P24202 (MRR_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mrr restriction system protein

Alternative name(s):
EcoKMrr

Gene names

Name:	mrr
Ordered Locus Names:	b4351, JW4314

Organism

Escherichia coli (strain K12)

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	304 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function

Involved in the acceptance of foreign DNA which is modified. Restricts both adenine- and cytosine-methylated DNA.

Ontologies

Keywords
Biological process	Restriction system
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	DNA restriction-modification system Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	DNA binding Inferred from electronic annotation. Source: InterPro endonuclease activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 304	304	Mrr restriction system protein		PRO_0000077382

Sequences

	Sequence		Length	Mass (Da)
	P24202 [UniParc]. Last modified March 1, 1992. Version 1. Checksum: 6DE16E229E9EC9AE	FASTA	304	33,520
	10 20 30 40 50 60 MTVPTYDKFI EPVLRYLATK PEGAAARDVH EAAADALGLD DSQRAKVITS GQLVYKNRAG 70 80 90 100 110 120 WAHDRLKRAG LSQSLSRGKW CLTPAGFDWV ASHPQPMTEQ ETNHLAFAFV NVKLKSRPDA 130 140 150 160 170 180 VDLDPKADSP DHEELAKSSP DDRLDQALKE LRDAVADEVL ENLLQVSPSR FEVIVLDVLH 190 200 210 220 230 240 RLGYGGHRDD LQRVGGTGDG GIDGVISLDK LGLEKVYVQA KRWQNTVGRP ELQAFYGALA 250 260 270 280 290 300 GQKAKRGVFI TTSGFTSQAR DFAQSVEGMV LVDGERLVHL MIENEVGVSS RLLKVPKLDM DYFE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization and expression of the Escherichia coli Mrr restriction system." Waite-Rees P.A., Keating C.J., Moran L.S., Slatko B.E., Hornstra L.J., Benner J.S. J. Bacteriol. 173:5207-5219(1991) [PubMed: 1650347] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-35. Strain: K12.
[2]	"Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes." Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R. Nucleic Acids Res. 23:2105-2119(1995) [PubMed: 7610040] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[4]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X54198 Genomic DNA. Translation: CAA38117.1. U14003 Genomic DNA. Translation: AAA97248.1. U00096 Genomic DNA. Translation: AAC77307.1. AP009048 Genomic DNA. Translation: BAE78341.1.
PIR	A40368.
RefSeq	NP_418771.1. NC_000913.2.
3D structure databases
ProteinModelPortal	P24202.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-10259N.
IntAct	P24202. 1 interaction.
MINT	MINT-1267575.
Protein family/group databases
REBASE	13381. EcoW3110MrrP.
2D gel databases
ECO2DBASE	G033.6. 6TH EDITION.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBESCT00000004143; EBESCP00000004143; EBESCG00000003382. EBESCT00000017204; EBESCP00000016495; EBESCG00000016263.
GeneID	948898.
GenomeReviews	Gene locus JW4314 in contig AP009048_GR. Gene locus b4351 in contig U00096_GR.
KEGG	ecj:JW4314. eco:b4351.
PATRIC	32124308. VBIEscCol129921_4497.
Organism-specific databases
EchoBASE	EB0607.
EcoGene	EG10612. mrr.
Phylogenomic databases
eggNOG	COG1715.
GeneTree	EBGT00050000012133.
HOGENOM	HBG482932.
OMA	IQAKRWE.
PhylomeDB	P24202.
ProtClustDB	CLSK891833.
Enzyme and pathway databases
BioCyc	EcoCyc:EG10612-MONOMER.
Gene expression databases
Genevestigator	P24202.
Family and domain databases
InterPro	IPR011856. Endonuc_TnsA/Hjc/tRNA. IPR011335. Restrct_endonuc_II-like. IPR007560. Restrct_endonuc_IV-like_Mrr. [Graphical view]
Gene3D	G3DSA:3.40.1350.10. Endonuc_TnsA/Hjc/tRNA. 1 hit.
KO	K07448.
Pfam	PF04471. Mrr_cat. 1 hit. [Graphical view]
SUPFAM	SSF52980. Restrict_endonuc_II-like_core. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MRR_ECOLI

Accession

Primary (citable) accession number: P24202
Secondary accession number(s): Q2M5W5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
Last sequence update:	March 1, 1992
Last modified:	January 25, 2012
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program