Hydrogenase isoenzymes formation protein hypE - Escherichia coli (strain K12)

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P24193 (HYPE_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 88. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Hydrogenase isoenzymes formation protein hypE

Gene names

Name:	hypE
Ordered Locus Names:	b2730, JW2700

Organism

Escherichia coli (strain K12)

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	336 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the hypE family.

Sequence caution

The sequence AAA69240.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAE76807.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAA38416.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	peptidyl-S-carbamoyl-L-cysteine dehydration Inferred from direct assay. Source: EcoCyc protein maturation Inferred from mutant phenotype. Source: EcoCyc
Molecular function	catalytic activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 336

336

Hydrogenase isoenzymes formation protein hypE

PRO_0000201459

Secondary structure

336

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P24193 [UniParc].

Last modified May 5, 2009. Version 2.
Checksum: 0811EE415F11AF6C
Show »

FASTA

336

35,092

        10         20         30         40         50         60 
MNNIQLAHGS GGQAMQQLIN SLFMEAFANP WLAEQEDQAR LDLAQLVAEG DRLAFSTDSY 

        70         80         90        100        110        120 
VIDPLFFPGG NIGKLAICGT ANDVAVSGAI PRYLSCGFIL EEGLPMETLK AVVTSMAETA 

       130        140        150        160        170        180 
RAAGIAIVTG DTKVVQRGAV DKLFINTAGM GAIPANIHWG AQTLTAGDVL LVSGTLGDHG 

       190        200        210        220        230        240 
ATILNLREQL GLDGELVSDC AVLTPLIQTL RDIPGVKALR DATRGGVNAV VHEFAAACGC 

       250        260        270        280        290        300 
GIELSEAALP VKPAVRGVCE LLGLDALNFA NEGKLVIAVE RNAAEQVLAA LHSHPLGKDA 

       310        320        330 
ALIGEVVERK GVRLAGLYGV KRTLDLPHAE PLPRIC

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular characterization of an operon (hyp) necessary for the activity of the three hydrogenase isoenzymes in Escherichia coli." Lutz S., Jacobi A., Schlensog V., Boehm R., Sawers G., Boeck A. Mol. Microbiol. 5:123-135(1991) [PubMed: 1849603] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X54543 Genomic DNA. Translation: CAA38416.1. Different initiation.
U29579 Genomic DNA. Translation: AAA69240.1. Different initiation.
U00096 Genomic DNA. Translation: AAC75772.2.
AP009048 Genomic DNA. Translation: BAE76807.1. Different initiation.

PIR

S15201.

RefSeq

NP_417210.2. NC_000913.2.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2I6R	X-ray	2.51	A/B/C/D	15-336	[»]

ProteinModelPortal

P24193.

SMR

P24193. Positions 14-336.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-9999N.

IntAct

P24193. 4 interactions.

MINT

MINT-1239514.

2D gel databases

ECO2DBASE

C031.9. 6TH EDITION.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

EBESCT00000003460; EBESCP00000003460; EBESCG00000002839.
EBESCT00000003461; EBESCP00000003461; EBESCG00000002839.
EBESCT00000003462; EBESCP00000003462; EBESCG00000002839.
EBESCT00000003463; EBESCP00000003463; EBESCG00000002839.
EBESCT00000016316; EBESCP00000015607; EBESCG00000015376.

GeneID

947182.

GenomeReviews

Gene locus JW2700 in contig AP009048_GR.
Gene locus b2730 in contig U00096_GR.

KEGG

ecj:JW2700.
eco:b2730.

PATRIC

32120860. VBIEscCol129921_2822.

Organism-specific databases

EchoBASE

EB0482.

EcoGene

EG10487. hypE.

Phylogenomic databases

eggNOG

COG0309.

GeneTree

EBGT00050000011488.

HOGENOM

HBG287946.

PhylomeDB

P24193.

ProtClustDB

CLSK880468.

Enzyme and pathway databases

BioCyc

EcoCyc:EG10487-MONOMER.

Gene expression databases

Genevestigator

P24193.

Family and domain databases

InterPro

IPR000728. AIR_synth.
IPR010918. AIR_synth_C.
IPR011854. HypE.
IPR016188. PurM_N-like.
[Graphical view]

K04655.

Pfam

PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]

PIRSF

PIRSF005644. Hdrgns_mtr_HypE. 1 hit.

SUPFAM

SSF56042. AIR_synth_C. 1 hit.
SSF55326. PurM_N-like. 1 hit.

TIGRFAMs

TIGR02124. HypE. 1 hit.

ProtoNet

Search...

Entry information

Entry name

HYPE_ECOLI

Accession

Primary (citable) accession number: P24193
Secondary accession number(s): Q2MA99, Q46886

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
Last sequence update:	May 5, 2009
Last modified:	January 25, 2012
This is version 88 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

2D gel databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Entry information

Relevant documents