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P24131

- BGAL_CLOAT

UniProt

P24131 - BGAL_CLOAT

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Protein

Beta-galactosidase

Gene
cbgA
Organism
Clostridium acetobutylicum
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei459 – 4591Proton donor By similarity
Active sitei503 – 5031Nucleophile By similarity

GO - Molecular functioni

  1. beta-galactosidase activity Source: UniProtKB-EC
  2. carbohydrate binding Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH2. Glycoside Hydrolase Family 2.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidase (EC:3.2.1.23)
Short name:
Beta-gal
Alternative name(s):
Lactase
Gene namesi
Name:cbgA
OrganismiClostridium acetobutylicum
Taxonomic identifieri1488 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Subcellular locationi

GO - Cellular componenti

  1. beta-galactosidase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 897897Beta-galactosidasePRO_0000057660Add
BLAST

Expressioni

Inductioni

Late in the ABE (acetone, butanol, and ethanol) fermentation and subject to glucose repression.

Structurei

3D structure databases

ProteinModelPortaliP24131.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
2.60.40.320. 2 hits.
2.70.98.10. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR004199. B-gal_small/dom_5.
IPR011013. Gal_mutarotase_SF_dom.
IPR008979. Galactose-bd-like.
IPR014718. Glyco_hydro-type_carb-bd_sub.
IPR006101. Glyco_hydro_2.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR023232. Glyco_hydro_2_AS.
IPR023230. Glyco_hydro_2_CS.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR006103. Glyco_hydro_2_TIM.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF02929. Bgal_small_N. 1 hit.
PF00703. Glyco_hydro_2. 1 hit.
PF02836. Glyco_hydro_2_C. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view]
PRINTSiPR00132. GLHYDRLASE2.
SMARTiSM01038. Bgal_small_N. 1 hit.
[Graphical view]
SUPFAMiSSF49303. SSF49303. 2 hits.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
SSF74650. SSF74650. 1 hit.
PROSITEiPS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24131-1 [UniParc]FASTAAdd to Basket

« Hide

MINNKPSLDW LENPEIFRVN RIDAHSDTWF YEKFEDVKLE DTMPLKQNLN    50
GKWRFSYSEN SSLRIKEFYK DEFDVSWIDY IEVPGHIQLQ GYDKCQYINT 100
MYPWEGHDEL RPPHISKTYN PVGSYVTFFE VKDELKNKQT FISFQGVETA 150
FYVWVNGEFV GYSEDTFTPS EFDITDYLRE GENKLAVEVY KRSSASWIED 200
QDFWRFSGIF RDVYLYAVPE THVNDIFIKT DLYDDFKNAK LNAELKMIGN 250
SETTVETYLE DKEGNKIAIS EKIPFSDELT LYLDAQNINL WSAEEPNLYT 300
LYILVNKKDG NLIEVVTQKI GFRHFEMKDK IMCLKWKRII FKGVNRHEFS 350
ARRGRSITKE DMLWDIKFLK QHNINAVRTS HYPNQSLWYR LCDEYGIYLI 400
DETNLESHGS WQKMGQIEPS WNVPGSLPQW QAAVLDRASS MVERDKNHPS 450
VLIWSCGNES YAGEDIYQMS KYFRKKDPSR LVHYEGVTRC REFMTRRHES 500
RMYAKAAEIE EYLNDNPKKP YISCEYMHSM GNSTGGMMKY TELEDKYLMY 550
QGGFIWDYGD QALYRKLPDG KEVLAYGGDF TDRPTDYNFS GNGLIYADRT 600
ISPKAQEVKY LYQNVKLEPD EKGVTIKNQN LFVNTDKYDL YYIVERDGKL 650
IKDGYLNVSV APDEEKYIEL PIGNYNFPEE IVLTTSLRLA QATLWAEKGY 700
EIAFGQKVIK EKSDMNNHNS ESKMKIIHGD VNIGVHGKDF KAIFSKQEGG 750
IVSLRYNNKE FITRTPKTFY WRATTDNDRG NRHEFRCSQW LAATMGQKYV 800
DFSVEEFDEK ITLYYTYQLP TVPSTNVKIT YEVSGEGIIK VNVKYKGVSG 850
LPELPVLGMD FKLLAEFNSF SWYGMGPEEN YIDRCEGAKL GIYESTQ 897
Length:897
Mass (Da):105,020
Last modified:February 1, 1996 - v2
Checksum:iE13DB8674992A32F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M35107 Genomic DNA. Translation: AAA23216.1.
PIRiA39405.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M35107 Genomic DNA. Translation: AAA23216.1 .
PIRi A39405.

3D structure databases

ProteinModelPortali P24131.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH2. Glycoside Hydrolase Family 2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.60.120.260. 1 hit.
2.60.40.320. 2 hits.
2.70.98.10. 1 hit.
3.20.20.80. 1 hit.
InterProi IPR004199. B-gal_small/dom_5.
IPR011013. Gal_mutarotase_SF_dom.
IPR008979. Galactose-bd-like.
IPR014718. Glyco_hydro-type_carb-bd_sub.
IPR006101. Glyco_hydro_2.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR023232. Glyco_hydro_2_AS.
IPR023230. Glyco_hydro_2_CS.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR006103. Glyco_hydro_2_TIM.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF02929. Bgal_small_N. 1 hit.
PF00703. Glyco_hydro_2. 1 hit.
PF02836. Glyco_hydro_2_C. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view ]
PRINTSi PR00132. GLHYDRLASE2.
SMARTi SM01038. Bgal_small_N. 1 hit.
[Graphical view ]
SUPFAMi SSF49303. SSF49303. 2 hits.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
SSF74650. SSF74650. 1 hit.
PROSITEi PS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Expression and nucleotide sequence of the Clostridium acetobutylicum beta-galactosidase gene cloned in Escherichia coli."
    Hancock K.R., Rockman E., Young C.A., Pearce L., Maddox I.S., Scott D.B.
    J. Bacteriol. 173:3084-3095(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: DSM 1732 / NCIB 2951.

Entry informationi

Entry nameiBGAL_CLOAT
AccessioniPrimary (citable) accession number: P24131
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: February 1, 1996
Last modified: October 16, 2013
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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