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P24226

- HISX_BRAOC

UniProt

P24226 - HISX_BRAOC

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Protein

Histidinol dehydrogenase, chloroplastic

Gene

HDH

Organism
Brassica oleracea var. capitata (Cabbage)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

Cofactori

Binds 1 zinc ion per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei156 – 1561NADBy similarity
Binding sitei218 – 2181NADBy similarity
Binding sitei241 – 2411NADBy similarity
Binding sitei267 – 2671SubstrateBy similarity
Metal bindingi289 – 2891ZincBy similarity
Binding sitei289 – 2891SubstrateBy similarity
Metal bindingi292 – 2921ZincBy similarity
Binding sitei292 – 2921SubstrateBy similarity
Active sitei357 – 3571Proton acceptorBy similarity
Active sitei358 – 3581Proton acceptorBy similarity
Binding sitei358 – 3581SubstrateBy similarity
Metal bindingi391 – 3911ZincBy similarity
Binding sitei391 – 3911SubstrateBy similarity
Binding sitei445 – 4451SubstrateBy similarity
Metal bindingi450 – 4501ZincBy similarity
Binding sitei450 – 4501SubstrateBy similarity

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-EC
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase, chloroplastic (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:HDH
OrganismiBrassica oleracea var. capitata (Cabbage)
Taxonomic identifieri3716 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeBrassiceaeBrassica

Subcellular locationi

GO - Cellular componenti

  1. chloroplast Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3131ChloroplastAdd
BLAST
Chaini32 – 469438Histidinol dehydrogenase, chloroplasticPRO_0000007216Add
BLAST

Interactioni

Structurei

3D structure databases

ProteinModelPortaliP24226.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.Curated

Keywords - Domaini

Transit peptide

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24226-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSFDLSRLSL TSSPRLSFLT RTATKKGFVR CSMKSYRLSE LSFSQVENLK
60 70 80 90 100
ARPRIDFSSI FTTVNPIIDA VRSKGDTAVK EYTERFDKVQ LNKVVEDVSE
110 120 130 140 150
LDIPELDSAV KEAFDVAYDN IYAFHFAQMS TEKSVENMKG VRCKRVSRSI
160 170 180 190 200
GSVGLYVPGG TAVLPSTALM LAIPAQIAGC KTVVLATPPT KEGSICKEVL
210 220 230 240 250
YCAKRAGVTH ILKAGGAQAI AAMAWGTDSC PKVEKIFGPG NQYVTAAKMI
260 270 280 290 300
LQNSEAMVSI DMPAGPSEVL VIADEHASPV YIAADLLSQA EHGPDSQVVL
310 320 330 340 350
VVVGDGVNLK AIEEEIAKQC KSLPRGEFAS KALSHSFTVF ARDMIEAITF
360 370 380 390 400
SNLYAPEHLI INVKDAEKWE GLIENAGSVF IGPWTPESVG DYASGTNHVL
410 420 430 440 450
PTYGYARMYS GVSLDSFLKF MTVQSLTEEG LRNLGPYVAT MAEIEGLDAH
460
KRAVTLRLKD IEAKQTQTK
Length:469
Mass (Da):50,959
Last modified:March 1, 1992 - v1
Checksum:iEC63FA4B7B2E19CA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M60466 mRNA. Translation: AAA32991.1.
PIRiA39358.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M60466 mRNA. Translation: AAA32991.1 .
PIRi A39358.

3D structure databases

ProteinModelPortali P24226.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi P24226.
ChEMBLi CHEMBL4350.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structural and functional conservation of histidinol dehydrogenase between plants and microbes."
    Nagai A., Ward E., Beck J., Tada S., Chang J.-Y., Scheidegger A., Ryals J.
    Proc. Natl. Acad. Sci. U.S.A. 88:4133-4137(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.

Entry informationi

Entry nameiHISX_BRAOC
AccessioniPrimary (citable) accession number: P24226
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: October 29, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Cabbage may contain multiple HDH isozymes encoded by different genes.

Keywords - Technical termi

Direct protein sequencing

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3