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Protein

Prophage integrase IntD

Gene

intD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Integrase from the cryptic lambdoic prophage DLP12. Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase, integrase is also necessary for excision of the prophage from the host genome.

Miscellaneous

Encoded by the cryptic lambdoid prophage DLP12.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei349O-(3'-phospho-DNA)-tyrosine intermediateBy similarity1

GO - Molecular functioni

  • DNA binding Source: InterPro
  • prophage integrase activity Source: EcoCyc

GO - Biological processi

Keywordsi

Biological processDNA integration, DNA recombination, Viral genome integration, Virus entry into host cell

Enzyme and pathway databases

BioCyciEcoCyc:EG10507-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Prophage integrase IntDCurated
Alternative name(s):
Prophage DLP12 integrase
Prophage QSR' integrase
Gene namesi
Name:intD
Synonyms:int
Ordered Locus Names:b0537, JW0525
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10507 intD

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001975131 – 387Prophage integrase IntDAdd BLAST387

Proteomic databases

PaxDbiP24218
PRIDEiP24218

Interactioni

Protein-protein interaction databases

BioGridi4259881, 12 interactors
IntActiP24218, 20 interactors
STRINGi316385.ECDH10B_0493

Structurei

3D structure databases

ProteinModelPortaliP24218
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 'phage' integrase family.Curated

Phylogenomic databases

eggNOGiENOG4108KU3 Bacteria
COG0582 LUCA
HOGENOMiHOG000227532
InParanoidiP24218
OMAiAWIHADQ
PhylomeDBiP24218

Family and domain databases

Gene3Di1.10.150.130, 1 hit
1.10.443.10, 1 hit
InterProiView protein in InterPro
IPR011010 DNA_brk_join_enz
IPR013762 Integrase-like_cat_sf
IPR002104 Integrase_catalytic
IPR010998 Integrase_recombinase_N
PfamiView protein in Pfam
PF00589 Phage_integrase, 1 hit
SUPFAMiSSF56349 SSF56349, 2 hits

Sequencei

Sequence statusi: Complete.

P24218-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLFRRNEIW YASYSLPGGK RIKESLGTKD KRQAQELHDK RKAELWRVEK
60 70 80 90 100
LGDLPDVTFE EACLRWLEEK ADKKSLDSDK SRIEFWLEHF EGIRLKDISE
110 120 130 140 150
AKIYSAVSRM HNRKTKEIWK QKVQAAIRKG KELPVYEPKP VSTQTKAKHL
160 170 180 190 200
AMIKAILRAA ERDWKWLEKA PVIKIPAVRN KRVRWLEKEE AKRLIDECPE
210 220 230 240 250
PLKSVVKFAL ATGLRKSNII NLEWQQIDMQ RRVAWVNPEE SKSNRAIGVA
260 270 280 290 300
LNDTACKVLR DQIGKHHKWV FVHTKAAKRA DGTSTPAVRK MRIDSKTSWL
310 320 330 340 350
SACRRAGIED FRFHDLRHTW ASWLIQSGVP LSVLQEMGGW ESIEMVRRYA
360 370 380
HLAPNHLTEH ARKIDDIFGD NVPNMSHSEI MEDIKKA
Length:387
Mass (Da):45,090
Last modified:March 1, 1992 - v1
Checksum:iE3DB8A8D0A613F64
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31074 Genomic DNA Translation: AAA65483.1
M27155 Genomic DNA Translation: AAA24030.1
X51662 Genomic DNA Translation: CAA35974.1
U82598 Genomic DNA Translation: AAB40734.1
U00096 Genomic DNA Translation: AAC73638.1
AP009048 Genomic DNA Translation: BAE76313.1
PIRiA33497
RefSeqiNP_415069.1, NC_000913.3
WP_001350488.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73638; AAC73638; b0537
BAE76313; BAE76313; BAE76313
GeneIDi947162
KEGGiecj:JW0525
eco:b0537
PATRICifig|1411691.4.peg.1741

Similar proteinsi

Entry informationi

Entry nameiINTD_ECOLI
AccessioniPrimary (citable) accession number: P24218
Secondary accession number(s): Q2MBP3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: April 25, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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