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Protein

Protein Rev

Gene

rev

Organism
Bovine immunodeficiency virus (strain R29) (BIV) (Bovine immunodeficiency-like virus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Escorts unspliced or incompletely spliced viral pre-mRNAs (late transcripts) out of the nucleus of infected cells. These pre-mRNAs carry a recognition sequence called Rev responsive element (RRE) located in the env gene, that is not present in fully spliced viral mRNAs (early transcripts). This function is essential since most viral proteins are translated from unspliced or partially spliced pre-mRNAs which cannot exit the nucleus by the pathway used by fully processed cellular mRNAs (By similarity).By similarity

Miscellaneous

The sequence shown is that of isolate R29-127.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processmRNA transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Rev
Gene namesi
Name:rev
OrganismiBovine immunodeficiency virus (strain R29) (BIV) (Bovine immunodeficiency-like virus)
Taxonomic identifieri417296 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusBovine lentivirus group
Virus hostiBos taurus (Bovine) [TaxID: 9913]

Subcellular locationi

  • Host nucleushost nucleolus By similarity
  • Host cytoplasm By similarity

  • Note: The presence of both nuclear import and nuclear export signals leads to continuous shuttling between the nucleus and cytoplasm.By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000854731 – 186Protein RevAdd BLAST186

Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Homomultimer; when bound to the RRE. Multimeric assembly is essential for activity (By similarity).By similarity

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili85 – 120Sequence analysisAdd BLAST36

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi73 – 97Nuclear localization signal and RNA-binding (RRE)By similarityAdd BLAST25
Motifi102 – 115Nuclear export signalBy similarityAdd BLAST14

Domaini

The RNA-binding motif binds to the RRE present in incompletely spliced viral pre-mRNAs. This region also contains the NLS which mediates nuclear localization. These overlapping functions prevent Rev bound to RRE from undesirable return to the nucleus. When Rev binds the RRE, the NLS becomes masked while the NES remains accessible (By similarity).By similarity

Keywords - Domaini

Coiled coil

Family and domain databases

InterProiView protein in InterPro
IPR008411. BIV_Surface_Envelope.
PfamiView protein in Pfam
PF05858. BIV_Env. 1 hit.

Sequencei

Sequence statusi: Complete.

P24097-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQDLDRAER GERGGGSEEL LQEEINEGRL TAREALQTWI NNDSPRYVKK
60 70 80 90 100
LRQGQPELPT SPGGGGGRGH RARKLPGERR PGFWKSLREL VEQNRRKQER
110 120 130 140 150
RLSGLDRRIQ QLEDLVRHMS LGSPDPSTPS ASVLSVNPPA QTPLGHLPPR
160 170 180
SYFKLKRVDC GAGWDLRTTA APGLPICELD WIQGTK
Length:186
Mass (Da):20,844
Last modified:January 23, 2007 - v2
Checksum:iB3A0D4F25823EC26
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti14G → E in strain: Isolate R29-Nadin. 1
Natural varianti24E → K in strain: Isolate R29-Nadin. 1
Natural varianti57E → K in strain: Isolate R29-Nadin. 1
Natural varianti63G → D in strain: Isolate R29-Nadin. 1
Natural varianti113E → K in strain: Isolate R29-Nadin. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32690 Genomic RNA. No translation available.
M74712 mRNA. Translation: AAA42772.1.
L06504 mRNA. Translation: AAA42774.1.
PIRiH34742. VKLJBT.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiREV_BIV29
AccessioniPrimary (citable) accession number: P24097
Secondary accession number(s): Q04143, Q65598
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: January 23, 2007
Last modified: June 24, 2015
This is version 51 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program