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Protein

Putative cytochrome bd-II ubiquinol oxidase subunit AppX

Gene

appX

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Might be part of cytochrome bd-II oxidase (appB and appC). Able to restore reductant resistance to a cydX deletion mutant upon overexpression. CyxD and this protein may have some functional overlap.1 Publication

Keywords - Biological processi

Stress response

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-2817.

Protein family/group databases

TCDBi9.B.85.1.2. the 1 tms cydx/appx cytochrome bd oxidase activating (cydx/appx) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative cytochrome bd-II ubiquinol oxidase subunit AppX
Gene namesi
Name:appX
Synonyms:yccB
Ordered Locus Names:b4592, JW0961.1
ORF Names:b0979.1
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11114. appX.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei4 – 2421HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell outer membrane Source: EcoCyc
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Not essential, no change in sensitivity to reductant (beta-mercaptoethanol).1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3030Putative cytochrome bd-II ubiquinol oxidase subunit AppXPRO_0000168781Add
BLAST

Proteomic databases

PaxDbiP24244.

Expressioni

Inductioni

Expressed during stationary phase (PubMed:19121005) and in minimal glycerol medium, at 45 degrees Celsius, strongly (30-fold) induced in low oxygen (PubMed:19734316) (at protein level).2 Publications

Interactioni

Subunit structurei

Able to interact with CydA and CydB upon overexpression.

Protein-protein interaction databases

STRINGi511145.b4592.

Structurei

3D structure databases

ProteinModelPortaliP24244.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000009400.

Family and domain databases

InterProiIPR012994. YbgT_YccB.
[Graphical view]
PfamiPF08173. YbgT_YccB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24244-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30
MWYLLWFVGI LLMCSLSTLV LVWLDPRLKS
Length:30
Mass (Da):3,597
Last modified:March 1, 1992 - v1
Checksum:i9E27FCD533329606
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58708 Genomic DNA. Translation: AAA72085.1.
S63811 Genomic DNA. Translation: AAB20287.1.
U00096 Genomic DNA. Translation: ABP93439.1.
AP009048 Genomic DNA. No translation available.
PIRiA36733.
RefSeqiWP_000270305.1. NZ_LN832404.1.
YP_001165313.1. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiABP93439; ABP93439; b4592.
GeneIDi948955.
KEGGieco:b4592.
PATRICi32117181. VBIEscCol129921_1014.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58708 Genomic DNA. Translation: AAA72085.1.
S63811 Genomic DNA. Translation: AAB20287.1.
U00096 Genomic DNA. Translation: ABP93439.1.
AP009048 Genomic DNA. No translation available.
PIRiA36733.
RefSeqiWP_000270305.1. NZ_LN832404.1.
YP_001165313.1. NC_000913.3.

3D structure databases

ProteinModelPortaliP24244.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi511145.b4592.

Protein family/group databases

TCDBi9.B.85.1.2. the 1 tms cydx/appx cytochrome bd oxidase activating (cydx/appx) family.

Proteomic databases

PaxDbiP24244.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABP93439; ABP93439; b4592.
GeneIDi948955.
KEGGieco:b4592.
PATRICi32117181. VBIEscCol129921_1014.

Organism-specific databases

EchoBASEiEB1105.
EcoGeneiEG11114. appX.

Phylogenomic databases

HOGENOMiHOG000009400.

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-2817.

Miscellaneous databases

PROiP24244.

Family and domain databases

InterProiIPR012994. YbgT_YccB.
[Graphical view]
PfamiPF08173. YbgT_YccB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAPPX_ECOLI
AccessioniPrimary (citable) accession number: P24244
Secondary accession number(s): A5A610
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: September 7, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.