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P24220 (PYRF_MYXXD) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Gene names
Name:pyrF
Synonyms:uraA
Ordered Locus Names:MXAN_5910
OrganismMyxococcus xanthus (strain DK 1622) [Complete proteome] [HAMAP]
Taxonomic identifier246197 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeMyxococcus

Protein attributes

Sequence length288 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Ontologies

Keywords
   Biological processPyrimidine biosynthesis
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process'de novo' UMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

'de novo' pyrimidine nucleobase biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionorotidine-5'-phosphate decarboxylase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 288288Orotidine 5'-phosphate decarboxylase HAMAP-Rule MF_01215
PRO_0000134632

Sites

Active site991Proton donor By similarity

Sequences

Sequence LengthMass (Da)Tools
P24220 [UniParc].

Last modified March 1, 1992. Version 1.
Checksum: 341E002170214DF9

FASTA28830,468
        10         20         30         40         50         60 
MTTPQPFAHR FSQLAEQRSP FCLGIDPSRD LLTRWGLPDN ARGLRDFCER VADAAGSSVA 

        70         80         90        100        110        120 
VVKPQSAFFE RHGPEGLQVL QELMRRFKSV GTLTLLDVKR GDIGSTMEAY AETVFGEGSA 

       130        140        150        160        170        180 
YEADAATFTA YLGLGALLKT LERARASGAA AFLVVRSSNP EGTSLQMSRG EDGRTVAEAL 

       190        200        210        220        230        240 
ADGLRAFNEK PGQDAAPVAG AVMGATLPDS DRGVIERLGG ALLLTPGIGA QGAGFDDLKR 

       250        260        270        280 
LFAGREAQVI PTATRSVLEA GPDTAALRQA LERHLAPARA FRATARPS 

« Hide

References

« Hide 'large scale' references
[1]"The orotidine-5'-monophosphate decarboxylase gene of Myxococcus xanthus. Comparison to the OMP decarboxylase gene family."
Kimsey H.H., Kaiser D.
J. Biol. Chem. 267:819-824(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Evolution of sensory complexity recorded in a myxobacterial genome."
Goldman B.S., Nierman W.C., Kaiser D., Slater S.C., Durkin A.S., Eisen J., Ronning C.M., Barbazuk W.B., Blanchard M., Field C., Halling C., Hinkle G., Iartchuk O., Kim H.S., Mackenzie C., Madupu R., Miller N., Shvartsbeyn A. expand/collapse author list , Sullivan S.A., Vaudin M., Wiegand R., Kaplan H.B.
Proc. Natl. Acad. Sci. U.S.A. 103:15200-15205(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DK 1622.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M79324 Genomic DNA. Translation: AAA25401.1.
CP000113 Genomic DNA. Translation: ABF86406.1.
PIRB41768.
RefSeqYP_634047.1. NC_008095.1.

3D structure databases

ProteinModelPortalP24220.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING246197.MXAN_5910.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABF86406; ABF86406; MXAN_5910.
GeneID4101158.
KEGGmxa:MXAN_5910.
PATRIC22654349. VBIMyxXan43560_5819.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0284.
HOGENOMHOG000245748.
KOK01591.
OMAGSTMGAY.
OrthoDBEOG6DZF33.

Enzyme and pathway databases

BioCycMXAN246197:GIWU-5867-MONOMER.
UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01215. OMPdecase_type2.
InterProIPR013785. Aldolase_TIM.
IPR018089. OMPdecase_AS.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR02127. pyrF_sub2. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_MYXXD
AccessionPrimary (citable) accession number: P24220
Secondary accession number(s): Q1CZX6
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: May 14, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways