P24181 (ACRF_ECOLI) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 101.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Acriflavine resistance protein F Alternative name(s): Protein EnvD | ||||||
| Gene names |
| ||||||
| Organism | Escherichia coli (strain K12) | ||||||
| Taxonomic identifier | 83333 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia |
Protein attributes
| Sequence length | 1034 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Involved in cell envelope formation. Is produced in extremely low amounts. |
| Subcellular location | |
| Sequence similarities | Belongs to the AcrB/AcrD/AcrF (TC 2.A.6) family. [View classification] |
Ontologies
| Keywords | |
|---|---|
| Biological process | Cell cycle Cell division Transport |
| Cellular component | Cell inner membrane Cell membrane Membrane |
| Domain | Transmembrane Transmembrane helix |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell divisionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | transporter activity Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1034 | 1034 | Acriflavine resistance protein F | PRO_0000161813 | |||||
Regions | |||||||||
| Topological domain | 1 – 9 | 9 | Cytoplasmic By similarity | ||||||
| Transmembrane | 10 – 28 | 19 | Helical; Name=1; By similarity | ||||||
| Topological domain | 29 – 339 | 311 | Periplasmic By similarity | ||||||
| Transmembrane | 340 – 359 | 20 | Helical; Name=2; By similarity | ||||||
| Topological domain | 360 – 365 | 6 | Cytoplasmic By similarity | ||||||
| Transmembrane | 366 – 385 | 20 | Helical; Name=3; By similarity | ||||||
| Topological domain | 386 – 391 | 6 | Periplasmic By similarity | ||||||
| Transmembrane | 392 – 413 | 22 | Helical; Name=4; By similarity | ||||||
| Topological domain | 414 – 441 | 28 | Cytoplasmic By similarity | ||||||
| Transmembrane | 442 – 460 | 19 | Helical; Name=5; By similarity | ||||||
| Topological domain | 461 – 473 | 13 | Periplasmic By similarity | ||||||
| Transmembrane | 474 – 496 | 23 | Helical; Name=6; By similarity | ||||||
| Topological domain | 497 – 537 | 41 | Cytoplasmic By similarity | ||||||
| Transmembrane | 538 – 556 | 19 | Helical; Name=7; By similarity | ||||||
| Topological domain | 557 – 871 | 315 | Periplasmic By similarity | ||||||
| Transmembrane | 872 – 891 | 20 | Helical; Name=8; By similarity | ||||||
| Topological domain | 892 – 897 | 6 | Cytoplasmic By similarity | ||||||
| Transmembrane | 898 – 917 | 20 | Helical; Name=9; By similarity | ||||||
| Topological domain | 918 – 923 | 6 | Periplasmic By similarity | ||||||
| Transmembrane | 924 – 945 | 22 | Helical; Name=10; By similarity | ||||||
| Topological domain | 946 – 973 | 28 | Cytoplasmic By similarity | ||||||
| Transmembrane | 974 – 992 | 19 | Helical; Name=11; By similarity | ||||||
| Topological domain | 993 – 1005 | 13 | Periplasmic By similarity | ||||||
| Transmembrane | 1006 – 1028 | 23 | Helical; Name=12; By similarity | ||||||
| Topological domain | 1029 – 1034 | 6 | Cytoplasmic By similarity | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Nucleotide sequence of the acrEF operon from Escherichia coli." Xu J., Nilles M.L., Bertrand K.P. Submitted (MAY-1993) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12. |
| [2] | "Molecular analysis and nucleotide sequence of the envCD operon of Escherichia coli." Klein J.R., Henrich B., Plapp R. Mol. Gen. Genet. 230:230-240(1991) [PubMed: 1720861] [Abstract] Cited for: PRELIMINARY NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12. |
| [3] | "Molecular cloning and characterization of acrA and acrE genes of Escherichia coli." Ma D., Cook D.N., Alberti M., Pon N.G., Nikaido H., Hearst J.E. J. Bacteriol. 175:6299-6313(1993) [PubMed: 8407802] [Abstract] Cited for: SEQUENCE REVISION. |
| [4] | "The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076. |
| [5] | "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911. |
| [6] | "Global topology analysis of the Escherichia coli inner membrane proteome." Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G. Science 308:1321-1323(2005) [PubMed: 15919996] [Abstract] Cited for: SUBCELLULAR LOCATION. Strain: K12 / MG1655 / ATCC 47076. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | M96848 Unassigned DNA. Translation: AAA02932.1. X57948 Genomic DNA. Translation: CAA41017.1. U18997 Genomic DNA. Translation: AAA58070.1. U00096 Genomic DNA. Translation: AAC76298.1. AP009048 Genomic DNA. Translation: BAE77307.1. |
| PIR | D65119. |
| RefSeq | NP_417732.1. NC_000913.2. |
3D structure databases | |
| ProteinModelPortal | P24181. |
| SMR | P24181. Positions 1-1018. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP-9052N. |
| IntAct | P24181. 1 interaction. |
| MINT | MINT-1267966. |
Protein family/group databases | |
| TCDB | 2.A.6.2.1. resistance-nodulation-cell division (RND) superfamily. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | EBESCT00000002266; EBESCP00000002266; EBESCG00000001854. EBESCT00000015529; EBESCP00000014820; EBESCG00000014589. |
| GeneID | 947768. |
| GenomeReviews | Gene locus JW3234 in contig AP009048_GR. Gene locus b3266 in contig U00096_GR. |
| KEGG | ecj:JW3234. eco:b3266. |
| PATRIC | 32121962. VBIEscCol129921_3365. |
Organism-specific databases | |
| EchoBASE | EB0263. |
| EcoGene | EG10267. acrF. |
Phylogenomic databases | |
| eggNOG | COG0841. |
| GeneTree | EBGT00050000009201. |
| HOGENOM | HBG293864. |
| OMA | MMERLAN. |
| PhylomeDB | P24181. |
| ProtClustDB | CLSK2502648. |
Enzyme and pathway databases | |
| BioCyc | EcoCyc:ACRF-MONOMER. |
Gene expression databases | |
| Genevestigator | P24181. |
Family and domain databases | |
| InterPro | IPR001036. Acrflvin-R. IPR004764. HAE1. [Graphical view] |
| KO | K03296. |
| Pfam | PF00873. ACR_tran. 1 hit. [Graphical view] |
| PRINTS | PR00702. ACRIFLAVINRP. |
| TIGRFAMs | TIGR00915. 2A0602. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | ACRF_ECOLI | ||||||||
| Accession | Primary (citable) accession number: P24181 Secondary accession number(s): Q2M8U9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| Escherichia coli Escherichia coli (strain K12): entries and cross-references to EcoGene |
| SIMILARITY comments Index of protein domains and families |

Clusters with