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Protein

Prophage DLP12 integrase

Gene

intD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Integrase from the cryptic lambdoic prophage DLP12. Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase, integrase is also necessary for excision of the prophage from the host genome.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei349 – 3491O-(3'-phospho-DNA)-tyrosine intermediateBy similarity

GO - Molecular functioni

  • DNA binding Source: InterPro
  • prophage integrase activity Source: EcoCyc

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA integration, DNA recombination, Viral genome integration, Virus entry into host cell

Enzyme and pathway databases

BioCyciEcoCyc:EG10507-MONOMER.
ECOL316407:JW0525-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Prophage DLP12 integrase
Alternative name(s):
Prophage QSR' integrase
Gene namesi
Name:intD
Synonyms:int
Ordered Locus Names:b0537, JW0525
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10507. intD.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 387387Prophage DLP12 integrasePRO_0000197513Add
BLAST

Proteomic databases

PaxDbiP24218.
PRIDEiP24218.

Interactioni

Protein-protein interaction databases

BioGridi4259881. 12 interactions.
IntActiP24218. 20 interactions.
STRINGi511145.b0537.

Structurei

3D structure databases

ProteinModelPortaliP24218.
SMRiP24218. Positions 185-357.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 'phage' integrase family.Curated

Phylogenomic databases

eggNOGiENOG4108KU3. Bacteria.
COG0582. LUCA.
HOGENOMiHOG000227532.
InParanoidiP24218.
OMAiAWIHADQ.
PhylomeDBiP24218.

Family and domain databases

Gene3Di1.10.443.10. 1 hit.
InterProiIPR011010. DNA_brk_join_enz.
IPR013762. Integrase-like_cat.
IPR002104. Integrase_catalytic.
[Graphical view]
PfamiPF00589. Phage_integrase. 1 hit.
[Graphical view]
SUPFAMiSSF56349. SSF56349. 2 hits.

Sequencei

Sequence statusi: Complete.

P24218-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLFRRNEIW YASYSLPGGK RIKESLGTKD KRQAQELHDK RKAELWRVEK
60 70 80 90 100
LGDLPDVTFE EACLRWLEEK ADKKSLDSDK SRIEFWLEHF EGIRLKDISE
110 120 130 140 150
AKIYSAVSRM HNRKTKEIWK QKVQAAIRKG KELPVYEPKP VSTQTKAKHL
160 170 180 190 200
AMIKAILRAA ERDWKWLEKA PVIKIPAVRN KRVRWLEKEE AKRLIDECPE
210 220 230 240 250
PLKSVVKFAL ATGLRKSNII NLEWQQIDMQ RRVAWVNPEE SKSNRAIGVA
260 270 280 290 300
LNDTACKVLR DQIGKHHKWV FVHTKAAKRA DGTSTPAVRK MRIDSKTSWL
310 320 330 340 350
SACRRAGIED FRFHDLRHTW ASWLIQSGVP LSVLQEMGGW ESIEMVRRYA
360 370 380
HLAPNHLTEH ARKIDDIFGD NVPNMSHSEI MEDIKKA
Length:387
Mass (Da):45,090
Last modified:March 1, 1992 - v1
Checksum:iE3DB8A8D0A613F64
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31074 Genomic DNA. Translation: AAA65483.1.
M27155 Genomic DNA. Translation: AAA24030.1.
X51662 Genomic DNA. Translation: CAA35974.1.
U82598 Genomic DNA. Translation: AAB40734.1.
U00096 Genomic DNA. Translation: AAC73638.1.
AP009048 Genomic DNA. Translation: BAE76313.1.
PIRiA33497.
RefSeqiNP_415069.1. NC_000913.3.
WP_001350488.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73638; AAC73638; b0537.
BAE76313; BAE76313; BAE76313.
GeneIDi947162.
KEGGiecj:JW0525.
eco:b0537.
PATRICi32116236. VBIEscCol129921_0558.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31074 Genomic DNA. Translation: AAA65483.1.
M27155 Genomic DNA. Translation: AAA24030.1.
X51662 Genomic DNA. Translation: CAA35974.1.
U82598 Genomic DNA. Translation: AAB40734.1.
U00096 Genomic DNA. Translation: AAC73638.1.
AP009048 Genomic DNA. Translation: BAE76313.1.
PIRiA33497.
RefSeqiNP_415069.1. NC_000913.3.
WP_001350488.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP24218.
SMRiP24218. Positions 185-357.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259881. 12 interactions.
IntActiP24218. 20 interactions.
STRINGi511145.b0537.

Proteomic databases

PaxDbiP24218.
PRIDEiP24218.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73638; AAC73638; b0537.
BAE76313; BAE76313; BAE76313.
GeneIDi947162.
KEGGiecj:JW0525.
eco:b0537.
PATRICi32116236. VBIEscCol129921_0558.

Organism-specific databases

EchoBASEiEB0502.
EcoGeneiEG10507. intD.

Phylogenomic databases

eggNOGiENOG4108KU3. Bacteria.
COG0582. LUCA.
HOGENOMiHOG000227532.
InParanoidiP24218.
OMAiAWIHADQ.
PhylomeDBiP24218.

Enzyme and pathway databases

BioCyciEcoCyc:EG10507-MONOMER.
ECOL316407:JW0525-MONOMER.

Miscellaneous databases

PROiP24218.

Family and domain databases

Gene3Di1.10.443.10. 1 hit.
InterProiIPR011010. DNA_brk_join_enz.
IPR013762. Integrase-like_cat.
IPR002104. Integrase_catalytic.
[Graphical view]
PfamiPF00589. Phage_integrase. 1 hit.
[Graphical view]
SUPFAMiSSF56349. SSF56349. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiINTD_ECOLI
AccessioniPrimary (citable) accession number: P24218
Secondary accession number(s): Q2MBP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: September 7, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Encoded by the cryptic lambdoid prophage DLP12.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.