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P24269

- PGK_BACMD

UniProt

P24269 - PGK_BACMD

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Protein

Phosphoglycerate kinase

Gene
pgk, BMD_5037
Organism
Bacillus megaterium (strain DSM 319)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei36 – 361Substrate By similarity
Binding sitei118 – 1181Substrate By similarity
Binding sitei151 – 1511Substrate By similarity
Binding sitei201 – 2011ATP By similarity
Binding sitei292 – 2921ATP; via carbonyl oxygen By similarity
Binding sitei323 – 3231ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi350 – 3534ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoglycerate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBMEG592022:GIVX-5037-MONOMER.
UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:pgk
Ordered Locus Names:BMD_5037
OrganismiBacillus megaterium (strain DSM 319)
Taxonomic identifieri592022 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000002365: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 394394Phosphoglycerate kinaseUniRule annotationPRO_0000145903Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei183 – 1831Phosphoserine By similarity
Modified residuei299 – 2991Phosphothreonine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP24269.

Interactioni

Subunit structurei

Monomer.

Structurei

3D structure databases

ProteinModelPortaliP24269.
SMRiP24269. Positions 1-394.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni21 – 233Substrate binding By similarity
Regioni59 – 624Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000227108.
KOiK00927.
OMAiWEALDIG.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24269-1 [UniParc]FASTAAdd to Basket

« Hide

MNKKTLKDID VKGKRVFCRV DFNVPMKDGK VTDETRIRAA IPTIQYLVEQ    50
GAKVILASHL GRPKGEVVEE LRLNAVAERL QALLGKDVAK ADEAFGEEVK 100
KTIDGMSEGD VLVLENVRFY PGEEKNDPEL AKAFAELADV YVNDAFGAAH 150
RAHASTEGIA QHIPAVAGFL MEKELDVLSK ALSNPERPFT AIVGGAKVKD 200
KIGVIDHLLD KVDNLIIGGG LSYTFIKALG HEVGKSLLEE DKIELAKSFM 250
EKAKKNGVNF YMPVDVVVAD DFSNDANIQV VSIEDIPSDW EGLDAGPKTR 300
EIYADVIKNS KLVIWNGPMG VFELDAFANG TKAVAEALAE ATDTYSVIGG 350
GDSAAAVEKF NLADKMSHIS TGGGASLEFM EGKELPGVVA LNDK 394
Length:394
Mass (Da):42,457
Last modified:March 1, 1992 - v1
Checksum:i7A2E6B978FA7008B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X54519 Genomic DNA. Translation: CAA38375.1.
M87647 Genomic DNA. Translation: AAA73203.1.
M87648 Genomic DNA. Translation: AAA73206.1.
CP001982 Genomic DNA. Translation: ADF41837.1.
PIRiS13125. KIBSGM.
RefSeqiYP_003600187.1. NC_014103.1.

Genome annotation databases

EnsemblBacteriaiADF41837; ADF41837; BMD_5037.
GeneIDi9120428.
KEGGibmd:BMD_5037.
PATRICi37260261. VBIBacMeg104484_5015.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X54519 Genomic DNA. Translation: CAA38375.1 .
M87647 Genomic DNA. Translation: AAA73203.1 .
M87648 Genomic DNA. Translation: AAA73206.1 .
CP001982 Genomic DNA. Translation: ADF41837.1 .
PIRi S13125. KIBSGM.
RefSeqi YP_003600187.1. NC_014103.1.

3D structure databases

ProteinModelPortali P24269.
SMRi P24269. Positions 1-394.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P24269.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADF41837 ; ADF41837 ; BMD_5037 .
GeneIDi 9120428.
KEGGi bmd:BMD_5037.
PATRICi 37260261. VBIBacMeg104484_5015.

Phylogenomic databases

HOGENOMi HOG000227108.
KOi K00927.
OMAi WEALDIG.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00185 .
BioCyci BMEG592022:GIVX-5037-MONOMER.

Family and domain databases

Gene3Di 3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPi MF_00145. Phosphoglyc_kinase.
InterProi IPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view ]
PANTHERi PTHR11406. PTHR11406. 1 hit.
Pfami PF00162. PGK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000724. Pgk. 1 hit.
PRINTSi PR00477. PHGLYCKINASE.
SUPFAMi SSF53748. SSF53748. 1 hit.
PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of the phosphoglycerate kinase gene from Bacillus megaterium."
    Schlaepfer B.S., Branlant C., Branlant G., Zuber H.
    Nucleic Acids Res. 18:6423-6423(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Cloning and sequencing of the genes encoding glyceraldehyde-3-phosphate dehydrogenase, phosphoglycerate kinase and triosephosphate isomerase (gap operon) from mesophilic Bacillus megaterium: comparison with corresponding sequences from thermophilic Bacillus stearothermophilus."
    Schlaepfer B.S., Zuber H.
    Gene 122:53-62(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Genome sequences of the industrial vitamin B12-producers B. megaterium QM B1551 and DSM319 reveal new insights into the Bacillus genome evolution and pan-genome structure."
    Eppinger M., Bunk B., Johns M.A., Edirisinghe J.N., Kutumbaka K.K., Riley D.R., Creasy H.H., Koenig S.S.K., Galens K., Orvis J., Creasy T., Biedendieck R., Braun C., Grayburn S., Jahn D., Ravel J., Vary P.S.
    Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 319.

Entry informationi

Entry nameiPGK_BACMD
AccessioniPrimary (citable) accession number: P24269
Secondary accession number(s): D5DNB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: June 11, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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