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P24118

- CISY_TETTH

UniProt

P24118 - CISY_TETTH

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Protein

Citrate synthase, mitochondrial

Gene
N/A
Organism
Tetrahymena thermophila
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Structural protein involved in oral morphogenesis and in pronuclear behavior during conjugation. Respiratory enzyme.1 Publication

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei300 – 3001PROSITE-ProRule annotation
Active sitei346 – 3461PROSITE-ProRule annotation
Active sitei401 – 4011PROSITE-ProRule annotation

GO - Molecular functioni

  1. transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer Source: InterPro

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthase, mitochondrial (EC:2.3.3.16)
Alternative name(s):
14 nm filament-forming protein
49 kDa protein
OrganismiTetrahymena thermophila
Taxonomic identifieri5911 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaHymenostomatidaTetrahymeninaTetrahymenidaeTetrahymena

Subcellular locationi

Mitochondrion matrix 1 Publication. Cytoplasm 1 Publication. Cytoplasmcytoskeleton 1 Publication

GO - Cellular componenti

  1. cytoskeleton Source: UniProtKB-KW
  2. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2121Mitochondrion1 PublicationAdd
BLAST
Chaini22 – 462441Citrate synthase, mitochondrialPRO_0000005474Add
BLAST

Proteomic databases

PRIDEiP24118.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi5911.P24118.

Structurei

3D structure databases

ProteinModelPortaliP24118.
SMRiP24118. Positions 24-455.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0372.

Family and domain databases

Gene3Di1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24118-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRSINQLLKQ ASLSQKSQYN FSQTNLKKVI AEIIPQKQAE LKEVKEKYGD
60 70 80 90 100
KVVGQYTVKQ VIGGMRGMKG LMSDLSRCDP YQGIIFRGYT IPQLKEFLPK
110 120 130 140 150
ADPKAADQAN QEPLPEGIFW LLMTGQLPTH AQVDALKHEW QNRGTVNQDC
160 170 180 190 200
VNFILNLPKD LHSMTMLSMA LLYLQKDSKF AKLYDEGKIS KKDYWEPFYE
210 220 230 240 250
DSMDLIAKIP RVAAIIYRHK YRDSKLIDSD SKLDWAGNYA HMMGFEQHVV
260 270 280 290 300
KECIRGYLSI HCDHEGGNVS AHTTHLVGSA LSDPYLSYSA GVNGLAGPLH
310 320 330 340 350
GLANQEVLKW LLQFIEEKGT KVSDKDIEDY VDHVISSGRV VPGYGHAVLR
360 370 380 390 400
DTDPRFHHQV DFSKFHLKDD QMIKLLHQCA DVIPKKLLTY KKIANPYPNV
410 420 430 440 450
DCHSGVLLYS LGLTEYQYYT VVFAVSRALG CMANLIWSRA FGLPIERPGS
460
ADLKWFHDKY RE
Length:462
Mass (Da):52,575
Last modified:March 1, 1992 - v1
Checksum:iF4F4EFDAE62243A6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D90117 mRNA. Translation: BAA14145.1.
PIRiJC5625.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D90117 mRNA. Translation: BAA14145.1 .
PIRi JC5625.

3D structure databases

ProteinModelPortali P24118.
SMRi P24118. Positions 24-455.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5911.P24118.

Proteomic databases

PRIDEi P24118.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG0372.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER00717 .

Family and domain databases

Gene3Di 1.10.580.10. 1 hit.
InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
[Graphical view ]
PANTHERi PTHR11739. PTHR11739. 1 hit.
Pfami PF00285. Citrate_synt. 1 hit.
[Graphical view ]
PRINTSi PR00143. CITRTSNTHASE.
SUPFAMi SSF48256. SSF48256. 1 hit.
PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Tetrahymena 14-nm filament-forming protein has citrate synthase activity."
    Numata O., Takemasa T., Takagi I., Hirono M., Hirano H., Chiba J., Watanabe Y.
    Biochem. Biophys. Res. Commun. 174:1028-1034(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 22-40, SUBCELLULAR LOCATION, FUNCTION.

Entry informationi

Entry nameiCISY_TETTH
AccessioniPrimary (citable) accession number: P24118
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: October 29, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Keywords - Technical termi

Direct protein sequencing

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3