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Protein

Thymidine kinase

Gene

TK

Organism
Bovine herpesvirus 1 (strain 6660) (BoHV-1) (Infectious bovine rhinotracheitis virus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome.By similarity

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei45 – 451Proton acceptorSequence Analysis
Binding sitei100 – 1001SubstrateBy similarity
Binding sitei142 – 1421SubstrateBy similarity
Binding sitei186 – 1861ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi17 – 248ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. thymidine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA biosynthetic process Source: UniProtKB-KW
  2. TMP biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

DNA synthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinase (EC:2.7.1.21)
Gene namesi
Name:TK
OrganismiBovine herpesvirus 1 (strain 6660) (BoHV-1) (Infectious bovine rhinotracheitis virus)
Taxonomic identifieri10322 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
Virus hostiBos taurus (Bovine) [TaxID: 9913]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 357357Thymidine kinasePRO_0000175061Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR001889. Herpes_TK.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00693. Herpes_TK. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

P24096-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEPARALRV VRIYLDGAHG LGKTTTGRAL AAASTAGEGV LFFPEPMAYW
60 70 80 90 100
RTMFGTDALS GILAASARCA AASHGSARAR RAGAPRRRGR GGPGCVLPGQ
110 120 130 140 150
VRGPVLNFAR ARVRAAAPPG PAPGGTVTLV FDRHPVAACL CYPFARYCLR
160 170 180 190 200
EINAEDLLML AAAMPPEAPG ANLVVCTLPP AEQQRRLAAR ARPGDRADAG
210 220 230 240 250
FLVAVRNAYA LLVNTCAFLR AGGDGATAGT RWSGRTQMHW PRSQTPVVMN
260 270 280 290 300
AKCAGAGLRD TLFAALKCRE LYPGGGTGLP AVHAWALDAL AGRLAALEVF
310 320 330 340 350
VLDVSAAPDA CAAAVLDMRP AMQAACADGA AGATLATLAR QFALEMAGEA

TAGPRGL
Length:357
Mass (Da):36,760
Last modified:March 1, 1992 - v1
Checksum:iB2099A05D5BDCD2D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00438 Genomic DNA. Translation: BAA00339.1.
PIRiA31330. KIBEBR.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00438 Genomic DNA. Translation: BAA00339.1.
PIRiA31330. KIBEBR.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR001889. Herpes_TK.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00693. Herpes_TK. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Analysis of the bovine herpesvirus type 1 thymidine kinase (TK) gene from wild-type virus and TK-deficient mutants."
    Mittal S.K., Field H.J.
    J. Gen. Virol. 70:901-918(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiKITH_BHV16
AccessioniPrimary (citable) accession number: P24096
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: April 1, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.