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Protein

Alkanal monooxygenase alpha chain

Gene

luxA

Organism
Photobacterium phosphoreum
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Light-emitting reaction in luminous bacteria.

Catalytic activityi

RCHO + reduced FMN + O2 = RCOOH + FMN + H2O + light.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase, Photoprotein

Keywords - Biological processi

Luminescence

Keywords - Ligandi

Flavoprotein, FMN

Names & Taxonomyi

Protein namesi
Recommended name:
Alkanal monooxygenase alpha chain (EC:1.14.14.3)
Alternative name(s):
Bacterial luciferase alpha chain
Gene namesi
Name:luxA
OrganismiPhotobacterium phosphoreum
Taxonomic identifieri659 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346Alkanal monooxygenase alpha chainPRO_0000220169Add
BLAST

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain.

Structurei

3D structure databases

ProteinModelPortaliP24113.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

Gene3Di3.20.20.30. 3 hits.
InterProiIPR018235. Bacterial_luciferase_CS.
IPR011251. Luciferase-like_dom.
IPR002103. Luciferase_bac.
[Graphical view]
PfamiPF00296. Bac_luciferase. 1 hit.
[Graphical view]
PRINTSiPR00089. LUCIFERASE.
SUPFAMiSSF51679. SSF51679. 1 hit.
PROSITEiPS00494. BACTERIAL_LUCIFERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24113-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFGNIFSYQ PPGESHKEVM DRFVRLGVAS EELNFDTYWL EHHFTEFGLT
60 70 80 90 100
GNLFVACANL LGRTTKLNVG TMIVLPTAHP ARQMEDLLLL DQMSKGRFNF
110 120 130 140 150
GVVRGYHKDF RVFGVTMEDS RAITEDFHTM IMDGTKTGLH TDGKNIEFPD
160 170 180 190 200
VNVYPEAYLE KIPTCMTAES ATTTWLAERG LPMVLSWIIT TSEKKAQMEL
210 220 230 240 250
YNAVRDSGYS EEYIKNVDHS MTLICSVDED GKKAEDVREF LGNWYDSYVN
260 270 280 290 300
ATNIFSESNQ TRGYDYHKGQ KDFVLQGHTN TKRRVDYSND LNPVGTPEKC
310 320 330 340
IEIQRDIDAT GITNITLGFE ANGSEEEIIA SMKRFMQVAP FLKDPK
Length:346
Mass (Da):39,364
Last modified:March 1, 1992 - v1
Checksum:i360EC324E0A438A0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61I → IC in AAA25627 (PubMed:2071574).Curated
Sequence conflicti40 – 412LE → TL in AAA25627 (PubMed:2071574).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65067 Genomic DNA. Translation: AAA70297.1.
M64224 Genomic DNA. Translation: AAA25627.1.
PIRiJH0387.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65067 Genomic DNA. Translation: AAA70297.1.
M64224 Genomic DNA. Translation: AAA25627.1.
PIRiJH0387.

3D structure databases

ProteinModelPortaliP24113.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.20.20.30. 3 hits.
InterProiIPR018235. Bacterial_luciferase_CS.
IPR011251. Luciferase-like_dom.
IPR002103. Luciferase_bac.
[Graphical view]
PfamiPF00296. Bac_luciferase. 1 hit.
[Graphical view]
PRINTSiPR00089. LUCIFERASE.
SUPFAMiSSF51679. SSF51679. 1 hit.
PROSITEiPS00494. BACTERIAL_LUCIFERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Structure and properties of luciferase from Photobacterium phosphoreum."
    Ferri S.R., Soly R.R., Szittner R.B., Meighen E.A.
    Biochem. Biophys. Res. Commun. 176:541-548(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "A lux-specific myristoyl transferase in luminescent bacteria related to eukaryotic serine esterases."
    Ferri S.R., Meighen E.A.
    J. Biol. Chem. 266:12852-12857(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-41.

Entry informationi

Entry nameiLUXA_PHOPO
AccessioniPrimary (citable) accession number: P24113
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: October 1, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.