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Protein

Zinc finger and BTB domain-containing protein 25

Gene

ZBTB25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri238 – 26023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri349 – 37123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • transcription factor activity, sequence-specific DNA binding Source: ProtInc

GO - Biological processi

  • gene expression Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 25
Alternative name(s):
Zinc finger protein 46
Zinc finger protein KUP
Gene namesi
Name:ZBTB25
Synonyms:C14orf51, KUP, ZNF46
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:13112. ZBTB25.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleoplasm Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37687.

Polymorphism and mutation databases

BioMutaiZBTB25.
DMDMi116242849.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 435435Zinc finger and BTB domain-containing protein 25PRO_0000047738Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki204 – 204Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiP24278.
PaxDbiP24278.
PRIDEiP24278.

PTM databases

iPTMnetiP24278.
PhosphoSiteiP24278.

Expressioni

Tissue specificityi

Expressed mainly in hematopoietic cells and testis.

Gene expression databases

BgeeiP24278.
CleanExiHS_ZBTB25.
ExpressionAtlasiP24278. baseline and differential.
GenevisibleiP24278. HS.

Organism-specific databases

HPAiHPA054699.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
APIPQ96GX93EBI-739899,EBI-359248
DDIT3P35638-23EBI-739899,EBI-10173632
KCTD1Q719H93EBI-739899,EBI-9027502
LZTS2Q9BRK43EBI-739899,EBI-741037
MDFIQ997502EBI-739899,EBI-724076
PNMA5Q96PV43EBI-739899,EBI-10171633
SEPHS1P499034EBI-739899,EBI-714091
TNIP1Q150253EBI-739899,EBI-357849
TRAF2Q129334EBI-739899,EBI-355744
TSSK3Q96PN83EBI-739899,EBI-3918381

Protein-protein interaction databases

BioGridi113422. 28 interactions.
IntActiP24278. 23 interactions.
MINTiMINT-1458650.
STRINGi9606.ENSP00000261683.

Structurei

3D structure databases

ProteinModelPortaliP24278.
SMRiP24278. Positions 1-103, 231-270, 341-379.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 107107BTBPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 2 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri238 – 26023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri349 – 37123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129682.
HOGENOMiHOG000013138.
HOVERGENiHBG095695.
InParanoidiP24278.
KOiK10504.
OMAiECHRLSS.
PhylomeDBiP24278.
TreeFamiTF332229.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 2 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24278-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTASHSLVL LQQLNMQREF GFLCDCTVAI GDVYFKAHRA VLAAFSNYFK
60 70 80 90 100
MIFIHQTSEC IKIQPTDIQP DIFSYLLHIM YTGKGPKQIV DHSRLEEGIR
110 120 130 140 150
FLHADYLSHI ATEMNQVFSP ETVQSSNLYG IQISTTQKTV VKQGLEVKEA
160 170 180 190 200
PSSNSGNRAA VQGDHPQLQL SLAIGLDDGT ADQQRACPAT QALEEHQKPP
210 220 230 240 250
VSIKQERCDP ESVISQSHPS PSSEVTGPTF TENSVKIHLC HYCGERFDSR
260 270 280 290 300
SNLRQHLHTH VSGSLPFGVP ASILESNDLG EVHPLNENSE ALECRRLSSF
310 320 330 340 350
IVKENEQQPD HTNRGTTEPL QISQVSLISK DTEPVELNCN FSFSRKRKMS
360 370 380 390 400
CTICGHKFPR KSQLLEHMYT HKGKSYRYNR CQRFGNALAQ RFQPYCDSWS
410 420 430
DVSLKSSRLS QEHLDLPCAL ESELTQENVD TILVE
Length:435
Mass (Da):48,990
Last modified:October 17, 2006 - v2
Checksum:i5994E14B735AA0AE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti165 – 1651H → L in CAA34595 (PubMed:2027750).Curated
Sequence conflicti169 – 1702Missing in CAA34595 (PubMed:2027750).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16576 mRNA. Translation: CAA34595.1.
AK098181 mRNA. Translation: BAG53588.1.
CH471061 Genomic DNA. Translation: EAW80861.1.
BC035804 mRNA. Translation: AAH35804.1.
CCDSiCCDS9765.1.
PIRiS15647.
RefSeqiNP_001291436.1. NM_001304507.1.
NP_008908.2. NM_006977.3.
XP_005268110.1. XM_005268053.3.
XP_006720314.1. XM_006720251.2.
XP_006720315.1. XM_006720252.2.
XP_011535444.1. XM_011537142.1.
XP_011535445.1. XM_011537143.1.
XP_011535446.1. XM_011537144.1.
XP_011535447.1. XM_011537145.1.
UniGeneiHs.654571.

Genome annotation databases

EnsembliENST00000394715; ENSP00000378204; ENSG00000089775.
ENST00000608382; ENSP00000476746; ENSG00000089775.
GeneIDi7597.
KEGGihsa:7597.
UCSCiuc001xhf.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16576 mRNA. Translation: CAA34595.1.
AK098181 mRNA. Translation: BAG53588.1.
CH471061 Genomic DNA. Translation: EAW80861.1.
BC035804 mRNA. Translation: AAH35804.1.
CCDSiCCDS9765.1.
PIRiS15647.
RefSeqiNP_001291436.1. NM_001304507.1.
NP_008908.2. NM_006977.3.
XP_005268110.1. XM_005268053.3.
XP_006720314.1. XM_006720251.2.
XP_006720315.1. XM_006720252.2.
XP_011535444.1. XM_011537142.1.
XP_011535445.1. XM_011537143.1.
XP_011535446.1. XM_011537144.1.
XP_011535447.1. XM_011537145.1.
UniGeneiHs.654571.

3D structure databases

ProteinModelPortaliP24278.
SMRiP24278. Positions 1-103, 231-270, 341-379.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113422. 28 interactions.
IntActiP24278. 23 interactions.
MINTiMINT-1458650.
STRINGi9606.ENSP00000261683.

PTM databases

iPTMnetiP24278.
PhosphoSiteiP24278.

Polymorphism and mutation databases

BioMutaiZBTB25.
DMDMi116242849.

Proteomic databases

MaxQBiP24278.
PaxDbiP24278.
PRIDEiP24278.

Protocols and materials databases

DNASUi7597.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000394715; ENSP00000378204; ENSG00000089775.
ENST00000608382; ENSP00000476746; ENSG00000089775.
GeneIDi7597.
KEGGihsa:7597.
UCSCiuc001xhf.4. human.

Organism-specific databases

CTDi7597.
GeneCardsiZBTB25.
HGNCiHGNC:13112. ZBTB25.
HPAiHPA054699.
MIMi194541. gene.
neXtProtiNX_P24278.
PharmGKBiPA37687.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129682.
HOGENOMiHOG000013138.
HOVERGENiHBG095695.
InParanoidiP24278.
KOiK10504.
OMAiECHRLSS.
PhylomeDBiP24278.
TreeFamiTF332229.

Miscellaneous databases

ChiTaRSiZBTB25. human.
GenomeRNAii7597.
NextBioi29687.
PROiP24278.
SOURCEiSearch...

Gene expression databases

BgeeiP24278.
CleanExiHS_ZBTB25.
ExpressionAtlasiP24278. baseline and differential.
GenevisibleiP24278. HS.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 2 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The KUP gene, located on human chromosome 14, encodes a protein with two distant zinc fingers."
    Chardin P., Courtois G., Mattei M.-G., Gisselbrecht S.
    Nucleic Acids Res. 19:1431-1436(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Trachea.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Blood.
  5. "System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability."
    Xiao Z., Chang J.G., Hendriks I.A., Sigurdsson J.O., Olsen J.V., Vertegaal A.C.
    Mol. Cell. Proteomics 14:1419-1434(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-204, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZBT25_HUMAN
AccessioniPrimary (citable) accession number: P24278
Secondary accession number(s): B3KUX6, Q8IYH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: October 17, 2006
Last modified: May 11, 2016
This is version 153 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.