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P24226

- HISX_BRAOC

UniProt

P24226 - HISX_BRAOC

Protein

Histidinol dehydrogenase, chloroplastic

Gene

HDH

Organism
Brassica oleracea var. capitata (Cabbage)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Mar 1992)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei156 – 1561NADBy similarity
    Binding sitei218 – 2181NADBy similarity
    Binding sitei241 – 2411NADBy similarity
    Binding sitei267 – 2671SubstrateBy similarity
    Metal bindingi289 – 2891ZincBy similarity
    Binding sitei289 – 2891SubstrateBy similarity
    Metal bindingi292 – 2921ZincBy similarity
    Binding sitei292 – 2921SubstrateBy similarity
    Active sitei357 – 3571Proton acceptorBy similarity
    Active sitei358 – 3581Proton acceptorBy similarity
    Binding sitei358 – 3581SubstrateBy similarity
    Metal bindingi391 – 3911ZincBy similarity
    Binding sitei391 – 3911SubstrateBy similarity
    Binding sitei445 – 4451SubstrateBy similarity
    Metal bindingi450 – 4501ZincBy similarity
    Binding sitei450 – 4501SubstrateBy similarity

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-EC
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenase, chloroplastic (EC:1.1.1.23)
    Short name:
    HDH
    Gene namesi
    Name:HDH
    OrganismiBrassica oleracea var. capitata (Cabbage)
    Taxonomic identifieri3716 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeBrassiceaeBrassica

    Subcellular locationi

    GO - Cellular componenti

    1. chloroplast Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Chloroplast, Plastid

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3131ChloroplastAdd
    BLAST
    Chaini32 – 469438Histidinol dehydrogenase, chloroplasticPRO_0000007216Add
    BLAST

    Interactioni

    Structurei

    3D structure databases

    ProteinModelPortaliP24226.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.Curated

    Keywords - Domaini

    Transit peptide

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P24226-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSFDLSRLSL TSSPRLSFLT RTATKKGFVR CSMKSYRLSE LSFSQVENLK    50
    ARPRIDFSSI FTTVNPIIDA VRSKGDTAVK EYTERFDKVQ LNKVVEDVSE 100
    LDIPELDSAV KEAFDVAYDN IYAFHFAQMS TEKSVENMKG VRCKRVSRSI 150
    GSVGLYVPGG TAVLPSTALM LAIPAQIAGC KTVVLATPPT KEGSICKEVL 200
    YCAKRAGVTH ILKAGGAQAI AAMAWGTDSC PKVEKIFGPG NQYVTAAKMI 250
    LQNSEAMVSI DMPAGPSEVL VIADEHASPV YIAADLLSQA EHGPDSQVVL 300
    VVVGDGVNLK AIEEEIAKQC KSLPRGEFAS KALSHSFTVF ARDMIEAITF 350
    SNLYAPEHLI INVKDAEKWE GLIENAGSVF IGPWTPESVG DYASGTNHVL 400
    PTYGYARMYS GVSLDSFLKF MTVQSLTEEG LRNLGPYVAT MAEIEGLDAH 450
    KRAVTLRLKD IEAKQTQTK 469
    Length:469
    Mass (Da):50,959
    Last modified:March 1, 1992 - v1
    Checksum:iEC63FA4B7B2E19CA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M60466 mRNA. Translation: AAA32991.1.
    PIRiA39358.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M60466 mRNA. Translation: AAA32991.1 .
    PIRi A39358.

    3D structure databases

    ProteinModelPortali P24226.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi P24226.
    ChEMBLi CHEMBL4350.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structural and functional conservation of histidinol dehydrogenase between plants and microbes."
      Nagai A., Ward E., Beck J., Tada S., Chang J.-Y., Scheidegger A., Ryals J.
      Proc. Natl. Acad. Sci. U.S.A. 88:4133-4137(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.

    Entry informationi

    Entry nameiHISX_BRAOC
    AccessioniPrimary (citable) accession number: P24226
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: March 1, 1992
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Cabbage may contain multiple HDH isozymes encoded by different genes.

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3