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Protein

Catalase

Gene

Cat

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.

Catalytic activityi

2 H2O2 = O2 + 2 H2O.PROSITE-ProRule annotation

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei75PROSITE-ProRule annotation1
Active sitei148PROSITE-ProRule annotation1
Metal bindingi358Iron (heme axial ligand)By similarity1

GO - Molecular functioni

  • aminoacylase activity Source: MGI
  • antioxidant activity Source: MGI
  • catalase activity Source: MGI
  • enzyme binding Source: MGI
  • heme binding Source: MGI
  • metal ion binding Source: UniProtKB-KW
  • NADP binding Source: MGI
  • oxidoreductase activity, acting on peroxide as acceptor Source: MGI
  • protein homodimerization activity Source: MGI
  • receptor binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionMitogen, Oxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandHeme, Iron, Metal-binding, NADP

Enzyme and pathway databases

ReactomeiR-MMU-3299685. Detoxification of Reactive Oxygen Species.
R-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase (EC:1.11.1.6)
Gene namesi
Name:Cat
Synonyms:Cas-1, Cas1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:88271. Cat.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi11Q → H: Acatalasemia. 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00000849022 – 527CatalaseAdd BLAST526

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1 Publication1
Modified residuei9PhosphoserineBy similarity1
Modified residuei13N6-succinyllysineCombined sources1
Modified residuei21PhosphoserineCombined sources1
Modified residuei221N6-succinyllysineCombined sources1
Modified residuei233N6-acetyllysineCombined sources1
Modified residuei306N6-acetyllysine; alternateCombined sources1
Modified residuei306N6-succinyllysine; alternateCombined sources1
Modified residuei417PhosphoserineCombined sources1
Modified residuei422PhosphoserineCombined sources1
Modified residuei430N6-acetyllysine; alternateCombined sources1
Modified residuei430N6-succinyllysine; alternateCombined sources1
Modified residuei434PhosphoserineCombined sources1
Modified residuei449N6-acetyllysine; alternateCombined sources1
Modified residuei449N6-succinyllysine; alternateCombined sources1
Modified residuei480N6-acetyllysine; alternateCombined sources1
Modified residuei480N6-succinyllysine; alternateCombined sources1
Modified residuei499N6-acetyllysineCombined sources1
Modified residuei511PhosphothreonineBy similarity1
Modified residuei517PhosphoserineCombined sources1
Modified residuei522N6-succinyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP24270.
MaxQBiP24270.
PaxDbiP24270.
PeptideAtlasiP24270.
PRIDEiP24270.

2D gel databases

SWISS-2DPAGEiP24270.

PTM databases

iPTMnetiP24270.
PhosphoSitePlusiP24270.
SwissPalmiP24270.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027187.
CleanExiMM_CAT.
ExpressionAtlasiP24270. baseline and differential.
GenevisibleiP24270. MM.

Interactioni

Subunit structurei

Homotetramer.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198490. 1 interactor.
IntActiP24270. 3 interactors.
MINTiMINT-1859622.
STRINGi10090.ENSMUSP00000028610.

Structurei

3D structure databases

ProteinModelPortaliP24270.
SMRiP24270.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the catalase family.Curated

Phylogenomic databases

eggNOGiKOG0047. Eukaryota.
COG0753. LUCA.
GeneTreeiENSGT00390000018100.
HOGENOMiHOG000087852.
HOVERGENiHBG003986.
InParanoidiP24270.
KOiK03781.
OMAiHADFGRM.
OrthoDBiEOG091G04V5.
TreeFamiTF300540.

Family and domain databases

Gene3Di2.40.180.10. 1 hit.
InterProiView protein in InterPro
IPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024708. Catalase_AS.
IPR024711. Catalase_clade1/3.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
PANTHERiPTHR11465. PTHR11465. 1 hit.
PfamiView protein in Pfam
PF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
PIRSFiPIRSF038928. Catalase_clade1-3. 1 hit.
PRINTSiPR00067. CATALASE.
SMARTiView protein in SMART
SM01060. Catalase. 1 hit.
SUPFAMiSSF56634. SSF56634. 1 hit.
PROSITEiView protein in PROSITE
PS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24270-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDSRDPASD QMKQWKEQRA SQRPDVLTTG GGNPIGDKLN IMTAGSRGPL
60 70 80 90 100
LVQDVVFTDE MAHFDRERIP ERVVHAKGAG AFGYFEVTHD ITRYSKAKVF
110 120 130 140 150
EHIGKRTPIA VRFSTVTGES GSADTVRDPR GFAVKFYTED GNWDLVGNNT
160 170 180 190 200
PIFFIRDAIL FPSFIHSQKR NPQTHLKDPD MVWDFWSLRP ESLHQVSFLF
210 220 230 240 250
SDRGIPDGHR HMNGYGSHTF KLVNADGEAV YCKFHYKTDQ GIKNLPVGEA
260 270 280 290 300
GRLAQEDPDY GLRDLFNAIA NGNYPSWTFY IQVMTFKEAE TFPFNPFDLT
310 320 330 340 350
KVWPHKDYPL IPVGKLVLNK NPVNYFAEVE QMAFDPSNMP PGIEPSPDKM
360 370 380 390 400
LQGRLFAYPD THRHRLGPNY LQIPVNCPYR ARVANYQRDG PMCMHDNQGG
410 420 430 440 450
APNYYPNSFS APEQQRSALE HSVQCAVDVK RFNSANEDNV TQVRTFYTKV
460 470 480 490 500
LNEEERKRLC ENIAGHLKDA QLFIQKKAVK NFTDVHPDYG ARIQALLDKY
510 520
NAEKPKNAIH TYTQAGSHMA AKGKANL
Length:527
Mass (Da):59,795
Last modified:July 27, 2011 - v4
Checksum:i4D86F3C9D1A3DF9E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti97A → G in AAA66054 (PubMed:8088826).Curated1
Sequence conflicti117T → A in AAA37373 (PubMed:2268310).Curated1
Sequence conflicti117T → A in CAA36342 (PubMed:2395665).Curated1
Sequence conflicti117T → A in AAA66054 (PubMed:8088826).Curated1
Sequence conflicti117T → A in AAH13447 (PubMed:16141072).Curated1
Sequence conflicti316L → V in AAA66054 (PubMed:8088826).Curated1
Sequence conflicti350M → K in AAA66054 (PubMed:8088826).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62897 mRNA. Translation: AAA37373.1.
X52108 mRNA. Translation: CAA36342.1.
L25069 mRNA. Translation: AAA66054.1.
AK150893 mRNA. Translation: BAE29939.1.
AK159152 mRNA. Translation: BAE34859.1.
AK159885 mRNA. Translation: BAE35454.1.
AK159891 mRNA. Translation: BAE35458.1.
AK169069 mRNA. Translation: BAE40856.1.
AL773505 Genomic DNA. Translation: CAM17512.1.
CH466519 Genomic DNA. Translation: EDL27697.1.
BC013447 mRNA. Translation: AAH13447.1.
M29394 mRNA. Translation: AAA37371.1.
CCDSiCCDS16478.1.
PIRiA36695.
RefSeqiNP_033934.2. NM_009804.2.
UniGeneiMm.4215.

Genome annotation databases

EnsembliENSMUST00000028610; ENSMUSP00000028610; ENSMUSG00000027187.
GeneIDi12359.
KEGGimmu:12359.
UCSCiuc008liw.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiCATA_MOUSE
AccessioniPrimary (citable) accession number: P24270
Secondary accession number(s): Q3TXQ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: July 27, 2011
Last modified: August 30, 2017
This is version 165 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families