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Reviewed, UniProtKB/Swiss-Prot P24180 (ACRE_ECOLI)

Last modified June 16, 2009. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Acriflavine resistance protein E
Alternative name(s):
    Protein envC
Gene names
Name: acrE
Synonyms: envC
Ordered Locus Names: b3265, JW3233
OrganismEscherichia coli (strain K12) [Complete proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length385 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology.

General annotation (Comments)

Function

May affect specific membrane functions, such as septum formation during cell division, and cell membrane permeability.

Subcellular location

Cell inner membrane; Lipid-anchor Potential.

Sequence similarities

Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. [View classification]

Ontologies

Keywords
   Biological processCell cycle
Cell division
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainSignal
   PTMLipoprotein
Palmitate
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processcell cycle

Inferred from electronic annotation. Source: UniProtKB-KW

cell division

Inferred from electronic annotation. Source: UniProtKB-KW

protein secretion

Inferred from electronic annotation. Source: InterPro

   Cellular componentplasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionprotein transporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 385362Acriflavine resistance protein E
PRO_0000018688

Amino acid modifications

Lipidation241N-palmitoyl cysteine Potential
Lipidation241S-diacylglycerol cysteine Potential

Experimental info

Sequence conflict191 – 21222GALVT…LDPIY → ALLSLMGKRLNWRLSSSSIL ST Ref.2
Sequence conflict313 – 3142SR → T Ref.2

Sequences

Sequence LengthMass (Da)Tools
P24180-1 [UniParc].

Last modified July 1, 1993. Version 2.
Checksum: EDBF82C853CF42A9

FASTA38541,318
        10         20         30         40         50         60 
MTKHARFFLL PSFILISAAL IAGCNDKGEE KAHVGEPQVT VHIVKTAPLE VKTELPGRTN 

        70         80         90        100        110        120 
AYRIAEVRPQ VSGIVLNRNF TEGSDVQAGQ SLYQIDPATY QANYDSAKGE LAKSEAAAAI 

       130        140        150        160        170        180 
AHLTVKRYVP LVGTKYISQQ EYDQAIADAR QADAAVIAAK ATVESARINL AYTKVTAPIS 

       190        200        210        220        230        240 
GRIGKSTVTE GALVTNGQTT ELATVQQLDP IYVDVTQSSN DFMRLKQSVE QGNLHKENAT 

       250        260        270        280        290        300 
SNVELVMENG QTYPLKGTLQ FSDVTVDEST GSITLRAVFP NPQHTLLPGM FVRARIDEGV 

       310        320        330        340        350        360 
QPDAILIPQQ GVSRTPRGDA TVLIVNDKSQ VEARPVVASQ AIGDKWLISE GLKSGDQVIV 

       370        380 
SGLQKARPGE QVKATTDTPA DTASK 

« Hide

References

« Hide 'large scale' references
[1]"Nucleotide sequence of the acrEF operon from Escherichia coli."
Xu J., Bertrand K.P.
Submitted (MAY-1993) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: K12.
[2]"Molecular analysis and nucleotide sequence of the envCD operon of Escherichia coli."
Klein J.R., Henrich B., Plapp R.
Mol. Gen. Genet. 230:230-240(1991) [PubMed: 1720861] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: K12.
[3]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[4]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[5]"Molecular cloning of the envC gene of Escherichia coli."
Klein J.R., Henrich B., Plapp R.
Curr. Microbiol. 21:341-347(1990)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-96.
Strain: K12.

Cross-references

Sequence databases

M96848 Unassigned DNA. Translation: AAA02931.1.
X57948 Genomic DNA. Translation: CAA41016.1.
U18997 Genomic DNA. Translation: AAA58069.1.
U00096 Genomic DNA. Translation: AAC76297.1.
AP009048 Genomic DNA. Translation: BAE77306.1.
PIRC65119.
RefSeqAP_003805.1.
NP_417731.1.

3D structure databases

SMRP24180. Positions 53-298.
ModBaseSearch...

Genome annotation databases

GeneID947706.
GenomeReviewsGene locus JW3233 in contig AP009048_GR.
Gene locus b3265 in contig U00096_GR.
KEGGecj:JW3233.
eco:b3265.

Organism-specific databases

EchoBASEEB0262.
EcoGeneEG10266. acrE.
CMRSearch...

Phylogenomic databases

HOGENOMP24180.
OMAP24180. QAPQVTV.

Enzyme and pathway databases

BioCycEcoCyc:EG10266-MON.

Family and domain databases

InterProIPR006143. Secretion_HlyD.
[Graphical view]
PfamPF00529. HlyD. 1 hit.
[Graphical view]
TIGRFAMsTIGR01730. RND_mfp. 1 hit.
PROSITEPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACRE_ECOLI
AccessionPrimary (citable) accession number: P24180
Secondary accession number(s): Q2M8V0
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: July 1, 1993
Last modified: June 16, 2009
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents