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Protein

Hydrogenase isoenzymes formation protein HypE

Gene

hypE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • peptidyl-S-carbamoyl-L-cysteine dehydration Source: EcoCyc
  • protein maturation Source: EcoCyc
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:EG10487-MONOMER.
ECOL316407:JW2700-MONOMER.
MetaCyc:EG10487-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydrogenase isoenzymes formation protein HypE
Gene namesi
Name:hypE
Ordered Locus Names:b2730, JW2700
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10487. hypE.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002014591 – 336Hydrogenase isoenzymes formation protein HypEAdd BLAST336

Proteomic databases

PaxDbiP24193.
PRIDEiP24193.

Interactioni

Protein-protein interaction databases

BioGridi4261424. 5 interactors.
DIPiDIP-9999N.
IntActiP24193. 10 interactors.
MINTiMINT-1239514.
STRINGi511145.b2730.

Structurei

Secondary structure

1336
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi15 – 27Combined sources13
Turni30 – 32Combined sources3
Beta strandi37 – 42Combined sources6
Helixi43 – 49Combined sources7
Beta strandi51 – 60Combined sources10
Beta strandi63 – 67Combined sources5
Helixi72 – 85Combined sources14
Turni86 – 88Combined sources3
Beta strandi93 – 101Combined sources9
Helixi106 – 122Combined sources17
Beta strandi126 – 135Combined sources10
Beta strandi139 – 153Combined sources15
Helixi161 – 163Combined sources3
Beta strandi169 – 174Combined sources6
Helixi178 – 188Combined sources11
Helixi204 – 207Combined sources4
Turni208 – 212Combined sources5
Beta strandi216 – 221Combined sources6
Helixi226 – 237Combined sources12
Beta strandi240 – 245Combined sources6
Turni246 – 248Combined sources3
Helixi253 – 262Combined sources10
Turni266 – 268Combined sources3
Beta strandi275 – 279Combined sources5
Helixi281 – 283Combined sources3
Helixi284 – 292Combined sources9
Helixi295 – 297Combined sources3
Beta strandi301 – 309Combined sources9
Beta strandi311 – 315Combined sources5
Helixi317 – 319Combined sources3
Beta strandi321 – 323Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2I6RX-ray2.51A/B/C/D15-336[»]
ProteinModelPortaliP24193.
SMRiP24193.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP24193.

Family & Domainsi

Sequence similaritiesi

Belongs to the HypE family.Curated

Phylogenomic databases

eggNOGiENOG4105C45. Bacteria.
COG0309. LUCA.
HOGENOMiHOG000278777.
InParanoidiP24193.
KOiK04655.
PhylomeDBiP24193.

Family and domain databases

CDDicd02197. HypE. 1 hit.
Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
InterProiIPR010918. AIR_synth_C_dom.
IPR011854. HypE.
IPR016188. PurM-like_N.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
PIRSFiPIRSF005644. Hdrgns_mtr_HypE. 1 hit.
SUPFAMiSSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR02124. hypE. 1 hit.

Sequencei

Sequence statusi: Complete.

P24193-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNIQLAHGS GGQAMQQLIN SLFMEAFANP WLAEQEDQAR LDLAQLVAEG
60 70 80 90 100
DRLAFSTDSY VIDPLFFPGG NIGKLAICGT ANDVAVSGAI PRYLSCGFIL
110 120 130 140 150
EEGLPMETLK AVVTSMAETA RAAGIAIVTG DTKVVQRGAV DKLFINTAGM
160 170 180 190 200
GAIPANIHWG AQTLTAGDVL LVSGTLGDHG ATILNLREQL GLDGELVSDC
210 220 230 240 250
AVLTPLIQTL RDIPGVKALR DATRGGVNAV VHEFAAACGC GIELSEAALP
260 270 280 290 300
VKPAVRGVCE LLGLDALNFA NEGKLVIAVE RNAAEQVLAA LHSHPLGKDA
310 320 330
ALIGEVVERK GVRLAGLYGV KRTLDLPHAE PLPRIC
Length:336
Mass (Da):35,092
Last modified:May 5, 2009 - v2
Checksum:i0811EE415F11AF6C
GO

Sequence cautioni

The sequence AAA69240 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE76807 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA38416 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54543 Genomic DNA. Translation: CAA38416.1. Different initiation.
U29579 Genomic DNA. Translation: AAA69240.1. Different initiation.
U00096 Genomic DNA. Translation: AAC75772.2.
AP009048 Genomic DNA. Translation: BAE76807.1. Different initiation.
PIRiS15201.
RefSeqiNP_417210.2. NC_000913.3.
WP_001059922.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75772; AAC75772; b2730.
BAE76807; BAE76807; BAE76807.
GeneIDi947182.
KEGGiecj:JW2700.
eco:b2730.
PATRICi32120860. VBIEscCol129921_2822.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54543 Genomic DNA. Translation: CAA38416.1. Different initiation.
U29579 Genomic DNA. Translation: AAA69240.1. Different initiation.
U00096 Genomic DNA. Translation: AAC75772.2.
AP009048 Genomic DNA. Translation: BAE76807.1. Different initiation.
PIRiS15201.
RefSeqiNP_417210.2. NC_000913.3.
WP_001059922.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2I6RX-ray2.51A/B/C/D15-336[»]
ProteinModelPortaliP24193.
SMRiP24193.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261424. 5 interactors.
DIPiDIP-9999N.
IntActiP24193. 10 interactors.
MINTiMINT-1239514.
STRINGi511145.b2730.

Proteomic databases

PaxDbiP24193.
PRIDEiP24193.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75772; AAC75772; b2730.
BAE76807; BAE76807; BAE76807.
GeneIDi947182.
KEGGiecj:JW2700.
eco:b2730.
PATRICi32120860. VBIEscCol129921_2822.

Organism-specific databases

EchoBASEiEB0482.
EcoGeneiEG10487. hypE.

Phylogenomic databases

eggNOGiENOG4105C45. Bacteria.
COG0309. LUCA.
HOGENOMiHOG000278777.
InParanoidiP24193.
KOiK04655.
PhylomeDBiP24193.

Enzyme and pathway databases

BioCyciEcoCyc:EG10487-MONOMER.
ECOL316407:JW2700-MONOMER.
MetaCyc:EG10487-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP24193.
PROiP24193.

Family and domain databases

CDDicd02197. HypE. 1 hit.
Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
InterProiIPR010918. AIR_synth_C_dom.
IPR011854. HypE.
IPR016188. PurM-like_N.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
PIRSFiPIRSF005644. Hdrgns_mtr_HypE. 1 hit.
SUPFAMiSSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR02124. hypE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHYPE_ECOLI
AccessioniPrimary (citable) accession number: P24193
Secondary accession number(s): Q2MA99, Q46886
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: May 5, 2009
Last modified: November 2, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.