Reviewed, UniProtKB/Swiss-Prot P24180 (ACRE_ECOLI)

Names and origin

Protein names

Recommended name:
    Acriflavine resistance protein E
Alternative name(s):
    Protein envC

Gene names

Name:	acrE
Synonyms:	envC
Ordered Locus Names:	b3265, JW3233

Organism

Escherichia coli (strain K12) [Complete proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	385 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	May affect specific membrane functions, such as septum formation during cell division, and cell membrane permeability.
Subcellular location	Cell inner membrane; Lipid-anchor Potential.
Sequence similarities	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. [View classification]

Ontologies

Keywords
Biological process	Cell cycle Cell division
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Signal
PTM	Lipoprotein Palmitate
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW protein secretion Inferred from electronic annotation. Source: InterPro
Cellular component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 385	362	Acriflavine resistance protein E		PRO_0000018688
Amino acid modifications
	Lipidation	24	1	N-palmitoyl cysteine Potential
	Lipidation	24	1	S-diacylglycerol cysteine Potential
Experimental info
	Sequence conflict	191 – 212	22	GALVT…LDPIY → ALLSLMGKRLNWRLSSSSIL ST Ref.2
	Sequence conflict	313 – 314	2	SR → T Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P24180-1 [UniParc]. Last modified July 1, 1993. Version 2. Checksum: EDBF82C853CF42A9	FASTA	385	41,318
	10 20 30 40 50 60 MTKHARFFLL PSFILISAAL IAGCNDKGEE KAHVGEPQVT VHIVKTAPLE VKTELPGRTN 70 80 90 100 110 120 AYRIAEVRPQ VSGIVLNRNF TEGSDVQAGQ SLYQIDPATY QANYDSAKGE LAKSEAAAAI 130 140 150 160 170 180 AHLTVKRYVP LVGTKYISQQ EYDQAIADAR QADAAVIAAK ATVESARINL AYTKVTAPIS 190 200 210 220 230 240 GRIGKSTVTE GALVTNGQTT ELATVQQLDP IYVDVTQSSN DFMRLKQSVE QGNLHKENAT 250 260 270 280 290 300 SNVELVMENG QTYPLKGTLQ FSDVTVDEST GSITLRAVFP NPQHTLLPGM FVRARIDEGV 310 320 330 340 350 360 QPDAILIPQQ GVSRTPRGDA TVLIVNDKSQ VEARPVVASQ AIGDKWLISE GLKSGDQVIV 370 380 SGLQKARPGE QVKATTDTPA DTASK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence of the acrEF operon from Escherichia coli." Xu J., Bertrand K.P. Submitted (MAY-1993) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12.
[2]	"Molecular analysis and nucleotide sequence of the envCD operon of Escherichia coli." Klein J.R., Henrich B., Plapp R. Mol. Gen. Genet. 230:230-240(1991) [PubMed: 1720861] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12.
[3]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[4]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[5]	"Molecular cloning of the envC gene of Escherichia coli." Klein J.R., Henrich B., Plapp R. Curr. Microbiol. 21:341-347(1990) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-96. Strain: K12.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M96848 Unassigned DNA. Translation: AAA02931.1. X57948 Genomic DNA. Translation: CAA41016.1. U18997 Genomic DNA. Translation: AAA58069.1. U00096 Genomic DNA. Translation: AAC76297.1. AP009048 Genomic DNA. Translation: BAE77306.1.
PIR	C65119.
RefSeq	AP_003805.1. NP_417731.1.
3D structure databases
SMR	P24180. Positions 53-298.
ModBase	Search...
Genome annotation databases
GeneID	947706.
GenomeReviews	Gene locus JW3233 in contig AP009048_GR. Gene locus b3265 in contig U00096_GR.
KEGG	ecj:JW3233. eco:b3265.
Organism-specific databases
EchoBASE	EB0262.
EcoGene	EG10266. acrE.
CMR	Search...
Phylogenomic databases
HOGENOM	P24180.
OMA	P24180. QAPQVTV.
Enzyme and pathway databases
BioCyc	EcoCyc:EG10266-MON.
Family and domain databases
InterPro	IPR006143. Secretion_HlyD. [Graphical view]
Pfam	PF00529. HlyD. 1 hit. [Graphical view]
TIGRFAMs	TIGR01730. RND_mfp. 1 hit.
PROSITE	PS51257. PROKAR_LIPOPROTEIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACRE_ECOLI

Accession

Primary (citable) accession number: P24180
Secondary accession number(s): Q2M8V0

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
Last sequence update:	July 1, 1993
Last modified:	June 16, 2009
This is version 74 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)