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P24220

- PYRF_MYXXD

UniProt

P24220 - PYRF_MYXXD

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Protein

Orotidine 5'-phosphate decarboxylase

Gene
pyrF, uraA, MXAN_5910
Organism
Myxococcus xanthus (strain DK 1622)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei99 – 991Proton donor By similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

BioCyciMXAN246197:GIWU-5867-MONOMER.
UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Gene namesi
Name:pyrF
Synonyms:uraA
Ordered Locus Names:MXAN_5910
OrganismiMyxococcus xanthus (strain DK 1622)
Taxonomic identifieri246197 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeMyxococcus
ProteomesiUP000002402: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288Orotidine 5'-phosphate decarboxylaseUniRule annotationPRO_0000134632Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi246197.MXAN_5910.

Structurei

3D structure databases

ProteinModelPortaliP24220.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0284.
HOGENOMiHOG000245748.
KOiK01591.
OMAiGSTMGAY.
OrthoDBiEOG6DZF33.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01215. OMPdecase_type2.
InterProiIPR013785. Aldolase_TIM.
IPR018089. OMPdecase_AS.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR02127. pyrF_sub2. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24220-1 [UniParc]FASTAAdd to Basket

« Hide

MTTPQPFAHR FSQLAEQRSP FCLGIDPSRD LLTRWGLPDN ARGLRDFCER    50
VADAAGSSVA VVKPQSAFFE RHGPEGLQVL QELMRRFKSV GTLTLLDVKR 100
GDIGSTMEAY AETVFGEGSA YEADAATFTA YLGLGALLKT LERARASGAA 150
AFLVVRSSNP EGTSLQMSRG EDGRTVAEAL ADGLRAFNEK PGQDAAPVAG 200
AVMGATLPDS DRGVIERLGG ALLLTPGIGA QGAGFDDLKR LFAGREAQVI 250
PTATRSVLEA GPDTAALRQA LERHLAPARA FRATARPS 288
Length:288
Mass (Da):30,468
Last modified:March 1, 1992 - v1
Checksum:i341E002170214DF9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M79324 Genomic DNA. Translation: AAA25401.1.
CP000113 Genomic DNA. Translation: ABF86406.1.
PIRiB41768.
RefSeqiYP_634047.1. NC_008095.1.

Genome annotation databases

EnsemblBacteriaiABF86406; ABF86406; MXAN_5910.
GeneIDi4101158.
KEGGimxa:MXAN_5910.
PATRICi22654349. VBIMyxXan43560_5819.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M79324 Genomic DNA. Translation: AAA25401.1 .
CP000113 Genomic DNA. Translation: ABF86406.1 .
PIRi B41768.
RefSeqi YP_634047.1. NC_008095.1.

3D structure databases

ProteinModelPortali P24220.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 246197.MXAN_5910.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF86406 ; ABF86406 ; MXAN_5910 .
GeneIDi 4101158.
KEGGi mxa:MXAN_5910.
PATRICi 22654349. VBIMyxXan43560_5819.

Phylogenomic databases

eggNOGi COG0284.
HOGENOMi HOG000245748.
KOi K01591.
OMAi GSTMGAY.
OrthoDBi EOG6DZF33.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .
BioCyci MXAN246197:GIWU-5867-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01215. OMPdecase_type2.
InterProi IPR013785. Aldolase_TIM.
IPR018089. OMPdecase_AS.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR02127. pyrF_sub2. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The orotidine-5'-monophosphate decarboxylase gene of Myxococcus xanthus. Comparison to the OMP decarboxylase gene family."
    Kimsey H.H., Kaiser D.
    J. Biol. Chem. 267:819-824(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DK 1622.

Entry informationi

Entry nameiPYRF_MYXXD
AccessioniPrimary (citable) accession number: P24220
Secondary accession number(s): Q1CZX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: May 14, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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