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Protein

Protein SSD1

Gene

SSD1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Can suppress the lethality due to deletion of SIT4, and partially the defects due to BCY1 disruption. Is implicated in the control of the cell cycle G1 phase.

GO - Molecular functioni

  • 3'-5'-exoribonuclease activity Source: GO_Central
  • mRNA 3'-UTR binding Source: SGD
  • mRNA 5'-UTR binding Source: SGD
  • mRNA binding Source: SGD
  • translation repressor activity, nucleic acid binding Source: SGD

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • intracellular mRNA localization Source: SGD
  • mitotic nuclear division Source: UniProtKB-KW
  • mRNA catabolic process Source: GO_Central
  • negative regulation of translation Source: SGD
  • regulation of fungal-type cell wall organization Source: SGD
  • rRNA catabolic process Source: GO_Central
  • rRNA processing Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

BioCyciYEAST:G3O-29856-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SSD1
Alternative name(s):
Protein SRK1
Gene namesi
Name:SSD1
Synonyms:CLA1, RLD1, SRK1
Ordered Locus Names:YDR293C
ORF Names:D9819.4
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR293C.
SGDiS000002701. SSD1.

Subcellular locationi

GO - Cellular componenti

  • cellular bud Source: SGD
  • cellular bud neck Source: SGD
  • cytoplasm Source: SGD
  • cytoplasmic exosome (RNase complex) Source: GO_Central
  • cytoplasmic mRNA processing body Source: SGD
  • cytoplasmic stress granule Source: SGD
  • nuclear exosome (RNase complex) Source: GO_Central
  • nucleus Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 12501249Protein SSD1PRO_0000166424Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineCombined sources
Modified residuei40 – 401PhosphoserineCombined sources
Modified residuei164 – 1641PhosphoserineCombined sources
Modified residuei183 – 1831PhosphoserineCombined sources
Modified residuei227 – 2271PhosphothreonineCombined sources
Modified residuei286 – 2861PhosphoserineCombined sources
Modified residuei322 – 3221PhosphoserineCombined sources
Modified residuei491 – 4911PhosphoserineCombined sources
Modified residuei492 – 4921PhosphoserineCombined sources
Modified residuei688 – 6881PhosphotyrosineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP24276.
PRIDEiP24276.

PTM databases

iPTMnetiP24276.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HMT1P380742EBI-18153,EBI-8394

Protein-protein interaction databases

BioGridi32345. 478 interactions.
DIPiDIP-6449N.
IntActiP24276. 26 interactions.
MINTiMINT-605909.

Structurei

3D structure databases

ProteinModelPortaliP24276.
SMRiP24276. Positions 340-408, 521-1151.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi60 – 678Poly-Gln
Compositional biasi71 – 744Poly-Gln
Compositional biasi135 – 1417Poly-Asn
Compositional biasi214 – 2174Poly-Pro
Compositional biasi527 – 5304Poly-Glu

Sequence similaritiesi

Belongs to the RNR ribonuclease family.Curated

Phylogenomic databases

GeneTreeiENSGT00530000069300.
HOGENOMiHOG000207194.
InParanoidiP24276.
KOiK18748.
OMAiIEKRVHG.
OrthoDBiEOG092C0JUY.

Family and domain databases

InterProiIPR012340. NA-bd_OB-fold.
IPR022966. RNase_II/R_CS.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 4 hits.
PROSITEiPS01175. RIBONUCLEASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24276-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKNSNVNNN RSQEPNNMFV QTTGGGKNAP KQIHVAHRRS QSELTNLMIE
60 70 80 90 100
QFTLQKQLEQ VQAQQQQLMA QQQQLAQQTG QYLSGNSGSN NHFTPQPPHP
110 120 130 140 150
HYNSNGNSPG MSAGGSRSRT HSRNNSGYYH NSYDNNNNSN NPGSNSHRKT
160 170 180 190 200
SSQSSIYGHS RRHSLGLNEA KKAAAEEQAK RISGGEAGVT VKIDSVQADS
210 220 230 240 250
GSNSTTEQSD FKFPPPPNAH QGHRRATSNL SPPSFKFPPN SHGDNDDEFI
260 270 280 290 300
ATSSTHRRSK TRNNEYSPGI NSNWRNQSQQ PQQQLSPFRH RGSNSRDYNS
310 320 330 340 350
FNTLEPPAIF QQGHKHRASN SSVHSFSSQG NNNGGGRKSL FAPYLPQANI
360 370 380 390 400
PELIQEGRLV AGILRVNKKN RSDAWVSTDG ALDADIYICG SKDRNRALEG
410 420 430 440 450
DLVAVELLVV DDVWESKKEK EEKKRRKDAS MQHDLIPLNS SDDYHNDASV
460 470 480 490 500
TAATSNNFLS SPSSSDSLSK DDLSVRRKRS STINNDSDSL SSPTKSGVRR
510 520 530 540 550
RSSLKQRPTQ KKNDDVEVEG QSLLLVEEEE INDKYKPLYA GHVVAVLDRI
560 570 580 590 600
PGQLFSGTLG LLRPSQQANS DNNKPPQSPK IAWFKPTDKK VPLIAIPTEL
610 620 630 640 650
APKDFVENAD KYSEKLFVAS IKRWPITSLH PFGILVSELG DIHDPDTEID
660 670 680 690 700
SILRDNNFLS NEYLDQKNPQ KEKPSFQPLP LTAESLEYRR NFTDTNEYNI
710 720 730 740 750
FAISELGWVS EFALHVRNNG NGTLELGCHV VDVTSHIEEG SSVDRRARKR
760 770 780 790 800
SSAVFMPQKL VNLLPQSFND ELSLAPGKES ATLSVVYTLD SSTLRIKSTW
810 820 830 840 850
VGESTISPSN ILSLEQLDEK LSTGSPTSYL STVQEIARSF YARRINDPEA
860 870 880 890 900
TLLPTLSLLE SLDDEKVKVD LNILDRTLGF VVINEIKRKV NSTVAEKIYT
910 920 930 940 950
KLGDLALLRR QMQPIATKMA SFRKKIQNFG YNFDTNTADE LIKGVLKIKD
960 970 980 990 1000
DDVRVGIEIL LFKTMPRARY FIAGKVDPDQ YGHYALNLPI YTHFTAPMRR
1010 1020 1030 1040 1050
YADHVVHRQL KAVIHDTPYT EDMEALKITS EYCNFKKDCA YQAQEQAIHL
1060 1070 1080 1090 1100
LLCKTINDMG NTTGQLLTMA TVLQVYESSF DVFIPEFGIE KRVHGDQLPL
1110 1120 1130 1140 1150
IKAEFDGTNR VLELHWQPGV DSATFIPADE KNPKSYRNSI KNKFRSTAAE
1160 1170 1180 1190 1200
IANIELDKEA ESEPLISDPL SKELSDLHLT VPNLRLPSAS DNKQNALEKF
1210 1220 1230 1240 1250
ISTTETRIEN DNYIQEIHEL QKIPILLRAE VGMALPCLTV RALNPFMKRV
Length:1,250
Mass (Da):139,954
Last modified:March 1, 1992 - v1
Checksum:i3D50FD6838ECA514
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60318 Genomic DNA. Translation: AAA35047.1.
M63004 Genomic DNA. Translation: AAA35089.1.
U51031 Genomic DNA. Translation: AAB64469.1.
BK006938 Genomic DNA. Translation: DAA12132.1.
PIRiA39578.
RefSeqiNP_010579.1. NM_001180601.1.

Genome annotation databases

EnsemblFungiiYDR293C; YDR293C; YDR293C.
GeneIDi851887.
KEGGisce:YDR293C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60318 Genomic DNA. Translation: AAA35047.1.
M63004 Genomic DNA. Translation: AAA35089.1.
U51031 Genomic DNA. Translation: AAB64469.1.
BK006938 Genomic DNA. Translation: DAA12132.1.
PIRiA39578.
RefSeqiNP_010579.1. NM_001180601.1.

3D structure databases

ProteinModelPortaliP24276.
SMRiP24276. Positions 340-408, 521-1151.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32345. 478 interactions.
DIPiDIP-6449N.
IntActiP24276. 26 interactions.
MINTiMINT-605909.

PTM databases

iPTMnetiP24276.

Proteomic databases

MaxQBiP24276.
PRIDEiP24276.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR293C; YDR293C; YDR293C.
GeneIDi851887.
KEGGisce:YDR293C.

Organism-specific databases

EuPathDBiFungiDB:YDR293C.
SGDiS000002701. SSD1.

Phylogenomic databases

GeneTreeiENSGT00530000069300.
HOGENOMiHOG000207194.
InParanoidiP24276.
KOiK18748.
OMAiIEKRVHG.
OrthoDBiEOG092C0JUY.

Enzyme and pathway databases

BioCyciYEAST:G3O-29856-MONOMER.

Miscellaneous databases

PROiP24276.

Family and domain databases

InterProiIPR012340. NA-bd_OB-fold.
IPR022966. RNase_II/R_CS.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 4 hits.
PROSITEiPS01175. RIBONUCLEASE_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSSD1_YEAST
AccessioniPrimary (citable) accession number: P24276
Secondary accession number(s): D6VSS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: September 7, 2016
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Several alleles of SSD1 exist in different yeast strains.
Present with 1100 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.