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Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Myxococcus xanthus (strain DK 1622)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes UMP from orotate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Orotate phosphoribosyltransferase (pyrE)
  2. Orotidine 5'-phosphate decarboxylase (pyrF)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei99Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processPyrimidine biosynthesis

Enzyme and pathway databases

BioCyciMXAN246197:G1G53-5813-MONOMER
UniPathwayiUPA00070; UER00120

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Gene namesi
Name:pyrF
Synonyms:uraA
Ordered Locus Names:MXAN_5910
OrganismiMyxococcus xanthus (strain DK 1622)
Taxonomic identifieri246197 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeMyxococcus
Proteomesi
  • UP000002402 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001346321 – 288Orotidine 5'-phosphate decarboxylaseAdd BLAST288

Proteomic databases

PRIDEiP24220

Interactioni

Protein-protein interaction databases

STRINGi246197.MXAN_5910

Structurei

3D structure databases

ProteinModelPortaliP24220
SMRiP24220
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105SKN Bacteria
COG0284 LUCA
HOGENOMiHOG000245748
KOiK01591
OMAiQSAFFER
OrthoDBiPOG091H09O1

Family and domain databases

Gene3Di3.20.20.70, 1 hit
HAMAPiMF_01215 OMPdecase_type2, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR018089 OMPdecase_AS
IPR011995 OMPdecase_type-2
IPR001754 OMPdeCOase_dom
IPR011060 RibuloseP-bd_barrel
PANTHERiPTHR43375 PTHR43375, 1 hit
PfamiView protein in Pfam
PF00215 OMPdecase, 1 hit
SMARTiView protein in SMART
SM00934 OMPdecase, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
TIGRFAMsiTIGR02127 pyrF_sub2, 1 hit
PROSITEiView protein in PROSITE
PS00156 OMPDECASE, 1 hit

Sequencei

Sequence statusi: Complete.

P24220-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTPQPFAHR FSQLAEQRSP FCLGIDPSRD LLTRWGLPDN ARGLRDFCER
60 70 80 90 100
VADAAGSSVA VVKPQSAFFE RHGPEGLQVL QELMRRFKSV GTLTLLDVKR
110 120 130 140 150
GDIGSTMEAY AETVFGEGSA YEADAATFTA YLGLGALLKT LERARASGAA
160 170 180 190 200
AFLVVRSSNP EGTSLQMSRG EDGRTVAEAL ADGLRAFNEK PGQDAAPVAG
210 220 230 240 250
AVMGATLPDS DRGVIERLGG ALLLTPGIGA QGAGFDDLKR LFAGREAQVI
260 270 280
PTATRSVLEA GPDTAALRQA LERHLAPARA FRATARPS
Length:288
Mass (Da):30,468
Last modified:March 1, 1992 - v1
Checksum:i341E002170214DF9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M79324 Genomic DNA Translation: AAA25401.1
CP000113 Genomic DNA Translation: ABF86406.1
PIRiB41768
RefSeqiWP_011555861.1, NC_008095.1

Genome annotation databases

EnsemblBacteriaiABF86406; ABF86406; MXAN_5910
KEGGimxa:MXAN_5910

Similar proteinsi

Entry informationi

Entry nameiPYRF_MYXXD
AccessioniPrimary (citable) accession number: P24220
Secondary accession number(s): Q1CZX6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: May 23, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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