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Protein

Ornithine decarboxylase, inducible

Gene

speF

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

L-ornithine = putrescine + CO2.

Cofactori

Pathwayi: putrescine biosynthesis via L-ornithine pathway

This protein is involved in step 1 of the subpathway that synthesizes putrescine from L-ornithine.
Proteins known to be involved in this subpathway in this organism are:
  1. Ornithine decarboxylase, constitutive (speC), Ornithine decarboxylase, inducible (speF)
This subpathway is part of the pathway putrescine biosynthesis via L-ornithine pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes putrescine from L-ornithine, the pathway putrescine biosynthesis via L-ornithine pathway and in Amine and polyamine biosynthesis.

GO - Molecular functioni

  • ornithine decarboxylase activity Source: EcoCyc
  • pyridoxal phosphate binding Source: EcoCyc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Spermidine biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciEcoCyc:ORNDECARBOXDEG-MONOMER.
ECOL316407:JW0680-MONOMER.
MetaCyc:ORNDECARBOXDEG-MONOMER.
UniPathwayiUPA00535; UER00288.

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine decarboxylase, inducible (EC:4.1.1.17)
Gene namesi
Name:speF
Ordered Locus Names:b0693, JW0680
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10964. speF.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 732732Ornithine decarboxylase, induciblePRO_0000201135Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei355 – 3551N6-(pyridoxal phosphate)lysineBy similarity

Proteomic databases

PaxDbiP24169.
PRIDEiP24169.

Expressioni

Inductioni

By low environmental pH.

Interactioni

Protein-protein interaction databases

BioGridi4261018. 15 interactions.
DIPiDIP-154N.
IntActiP24169. 4 interactions.
STRINGi511145.b0693.

Structurei

3D structure databases

ProteinModelPortaliP24169.
SMRiP24169. Positions 2-712.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CXN. Bacteria.
COG1982. LUCA.
HOGENOMiHOG000164393.
InParanoidiP24169.
KOiK01581.
OMAiHIKGQPR.
OrthoDBiEOG696BRZ.
PhylomeDBiP24169.

Family and domain databases

Gene3Di3.40.50.220. 1 hit.
3.40.640.10. 1 hit.
3.90.100.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR027568. ODC_inducible.
IPR005308. OKR_de-COase_N.
IPR011193. Orn/lys/arg_de-COase.
IPR000310. Orn/Lys/Arg_deCO2ase_major_dom.
IPR027464. Ornithine_deCO2ase_N.
IPR008286. Prn/Lys/Arg_de-COase_C.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF01276. OKR_DC_1. 1 hit.
PF03711. OKR_DC_1_C. 1 hit.
PF03709. OKR_DC_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF009393. Orn_decarb. 1 hit.
SUPFAMiSSF52172. SSF52172. 1 hit.
SSF53383. SSF53383. 1 hit.
SSF55904. SSF55904. 1 hit.
TIGRFAMsiTIGR04301. ODC_inducible. 1 hit.
PROSITEiPS00703. OKR_DC_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24169-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKLKIAVSD SCPDCFTTQR ECIYINESRN IDVAAIVLSL NDVTCGKLDE
60 70 80 90 100
IDATGYGIPV FIATENQERV PAEYLPRISG VFENCESRRE FYGRQLETAA
110 120 130 140 150
SHYETQLRPP FFRALVDYVN QGNSAFDCPG HQGGEFFRRH PAGNQFVEYF
160 170 180 190 200
GEALFRADLC NADVAMGDLL IHEGAPCIAQ QHAAKVFNAD KTYFVLNGTS
210 220 230 240 250
SSNKVVLNAL LTPGDLVLFD RNNHKSNHHG ALLQAGATPV YLETARNPYG
260 270 280 290 300
FIGGIDAHCF EESYLRELIA EVAPQRAKEA RPFRLAVIQL GTYDGTIYNA
310 320 330 340 350
RQVVDKIGHL CDYILFDSAW VGYEQFIPMM ADCSPLLLDL NENDPGILVT
360 370 380 390 400
QSVHKQQAGF SQTSQIHKKD SHIKGQQRYV PHKRMNNAFM MHASTSPFYP
410 420 430 440 450
LFAALNINAK MHEGVSGRNM WMDCVVNGIN ARKLILDNCQ HIRPFVPELV
460 470 480 490 500
DGKPWQSYET AQIAVDLRFF QFVPGEHWHS FEGYAENQYF VDPCKLLLTT
510 520 530 540 550
PGIDARNGEY EAFGVPATIL ANFLRENGVV PEKCDLNSIL FLLTPAEDMA
560 570 580 590 600
KLQQLVALLV RFEKLLESDA PLAEVLPSIY KQHEERYAGY TLRQLCQEMH
610 620 630 640 650
DLYARHNVKQ LQKEMFRKEH FPRVSMNPQE ANYAYLRGEV ELVRLPDAEG
660 670 680 690 700
RIAAEGALPY PPGVLCVVPG EIWGGAVLRY FSALEEGINL LPGFAPELQG
710 720 730
VYIEEHDGRK QVWCYVIKPR DAQSTLLKGE KL
Length:732
Mass (Da):82,416
Last modified:March 1, 1992 - v1
Checksum:iC2C030BEAB9D23F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64495 Genomic DNA. Translation: AAA62785.1.
U00096 Genomic DNA. Translation: AAC73787.1.
AP009048 Genomic DNA. Translation: BAA35349.1.
PIRiA40839.
RefSeqiNP_415220.1. NC_000913.3.
WP_000040195.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73787; AAC73787; b0693.
BAA35349; BAA35349; BAA35349.
GeneIDi945297.
KEGGiecj:JW0680.
eco:b0693.
PATRICi32116581. VBIEscCol129921_0723.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64495 Genomic DNA. Translation: AAA62785.1.
U00096 Genomic DNA. Translation: AAC73787.1.
AP009048 Genomic DNA. Translation: BAA35349.1.
PIRiA40839.
RefSeqiNP_415220.1. NC_000913.3.
WP_000040195.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP24169.
SMRiP24169. Positions 2-712.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261018. 15 interactions.
DIPiDIP-154N.
IntActiP24169. 4 interactions.
STRINGi511145.b0693.

Proteomic databases

PaxDbiP24169.
PRIDEiP24169.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73787; AAC73787; b0693.
BAA35349; BAA35349; BAA35349.
GeneIDi945297.
KEGGiecj:JW0680.
eco:b0693.
PATRICi32116581. VBIEscCol129921_0723.

Organism-specific databases

EchoBASEiEB0957.
EcoGeneiEG10964. speF.

Phylogenomic databases

eggNOGiENOG4105CXN. Bacteria.
COG1982. LUCA.
HOGENOMiHOG000164393.
InParanoidiP24169.
KOiK01581.
OMAiHIKGQPR.
OrthoDBiEOG696BRZ.
PhylomeDBiP24169.

Enzyme and pathway databases

UniPathwayiUPA00535; UER00288.
BioCyciEcoCyc:ORNDECARBOXDEG-MONOMER.
ECOL316407:JW0680-MONOMER.
MetaCyc:ORNDECARBOXDEG-MONOMER.

Miscellaneous databases

PROiP24169.

Family and domain databases

Gene3Di3.40.50.220. 1 hit.
3.40.640.10. 1 hit.
3.90.100.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR027568. ODC_inducible.
IPR005308. OKR_de-COase_N.
IPR011193. Orn/lys/arg_de-COase.
IPR000310. Orn/Lys/Arg_deCO2ase_major_dom.
IPR027464. Ornithine_deCO2ase_N.
IPR008286. Prn/Lys/Arg_de-COase_C.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF01276. OKR_DC_1. 1 hit.
PF03711. OKR_DC_1_C. 1 hit.
PF03709. OKR_DC_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF009393. Orn_decarb. 1 hit.
SUPFAMiSSF52172. SSF52172. 1 hit.
SSF53383. SSF53383. 1 hit.
SSF55904. SSF55904. 1 hit.
TIGRFAMsiTIGR04301. ODC_inducible. 1 hit.
PROSITEiPS00703. OKR_DC_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Coexistence of the genes for putrescine transport protein and ornithine decarboxylase at 16 min on Escherichia coli chromosome."
    Kashiwagi K., Suzuki T., Suzuki F., Furuchi T., Kobayashi H., Igarashi K.
    J. Biol. Chem. 266:20922-20927(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiDCOS_ECOLI
AccessioniPrimary (citable) accession number: P24169
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: January 20, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.