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P24203

- YJIA_ECOLI

UniProt

P24203 - YJIA_ECOLI

Protein

Uncharacterized GTP-binding protein YjiA

Gene

yjiA

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 3 (27 Apr 2001)
      Previous versions | rss
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    Functioni

    Binds GTP. May function as GTP-dependent regulator.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 188GTPSequence Analysis
    Nucleotide bindingi67 – 715GTPSequence Analysis
    Nucleotide bindingi158 – 1614GTPSequence Analysis

    GO - Molecular functioni

    1. GTPase activity Source: EcoCyc
    2. GTP binding Source: UniProtKB-KW
    3. identical protein binding Source: EcoCyc
    4. transition metal ion binding Source: EcoCyc

    GO - Biological processi

    1. cellular response to DNA damage stimulus Source: EcoliWiki
    2. GTP catabolic process Source: EcoCyc
    3. metabolic process Source: EcoCyc

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciEcoCyc:EG10021-MONOMER.
    ECOL316407:JW5790-MONOMER.
    MetaCyc:EG10021-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uncharacterized GTP-binding protein YjiA
    Gene namesi
    Name:yjiA
    Ordered Locus Names:b4352, JW5790
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

    Organism-specific databases

    EcoGeneiEG10021. yjiA.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 318318Uncharacterized GTP-binding protein YjiAPRO_0000169785Add
    BLAST

    Proteomic databases

    PaxDbiP24203.
    PRIDEiP24203.

    Expressioni

    Gene expression databases

    GenevestigatoriP24203.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-12630N.
    IntActiP24203. 2 interactions.
    STRINGi511145.b4352.

    Structurei

    Secondary structure

    1
    318
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi4 – 1613
    Helixi18 – 269
    Beta strandi33 – 364
    Beta strandi45 – 506
    Beta strandi56 – 605
    Beta strandi65 – 673
    Helixi73 – 8513
    Beta strandi92 – 998
    Helixi104 – 11310
    Helixi115 – 1206
    Beta strandi121 – 13111
    Turni132 – 1343
    Helixi135 – 1417
    Helixi143 – 1508
    Beta strandi153 – 1586
    Turni160 – 1623
    Helixi167 – 17610
    Beta strandi178 – 1803
    Beta strandi182 – 1843
    Beta strandi187 – 1893
    Helixi192 – 1954
    Helixi218 – 2214
    Beta strandi223 – 23311
    Helixi237 – 25014
    Turni251 – 2544
    Beta strandi255 – 2628
    Beta strandi268 – 2769
    Beta strandi279 – 2879
    Beta strandi295 – 3039
    Helixi306 – 3149

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1NIJX-ray2.00A1-318[»]
    4IXMX-ray2.57A/B1-318[»]
    4IXNX-ray2.05A/B1-318[»]
    ProteinModelPortaliP24203.
    SMRiP24203. Positions 2-318.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP24203.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini224 – 31794CobW C-terminalAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CobW family.Curated
    Contains 1 cobW C-terminal domain.Curated

    Phylogenomic databases

    eggNOGiCOG0523.
    HOGENOMiHOG000182211.
    OMAiRINRRAP.
    OrthoDBiEOG63RGPZ.
    PhylomeDBiP24203.

    Family and domain databases

    Gene3Di3.30.1220.10. 1 hit.
    3.40.50.300. 1 hit.
    InterProiIPR011629. Cbl_biosynth_CobW-like_C.
    IPR003495. CobW/HypB/UreG_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF02492. cobW. 1 hit.
    PF07683. CobW_C. 1 hit.
    [Graphical view]
    SMARTiSM00833. CobW_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    SSF90002. SSF90002. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P24203-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNPIAVTLLT GFLGAGKTTL LRHILNEQHG YKIAVIENEF GEVSVDDQLI    50
    GDRATQIKTL TNGCICCSRS NELEDALLDL LDNLDKGNIQ FDRLVIECTG 100
    MADPGPIIQT FFSHEVLCQR YLLDGVIALV DAVHADEQMN QFTIAQSQVG 150
    YADRILLTKT DVAGEAEKLH ERLARINARA PVYTVTHGDI DLGLLFNTNG 200
    FMLEENVVST KPRFHFIADK QNDISSIVVE LDYPVDISEV SRVMENLLLE 250
    SADKLLRYKG MLWIDGEPNR LLFQGVQRLY SADWDRPWGD EKPHSTMVFI 300
    GIQLPEEEIR AAFAGLRK 318
    Length:318
    Mass (Da):35,660
    Last modified:April 27, 2001 - v3
    Checksum:i6D68463182031C41
    GO

    Sequence cautioni

    The sequence AAA97249.1 differs from that shown. Reason: Frameshift at position 22.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U14003 Genomic DNA. Translation: AAA97249.1. Frameshift.
    U00096 Genomic DNA. Translation: AAC77308.2.
    AP009048 Genomic DNA. Translation: BAE78342.1.
    X54198 Genomic DNA. Translation: CAA38118.1.
    PIRiS56578.
    RefSeqiNP_418772.4. NC_000913.3.
    YP_492483.1. NC_007779.1.

    Genome annotation databases

    EnsemblBacteriaiAAC77308; AAC77308; b4352.
    BAE78342; BAE78342; BAE78342.
    GeneIDi12933777.
    948882.
    KEGGiecj:Y75_p4237.
    eco:b4352.
    PATRICi32124310. VBIEscCol129921_4498.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U14003 Genomic DNA. Translation: AAA97249.1 . Frameshift.
    U00096 Genomic DNA. Translation: AAC77308.2 .
    AP009048 Genomic DNA. Translation: BAE78342.1 .
    X54198 Genomic DNA. Translation: CAA38118.1 .
    PIRi S56578.
    RefSeqi NP_418772.4. NC_000913.3.
    YP_492483.1. NC_007779.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1NIJ X-ray 2.00 A 1-318 [» ]
    4IXM X-ray 2.57 A/B 1-318 [» ]
    4IXN X-ray 2.05 A/B 1-318 [» ]
    ProteinModelPortali P24203.
    SMRi P24203. Positions 2-318.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-12630N.
    IntActi P24203. 2 interactions.
    STRINGi 511145.b4352.

    Proteomic databases

    PaxDbi P24203.
    PRIDEi P24203.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC77308 ; AAC77308 ; b4352 .
    BAE78342 ; BAE78342 ; BAE78342 .
    GeneIDi 12933777.
    948882.
    KEGGi ecj:Y75_p4237.
    eco:b4352.
    PATRICi 32124310. VBIEscCol129921_4498.

    Organism-specific databases

    EchoBASEi EB0020.
    EcoGenei EG10021. yjiA.

    Phylogenomic databases

    eggNOGi COG0523.
    HOGENOMi HOG000182211.
    OMAi RINRRAP.
    OrthoDBi EOG63RGPZ.
    PhylomeDBi P24203.

    Enzyme and pathway databases

    BioCyci EcoCyc:EG10021-MONOMER.
    ECOL316407:JW5790-MONOMER.
    MetaCyc:EG10021-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P24203.
    PROi P24203.

    Gene expression databases

    Genevestigatori P24203.

    Family and domain databases

    Gene3Di 3.30.1220.10. 1 hit.
    3.40.50.300. 1 hit.
    InterProi IPR011629. Cbl_biosynth_CobW-like_C.
    IPR003495. CobW/HypB/UreG_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF02492. cobW. 1 hit.
    PF07683. CobW_C. 1 hit.
    [Graphical view ]
    SMARTi SM00833. CobW_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    SSF90002. SSF90002. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes."
      Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.
      Nucleic Acids Res. 23:2105-2119(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
      Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
      Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    4. "Characterization and expression of the Escherichia coli Mrr restriction system."
      Waite-Rees P.A., Keating C.J., Moran L.S., Slatko B.E., Hornstra L.J., Benner J.S.
      J. Bacteriol. 173:5207-5219(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 39-318.
      Strain: K12.
    5. "Crystal structure of the Escherichia coli YjiA protein suggests a GTP-dependent regulatory function."
      Khil P.P., Obmolova G., Teplyakov A., Howard A.J., Gilliland G.L., Camerini-Otero R.D.
      Proteins 54:371-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS), FUNCTION.

    Entry informationi

    Entry nameiYJIA_ECOLI
    AccessioniPrimary (citable) accession number: P24203
    Secondary accession number(s): Q2M5W4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: April 27, 2001
    Last modified: October 1, 2014
    This is version 110 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3