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Protein

Hydrogenase isoenzymes formation protein HypD

Gene

hypD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for the formation of all three hydrogenase isoenzymes.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi69 – 691Sequence analysis
Metal bindingi72 – 721Sequence analysis

GO - Molecular functioni

  • 4 iron, 4 sulfur cluster binding Source: EcoCyc
  • carbon monoxide binding Source: EcoCyc
  • iron ion binding Source: EcoCyc

GO - Biological processi

  • cellular protein modification process Source: EcoCyc
  • protein maturation Source: EcoCyc
Complete GO annotation...

Keywords - Ligandi

Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG10486-MONOMER.
ECOL316407:JW2699-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydrogenase isoenzymes formation protein HypD
Gene namesi
Name:hypD
Ordered Locus Names:b2729, JW2699
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10486. hypD.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 373373Hydrogenase isoenzymes formation protein HypDPRO_0000201451Add
BLAST

Proteomic databases

PaxDbiP24192.
PRIDEiP24192.

2D gel databases

SWISS-2DPAGEP24192.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
hybGP0AAM77EBI-552711,EBI-562426

Protein-protein interaction databases

BioGridi4261425. 11 interactions.
DIPiDIP-9998N.
IntActiP24192. 8 interactions.
MINTiMINT-1239502.
STRINGi511145.b2729.

Structurei

3D structure databases

ProteinModelPortaliP24192.
SMRiP24192. Positions 7-366.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HypD family.Curated

Phylogenomic databases

eggNOGiENOG4105CQS. Bacteria.
COG0409. LUCA.
HOGENOMiHOG000278766.
InParanoidiP24192.
KOiK04654.
OMAiLFFHINH.
PhylomeDBiP24192.

Family and domain databases

InterProiIPR002780. Hyd_form_HypD.
[Graphical view]
PfamiPF01924. HypD. 1 hit.
[Graphical view]
PIRSFiPIRSF005622. Hydrgn_mat_hypD. 1 hit.
TIGRFAMsiTIGR00075. hypD. 1 hit.

Sequencei

Sequence statusi: Complete.

P24192-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFVDEYRAP EQVMQLIEHL RERASHLSYT AERPLRIMEV CGGHTHAIFK
60 70 80 90 100
FGLDQLLPEN VEFIHGPGCP VCVLPMGRID TCVEIASHPE VIFCTFGDAM
110 120 130 140 150
RVPGKQGSLL QAKARGADVR IVYSPMDALK LAQENPTRKV VFFGLGFETT
160 170 180 190 200
MPTTAITLQQ AKARDVQNFY FFCQHITLIP TLRSLLEQPD NGIDAFLAPG
210 220 230 240 250
HVSMVIGTDA YNFIASDFHR PLVVAGFEPL DLLQGVVMLV QQKIAAHSKV
260 270 280 290 300
ENQYRRVVPD AGNLLAQQAI ADVFCVNGDS EWRGLGVIES SGVHLTPDYQ
310 320 330 340 350
RFDAEAHFRP APQQVCDDPR ARCGEVLTGK CKPHQCPLFG NTCNPQTAFG
360 370
ALMVSSEGAC AAWYQYRQQE SEA
Length:373
Mass (Da):41,363
Last modified:March 1, 1992 - v1
Checksum:i0E4186081FAA4C54
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54543 Genomic DNA. Translation: CAA38415.1.
U29579 Genomic DNA. Translation: AAA69239.1.
U00096 Genomic DNA. Translation: AAC75771.1.
AP009048 Genomic DNA. Translation: BAE76806.1.
PIRiS15200.
RefSeqiNP_417209.1. NC_000913.3.
WP_001212985.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75771; AAC75771; b2729.
BAE76806; BAE76806; BAE76806.
GeneIDi947189.
KEGGiecj:JW2699.
eco:b2729.
PATRICi32120858. VBIEscCol129921_2821.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54543 Genomic DNA. Translation: CAA38415.1.
U29579 Genomic DNA. Translation: AAA69239.1.
U00096 Genomic DNA. Translation: AAC75771.1.
AP009048 Genomic DNA. Translation: BAE76806.1.
PIRiS15200.
RefSeqiNP_417209.1. NC_000913.3.
WP_001212985.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP24192.
SMRiP24192. Positions 7-366.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261425. 11 interactions.
DIPiDIP-9998N.
IntActiP24192. 8 interactions.
MINTiMINT-1239502.
STRINGi511145.b2729.

2D gel databases

SWISS-2DPAGEP24192.

Proteomic databases

PaxDbiP24192.
PRIDEiP24192.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75771; AAC75771; b2729.
BAE76806; BAE76806; BAE76806.
GeneIDi947189.
KEGGiecj:JW2699.
eco:b2729.
PATRICi32120858. VBIEscCol129921_2821.

Organism-specific databases

EchoBASEiEB0481.
EcoGeneiEG10486. hypD.

Phylogenomic databases

eggNOGiENOG4105CQS. Bacteria.
COG0409. LUCA.
HOGENOMiHOG000278766.
InParanoidiP24192.
KOiK04654.
OMAiLFFHINH.
PhylomeDBiP24192.

Enzyme and pathway databases

BioCyciEcoCyc:EG10486-MONOMER.
ECOL316407:JW2699-MONOMER.

Miscellaneous databases

PROiP24192.

Family and domain databases

InterProiIPR002780. Hyd_form_HypD.
[Graphical view]
PfamiPF01924. HypD. 1 hit.
[Graphical view]
PIRSFiPIRSF005622. Hydrgn_mat_hypD. 1 hit.
TIGRFAMsiTIGR00075. hypD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHYPD_ECOLI
AccessioniPrimary (citable) accession number: P24192
Secondary accession number(s): Q2MAA0, Q46885
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: September 7, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.