGENOMiHOG000223371.
OMAiDWVCPMC.

Family and domain databases

CDDicd00730. rubredoxin. 1 hit.
Gene3Di2.20.28.10. 1 hit.
InterProiIPR024922. Rubredoxin.
IPR024934. Rubredoxin-like_dom.
IPR004039. Rubredoxin-type_fold.
IPR024935. Rubredoxin_dom.
IPR018527. Rubredoxin_Fe_BS.
[Graphical view]
PfamiPF00301. Rubredoxin. 1 hit.
[Graphical view]
PIRSFiPIRSF000071. Rubredoxin. 1 hit.
PRINTSiPR00163. RUBREDOXIN.
PROSITEiPS00202. RUBREDOXIN. 1 hit.
PS50903. RUBREDOXIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24297-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKWVCKICG YIYDEDAGDP DNGISPGTKF EELPDDWVCP ICGAPKSEFE

KLED
Length:54
Mass (Da):6,027
Last modified:January 23, 2007 - v2
Checksum:i7181BBB4A3E8B1A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156097 Genomic DNA. Translation: AAF03228.1.
AE009950 Genomic DNA. Translation: AAL81406.1.
PIRiT44570. RUPF.
RefSeqiWP_011012426.1. NC_003413.1.

Genome annotation databases

EnsemblBacteriaiAAL81406; AAL81406; PF1282.
GeneIDi1469155.
KEGGipfu:PF1282.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156097 Genomic DNA. Translation: AAF03228.1.
AE009950 Genomic DNA. Translation: AAL81406.1.
PIRiT44570. RUPF.
RefSeqiWP_011012426.1. NC_003413.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BQ8X-ray1.10A1-54[»]
1BQ9X-ray1.20A1-54[»]
1BRFX-ray0.95A2-54[»]
1CAAX-ray1.80A2-54[»]
1CADX-ray1.80A2-54[»]
1IU5X-ray1.50A2-54[»]
1IU6neutron diffraction1.60A2-54[»]
1QCVNMR-A2-54[»]
1RWDNMR-A2-54[»]
1VCXneutron diffraction1.50A2-54[»]
1ZRPNMR-A2-54[»]
2PVXX-ray1.04A/B/C/D/E/F/G/H1-54[»]
3KYUX-ray1.10A1-54[»]
3KYVX-ray1.10A1-54[»]
3KYWX-ray1.10A1-54[»]
3KYXOther1.68A1-54[»]
3KYYX-ray1.10A1-54[»]
3RYGneutron diffraction1.75A1-54[»]
3RZ6neutron diffraction1.75A1-54[»]
3RZTneutron diffraction1.75A1-54[»]
3SS2neutron diffraction1.75A1-54[»]
4AR3neutron diffraction1.05A1-54[»]
4AR4neutron diffraction1.38A1-54[»]
4AR5X-ray1.00A1-54[»]
4AR6X-ray0.92A1-54[»]
4K9Fneutron diffraction1.75A1-54[»]
5AI2neutron diffraction1.75A1-54[»]
5AI3X-ray1.02A1-54[»]
ProteinModelPortaliP24297.
SMRiP24297.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi186497.PF1282.

Proteomic databases

PRIDEiP24297.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL81406; AAL81406; PF1282.
GeneIDi1469155.
KEGGipfu:PF1282.

Phylogenomic databases

eggNOGiarCOG04391. Archaea.
COG1773. LUCA.
HOGENOMiHOG000223371.
OMAiDWVCPMC.

Miscellaneous databases

EvolutionaryTraceiP24297.

Family and domain databases

CDDicd00730. rubredoxin. 1 hit.
Gene3Di2.20.28.10. 1 hit.
InterProiIPR024922. Rubredoxin.
IPR024934. Rubredoxin-like_dom.
IPR004039. Rubredoxin-type_fold.
IPR024935. Rubredoxin_dom.
IPR018527. Rubredoxin_Fe_BS.
[Graphical view]
PfamiPF00301. Rubredoxin. 1 hit.
[Graphical view]
PIRSFiPIRSF000071. Rubredoxin. 1 hit.
PRINTSiPR00163. RUBREDOXIN.
PROSITEiPS00202. RUBREDOXIN. 1 hit.
PS50903. RUBREDOXIN_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRUBR_PYRFU
AccessioniPrimary (citable) accession number: P24297
Secondary accession number(s): Q9UWP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.