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Protein

Multidrug export protein AcrE

Gene

acrE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the tripartite efflux system AcrEF-TolC. Involved in the efflux of indole and organic solvents.2 Publications

GO - Molecular functioni

GO - Biological processi

  • drug transmembrane transport Source: GO_Central
  • response to antibiotic Source: GO_Central
  • response to drug Source: EcoliWiki

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciEcoCyc:EG10266-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug export protein AcrE
Alternative name(s):
Acriflavine resistance protein E
Protein EnvC
Gene namesi
Name:acrE
Synonyms:envC
Ordered Locus Names:b3265, JW3233
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10266 acrE

Subcellular locationi

  • Cell inner membrane 1 Publication; Lipid-anchor 1 Publication

GO - Cellular componenti

  • intrinsic component of plasma membrane Source: EcoliWiki
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23PROSITE-ProRule annotationAdd BLAST23
ChainiPRO_000001868824 – 385Multidrug export protein AcrEAdd BLAST362

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi24N-palmitoyl cysteinePROSITE-ProRule annotation1
Lipidationi24S-diacylglycerol cysteinePROSITE-ProRule annotation1

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiP24180
PRIDEiP24180

Expressioni

Inductioni

Induced by LeuO, part of the acrEF operon.1 Publication

Interactioni

Subunit structurei

Part of the tripartite efflux system AcrEF-TolC, which is composed of an inner membrane transporter, AcrF, a periplasmic membrane fusion protein, AcrE, and an outer membrane component, TolC. The complex forms a large protein conduit and can translocate molecules across both the inner and outer membranes (Probable).1 Publication

Protein-protein interaction databases

BioGridi4261953, 367 interactors
STRINGi316385.ECDH10B_3440

Structurei

3D structure databases

ProteinModelPortaliP24180
SMRiP24180
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105C1P Bacteria
ENOG410XNVN LUCA
HOGENOMiHOG000158247
InParanoidiP24180
KOiK18141
OMAiENGQAYP
PhylomeDBiP24180

Family and domain databases

InterProiView protein in InterPro
IPR032317 HlyD_D23
IPR006143 RND_pump_MFP
PfamiView protein in Pfam
PF00529 HlyD, 1 hit
PF16576 HlyD_D23, 1 hit
TIGRFAMsiTIGR01730 RND_mfp, 1 hit
PROSITEiView protein in PROSITE
PS51257 PROKAR_LIPOPROTEIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24180-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKHARFFLL PSFILISAAL IAGCNDKGEE KAHVGEPQVT VHIVKTAPLE
60 70 80 90 100
VKTELPGRTN AYRIAEVRPQ VSGIVLNRNF TEGSDVQAGQ SLYQIDPATY
110 120 130 140 150
QANYDSAKGE LAKSEAAAAI AHLTVKRYVP LVGTKYISQQ EYDQAIADAR
160 170 180 190 200
QADAAVIAAK ATVESARINL AYTKVTAPIS GRIGKSTVTE GALVTNGQTT
210 220 230 240 250
ELATVQQLDP IYVDVTQSSN DFMRLKQSVE QGNLHKENAT SNVELVMENG
260 270 280 290 300
QTYPLKGTLQ FSDVTVDEST GSITLRAVFP NPQHTLLPGM FVRARIDEGV
310 320 330 340 350
QPDAILIPQQ GVSRTPRGDA TVLIVNDKSQ VEARPVVASQ AIGDKWLISE
360 370 380
GLKSGDQVIV SGLQKARPGE QVKATTDTPA DTASK
Length:385
Mass (Da):41,318
Last modified:July 1, 1993 - v2
Checksum:iEDBF82C853CF42A9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti191 – 212GALVT…LDPIY → ALLSLMGKRLNWRLSSSSIL ST (PubMed:1720861).CuratedAdd BLAST22
Sequence conflicti313 – 314SR → T (PubMed:1720861).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96848 Unassigned DNA Translation: AAA02931.1
X57948 Genomic DNA Translation: CAA41016.1
U18997 Genomic DNA Translation: AAA58069.1
U00096 Genomic DNA Translation: AAC76297.1
AP009048 Genomic DNA Translation: BAE77306.1
PIRiC65119
RefSeqiNP_417731.1, NC_000913.3
WP_000160334.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76297; AAC76297; b3265
BAE77306; BAE77306; BAE77306
GeneIDi947706
KEGGiecj:JW3233
eco:b3265
PATRICifig|1411691.4.peg.3463

Similar proteinsi

Entry informationi

Entry nameiACRE_ECOLI
AccessioniPrimary (citable) accession number: P24180
Secondary accession number(s): Q2M8V0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: July 1, 1993
Last modified: March 28, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

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