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Protein

Protein SSD1

Gene

SSD1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Can suppress the lethality due to deletion of SIT4, and partially the defects due to BCY1 disruption. Is implicated in the control of the cell cycle G1 phase.

Miscellaneous

Several alleles of SSD1 exist in different yeast strains.
Present with 1100 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • 3'-5'-exoribonuclease activity Source: GO_Central
  • mRNA 3'-UTR binding Source: SGD
  • mRNA 5'-UTR binding Source: SGD
  • mRNA binding Source: SGD
  • translation repressor activity, mRNA regulatory element binding Source: SGD

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • intracellular mRNA localization Source: SGD
  • negative regulation of translation Source: SGD
  • regulation of fungal-type cell wall organization Source: SGD
  • RNA catabolic process Source: GO_Central
  • rRNA processing Source: GO_Central

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

BioCyciYEAST:G3O-29856-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SSD1
Alternative name(s):
Protein SRK1
Gene namesi
Name:SSD1
Synonyms:CLA1, RLD1, SRK1
Ordered Locus Names:YDR293C
ORF Names:D9819.4
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR293C
SGDiS000002701 SSD1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001664242 – 1250Protein SSD1Add BLAST1249

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei40PhosphoserineCombined sources1
Modified residuei164PhosphoserineCombined sources1
Modified residuei183PhosphoserineCombined sources1
Modified residuei227PhosphothreonineCombined sources1
Modified residuei286PhosphoserineCombined sources1
Modified residuei322PhosphoserineCombined sources1
Modified residuei491PhosphoserineCombined sources1
Modified residuei492PhosphoserineCombined sources1
Modified residuei688PhosphotyrosineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP24276
PaxDbiP24276
PRIDEiP24276

PTM databases

iPTMnetiP24276

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi32345, 802 interactors
DIPiDIP-6449N
ELMiP24276
IntActiP24276, 32 interactors
MINTiP24276
STRINGi4932.YDR293C

Structurei

3D structure databases

ProteinModelPortaliP24276
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi60 – 67Poly-Gln8
Compositional biasi71 – 74Poly-Gln4
Compositional biasi135 – 141Poly-Asn7
Compositional biasi214 – 217Poly-Pro4
Compositional biasi527 – 530Poly-Glu4

Sequence similaritiesi

Belongs to the RNR ribonuclease family.Curated

Phylogenomic databases

HOGENOMiHOG000207194
InParanoidiP24276
KOiK18748
OMAiRVAGQMF
OrthoDBiEOG092C0JUY

Family and domain databases

InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR022966 RNase_II/R_CS
SUPFAMiSSF50249 SSF50249, 4 hits
PROSITEiView protein in PROSITE
PS01175 RIBONUCLEASE_II, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24276-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKNSNVNNN RSQEPNNMFV QTTGGGKNAP KQIHVAHRRS QSELTNLMIE
60 70 80 90 100
QFTLQKQLEQ VQAQQQQLMA QQQQLAQQTG QYLSGNSGSN NHFTPQPPHP
110 120 130 140 150
HYNSNGNSPG MSAGGSRSRT HSRNNSGYYH NSYDNNNNSN NPGSNSHRKT
160 170 180 190 200
SSQSSIYGHS RRHSLGLNEA KKAAAEEQAK RISGGEAGVT VKIDSVQADS
210 220 230 240 250
GSNSTTEQSD FKFPPPPNAH QGHRRATSNL SPPSFKFPPN SHGDNDDEFI
260 270 280 290 300
ATSSTHRRSK TRNNEYSPGI NSNWRNQSQQ PQQQLSPFRH RGSNSRDYNS
310 320 330 340 350
FNTLEPPAIF QQGHKHRASN SSVHSFSSQG NNNGGGRKSL FAPYLPQANI
360 370 380 390 400
PELIQEGRLV AGILRVNKKN RSDAWVSTDG ALDADIYICG SKDRNRALEG
410 420 430 440 450
DLVAVELLVV DDVWESKKEK EEKKRRKDAS MQHDLIPLNS SDDYHNDASV
460 470 480 490 500
TAATSNNFLS SPSSSDSLSK DDLSVRRKRS STINNDSDSL SSPTKSGVRR
510 520 530 540 550
RSSLKQRPTQ KKNDDVEVEG QSLLLVEEEE INDKYKPLYA GHVVAVLDRI
560 570 580 590 600
PGQLFSGTLG LLRPSQQANS DNNKPPQSPK IAWFKPTDKK VPLIAIPTEL
610 620 630 640 650
APKDFVENAD KYSEKLFVAS IKRWPITSLH PFGILVSELG DIHDPDTEID
660 670 680 690 700
SILRDNNFLS NEYLDQKNPQ KEKPSFQPLP LTAESLEYRR NFTDTNEYNI
710 720 730 740 750
FAISELGWVS EFALHVRNNG NGTLELGCHV VDVTSHIEEG SSVDRRARKR
760 770 780 790 800
SSAVFMPQKL VNLLPQSFND ELSLAPGKES ATLSVVYTLD SSTLRIKSTW
810 820 830 840 850
VGESTISPSN ILSLEQLDEK LSTGSPTSYL STVQEIARSF YARRINDPEA
860 870 880 890 900
TLLPTLSLLE SLDDEKVKVD LNILDRTLGF VVINEIKRKV NSTVAEKIYT
910 920 930 940 950
KLGDLALLRR QMQPIATKMA SFRKKIQNFG YNFDTNTADE LIKGVLKIKD
960 970 980 990 1000
DDVRVGIEIL LFKTMPRARY FIAGKVDPDQ YGHYALNLPI YTHFTAPMRR
1010 1020 1030 1040 1050
YADHVVHRQL KAVIHDTPYT EDMEALKITS EYCNFKKDCA YQAQEQAIHL
1060 1070 1080 1090 1100
LLCKTINDMG NTTGQLLTMA TVLQVYESSF DVFIPEFGIE KRVHGDQLPL
1110 1120 1130 1140 1150
IKAEFDGTNR VLELHWQPGV DSATFIPADE KNPKSYRNSI KNKFRSTAAE
1160 1170 1180 1190 1200
IANIELDKEA ESEPLISDPL SKELSDLHLT VPNLRLPSAS DNKQNALEKF
1210 1220 1230 1240 1250
ISTTETRIEN DNYIQEIHEL QKIPILLRAE VGMALPCLTV RALNPFMKRV
Length:1,250
Mass (Da):139,954
Last modified:March 1, 1992 - v1
Checksum:i3D50FD6838ECA514
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60318 Genomic DNA Translation: AAA35047.1
M63004 Genomic DNA Translation: AAA35089.1
U51031 Genomic DNA Translation: AAB64469.1
BK006938 Genomic DNA Translation: DAA12132.1
PIRiA39578
RefSeqiNP_010579.1, NM_001180601.1

Genome annotation databases

EnsemblFungiiYDR293C; YDR293C; YDR293C
GeneIDi851887
KEGGisce:YDR293C

Similar proteinsi

Entry informationi

Entry nameiSSD1_YEAST
AccessioniPrimary (citable) accession number: P24276
Secondary accession number(s): D6VSS2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: May 23, 2018
This is version 164 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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