P24169 (DCOS_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ornithine decarboxylase, inducible
EC=4.1.1.17

Gene names

Name:	speF
Ordered Locus Names:	b0693, JW0680

Organism

Escherichia coli (strain K12)

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	732 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	L-ornithine = putrescine + CO2.
Cofactor	Pyridoxal phosphate.
Pathway	Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.
Induction	By low environmental pH.
Sequence similarities	Belongs to the Orn/Lys/Arg decarboxylase class-I family.

Ontologies

Keywords
Biological process	Spermidine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro spermidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	ornithine decarboxylase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 732	732	Ornithine decarboxylase, inducible		PRO_0000201135
Amino acid modifications
	Modified residue	355	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P24169 [UniParc]. Last modified March 1, 1992. Version 1. Checksum: C2C030BEAB9D23F6	FASTA	732	82,416
	10 20 30 40 50 60 MSKLKIAVSD SCPDCFTTQR ECIYINESRN IDVAAIVLSL NDVTCGKLDE IDATGYGIPV 70 80 90 100 110 120 FIATENQERV PAEYLPRISG VFENCESRRE FYGRQLETAA SHYETQLRPP FFRALVDYVN 130 140 150 160 170 180 QGNSAFDCPG HQGGEFFRRH PAGNQFVEYF GEALFRADLC NADVAMGDLL IHEGAPCIAQ 190 200 210 220 230 240 QHAAKVFNAD KTYFVLNGTS SSNKVVLNAL LTPGDLVLFD RNNHKSNHHG ALLQAGATPV 250 260 270 280 290 300 YLETARNPYG FIGGIDAHCF EESYLRELIA EVAPQRAKEA RPFRLAVIQL GTYDGTIYNA 310 320 330 340 350 360 RQVVDKIGHL CDYILFDSAW VGYEQFIPMM ADCSPLLLDL NENDPGILVT QSVHKQQAGF 370 380 390 400 410 420 SQTSQIHKKD SHIKGQQRYV PHKRMNNAFM MHASTSPFYP LFAALNINAK MHEGVSGRNM 430 440 450 460 470 480 WMDCVVNGIN ARKLILDNCQ HIRPFVPELV DGKPWQSYET AQIAVDLRFF QFVPGEHWHS 490 500 510 520 530 540 FEGYAENQYF VDPCKLLLTT PGIDARNGEY EAFGVPATIL ANFLRENGVV PEKCDLNSIL 550 560 570 580 590 600 FLLTPAEDMA KLQQLVALLV RFEKLLESDA PLAEVLPSIY KQHEERYAGY TLRQLCQEMH 610 620 630 640 650 660 DLYARHNVKQ LQKEMFRKEH FPRVSMNPQE ANYAYLRGEV ELVRLPDAEG RIAAEGALPY 670 680 690 700 710 720 PPGVLCVVPG EIWGGAVLRY FSALEEGINL LPGFAPELQG VYIEEHDGRK QVWCYVIKPR 730 DAQSTLLKGE KL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Coexistence of the genes for putrescine transport protein and ornithine decarboxylase at 16 min on Escherichia coli chromosome." Kashiwagi K., Suzuki T., Suzuki F., Furuchi T., Kobayashi H., Igarashi K. J. Biol. Chem. 266:20922-20927(1991) [PubMed: 1939141] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map." Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A., Ikemoto K., Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K., Kimura S., Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K. , Mori H., Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N., Sampei G., Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y., Yano M., Horiuchi T. DNA Res. 3:137-155(1996) [PubMed: 8905232] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[3]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[4]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M64495 Genomic DNA. Translation: AAA62785.1. U00096 Genomic DNA. Translation: AAC73787.1. AP009048 Genomic DNA. Translation: BAA35349.1.
PIR	A40839.
RefSeq	NP_415220.1. NC_000913.2.
3D structure databases
ProteinModelPortal	P24169.
SMR	P24169. Positions 2-723.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-154N.
IntAct	P24169. 4 interactions.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBESCT00000003586; EBESCP00000003586; EBESCG00000002928. EBESCT00000017250; EBESCP00000016541; EBESCG00000016309.
GeneID	945297.
GenomeReviews	Gene locus JW0680 in contig AP009048_GR. Gene locus b0693 in contig U00096_GR.
KEGG	ecj:JW0680. eco:b0693.
PATRIC	32116581. VBIEscCol129921_0723.
Organism-specific databases
EchoBASE	EB0957.
EcoGene	EG10964. speF.
Phylogenomic databases
eggNOG	COG1982.
GeneTree	EBGT00050000009622.
HOGENOM	HBG301265.
OMA	ANDLRFF.
PhylomeDB	P24169.
ProtClustDB	PRK13578.
Enzyme and pathway databases
BioCyc	EcoCyc:ORNDECARBOXDEG-MONOMER. MetaCyc:ORNDECARBOXDEG-MONOMER.
Gene expression databases
Genevestigator	P24169.
Family and domain databases
InterPro	IPR011006. CheY-like_superfamily. IPR005308. OKR_de-COase_N. IPR011193. Orn/lys/arg_de-COase. IPR000310. Orn/Lys/Arg_deCO2ase_major_dom. IPR008286. Prn/Lys/Arg_de-COase_C. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.90.100.10. Decarbxylse_C. 1 hit. G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KO	K01581.
Pfam	PF01276. OKR_DC_1. 1 hit. PF03711. OKR_DC_1_C. 1 hit. PF03709. OKR_DC_1_N. 1 hit. [Graphical view]
PIRSF	PIRSF009393. Orn_decarb. 1 hit.
SUPFAM	SSF52172. CheY_like. 1 hit. SSF55904. Decarbxylse_C. 1 hit. SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
PROSITE	PS00703. OKR_DC_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DCOS_ECOLI

Accession

Primary (citable) accession number: P24169

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
Last sequence update:	March 1, 1992
Last modified:	January 25, 2012
This is version 98 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program