Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mannose-1-phosphate guanylyltransferase

Gene

manC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the capsular polysaccharide colanic acid.

Catalytic activityi

GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose.

Pathwayi: GDP-alpha-D-mannose biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route).
Proteins known to be involved in this subpathway in this organism are:
  1. Mannose-1-phosphate guanylyltransferase (manC)
This subpathway is part of the pathway GDP-alpha-D-mannose biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route), the pathway GDP-alpha-D-mannose biosynthesis and in Nucleotide-sugar biosynthesis.

GO - Molecular functioni

GO - Biological processi

  • colanic acid biosynthetic process Source: EcoCyc
  • GDP-mannose biosynthetic process Source: UniProtKB-UniPathway
  • hyperosmotic response Source: EcoCyc
  • lipopolysaccharide biosynthetic process Source: UniProtKB-KW

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processCapsule biogenesis/degradation, Lipopolysaccharide biosynthesis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:MANNPGUANYLTRANGDP-MONOMER
MetaCyc:MANNPGUANYLTRANGDP-MONOMER
UniPathwayiUPA00126; UER00930

Names & Taxonomyi

Protein namesi
Recommended name:
Mannose-1-phosphate guanylyltransferase (EC:2.7.7.13)
Alternative name(s):
GDP-mannose pyrophosphorylase
Short name:
GMP
Short name:
GMPP
Gene namesi
Name:manC
Synonyms:cpsB, rfbM
Ordered Locus Names:b2049, JW2034
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10161 manC

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001942531 – 478Mannose-1-phosphate guanylyltransferaseAdd BLAST478

Proteomic databases

PaxDbiP24174
PRIDEiP24174

Interactioni

Protein-protein interaction databases

BioGridi4263312, 190 interactors
IntActiP24174, 5 interactors
STRINGi316385.ECDH10B_2199

Structurei

3D structure databases

ProteinModelPortaliP24174
SMRiP24174
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CJT Bacteria
COG0662 LUCA
COG0836 LUCA
HOGENOMiHOG000153549
InParanoidiP24174
KOiK00971
OMAiWSDLGNF
PhylomeDBiP24174

Family and domain databases

Gene3Di2.60.120.10, 1 hit
3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR006375 Man1P_GuaTrfase/Man6P_Isoase
IPR001538 Man6P_isomerase-2_C
IPR005835 NTP_transferase_dom
IPR029044 Nucleotide-diphossugar_trans
IPR014710 RmlC-like_jellyroll
IPR011051 RmlC_Cupin_sf
PfamiView protein in Pfam
PF01050 MannoseP_isomer, 1 hit
PF00483 NTP_transferase, 1 hit
SUPFAMiSSF51182 SSF51182, 1 hit
SSF53448 SSF53448, 1 hit
TIGRFAMsiTIGR01479 GMP_PMI, 1 hit

Sequencei

Sequence statusi: Complete.

P24174-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQSKLYPVV MAGGSGSRLW PLSRVLYPKQ FLCLKGDLTM LQTTICRLNG
60 70 80 90 100
VECESPVVIC NEQHRFIVAE QLRQLNKLTE NIILEPAGRN TAPAIALAAL
110 120 130 140 150
AAKRHSPESD PLMLVLAADH VIADEDAFRA AVRNAMPYAE AGKLVTFGIV
160 170 180 190 200
PDLPETGYGY IRRGEVSAGE QDMVAFEVAQ FVEKPNLETA QAYVASGEYY
210 220 230 240 250
WNSGMFLFRA GRYLEELKKY RPDILDACEK AMSAVDPDLN FIRVDEEAFL
260 270 280 290 300
ACPEESVDYA VMERTADAVV VPMDAGWSDV GSWSSLWEIS AHTAEGNVCH
310 320 330 340 350
GDVINHKTEN SYVYAESGLV TTVGVKDLVV VQTKDAVLIA DRNAVQDVKK
360 370 380 390 400
VVEQIKADGR HEHRVHREVY RPWGKYDSID AGDRYQVKRI TVKPGEGLSV
410 420 430 440 450
QMHHHRAEHW VVVAGTAKVT IDGDIKLLGE NESIYIPLGA THCLENPGKI
460 470
PLDLIEVRSG SYLEEDDVVR FADRYGRV
Length:478
Mass (Da):53,016
Last modified:July 19, 2003 - v3
Checksum:i675C0EEA050B4186
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti325V → L (PubMed:7815923).Curated1
Sequence conflicti325V → L (PubMed:8759852).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38473 Genomic DNA Translation: AAC77846.1
U00096 Genomic DNA Translation: AAC75110.1
AP009048 Genomic DNA Translation: BAA15905.1
M77127 Genomic DNA Translation: AAA02893.1
PIRiH64970
RefSeqiNP_416553.1, NC_000913.3
WP_000079274.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75110; AAC75110; b2049
BAA15905; BAA15905; BAA15905
GeneIDi946580
KEGGiecj:JW2034
eco:b2049
PATRICifig|1411691.4.peg.202

Entry informationi

Entry nameiMANC_ECOLI
AccessioniPrimary (citable) accession number: P24174
Secondary accession number(s): P78084
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: July 19, 2003
Last modified: March 28, 2018
This is version 144 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health