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P24269

- PGK_BACMD

UniProt

P24269 - PGK_BACMD

Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Bacillus megaterium (strain DSM 319)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Mar 1992)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei36 – 361SubstrateBy similarity
    Binding sitei118 – 1181SubstrateBy similarity
    Binding sitei151 – 1511SubstrateBy similarity
    Binding sitei201 – 2011ATPBy similarity
    Binding sitei292 – 2921ATP; via carbonyl oxygenBy similarity
    Binding sitei323 – 3231ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi350 – 3534ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoglycerate kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBMEG592022:GIVX-5037-MONOMER.
    UniPathwayiUPA00109; UER00185.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoglycerate kinase (EC:2.7.2.3)
    Gene namesi
    Name:pgk
    Ordered Locus Names:BMD_5037
    OrganismiBacillus megaterium (strain DSM 319)
    Taxonomic identifieri592022 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000002365: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 394394Phosphoglycerate kinasePRO_0000145903Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei183 – 1831PhosphoserineBy similarity
    Modified residuei299 – 2991PhosphothreonineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiP24269.

    Interactioni

    Subunit structurei

    Monomer.

    Structurei

    3D structure databases

    ProteinModelPortaliP24269.
    SMRiP24269. Positions 1-394.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni21 – 233Substrate bindingBy similarity
    Regioni59 – 624Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the phosphoglycerate kinase family.Curated

    Phylogenomic databases

    HOGENOMiHOG000227108.
    KOiK00927.
    OMAiWEALDIG.

    Family and domain databases

    Gene3Di3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPiMF_00145. Phosphoglyc_kinase.
    InterProiIPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view]
    PANTHERiPTHR11406. PTHR11406. 1 hit.
    PfamiPF00162. PGK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000724. Pgk. 1 hit.
    PRINTSiPR00477. PHGLYCKINASE.
    SUPFAMiSSF53748. SSF53748. 1 hit.
    PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P24269-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNKKTLKDID VKGKRVFCRV DFNVPMKDGK VTDETRIRAA IPTIQYLVEQ    50
    GAKVILASHL GRPKGEVVEE LRLNAVAERL QALLGKDVAK ADEAFGEEVK 100
    KTIDGMSEGD VLVLENVRFY PGEEKNDPEL AKAFAELADV YVNDAFGAAH 150
    RAHASTEGIA QHIPAVAGFL MEKELDVLSK ALSNPERPFT AIVGGAKVKD 200
    KIGVIDHLLD KVDNLIIGGG LSYTFIKALG HEVGKSLLEE DKIELAKSFM 250
    EKAKKNGVNF YMPVDVVVAD DFSNDANIQV VSIEDIPSDW EGLDAGPKTR 300
    EIYADVIKNS KLVIWNGPMG VFELDAFANG TKAVAEALAE ATDTYSVIGG 350
    GDSAAAVEKF NLADKMSHIS TGGGASLEFM EGKELPGVVA LNDK 394
    Length:394
    Mass (Da):42,457
    Last modified:March 1, 1992 - v1
    Checksum:i7A2E6B978FA7008B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X54519 Genomic DNA. Translation: CAA38375.1.
    M87647 Genomic DNA. Translation: AAA73203.1.
    M87648 Genomic DNA. Translation: AAA73206.1.
    CP001982 Genomic DNA. Translation: ADF41837.1.
    PIRiS13125. KIBSGM.
    RefSeqiYP_003600187.1. NC_014103.1.

    Genome annotation databases

    EnsemblBacteriaiADF41837; ADF41837; BMD_5037.
    GeneIDi9120428.
    KEGGibmd:BMD_5037.
    PATRICi37260261. VBIBacMeg104484_5015.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X54519 Genomic DNA. Translation: CAA38375.1 .
    M87647 Genomic DNA. Translation: AAA73203.1 .
    M87648 Genomic DNA. Translation: AAA73206.1 .
    CP001982 Genomic DNA. Translation: ADF41837.1 .
    PIRi S13125. KIBSGM.
    RefSeqi YP_003600187.1. NC_014103.1.

    3D structure databases

    ProteinModelPortali P24269.
    SMRi P24269. Positions 1-394.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P24269.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADF41837 ; ADF41837 ; BMD_5037 .
    GeneIDi 9120428.
    KEGGi bmd:BMD_5037.
    PATRICi 37260261. VBIBacMeg104484_5015.

    Phylogenomic databases

    HOGENOMi HOG000227108.
    KOi K00927.
    OMAi WEALDIG.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00185 .
    BioCyci BMEG592022:GIVX-5037-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPi MF_00145. Phosphoglyc_kinase.
    InterProi IPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view ]
    PANTHERi PTHR11406. PTHR11406. 1 hit.
    Pfami PF00162. PGK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000724. Pgk. 1 hit.
    PRINTSi PR00477. PHGLYCKINASE.
    SUPFAMi SSF53748. SSF53748. 1 hit.
    PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of the phosphoglycerate kinase gene from Bacillus megaterium."
      Schlaepfer B.S., Branlant C., Branlant G., Zuber H.
      Nucleic Acids Res. 18:6423-6423(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Cloning and sequencing of the genes encoding glyceraldehyde-3-phosphate dehydrogenase, phosphoglycerate kinase and triosephosphate isomerase (gap operon) from mesophilic Bacillus megaterium: comparison with corresponding sequences from thermophilic Bacillus stearothermophilus."
      Schlaepfer B.S., Zuber H.
      Gene 122:53-62(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Genome sequences of the industrial vitamin B12-producers B. megaterium QM B1551 and DSM319 reveal new insights into the Bacillus genome evolution and pan-genome structure."
      Eppinger M., Bunk B., Johns M.A., Edirisinghe J.N., Kutumbaka K.K., Riley D.R., Creasy H.H., Koenig S.S.K., Galens K., Orvis J., Creasy T., Biedendieck R., Braun C., Grayburn S., Jahn D., Ravel J., Vary P.S.
      Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 319.

    Entry informationi

    Entry nameiPGK_BACMD
    AccessioniPrimary (citable) accession number: P24269
    Secondary accession number(s): D5DNB0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: March 1, 1992
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3