P24278 (ZBT25_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger and BTB domain-containing protein 25

Alternative name(s):
Zinc finger protein 46
Zinc finger protein KUP

Gene names

Name:	ZBTB25
Synonyms:	C14orf51, KUP, ZNF46

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	435 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus.
Tissue specificity	Expressed mainly in hematopoietic cells and testis.
Sequence similarities	Contains 1 BTB (POZ) domain. Contains 2 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from direct assay Ref.1. Source: UniProtKB nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from direct assay Ref.1. Source: UniProtKB protein binding Inferred from physical interaction. Source: IntAct sequence-specific DNA binding transcription factor activity Traceable author statement. Source: ProtInc zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
MDFI	Q99750	2	EBI-739899,EBI-724076

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 435	435	Zinc finger and BTB domain-containing protein 25		PRO_0000047738
Regions
	Domain	1 – 107	107	BTB
	Zinc finger	238 – 260	23	C2H2-type 1
	Zinc finger	349 – 371	23	C2H2-type 2
Experimental info
	Sequence conflict	165	1	H → L in CAA34595. Ref.1
	Sequence conflict	169 – 170	2	Missing in CAA34595. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P24278 [UniParc]. Last modified October 17, 2006. Version 2. Checksum: 5994E14B735AA0AE	FASTA	435	48,990
	10 20 30 40 50 60 MDTASHSLVL LQQLNMQREF GFLCDCTVAI GDVYFKAHRA VLAAFSNYFK MIFIHQTSEC 70 80 90 100 110 120 IKIQPTDIQP DIFSYLLHIM YTGKGPKQIV DHSRLEEGIR FLHADYLSHI ATEMNQVFSP 130 140 150 160 170 180 ETVQSSNLYG IQISTTQKTV VKQGLEVKEA PSSNSGNRAA VQGDHPQLQL SLAIGLDDGT 190 200 210 220 230 240 ADQQRACPAT QALEEHQKPP VSIKQERCDP ESVISQSHPS PSSEVTGPTF TENSVKIHLC 250 260 270 280 290 300 HYCGERFDSR SNLRQHLHTH VSGSLPFGVP ASILESNDLG EVHPLNENSE ALECRRLSSF 310 320 330 340 350 360 IVKENEQQPD HTNRGTTEPL QISQVSLISK DTEPVELNCN FSFSRKRKMS CTICGHKFPR 370 380 390 400 410 420 KSQLLEHMYT HKGKSYRYNR CQRFGNALAQ RFQPYCDSWS DVSLKSSRLS QEHLDLPCAL 430 ESELTQENVD TILVE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The KUP gene, located on human chromosome 14, encodes a protein with two distant zinc fingers." Chardin P., Courtois G., Mattei M.-G., Gisselbrecht S. Nucleic Acids Res. 19:1431-1436(1991) [PubMed: 2027750] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Trachea.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Blood.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X16576 mRNA. Translation: CAA34595.1. AK098181 mRNA. Translation: BAG53588.1. CH471061 Genomic DNA. Translation: EAW80861.1. BC035804 mRNA. Translation: AAH35804.1.
IPI	IPI00217777.
PIR	S15647.
RefSeq	NP_008908.2. NM_006977.2.
UniGene	Hs.654571.
3D structure databases
ProteinModelPortal	P24278.
SMR	P24278. Positions 1-115, 231-407.
ModBase	Search...
Protein-protein interaction databases
IntAct	P24278. 11 interactions.
MINT	MINT-1458650.
STRING	P24278.
Polymorphism databases
DMDM	116242849.
Proteomic databases
PRIDE	P24278.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000261683; ENSP00000261683; ENSG00000089775. ENST00000394715; ENSP00000378204; ENSG00000089775.
GeneID	7597.
KEGG	hsa:7597.
UCSC	uc001xhf.1. human.
Organism-specific databases
CTD	7597.
GeneCards	GC14M064953.
H-InvDB	HIX0011733.
HGNC	HGNC:13112. ZBTB25.
MIM	194541. gene.
neXtProt	NX_P24278.
PharmGKB	PA37687.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG06275.
GeneTree	ENSGT00530000063307.
HOGENOM	HBG713779.
HOVERGEN	HBG095695.
InParanoid	P24278.
OMA	CGHKFLR.
OrthoDB	EOG47PX5X.
PhylomeDB	P24278.
Gene expression databases
ArrayExpress	P24278.
Bgee	P24278.
CleanEx	HS_ZBTB25.
Genevestigator	P24278.
GermOnline	ENSG00000089775. Homo sapiens.
Family and domain databases
InterPro	IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR013069. BTB_POZ. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Gene3D	G3DSA:3.30.710.10. BTB/POZ_fold. 1 hit. G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 2 hits.
KO	K10504.
Pfam	PF00651. BTB. 1 hit. PF00096. zf-C2H2. 2 hits. [Graphical view]
SMART	SM00225. BTB. 1 hit. SM00355. ZnF_C2H2. 2 hits. [Graphical view]
SUPFAM	SSF54695. BTB/POZ_fold. 1 hit.
PROSITE	PS50097. BTB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 2 hits. PS50157. ZINC_FINGER_C2H2_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	29687.
SOURCE	Search...

Entry information

Entry name

ZBT25_HUMAN

Accession

Primary (citable) accession number: P24278
Secondary accession number(s): B3KUX6, Q8IYH9

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
Last sequence update:	October 17, 2006
Last modified:	January 25, 2012
This is version 110 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.