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Protein

Rubredoxin

Gene

rub

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

Cofactori

Fe3+Note: Binds 1 Fe3+ ion per subunit.

Temperature dependencei

Extremely thermostable, being unaffected after incubation for 24 hours at 95 degrees Celsius.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi6 – 61Iron
Metal bindingi9 – 91Iron
Metal bindingi39 – 391Iron
Metal bindingi42 – 421Iron

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Rubredoxin
Short name:
Rd
Gene namesi
Name:rub
Ordered Locus Names:PF1282
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000001013 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 5453RubredoxinPRO_0000135063Add
BLAST

Proteomic databases

PRIDEiP24297.

Interactioni

Protein-protein interaction databases

STRINGi186497.PF1282.

Structurei

Secondary structure

1
54
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 64Combined sources
Turni7 – 93Combined sources
Beta strandi12 – 143Combined sources
Turni15 – 173Combined sources
Helixi20 – 223Combined sources
Helixi30 – 323Combined sources
Turni40 – 423Combined sources
Helixi46 – 483Combined sources
Beta strandi49 – 524Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BQ8X-ray1.10A1-54[»]
1BQ9X-ray1.20A1-54[»]
1BRFX-ray0.95A2-54[»]
1CAAX-ray1.80A2-54[»]
1CADX-ray1.80A2-54[»]
1IU5X-ray1.50A2-54[»]
1IU6neutron diffraction1.60A2-54[»]
1QCVNMR-A2-54[»]
1RWDNMR-A2-54[»]
1VCXneutron diffraction1.50A2-54[»]
1ZRPNMR-A2-54[»]
2PVXX-ray1.04A/B/C/D/E/F/G/H1-54[»]
3KYUX-ray1.10A1-54[»]
3KYVX-ray1.10A1-54[»]
3KYWX-ray1.10A1-54[»]
3KYXOther1.68A1-54[»]
3KYYX-ray1.10A1-54[»]
3RYGneutron diffraction1.75A1-54[»]
3RZ6neutron diffraction1.75A1-54[»]
3RZTneutron diffraction1.75A1-54[»]
3SS2neutron diffraction1.75A1-54[»]
4AR3neutron diffraction1.05A1-54[»]
4AR4neutron diffraction1.38A1-54[»]
4AR5X-ray1.00A1-54[»]
4AR6X-ray0.92A1-54[»]
4K9Fneutron diffraction1.75A1-54[»]
5AI2neutron diffraction1.75A1-54[»]
5AI3X-ray1.02A1-54[»]
ProteinModelPortaliP24297.
SMRiP24297. Positions 1-54.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP24297.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 5251Rubredoxin-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the rubredoxin family.Curated
Contains 1 rubredoxin-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiarCOG04391. Archaea.
COG1773. LUCA.
HOGENOMiHOG000223371.
OMAiDWVCPMC.

Family and domain databases

CDDicd00730. rubredoxin. 1 hit.
Gene3Di2.20.28.10. 1 hit.
InterProiIPR024922. Rubredoxin.
IPR024934. Rubredoxin-like_dom.
IPR004039. Rubredoxin-type_fold.
IPR024935. Rubredoxin_dom.
IPR018527. Rubredoxin_Fe_BS.
[Graphical view]
PfamiPF00301. Rubredoxin. 1 hit.
[Graphical view]
PIRSFiPIRSF000071. Rubredoxin. 1 hit.
PRINTSiPR00163. RUBREDOXIN.
PROSITEiPS00202. RUBREDOXIN. 1 hit.
PS50903. RUBREDOXIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24297-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKWVCKICG YIYDEDAGDP DNGISPGTKF EELPDDWVCP ICGAPKSEFE

KLED
Length:54
Mass (Da):6,027
Last modified:January 23, 2007 - v2
Checksum:i7181BBB4A3E8B1A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156097 Genomic DNA. Translation: AAF03228.1.
AE009950 Genomic DNA. Translation: AAL81406.1.
PIRiT44570. RUPF.
RefSeqiWP_011012426.1. NC_003413.1.

Genome annotation databases

EnsemblBacteriaiAAL81406; AAL81406; PF1282.
GeneIDi1469155.
KEGGipfu:PF1282.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156097 Genomic DNA. Translation: AAF03228.1.
AE009950 Genomic DNA. Translation: AAL81406.1.
PIRiT44570. RUPF.
RefSeqiWP_011012426.1. NC_003413.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BQ8X-ray1.10A1-54[»]
1BQ9X-ray1.20A1-54[»]
1BRFX-ray0.95A2-54[»]
1CAAX-ray1.80A2-54[»]
1CADX-ray1.80A2-54[»]
1IU5X-ray1.50A2-54[»]
1IU6neutron diffraction1.60A2-54[»]
1QCVNMR-A2-54[»]
1RWDNMR-A2-54[»]
1VCXneutron diffraction1.50A2-54[»]
1ZRPNMR-A2-54[»]
2PVXX-ray1.04A/B/C/D/E/F/G/H1-54[»]
3KYUX-ray1.10A1-54[»]
3KYVX-ray1.10A1-54[»]
3KYWX-ray1.10A1-54[»]
3KYXOther1.68A1-54[»]
3KYYX-ray1.10A1-54[»]
3RYGneutron diffraction1.75A1-54[»]
3RZ6neutron diffraction1.75A1-54[»]
3RZTneutron diffraction1.75A1-54[»]
3SS2neutron diffraction1.75A1-54[»]
4AR3neutron diffraction1.05A1-54[»]
4AR4neutron diffraction1.38A1-54[»]
4AR5X-ray1.00A1-54[»]
4AR6X-ray0.92A1-54[»]
4K9Fneutron diffraction1.75A1-54[»]
5AI2neutron diffraction1.75A1-54[»]
5AI3X-ray1.02A1-54[»]
ProteinModelPortaliP24297.
SMRiP24297. Positions 1-54.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi186497.PF1282.

Proteomic databases

PRIDEiP24297.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL81406; AAL81406; PF1282.
GeneIDi1469155.
KEGGipfu:PF1282.

Phylogenomic databases

eggNOGiarCOG04391. Archaea.
COG1773. LUCA.
HOGENOMiHOG000223371.
OMAiDWVCPMC.

Miscellaneous databases

EvolutionaryTraceiP24297.

Family and domain databases

CDDicd00730. rubredoxin. 1 hit.
Gene3Di2.20.28.10. 1 hit.
InterProiIPR024922. Rubredoxin.
IPR024934. Rubredoxin-like_dom.
IPR004039. Rubredoxin-type_fold.
IPR024935. Rubredoxin_dom.
IPR018527. Rubredoxin_Fe_BS.
[Graphical view]
PfamiPF00301. Rubredoxin. 1 hit.
[Graphical view]
PIRSFiPIRSF000071. Rubredoxin. 1 hit.
PRINTSiPR00163. RUBREDOXIN.
PROSITEiPS00202. RUBREDOXIN. 1 hit.
PS50903. RUBREDOXIN_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRUBR_PYRFU
AccessioniPrimary (citable) accession number: P24297
Secondary accession number(s): Q9UWP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.