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Protein

Catalase

Gene

Cat

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.

Catalytic activityi

2 H2O2 = O2 + 2 H2O.PROSITE-ProRule annotation

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei75PROSITE-ProRule annotation1
Active sitei148PROSITE-ProRule annotation1
Metal bindingi358Iron (heme axial ligand)By similarity1

GO - Molecular functioni

  • aminoacylase activity Source: MGI
  • antioxidant activity Source: MGI
  • catalase activity Source: MGI
  • enzyme binding Source: MGI
  • heme binding Source: MGI
  • metal ion binding Source: UniProtKB-KW
  • NADP binding Source: MGI
  • oxidoreductase activity, acting on peroxide as acceptor Source: MGI
  • protein homodimerization activity Source: MGI
  • signaling receptor binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionMitogen, Oxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandHeme, Iron, Metal-binding, NADP

Enzyme and pathway databases

ReactomeiR-MMU-3299685 Detoxification of Reactive Oxygen Species
R-MMU-6798695 Neutrophil degranulation
R-MMU-9033241 Peroxisomal protein import

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase (EC:1.11.1.6)
Gene namesi
Name:Cat
Synonyms:Cas-1, Cas1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:88271 Cat

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi11Q → H: Acatalasemia. 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00000849022 – 527CatalaseAdd BLAST526

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1 Publication1
Modified residuei9PhosphoserineBy similarity1
Modified residuei13N6-succinyllysineCombined sources1
Modified residuei21PhosphoserineCombined sources1
Modified residuei221N6-succinyllysineCombined sources1
Modified residuei233N6-acetyllysineCombined sources1
Modified residuei306N6-acetyllysine; alternateCombined sources1
Modified residuei306N6-succinyllysine; alternateCombined sources1
Modified residuei417PhosphoserineCombined sources1
Modified residuei422PhosphoserineCombined sources1
Modified residuei430N6-acetyllysine; alternateCombined sources1
Modified residuei430N6-succinyllysine; alternateCombined sources1
Modified residuei434PhosphoserineCombined sources1
Modified residuei449N6-acetyllysine; alternateCombined sources1
Modified residuei449N6-succinyllysine; alternateCombined sources1
Modified residuei480N6-acetyllysine; alternateCombined sources1
Modified residuei480N6-succinyllysine; alternateCombined sources1
Modified residuei499N6-acetyllysineCombined sources1
Modified residuei511PhosphothreonineBy similarity1
Modified residuei517PhosphoserineCombined sources1
Modified residuei522N6-succinyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP24270
MaxQBiP24270
PaxDbiP24270
PeptideAtlasiP24270
PRIDEiP24270

2D gel databases

SWISS-2DPAGEP24270

PTM databases

iPTMnetiP24270
PhosphoSitePlusiP24270
SwissPalmiP24270

Expressioni

Gene expression databases

BgeeiENSMUSG00000027187
CleanExiMM_CAT
ExpressionAtlasiP24270 baseline and differential
GenevisibleiP24270 MM

Interactioni

Subunit structurei

Homotetramer.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198490, 2 interactors
IntActiP24270, 4 interactors
MINTiP24270
STRINGi10090.ENSMUSP00000028610

Structurei

3D structure databases

ProteinModelPortaliP24270
SMRiP24270
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the catalase family.Curated

Phylogenomic databases

eggNOGiKOG0047 Eukaryota
COG0753 LUCA
GeneTreeiENSGT00390000018100
HOGENOMiHOG000087852
HOVERGENiHBG003986
InParanoidiP24270
KOiK03781
OMAiHADFGRM
OrthoDBiEOG091G04V5
TreeFamiTF300540

Family and domain databases

Gene3Di2.40.180.10, 1 hit
InterProiView protein in InterPro
IPR018028 Catalase
IPR024708 Catalase_AS
IPR024711 Catalase_clade1/3
IPR011614 Catalase_core
IPR037060 Catalase_core_sf
IPR002226 Catalase_haem_BS
IPR010582 Catalase_immune_responsive
IPR020835 Catalase_sf
PANTHERiPTHR11465 PTHR11465, 1 hit
PfamiView protein in Pfam
PF00199 Catalase, 1 hit
PF06628 Catalase-rel, 1 hit
PIRSFiPIRSF038928 Catalase_clade1-3, 1 hit
PRINTSiPR00067 CATALASE
SMARTiView protein in SMART
SM01060 Catalase, 1 hit
SUPFAMiSSF56634 SSF56634, 1 hit
PROSITEiView protein in PROSITE
PS00437 CATALASE_1, 1 hit
PS00438 CATALASE_2, 1 hit
PS51402 CATALASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24270-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDSRDPASD QMKQWKEQRA SQRPDVLTTG GGNPIGDKLN IMTAGSRGPL
60 70 80 90 100
LVQDVVFTDE MAHFDRERIP ERVVHAKGAG AFGYFEVTHD ITRYSKAKVF
110 120 130 140 150
EHIGKRTPIA VRFSTVTGES GSADTVRDPR GFAVKFYTED GNWDLVGNNT
160 170 180 190 200
PIFFIRDAIL FPSFIHSQKR NPQTHLKDPD MVWDFWSLRP ESLHQVSFLF
210 220 230 240 250
SDRGIPDGHR HMNGYGSHTF KLVNADGEAV YCKFHYKTDQ GIKNLPVGEA
260 270 280 290 300
GRLAQEDPDY GLRDLFNAIA NGNYPSWTFY IQVMTFKEAE TFPFNPFDLT
310 320 330 340 350
KVWPHKDYPL IPVGKLVLNK NPVNYFAEVE QMAFDPSNMP PGIEPSPDKM
360 370 380 390 400
LQGRLFAYPD THRHRLGPNY LQIPVNCPYR ARVANYQRDG PMCMHDNQGG
410 420 430 440 450
APNYYPNSFS APEQQRSALE HSVQCAVDVK RFNSANEDNV TQVRTFYTKV
460 470 480 490 500
LNEEERKRLC ENIAGHLKDA QLFIQKKAVK NFTDVHPDYG ARIQALLDKY
510 520
NAEKPKNAIH TYTQAGSHMA AKGKANL
Length:527
Mass (Da):59,795
Last modified:July 27, 2011 - v4
Checksum:i4D86F3C9D1A3DF9E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti97A → G in AAA66054 (PubMed:8088826).Curated1
Sequence conflicti117T → A in AAA37373 (PubMed:2268310).Curated1
Sequence conflicti117T → A in CAA36342 (PubMed:2395665).Curated1
Sequence conflicti117T → A in AAA66054 (PubMed:8088826).Curated1
Sequence conflicti117T → A in AAH13447 (PubMed:16141072).Curated1
Sequence conflicti316L → V in AAA66054 (PubMed:8088826).Curated1
Sequence conflicti350M → K in AAA66054 (PubMed:8088826).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62897 mRNA Translation: AAA37373.1
X52108 mRNA Translation: CAA36342.1
L25069 mRNA Translation: AAA66054.1
AK150893 mRNA Translation: BAE29939.1
AK159152 mRNA Translation: BAE34859.1
AK159885 mRNA Translation: BAE35454.1
AK159891 mRNA Translation: BAE35458.1
AK169069 mRNA Translation: BAE40856.1
AL773505 Genomic DNA Translation: CAM17512.1
CH466519 Genomic DNA Translation: EDL27697.1
BC013447 mRNA Translation: AAH13447.1
M29394 mRNA Translation: AAA37371.1
CCDSiCCDS16478.1
PIRiA36695
RefSeqiNP_033934.2, NM_009804.2
UniGeneiMm.4215

Genome annotation databases

EnsembliENSMUST00000028610; ENSMUSP00000028610; ENSMUSG00000027187
GeneIDi12359
KEGGimmu:12359
UCSCiuc008liw.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCATA_MOUSE
AccessioniPrimary (citable) accession number: P24270
Secondary accession number(s): Q3TXQ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 170 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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