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Protein

Phenylalanine-specific permease

Gene

pheP

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Permease that is involved in the transport across the cytoplasmic membrane of phenylalanine.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAmino-acid transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:PHEP-MONOMER
MetaCyc:PHEP-MONOMER

Protein family/group databases

TCDBi2.A.3.1.1 the amino acid-polyamine-organocation (apc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Phenylalanine-specific permease
Gene namesi
Name:pheP
Ordered Locus Names:b0576, JW0565
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10708 pheP

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27CytoplasmicCuratedAdd BLAST27
Transmembranei28 – 48Helical; Name=ICuratedAdd BLAST21
Topological domaini49 – 50PeriplasmicCurated2
Transmembranei51 – 71Helical; Name=IICuratedAdd BLAST21
Topological domaini72 – 105CytoplasmicCuratedAdd BLAST34
Transmembranei106 – 126Helical; Name=IIICuratedAdd BLAST21
Topological domaini127 – 132PeriplasmicCurated6
Transmembranei133 – 153Helical; Name=IVCuratedAdd BLAST21
Topological domaini154 – 160CytoplasmicCurated7
Transmembranei161 – 181Helical; Name=VCuratedAdd BLAST21
Topological domaini182 – 196PeriplasmicCuratedAdd BLAST15
Transmembranei197 – 217Helical; Name=VICuratedAdd BLAST21
Topological domaini218 – 250CytoplasmicCuratedAdd BLAST33
Transmembranei251 – 271Helical; Name=VIICuratedAdd BLAST21
Topological domaini272 – 288PeriplasmicCuratedAdd BLAST17
Transmembranei289 – 309Helical; Name=VIIICuratedAdd BLAST21
Topological domaini310 – 341CytoplasmicCuratedAdd BLAST32
Transmembranei342 – 362Helical; Name=IXCuratedAdd BLAST21
Topological domaini363 – 367PeriplasmicCurated5
Transmembranei368 – 388Helical; Name=XCuratedAdd BLAST21
Topological domaini389 – 411CytoplasmicCuratedAdd BLAST23
Transmembranei412 – 432Helical; Name=XICuratedAdd BLAST21
Topological domaini433 – 434PeriplasmicCurated2
Transmembranei435 – 455Helical; Name=XIICuratedAdd BLAST21
Topological domaini456 – 458CytoplasmicCurated3

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000542061 – 458Phenylalanine-specific permeaseAdd BLAST458

Proteomic databases

PaxDbiP24207
PRIDEiP24207

Interactioni

Protein-protein interaction databases

BioGridi4259879, 6 interactors
DIPiDIP-10479N
IntActiP24207, 1 interactor
STRINGi316385.ECDH10B_0642

Structurei

3D structure databases

ProteinModelPortaliP24207
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C85 Bacteria
COG1113 LUCA
HOGENOMiHOG000261849
InParanoidiP24207
KOiK11732
OMAiLYPAGNY
PhylomeDBiP24207

Family and domain databases

InterProiView protein in InterPro
IPR004841 AA-permease/SLC12A_dom
IPR002293 AA/rel_permease1
IPR004840 Amoino_acid_permease_CS
PfamiView protein in Pfam
PF00324 AA_permease, 1 hit
PIRSFiPIRSF006060 AA_transporter, 1 hit
PROSITEiView protein in PROSITE
PS00218 AMINO_ACID_PERMEASE_1, 1 hit

Sequencei

Sequence statusi: Complete.

P24207-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNASTVSED TASNQEPTLH RGLHNRHIQL IALGGAIGTG LFLGIGPAIQ
60 70 80 90 100
MAGPAVLLGY GVAGIIAFLI MRQLGEMVVE EPVSGSFAHF AYKYWGPFAG
110 120 130 140 150
FLSGWNYWVM FVLVGMAELT AAGIYMQYWF PDVPTWIWAA AFFIIINAVN
160 170 180 190 200
LVNVRLYGET EFWFALIKVL AIIGMIGFGL WLLFSGHGGE KASIDNLWRY
210 220 230 240 250
GGFFATGWNG LILSLAVIMF SFGGLELIGI TAAEARDPEK SIPKAVNQVV
260 270 280 290 300
YRILLFYIGS LVVLLALYPW VEVKSNSSPF VMIFHNLDSN VVASALNFVI
310 320 330 340 350
LVASLSVYNS GVYSNSRMLF GLSVQGNAPK FLTRVSRRGV PINSLMLSGA
360 370 380 390 400
ITSLVVLINY LLPQKAFGLL MALVVATLLL NWIMICLAHL RFRAAMRRQG
410 420 430 440 450
RETQFKALLY PFGNYLCIAF LGMILLLMCT MDDMRLSAIL LPVWIVFLFM

AFKTLRRK
Length:458
Mass (Da):50,677
Last modified:March 1, 1992 - v1
Checksum:i69D865369249A1A8
GO

Sequence cautioni

The sequence AAB40774 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58000 Genomic DNA Translation: AAA24334.1
U82598 Genomic DNA Translation: AAB40774.1 Different initiation.
U00096 Genomic DNA Translation: AAC73677.1
AP009048 Genomic DNA Translation: BAA35216.1
PIRiA39431
RefSeqiNP_415108.1, NC_000913.3
WP_000786319.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73677; AAC73677; b0576
BAA35216; BAA35216; BAA35216
GeneIDi945199
KEGGiecj:JW0565
eco:b0576
PATRICifig|1411691.4.peg.1698

Similar proteinsi

Entry informationi

Entry nameiPHEP_ECOLI
AccessioniPrimary (citable) accession number: P24207
Secondary accession number(s): P77090
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: April 25, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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