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P24226

- HISX_BRAOC

UniProt

P24226 - HISX_BRAOC

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Protein
Histidinol dehydrogenase, chloroplastic
Gene
HDH
Organism
Brassica oleracea var. capitata (Cabbage)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei156 – 1561NAD By similarity
Binding sitei218 – 2181NAD By similarity
Binding sitei241 – 2411NAD By similarity
Binding sitei267 – 2671Substrate By similarity
Metal bindingi289 – 2891Zinc By similarity
Binding sitei289 – 2891Substrate By similarity
Metal bindingi292 – 2921Zinc By similarity
Binding sitei292 – 2921Substrate By similarity
Active sitei357 – 3571Proton acceptor By similarity
Active sitei358 – 3581Proton acceptor By similarity
Binding sitei358 – 3581Substrate By similarity
Metal bindingi391 – 3911Zinc By similarity
Binding sitei391 – 3911Substrate By similarity
Binding sitei445 – 4451Substrate By similarity
Metal bindingi450 – 4501Zinc By similarity
Binding sitei450 – 4501Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-EC
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase, chloroplastic (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:HDH
OrganismiBrassica oleracea var. capitata (Cabbage)
Taxonomic identifieri3716 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeBrassiceaeBrassica

Subcellular locationi

GO - Cellular componenti

  1. chloroplast Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3131ChloroplastUniRule annotation
Add
BLAST
Chaini32 – 469438Histidinol dehydrogenase, chloroplasticUniRule annotation
PRO_0000007216Add
BLAST

Interactioni

Structurei

3D structure databases

ProteinModelPortaliP24226.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24226-1 [UniParc]FASTAAdd to Basket

« Hide

MSFDLSRLSL TSSPRLSFLT RTATKKGFVR CSMKSYRLSE LSFSQVENLK    50
ARPRIDFSSI FTTVNPIIDA VRSKGDTAVK EYTERFDKVQ LNKVVEDVSE 100
LDIPELDSAV KEAFDVAYDN IYAFHFAQMS TEKSVENMKG VRCKRVSRSI 150
GSVGLYVPGG TAVLPSTALM LAIPAQIAGC KTVVLATPPT KEGSICKEVL 200
YCAKRAGVTH ILKAGGAQAI AAMAWGTDSC PKVEKIFGPG NQYVTAAKMI 250
LQNSEAMVSI DMPAGPSEVL VIADEHASPV YIAADLLSQA EHGPDSQVVL 300
VVVGDGVNLK AIEEEIAKQC KSLPRGEFAS KALSHSFTVF ARDMIEAITF 350
SNLYAPEHLI INVKDAEKWE GLIENAGSVF IGPWTPESVG DYASGTNHVL 400
PTYGYARMYS GVSLDSFLKF MTVQSLTEEG LRNLGPYVAT MAEIEGLDAH 450
KRAVTLRLKD IEAKQTQTK 469
Length:469
Mass (Da):50,959
Last modified:March 1, 1992 - v1
Checksum:iEC63FA4B7B2E19CA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M60466 mRNA. Translation: AAA32991.1.
PIRiA39358.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M60466 mRNA. Translation: AAA32991.1 .
PIRi A39358.

3D structure databases

ProteinModelPortali P24226.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi P24226.
ChEMBLi CHEMBL4350.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structural and functional conservation of histidinol dehydrogenase between plants and microbes."
    Nagai A., Ward E., Beck J., Tada S., Chang J.-Y., Scheidegger A., Ryals J.
    Proc. Natl. Acad. Sci. U.S.A. 88:4133-4137(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.

Entry informationi

Entry nameiHISX_BRAOC
AccessioniPrimary (citable) accession number: P24226
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: February 19, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Cabbage may contain multiple HDH isozymes encoded by different genes.

Keywords - Technical termi

Direct protein sequencing

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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