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Protein

Uncharacterized GTP-binding protein YjiA

Gene

yjiA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds GTP. May function as GTP-dependent regulator.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 188GTPSequence Analysis
Nucleotide bindingi67 – 715GTPSequence Analysis
Nucleotide bindingi158 – 1614GTPSequence Analysis

GO - Molecular functioni

  1. GTPase activity Source: EcoCyc
  2. GTP binding Source: UniProtKB-KW
  3. identical protein binding Source: EcoCyc
  4. transition metal ion binding Source: EcoCyc

GO - Biological processi

  1. cellular response to DNA damage stimulus Source: EcoliWiki
  2. metabolic process Source: EcoCyc
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG10021-MONOMER.
ECOL316407:JW5790-MONOMER.
MetaCyc:EG10021-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized GTP-binding protein YjiA
Gene namesi
Name:yjiA
Ordered Locus Names:b4352, JW5790
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318 Componenti: Chromosome UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10021. yjiA.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Uncharacterized GTP-binding protein YjiAPRO_0000169785Add
BLAST

Proteomic databases

PaxDbiP24203.
PRIDEiP24203.

Expressioni

Gene expression databases

GenevestigatoriP24203.

Interactioni

Protein-protein interaction databases

DIPiDIP-12630N.
IntActiP24203. 2 interactions.
STRINGi511145.b4352.

Structurei

Secondary structure

1
318
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 1613Combined sources
Helixi18 – 269Combined sources
Beta strandi33 – 364Combined sources
Beta strandi45 – 506Combined sources
Beta strandi56 – 605Combined sources
Beta strandi65 – 673Combined sources
Helixi73 – 8513Combined sources
Beta strandi92 – 998Combined sources
Helixi104 – 11310Combined sources
Helixi115 – 1206Combined sources
Beta strandi121 – 13111Combined sources
Turni132 – 1343Combined sources
Helixi135 – 1417Combined sources
Helixi143 – 1508Combined sources
Beta strandi153 – 1586Combined sources
Turni160 – 1623Combined sources
Helixi167 – 17610Combined sources
Beta strandi178 – 1803Combined sources
Beta strandi182 – 1843Combined sources
Beta strandi187 – 1893Combined sources
Helixi192 – 1954Combined sources
Helixi218 – 2214Combined sources
Beta strandi223 – 23311Combined sources
Helixi237 – 25014Combined sources
Turni251 – 2544Combined sources
Beta strandi255 – 2628Combined sources
Beta strandi268 – 2769Combined sources
Beta strandi279 – 2879Combined sources
Beta strandi295 – 3039Combined sources
Helixi306 – 3149Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1NIJX-ray2.00A1-318[»]
4IXMX-ray2.57A/B1-318[»]
4IXNX-ray2.05A/B1-318[»]
ProteinModelPortaliP24203.
SMRiP24203. Positions 2-318.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP24203.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini224 – 31794CobW C-terminalAdd
BLAST

Sequence similaritiesi

Belongs to the CobW family.Curated
Contains 1 cobW C-terminal domain.Curated

Phylogenomic databases

eggNOGiCOG0523.
HOGENOMiHOG000182211.
InParanoidiP24203.
OMAiNDILVQD.
OrthoDBiEOG63RGPZ.
PhylomeDBiP24203.

Family and domain databases

Gene3Di3.30.1220.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR011629. Cbl_biosynth_CobW-like_C.
IPR003495. CobW/HypB/UreG_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF02492. cobW. 1 hit.
PF07683. CobW_C. 1 hit.
[Graphical view]
SMARTiSM00833. CobW_C. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90002. SSF90002. 1 hit.

Sequencei

Sequence statusi: Complete.

P24203-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPIAVTLLT GFLGAGKTTL LRHILNEQHG YKIAVIENEF GEVSVDDQLI
60 70 80 90 100
GDRATQIKTL TNGCICCSRS NELEDALLDL LDNLDKGNIQ FDRLVIECTG
110 120 130 140 150
MADPGPIIQT FFSHEVLCQR YLLDGVIALV DAVHADEQMN QFTIAQSQVG
160 170 180 190 200
YADRILLTKT DVAGEAEKLH ERLARINARA PVYTVTHGDI DLGLLFNTNG
210 220 230 240 250
FMLEENVVST KPRFHFIADK QNDISSIVVE LDYPVDISEV SRVMENLLLE
260 270 280 290 300
SADKLLRYKG MLWIDGEPNR LLFQGVQRLY SADWDRPWGD EKPHSTMVFI
310
GIQLPEEEIR AAFAGLRK
Length:318
Mass (Da):35,660
Last modified:April 26, 2001 - v3
Checksum:i6D68463182031C41
GO

Sequence cautioni

The sequence AAA97249.1 differs from that shown. Reason: Frameshift at position 22. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA. Translation: AAA97249.1. Frameshift.
U00096 Genomic DNA. Translation: AAC77308.2.
AP009048 Genomic DNA. Translation: BAE78342.1.
X54198 Genomic DNA. Translation: CAA38118.1.
PIRiS56578.
RefSeqiNP_418772.4. NC_000913.3.
YP_492483.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC77308; AAC77308; b4352.
BAE78342; BAE78342; BAE78342.
GeneIDi12933777.
948882.
KEGGiecj:Y75_p4237.
eco:b4352.
PATRICi32124310. VBIEscCol129921_4498.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA. Translation: AAA97249.1. Frameshift.
U00096 Genomic DNA. Translation: AAC77308.2.
AP009048 Genomic DNA. Translation: BAE78342.1.
X54198 Genomic DNA. Translation: CAA38118.1.
PIRiS56578.
RefSeqiNP_418772.4. NC_000913.3.
YP_492483.1. NC_007779.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1NIJX-ray2.00A1-318[»]
4IXMX-ray2.57A/B1-318[»]
4IXNX-ray2.05A/B1-318[»]
ProteinModelPortaliP24203.
SMRiP24203. Positions 2-318.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-12630N.
IntActiP24203. 2 interactions.
STRINGi511145.b4352.

Proteomic databases

PaxDbiP24203.
PRIDEiP24203.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77308; AAC77308; b4352.
BAE78342; BAE78342; BAE78342.
GeneIDi12933777.
948882.
KEGGiecj:Y75_p4237.
eco:b4352.
PATRICi32124310. VBIEscCol129921_4498.

Organism-specific databases

EchoBASEiEB0020.
EcoGeneiEG10021. yjiA.

Phylogenomic databases

eggNOGiCOG0523.
HOGENOMiHOG000182211.
InParanoidiP24203.
OMAiNDILVQD.
OrthoDBiEOG63RGPZ.
PhylomeDBiP24203.

Enzyme and pathway databases

BioCyciEcoCyc:EG10021-MONOMER.
ECOL316407:JW5790-MONOMER.
MetaCyc:EG10021-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP24203.
PROiP24203.

Gene expression databases

GenevestigatoriP24203.

Family and domain databases

Gene3Di3.30.1220.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR011629. Cbl_biosynth_CobW-like_C.
IPR003495. CobW/HypB/UreG_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF02492. cobW. 1 hit.
PF07683. CobW_C. 1 hit.
[Graphical view]
SMARTiSM00833. CobW_C. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90002. SSF90002. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes."
    Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.
    Nucleic Acids Res. 23:2105-2119(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Characterization and expression of the Escherichia coli Mrr restriction system."
    Waite-Rees P.A., Keating C.J., Moran L.S., Slatko B.E., Hornstra L.J., Benner J.S.
    J. Bacteriol. 173:5207-5219(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 39-318.
    Strain: K12.
  5. "Crystal structure of the Escherichia coli YjiA protein suggests a GTP-dependent regulatory function."
    Khil P.P., Obmolova G., Teplyakov A., Howard A.J., Gilliland G.L., Camerini-Otero R.D.
    Proteins 54:371-374(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS), FUNCTION.

Entry informationi

Entry nameiYJIA_ECOLI
AccessioniPrimary (citable) accession number: P24203
Secondary accession number(s): Q2M5W4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 29, 1992
Last sequence update: April 26, 2001
Last modified: March 31, 2015
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.