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P24096 (KITH_BHV16) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidine kinase

EC=2.7.1.21
Gene names
Name:TK
OrganismBovine herpesvirus 1 (strain 6660) (BoHV-1) (Infectious bovine rhinotracheitis virus)
Taxonomic identifier10322 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
Virus hostBos taurus (Bovine) [TaxID: 9913]

Protein attributes

Sequence length357 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome By similarity.

Catalytic activity

ATP + thymidine = ADP + thymidine 5'-phosphate.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the herpesviridae thymidine kinase family.

Ontologies

Keywords
   Biological processDNA synthesis
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

TMP biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

thymidine kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 357357Thymidine kinase
PRO_0000175061

Regions

Nucleotide binding17 – 248ATP By similarity

Sites

Active site451Proton acceptor Potential
Binding site1001Substrate By similarity
Binding site1421Substrate By similarity
Binding site1861ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P24096 [UniParc].

Last modified March 1, 1992. Version 1.
Checksum: B2099A05D5BDCD2D

FASTA35736,760
        10         20         30         40         50         60 
MAEPARALRV VRIYLDGAHG LGKTTTGRAL AAASTAGEGV LFFPEPMAYW RTMFGTDALS 

        70         80         90        100        110        120 
GILAASARCA AASHGSARAR RAGAPRRRGR GGPGCVLPGQ VRGPVLNFAR ARVRAAAPPG 

       130        140        150        160        170        180 
PAPGGTVTLV FDRHPVAACL CYPFARYCLR EINAEDLLML AAAMPPEAPG ANLVVCTLPP 

       190        200        210        220        230        240 
AEQQRRLAAR ARPGDRADAG FLVAVRNAYA LLVNTCAFLR AGGDGATAGT RWSGRTQMHW 

       250        260        270        280        290        300 
PRSQTPVVMN AKCAGAGLRD TLFAALKCRE LYPGGGTGLP AVHAWALDAL AGRLAALEVF 

       310        320        330        340        350 
VLDVSAAPDA CAAAVLDMRP AMQAACADGA AGATLATLAR QFALEMAGEA TAGPRGL 

« Hide

References

[1]"Analysis of the bovine herpesvirus type 1 thymidine kinase (TK) gene from wild-type virus and TK-deficient mutants."
Mittal S.K., Field H.J.
J. Gen. Virol. 70:901-918(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D00438 Genomic DNA. Translation: BAA00339.1.
PIRKIBEBR. A31330.

3D structure databases

ProteinModelPortalP24096.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR001889. Herpes_TK.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00693. Herpes_TK. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKITH_BHV16
AccessionPrimary (citable) accession number: P24096
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: March 19, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families