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Protein

Inducible ornithine decarboxylase

Gene

speF

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

L-ornithine = putrescine + CO2.

Cofactori

Pathwayi: putrescine biosynthesis via L-ornithine pathway

This protein is involved in step 1 of the subpathway that synthesizes putrescine from L-ornithine.
Proteins known to be involved in this subpathway in this organism are:
  1. Inducible ornithine decarboxylase (speF), Constitutive ornithine decarboxylase (speC)
This subpathway is part of the pathway putrescine biosynthesis via L-ornithine pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes putrescine from L-ornithine, the pathway putrescine biosynthesis via L-ornithine pathway and in Amine and polyamine biosynthesis.

GO - Molecular functioni

  • ornithine decarboxylase activity Source: EcoCyc
  • pyridoxal phosphate binding Source: EcoCyc

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processSpermidine biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciEcoCyc:ORNDECARBOXDEG-MONOMER
MetaCyc:ORNDECARBOXDEG-MONOMER
UniPathwayiUPA00535; UER00288

Names & Taxonomyi

Protein namesi
Recommended name:
Inducible ornithine decarboxylase (EC:4.1.1.17)
Gene namesi
Name:speF
Ordered Locus Names:b0693, JW0680
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10964 speF

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002011351 – 732Inducible ornithine decarboxylaseAdd BLAST732

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei355N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PaxDbiP24169
PRIDEiP24169

Expressioni

Inductioni

By low environmental pH.

Interactioni

Protein-protein interaction databases

BioGridi4261018, 16 interactors
DIPiDIP-154N
IntActiP24169, 4 interactors
STRINGi316385.ECDH10B_0759

Structurei

3D structure databases

ProteinModelPortaliP24169
SMRiP24169
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CXN Bacteria
COG1982 LUCA
HOGENOMiHOG000164393
InParanoidiP24169
KOiK01581
OMAiHIKGQPR
PhylomeDBiP24169

Family and domain databases

CDDicd00615 Orn_deC_like, 1 hit
Gene3Di3.40.50.220, 1 hit
3.40.640.10, 1 hit
3.90.1150.10, 1 hit
InterProiView protein in InterPro
IPR011006 CheY-like_superfamily
IPR027568 ODC_inducible
IPR005308 OKR_de-COase_N
IPR011193 Orn/lys/arg_de-COase
IPR000310 Orn/Lys/Arg_deCO2ase_major_dom
IPR027464 Ornithine_deCO2ase_N
IPR008286 Prn/Lys/Arg_de-COase_C
IPR036633 Prn/Lys/Arg_de-COase_C_sf
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF01276 OKR_DC_1, 1 hit
PF03711 OKR_DC_1_C, 1 hit
PF03709 OKR_DC_1_N, 1 hit
PIRSFiPIRSF009393 Orn_decarb, 1 hit
SUPFAMiSSF52172 SSF52172, 1 hit
SSF53383 SSF53383, 1 hit
SSF55904 SSF55904, 1 hit
TIGRFAMsiTIGR04301 ODC_inducible, 1 hit
PROSITEiView protein in PROSITE
PS00703 OKR_DC_1, 1 hit

Sequencei

Sequence statusi: Complete.

P24169-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKLKIAVSD SCPDCFTTQR ECIYINESRN IDVAAIVLSL NDVTCGKLDE
60 70 80 90 100
IDATGYGIPV FIATENQERV PAEYLPRISG VFENCESRRE FYGRQLETAA
110 120 130 140 150
SHYETQLRPP FFRALVDYVN QGNSAFDCPG HQGGEFFRRH PAGNQFVEYF
160 170 180 190 200
GEALFRADLC NADVAMGDLL IHEGAPCIAQ QHAAKVFNAD KTYFVLNGTS
210 220 230 240 250
SSNKVVLNAL LTPGDLVLFD RNNHKSNHHG ALLQAGATPV YLETARNPYG
260 270 280 290 300
FIGGIDAHCF EESYLRELIA EVAPQRAKEA RPFRLAVIQL GTYDGTIYNA
310 320 330 340 350
RQVVDKIGHL CDYILFDSAW VGYEQFIPMM ADCSPLLLDL NENDPGILVT
360 370 380 390 400
QSVHKQQAGF SQTSQIHKKD SHIKGQQRYV PHKRMNNAFM MHASTSPFYP
410 420 430 440 450
LFAALNINAK MHEGVSGRNM WMDCVVNGIN ARKLILDNCQ HIRPFVPELV
460 470 480 490 500
DGKPWQSYET AQIAVDLRFF QFVPGEHWHS FEGYAENQYF VDPCKLLLTT
510 520 530 540 550
PGIDARNGEY EAFGVPATIL ANFLRENGVV PEKCDLNSIL FLLTPAEDMA
560 570 580 590 600
KLQQLVALLV RFEKLLESDA PLAEVLPSIY KQHEERYAGY TLRQLCQEMH
610 620 630 640 650
DLYARHNVKQ LQKEMFRKEH FPRVSMNPQE ANYAYLRGEV ELVRLPDAEG
660 670 680 690 700
RIAAEGALPY PPGVLCVVPG EIWGGAVLRY FSALEEGINL LPGFAPELQG
710 720 730
VYIEEHDGRK QVWCYVIKPR DAQSTLLKGE KL
Length:732
Mass (Da):82,416
Last modified:March 1, 1992 - v1
Checksum:iC2C030BEAB9D23F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64495 Genomic DNA Translation: AAA62785.1
U00096 Genomic DNA Translation: AAC73787.1
AP009048 Genomic DNA Translation: BAA35349.1
PIRiA40839
RefSeqiNP_415220.1, NC_000913.3
WP_000040195.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73787; AAC73787; b0693
BAA35349; BAA35349; BAA35349
GeneIDi945297
KEGGiecj:JW0680
eco:b0693
PATRICifig|1411691.4.peg.1583

Similar proteinsi

Entry informationi

Entry nameiDCOS_ECOLI
AccessioniPrimary (citable) accession number: P24169
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: March 28, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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