ID   PYRF_MYXXD              Reviewed;         288 AA.
AC   P24220; Q1CZX6;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-1992, sequence version 1.
DT   27-MAR-2024, entry version 136.
DE   RecName: Full=Orotidine 5'-phosphate decarboxylase;
DE            EC=4.1.1.23;
DE   AltName: Full=OMP decarboxylase;
DE            Short=OMPDCase;
DE            Short=OMPdecase;
GN   Name=pyrF; Synonyms=uraA; OrderedLocusNames=MXAN_5910;
OS   Myxococcus xanthus (strain DK1622).
OC   Bacteria; Myxococcota; Myxococcia; Myxococcales; Cystobacterineae;
OC   Myxococcaceae; Myxococcus.
OX   NCBI_TaxID=246197;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1730672; DOI=10.1016/s0021-9258(18)48357-3;
RA   Kimsey H.H., Kaiser D.;
RT   "The orotidine-5'-monophosphate decarboxylase gene of Myxococcus xanthus.
RT   Comparison to the OMP decarboxylase gene family.";
RL   J. Biol. Chem. 267:819-824(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DK1622;
RX   PubMed=17015832; DOI=10.1073/pnas.0607335103;
RA   Goldman B.S., Nierman W.C., Kaiser D., Slater S.C., Durkin A.S., Eisen J.,
RA   Ronning C.M., Barbazuk W.B., Blanchard M., Field C., Halling C., Hinkle G.,
RA   Iartchuk O., Kim H.S., Mackenzie C., Madupu R., Miller N., Shvartsbeyn A.,
RA   Sullivan S.A., Vaudin M., Wiegand R., Kaplan H.B.;
RT   "Evolution of sensory complexity recorded in a myxobacterial genome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15200-15205(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + orotidine 5'-phosphate = CO2 + UMP;
CC         Xref=Rhea:RHEA:11596, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:57538, ChEBI:CHEBI:57865; EC=4.1.1.23;
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway;
CC       UMP from orotate: step 2/2.
CC   -!- SIMILARITY: Belongs to the OMP decarboxylase family. Type 2 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; M79324; AAA25401.1; -; Genomic_DNA.
DR   EMBL; CP000113; ABF86406.1; -; Genomic_DNA.
DR   PIR; B41768; B41768.
DR   RefSeq; WP_011555861.1; NC_008095.1.
DR   AlphaFoldDB; P24220; -.
DR   SMR; P24220; -.
DR   STRING; 246197.MXAN_5910; -.
DR   EnsemblBacteria; ABF86406; ABF86406; MXAN_5910.
DR   GeneID; 41363148; -.
DR   KEGG; mxa:MXAN_5910; -.
DR   eggNOG; COG0284; Bacteria.
DR   HOGENOM; CLU_060704_0_0_7; -.
DR   OrthoDB; 9808470at2; -.
DR   UniPathway; UPA00070; UER00120.
DR   Proteomes; UP000002402; Chromosome.
DR   GO; GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR   GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd04725; OMP_decarboxylase_like; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   HAMAP; MF_01215; OMPdecase_type2; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR018089; OMPdecase_AS.
DR   InterPro; IPR011995; OMPdecase_type-2.
DR   InterPro; IPR001754; OMPdeCOase_dom.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   NCBIfam; TIGR02127; pyrF_sub2; 1.
DR   PANTHER; PTHR43375; OROTIDINE 5'-PHOSPHATE DECARBOXYLASE; 1.
DR   PANTHER; PTHR43375:SF1; OROTIDINE 5'-PHOSPHATE DECARBOXYLASE; 1.
DR   Pfam; PF00215; OMPdecase; 1.
DR   SMART; SM00934; OMPdecase; 1.
DR   SUPFAM; SSF51366; Ribulose-phoshate binding barrel; 1.
DR   PROSITE; PS00156; OMPDECASE; 1.
PE   3: Inferred from homology;
KW   Decarboxylase; Lyase; Pyrimidine biosynthesis; Reference proteome.
FT   CHAIN           1..288
FT                   /note="Orotidine 5'-phosphate decarboxylase"
FT                   /id="PRO_0000134632"
FT   ACT_SITE        99
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   288 AA;  30468 MW;  341E002170214DF9 CRC64;
     MTTPQPFAHR FSQLAEQRSP FCLGIDPSRD LLTRWGLPDN ARGLRDFCER VADAAGSSVA
     VVKPQSAFFE RHGPEGLQVL QELMRRFKSV GTLTLLDVKR GDIGSTMEAY AETVFGEGSA
     YEADAATFTA YLGLGALLKT LERARASGAA AFLVVRSSNP EGTSLQMSRG EDGRTVAEAL
     ADGLRAFNEK PGQDAAPVAG AVMGATLPDS DRGVIERLGG ALLLTPGIGA QGAGFDDLKR
     LFAGREAQVI PTATRSVLEA GPDTAALRQA LERHLAPARA FRATARPS
//