Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Dr hemagglutinin structural subunit

Gene

draA

Organism
Escherichia coli
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Hemagglutinins of uropathogenic E.coli mediate adherence to the upper urinary tract. These adhesins bind to the Dr blood group antigen and also agglutinate human erythrocytes in the presence of D-mannose (mannose-resistant hemagglutination (MRHA)).

Names & Taxonomyi

Protein namesi
Recommended name:
Dr hemagglutinin structural subunit
Gene namesi
Name:draA
OrganismiEscherichia coli
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Subcellular locationi

GO - Cellular componenti

  • pilus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Fimbrium

Pathology & Biotechi

Chemistry

DrugBankiDB00446. Chloramphenicol.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 21211 PublicationAdd
BLAST
Chaini22 – 160139Dr hemagglutinin structural subunitPRO_0000000874Add
BLAST

Structurei

Secondary structure

1
160
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi22 – 3716Combined sources
Beta strandi39 – 468Combined sources
Beta strandi50 – 523Combined sources
Helixi53 – 553Combined sources
Beta strandi61 – 7111Combined sources
Beta strandi75 – 817Combined sources
Helixi83 – 853Combined sources
Beta strandi90 – 956Combined sources
Beta strandi101 – 11111Combined sources
Beta strandi114 – 1174Combined sources
Beta strandi120 – 1256Combined sources
Beta strandi130 – 13910Combined sources
Beta strandi146 – 15914Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1USQX-ray1.90A/B/C/D/E/F21-160[»]
1UT1X-ray1.70A/B/C/D/E/F21-160[»]
2JKJX-ray2.30A/B/C/D/E/F23-160[»]
2JKLX-ray1.90A/B/C/D/E/F23-160[»]
2JKNX-ray1.90A/B/C/D/E/F23-160[»]
2W5PX-ray1.90A/B/C23-160[»]
ProteinModelPortaliP24093.
SMRiP24093. Positions 23-160.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP24093.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni22 – 7554Receptor-bindingSequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the Dr-adhesin family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.60.40.1570. 1 hit.
InterProiIPR021020. Adehsin_Dr_signal_peptide.
IPR006713. Adhesin_Dr.
IPR008966. Adhesion_dom.
[Graphical view]
PfamiPF04619. Adhesin_Dr. 1 hit.
PF12393. Dr_adhesin. 1 hit.
[Graphical view]
ProDomiPD008337. Adhesin_Dr. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF49401. SSF49401. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24093-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKLAIMAAA SMVFAVSSAH AGFTPSGTTG TTKLTVTEEC QVRVGDLTVA
60 70 80 90 100
KTRGQLTDAA PIGPVTVQAL GCDARQVALK ADTDNFEQGK FFLISDNNRD
110 120 130 140 150
KLYVNIRPTD NSAWTTDNGV FYKNDVGSWG GIIGIYVDGQ QTNTPPGNYT
160
LTLTGGYWAK
Length:160
Mass (Da):17,058
Last modified:March 1, 1992 - v1
Checksum:i8F282F8FF1500788
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti43 – 431R → Y in strain: 950 and 5026.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62834 Genomic DNA. Translation: AAA23709.1.
RefSeqiWP_063269203.1. NZ_LVTL01000054.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62834 Genomic DNA. Translation: AAA23709.1.
RefSeqiWP_063269203.1. NZ_LVTL01000054.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1USQX-ray1.90A/B/C/D/E/F21-160[»]
1UT1X-ray1.70A/B/C/D/E/F21-160[»]
2JKJX-ray2.30A/B/C/D/E/F23-160[»]
2JKLX-ray1.90A/B/C/D/E/F23-160[»]
2JKNX-ray1.90A/B/C/D/E/F23-160[»]
2W5PX-ray1.90A/B/C23-160[»]
ProteinModelPortaliP24093.
SMRiP24093. Positions 23-160.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

DrugBankiDB00446. Chloramphenicol.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP24093.

Family and domain databases

Gene3Di2.60.40.1570. 1 hit.
InterProiIPR021020. Adehsin_Dr_signal_peptide.
IPR006713. Adhesin_Dr.
IPR008966. Adhesion_dom.
[Graphical view]
PfamiPF04619. Adhesin_Dr. 1 hit.
PF12393. Dr_adhesin. 1 hit.
[Graphical view]
ProDomiPD008337. Adhesin_Dr. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF49401. SSF49401. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Molecular structure of the Dr adhesin: nucleotide sequence and mapping of receptor-binding domain by use of fusion constructs."
    Swanson T.S., Bilge S.S., Nowicki B., Moseley S.L.
    Infect. Immun. 59:261-268(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Serotype O75.
  2. "Purification and characterization of the Dr hemagglutinins expressed by two uropathogenic Escherichia coli strains."
    Kist M.L., Salit I.E., Hoffman T.
    Infect. Immun. 58:695-702(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 22-46.
    Strain: 5026 and 950.

Entry informationi

Entry nameiDRAA_ECOLX
AccessioniPrimary (citable) accession number: P24093
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: July 6, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.