Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P24118

- CISY_TETTH

UniProt

P24118 - CISY_TETTH

Protein

Citrate synthase, mitochondrial

Gene
N/A
Organism
Tetrahymena thermophila
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Mar 1992)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Structural protein involved in oral morphogenesis and in pronuclear behavior during conjugation. Respiratory enzyme.1 Publication

    Catalytic activityi

    Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei300 – 3001PROSITE-ProRule annotation
    Active sitei346 – 3461PROSITE-ProRule annotation
    Active sitei401 – 4011PROSITE-ProRule annotation

    GO - Molecular functioni

    1. transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer Source: InterPro

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Enzyme and pathway databases

    UniPathwayiUPA00223; UER00717.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Citrate synthase, mitochondrial (EC:2.3.3.16)
    Alternative name(s):
    14 nm filament-forming protein
    49 kDa protein
    OrganismiTetrahymena thermophila
    Taxonomic identifieri5911 [NCBI]
    Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaHymenostomatidaTetrahymeninaTetrahymenidaeTetrahymena

    Subcellular locationi

    Mitochondrion matrix 1 Publication. Cytoplasm 1 Publication. Cytoplasmcytoskeleton 1 Publication

    GO - Cellular componenti

    1. cytoskeleton Source: UniProtKB-SubCell
    2. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2121Mitochondrion1 PublicationAdd
    BLAST
    Chaini22 – 462441Citrate synthase, mitochondrialPRO_0000005474Add
    BLAST

    Proteomic databases

    PRIDEiP24118.

    Interactioni

    Subunit structurei

    Homodimer.

    Protein-protein interaction databases

    STRINGi5911.P24118.

    Structurei

    3D structure databases

    ProteinModelPortaliP24118.
    SMRiP24118. Positions 24-455.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the citrate synthase family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0372.

    Family and domain databases

    Gene3Di1.10.580.10. 1 hit.
    InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR019810. Citrate_synthase_AS.
    [Graphical view]
    PANTHERiPTHR11739. PTHR11739. 1 hit.
    PfamiPF00285. Citrate_synt. 1 hit.
    [Graphical view]
    PRINTSiPR00143. CITRTSNTHASE.
    SUPFAMiSSF48256. SSF48256. 1 hit.
    PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P24118-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRSINQLLKQ ASLSQKSQYN FSQTNLKKVI AEIIPQKQAE LKEVKEKYGD    50
    KVVGQYTVKQ VIGGMRGMKG LMSDLSRCDP YQGIIFRGYT IPQLKEFLPK 100
    ADPKAADQAN QEPLPEGIFW LLMTGQLPTH AQVDALKHEW QNRGTVNQDC 150
    VNFILNLPKD LHSMTMLSMA LLYLQKDSKF AKLYDEGKIS KKDYWEPFYE 200
    DSMDLIAKIP RVAAIIYRHK YRDSKLIDSD SKLDWAGNYA HMMGFEQHVV 250
    KECIRGYLSI HCDHEGGNVS AHTTHLVGSA LSDPYLSYSA GVNGLAGPLH 300
    GLANQEVLKW LLQFIEEKGT KVSDKDIEDY VDHVISSGRV VPGYGHAVLR 350
    DTDPRFHHQV DFSKFHLKDD QMIKLLHQCA DVIPKKLLTY KKIANPYPNV 400
    DCHSGVLLYS LGLTEYQYYT VVFAVSRALG CMANLIWSRA FGLPIERPGS 450
    ADLKWFHDKY RE 462
    Length:462
    Mass (Da):52,575
    Last modified:March 1, 1992 - v1
    Checksum:iF4F4EFDAE62243A6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D90117 mRNA. Translation: BAA14145.1.
    PIRiJC5625.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D90117 mRNA. Translation: BAA14145.1 .
    PIRi JC5625.

    3D structure databases

    ProteinModelPortali P24118.
    SMRi P24118. Positions 24-455.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5911.P24118.

    Proteomic databases

    PRIDEi P24118.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG0372.

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER00717 .

    Family and domain databases

    Gene3Di 1.10.580.10. 1 hit.
    InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR019810. Citrate_synthase_AS.
    [Graphical view ]
    PANTHERi PTHR11739. PTHR11739. 1 hit.
    Pfami PF00285. Citrate_synt. 1 hit.
    [Graphical view ]
    PRINTSi PR00143. CITRTSNTHASE.
    SUPFAMi SSF48256. SSF48256. 1 hit.
    PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Tetrahymena 14-nm filament-forming protein has citrate synthase activity."
      Numata O., Takemasa T., Takagi I., Hirono M., Hirano H., Chiba J., Watanabe Y.
      Biochem. Biophys. Res. Commun. 174:1028-1034(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 22-40, SUBCELLULAR LOCATION, FUNCTION.

    Entry informationi

    Entry nameiCISY_TETTH
    AccessioniPrimary (citable) accession number: P24118
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: March 1, 1992
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Miscellaneous

    Citrate synthase is found in nearly all cells capable of oxidative metabolism.

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3