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Protein

Sigma factor-binding protein Crl

Gene

crl

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes, such as the csgBAC operon encoding the subunits of curli proteins. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 (rpoD) and sigma-32 (rpoH).2 Publications

Caution

A pseudogene in strain MG1655 / ATCC 700926, but not its parent MG1655 / ATCC 47076. In ATCC 700926 IS1I has recently inserted into the gene (PubMed:22081388).1 Publication

GO - Biological processi

  • positive regulation of transcription, DNA-templated Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:EG11092-MONOMER
EcoCyc:MONOMER0-4385

Names & Taxonomyi

Protein namesi
Recommended name:
Sigma factor-binding protein Crl
Alternative name(s):
Curlin genes transcriptional activatory protein
Gene namesi
Name:crl
Ordered Locus Names:b0240, JW0230
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11092 crl

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000793552 – 133Sigma factor-binding protein CrlAdd BLAST132

Proteomic databases

EPDiP24251
PaxDbiP24251
PRIDEiP24251

Expressioni

Inductioni

Induced at stationary phase, and by low temperatures.

Interactioni

Protein-protein interaction databases

BioGridi4260821, 13 interactors
IntActiP24251, 11 interactors
STRINGi316385.ECDH10B_0222

Structurei

3D structure databases

ProteinModelPortaliP24251
SMRiP24251
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni99 – 122Essential for activityAdd BLAST24

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili90 – 116Sequence analysisAdd BLAST27

Sequence similaritiesi

Belongs to the Crl family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG4108UVK Bacteria
ENOG4111IQF LUCA
HOGENOMiHOG000282284
KOiK11926
OMAiFWGWWLE

Family and domain databases

Gene3Di3.30.310.230, 1 hit
HAMAPiMF_01178 Crl, 1 hit
InterProiView protein in InterPro
IPR009986 Tscrpt_reg_Crl
IPR038208 Tscrpt_reg_Crl_sf
PfamiView protein in Pfam
PF07417 Crl, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24251-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLPSGHPKS RLIKKFTALG PYIREGKCKD NRFFFDCLAV CVNVKPAPEV
60 70 80 90 100
REFWGWWMEL EAQESRFTYS YQFGLFDKAG DWKSVPVKDT EVVERLEHTL
110 120 130
REFHEKLREL LTTLNLKLEP ADDFRDEPVK LTA
Length:133
Mass (Da):15,655
Last modified:January 23, 2007 - v5
Checksum:iEA66172EF19586AA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8P → L in CAA23606 (PubMed:6341601).Curated1
Sequence conflicti13I → N in CAA23606 (PubMed:6341601).Curated1
Sequence conflicti29K → E (PubMed:2649795).Curated1
Sequence conflicti29K → E in CAA47646 (PubMed:1357528).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00316 Genomic DNA Translation: CAA23606.1
X67207 Genomic DNA Translation: CAA47646.1
U70214 Genomic DNA Translation: AAB08660.1
U00096 Genomic DNA No translation available.
AP009048 Genomic DNA Translation: BAA77909.2
M13422 Genomic DNA Translation: AAA23930.1
PIRiA64749
RefSeqiWP_000174689.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiBAA77909; BAA77909; BAA77909
KEGGiecj:JW0230
PATRICifig|1411691.4.peg.2043

Similar proteinsi

Entry informationi

Entry nameiCRL_ECOLI
AccessioniPrimary (citable) accession number: P24251
Secondary accession number(s): P77629, Q47242, Q47585
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 133 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

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