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P24071

- FCAR_HUMAN

UniProt

P24071 - FCAR_HUMAN

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Protein

Immunoglobulin alpha Fc receptor

Gene

FCAR

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production.1 Publication

GO - Biological processi

  1. immune response Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

IgA-binding protein

Protein family/group databases

MEROPSiI43.951.

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin alpha Fc receptor
Short name:
IgA Fc receptor
Alternative name(s):
CD_antigen: CD89
Gene namesi
Name:FCAR
Synonyms:CD89
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19, UP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:3608. FCAR.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 227206ExtracellularSequence AnalysisAdd
BLAST
Transmembranei228 – 24619HelicalSequence AnalysisAdd
BLAST
Topological domaini247 – 28741CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
  2. integral component of plasma membrane Source: ProtInc
  3. plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28055.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 287266Immunoglobulin alpha Fc receptorPRO_0000015138Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 100
Glycosylationi65 – 651N-linked (GlcNAc...)Sequence Analysis
Glycosylationi79 – 791N-linked (GlcNAc...)Sequence Analysis
Glycosylationi141 – 1411N-linked (GlcNAc...)1 Publication
Disulfide bondi146 ↔ 193
Glycosylationi177 – 1771N-linked (GlcNAc...)1 Publication
Glycosylationi186 – 1861N-linked (GlcNAc...)Sequence Analysis
Glycosylationi198 – 1981N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP24071.
PRIDEiP24071.

PTM databases

PhosphoSiteiP24071.

Expressioni

Tissue specificityi

Isoform A.1, isoform A.2 and isoform A.3 are differentially expressed between blood and mucosal myeloid cells. Isoform A.1, isoform A.2 and isoform A.3 are expressed in monocytes. Isoform A.1 and isoform A.2 are expressed in alveolar macrophages; however only one isoform is expressed at alveolar macrophages surfaces.2 Publications

Gene expression databases

BgeeiP24071.
CleanExiHS_FCAR.
ExpressionAtlasiP24071. baseline and differential.
GenevestigatoriP24071.

Organism-specific databases

HPAiHPA014050.

Interactioni

Subunit structurei

Associates with the Fc epsilon RI gamma 2 receptor inducing tyrosine phosphorylation of gamma 2.2 Publications

Protein-protein interaction databases

BioGridi108498. 5 interactions.
IntActiP24071. 2 interactions.

Structurei

Secondary structure

1
287
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi23 – 253Combined sources
Beta strandi31 – 355Combined sources
Beta strandi37 – 404Combined sources
Beta strandi45 – 495Combined sources
Beta strandi56 – 649Combined sources
Beta strandi67 – 704Combined sources
Beta strandi72 – 743Combined sources
Beta strandi77 – 793Combined sources
Beta strandi84 – 874Combined sources
Helixi92 – 943Combined sources
Beta strandi96 – 1049Combined sources
Turni105 – 1073Combined sources
Beta strandi108 – 1114Combined sources
Beta strandi115 – 1206Combined sources
Beta strandi127 – 1326Combined sources
Beta strandi134 – 1363Combined sources
Beta strandi143 – 1475Combined sources
Beta strandi149 – 1513Combined sources
Beta strandi154 – 1607Combined sources
Beta strandi168 – 1714Combined sources
Beta strandi173 – 1797Combined sources
Helixi185 – 1873Combined sources
Beta strandi189 – 1968Combined sources
Beta strandi198 – 2003Combined sources
Beta strandi211 – 2155Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OVZX-ray3.00A/B22-216[»]
1OW0X-ray3.10C/D22-216[»]
1UCTX-ray2.10A21-229[»]
DisProtiDP00311.
ProteinModelPortaliP24071.
SMRiP24071. Positions 27-216.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP24071.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 10766Ig-like C2-type 1Add
BLAST
Domaini139 – 20062Ig-like C2-type 2Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG41820.
GeneTreeiENSGT00760000119033.
HOGENOMiHOG000234395.
HOVERGENiHBG004337.
InParanoidiP24071.
KOiK06513.
OrthoDBiEOG78SQGZ.
PhylomeDBiP24071.
TreeFamiTF336644.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]

Sequences (11)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 11 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform A.1 (identifier: P24071-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDPKQTTLLC LVLCLGQRIQ AQEGDFPMPF ISAKSSPVIP LDGSVKIQCQ
60 70 80 90 100
AIREAYLTQL MIIKNSTYRE IGRRLKFWNE TDPEFVIDHM DANKAGRYQC
110 120 130 140 150
QYRIGHYRFR YSDTLELVVT GLYGKPFLSA DRGLVLMPGE NISLTCSSAH
160 170 180 190 200
IPFDRFSLAK EGELSLPQHQ SGEHPANFSL GPVDLNVSGI YRCYGWYNRS
210 220 230 240 250
PYLWSFPSNA LELVVTDSIH QDYTTQNLIR MAVAGLVLVA LLAILVENWH
260 270 280
SHTALNKEAS ADVAEPSWSQ QMCQPGLTFA RTPSVCK
Length:287
Mass (Da):32,265
Last modified:March 1, 1992 - v1
Checksum:iA2CCA68467CD45F7
GO
Isoform A.2 (identifier: P24071-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     195-216: Missing.

Show »
Length:265
Mass (Da):29,683
Checksum:i81F71B405469B93A
GO
Isoform A.3 (identifier: P24071-3) [UniParc]FASTAAdd to Basket

Also known as: RLA2

The sequence of this isoform differs from the canonical sequence as follows:
     121-216: Missing.

Show »
Length:191
Mass (Da):21,694
Checksum:iB5B6854F0437AEBE
GO
Isoform B (identifier: P24071-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     217-287: DSIHQDYTTQ...TFARTPSVCK → GRYRPVQPCVWVGCPGPCHRAGI

Show »
Length:239
Mass (Da):26,996
Checksum:i4B080309BFAB38E5
GO
Isoform B-delta-S2 (identifier: P24071-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-23: Missing.
     217-287: DSIHQDYTTQ...TFARTPSVCK → GRYRPVQPCVWVGCPGPCHRAGI

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:227
Mass (Da):25,656
Checksum:i6C8D9A590920EA83
GO
Isoform U02 (identifier: P24071-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-24: G → GRYISEHFWCRSLGCNPVNDASAQRPG
     195-216: Missing.

Show »
Length:291
Mass (Da):32,629
Checksum:i1DF65E4E613DA0C3
GO
Isoform L10 (identifier: P24071-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-23: Missing.
     24-120: Missing.

Show »
Length:178
Mass (Da):19,593
Checksum:iCD9549BF14EE74DF
GO
Isoform U09 (identifier: P24071-8) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-23: Missing.
     193-287: CYGWYNRSPY...TFARTPSVCK → LHPPRLHDAELDPHGRGRTGPRGSLGHTG

Show »
Length:209
Mass (Da):23,394
Checksum:i0C10F3D72BEC5366
GO
Isoform U10 (identifier: P24071-9) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-23: Missing.
     115-210: Missing.

Show »
Length:179
Mass (Da):20,354
Checksum:iD31062C1B384F6BB
GO
Isoform U11 (identifier: P24071-10) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-23: Missing.

Show »
Length:275
Mass (Da):30,925
Checksum:i47B8C498C56C82A8
GO
Isoform U13 (identifier: P24071-11) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-23: Missing.
     195-216: Missing.

Show »
Length:253
Mass (Da):28,343
Checksum:i6081B1C3F5BDED61
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti113 – 1131D → N.1 Publication
Corresponds to variant rs11666735 [ dbSNP | Ensembl ].
VAR_049996
Natural varianti269 – 2691S → G.1 Publication
Corresponds to variant rs16986050 [ dbSNP | Ensembl ].
VAR_049997

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei12 – 2312Missing in isoform B-delta-S2, isoform L10, isoform U09, isoform U10, isoform U11 and isoform U13. 1 PublicationVSP_002632Add
BLAST
Alternative sequencei24 – 12097Missing in isoform L10. 1 PublicationVSP_043565Add
BLAST
Alternative sequencei24 – 241G → GRYISEHFWCRSLGCNPVND ASAQRPG in isoform U02. 1 PublicationVSP_002633
Alternative sequencei115 – 21096Missing in isoform U10. 1 PublicationVSP_043566Add
BLAST
Alternative sequencei121 – 21696Missing in isoform A.3. 3 PublicationsVSP_002634Add
BLAST
Alternative sequencei193 – 28795CYGWY…PSVCK → LHPPRLHDAELDPHGRGRTG PRGSLGHTG in isoform U09. 1 PublicationVSP_043567Add
BLAST
Alternative sequencei195 – 21622Missing in isoform A.2, isoform U02 and isoform U13. 2 PublicationsVSP_002635Add
BLAST
Alternative sequencei217 – 28771DSIHQ…PSVCK → GRYRPVQPCVWVGCPGPCHR AGI in isoform B and isoform B-delta-S2. CuratedVSP_002636Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54150 mRNA. Translation: CAA38089.1.
X87767
, X87768, X87769, X87766, X87765 Genomic DNA. Translation: CAA61039.1.
U43774 mRNA. Translation: AAC50639.1.
U43677 mRNA. Translation: AAC50595.1.
U56236 mRNA. Translation: AAB00566.1.
U56237 mRNA. Translation: AAB00567.1.
S82919 mRNA. Translation: AAD14421.1.
D87853 mRNA. Translation: BAA13471.1.
D87854 mRNA. Translation: BAA13472.1.
D87855 mRNA. Translation: BAA13473.1.
D87856 mRNA. Translation: BAA13474.1.
D87857 mRNA. Translation: BAA13475.1.
D87859 mRNA. Translation: BAA13477.1.
D87861 mRNA. Translation: BAA13479.1.
D87862 mRNA. Translation: BAA13480.1.
DQ075334 mRNA. Translation: AAZ76577.1.
DQ075335 mRNA. Translation: AAZ76578.1.
DQ075336 mRNA. Translation: AAZ76579.1.
DQ075337 mRNA. Translation: AAZ76580.1.
DQ075338 mRNA. Translation: AAZ76581.1.
DQ075339 mRNA. Translation: AAZ76582.1.
AC011501 Genomic DNA. No translation available.
BC027953 mRNA. Translation: AAH27953.1.
CCDSiCCDS12907.1. [P24071-1]
CCDS12908.1. [P24071-3]
CCDS12909.1. [P24071-10]
CCDS12910.1. [P24071-7]
CCDS42622.1. [P24071-2]
CCDS42623.1. [P24071-11]
CCDS42624.1. [P24071-9]
CCDS42625.1. [P24071-8]
CCDS46180.1. [P24071-4]
PIRiG02630.
JH0332.
RefSeqiNP_001991.1. NM_002000.2. [P24071-1]
NP_579803.1. NM_133269.2. [P24071-2]
NP_579805.1. NM_133271.2. [P24071-3]
NP_579806.1. NM_133272.2. [P24071-10]
NP_579807.1. NM_133273.2. [P24071-9]
NP_579808.1. NM_133274.2. [P24071-8]
NP_579811.1. NM_133277.2. [P24071-7]
NP_579812.1. NM_133278.2. [P24071-11]
NP_579813.1. NM_133279.2. [P24071-4]
UniGeneiHs.659872.

Genome annotation databases

EnsembliENST00000345937; ENSP00000338257; ENSG00000186431. [P24071-3]
ENST00000353758; ENSP00000338058; ENSG00000186431. [P24071-7]
ENST00000355524; ENSP00000347714; ENSG00000186431. [P24071-1]
ENST00000359272; ENSP00000352218; ENSG00000186431. [P24071-10]
ENST00000391723; ENSP00000375603; ENSG00000186431. [P24071-8]
ENST00000391724; ENSP00000375604; ENSG00000186431. [P24071-11]
ENST00000391725; ENSP00000375605; ENSG00000186431. [P24071-2]
ENST00000391726; ENSP00000375606; ENSG00000186431. [P24071-9]
ENST00000469767; ENSP00000473814; ENSG00000186431. [P24071-4]
ENST00000488066; ENSP00000474512; ENSG00000186431. [P24071-5]
ENST00000610340; ENSP00000477610; ENSG00000275136. [P24071-8]
ENST00000610397; ENSP00000480965; ENSG00000275269. [P24071-3]
ENST00000610786; ENSP00000483121; ENSG00000276858. [P24071-8]
ENST00000611018; ENSP00000484483; ENSG00000275970. [P24071-11]
ENST00000611130; ENSP00000484917; ENSG00000273738. [P24071-11]
ENST00000611871; ENSP00000482976; ENSG00000273738. [P24071-10]
ENST00000611943; ENSP00000482273; ENSG00000275564. [P24071-2]
ENST00000612150; ENSP00000478233; ENSG00000275136. [P24071-3]
ENST00000612159; ENSP00000484662; ENSG00000276985. [P24071-9]
ENST00000612505; ENSP00000479792; ENSG00000276985. [P24071-8]
ENST00000612803; ENSP00000478454; ENSG00000275970. [P24071-8]
ENST00000612815; ENSP00000483503; ENSG00000275269. [P24071-8]
ENST00000612836; ENSP00000477977; ENSG00000278415.
ENST00000612918; ENSP00000482056; ENSG00000274580. [P24071-3]
ENST00000613199; ENSP00000478465; ENSG00000276858. [P24071-1]
ENST00000613201; ENSP00000482108; ENSG00000274580. [P24071-4]
ENST00000613298; ENSP00000482451; ENSG00000275269. [P24071-9]
ENST00000613318; ENSP00000481560; ENSG00000273738. [P24071-4]
ENST00000613663; ENSP00000483437; ENSG00000275564. [P24071-4]
ENST00000613685; ENSP00000481230; ENSG00000275564. [P24071-11]
ENST00000614226; ENSP00000483099; ENSG00000276985. [P24071-1]
ENST00000614298; ENSP00000483472; ENSG00000275970. [P24071-9]
ENST00000614433; ENSP00000480748; ENSG00000276985. [P24071-2]
ENST00000614689; ENSP00000480013; ENSG00000273738. [P24071-5]
ENST00000614893; ENSP00000477966; ENSG00000273738. [P24071-2]
ENST00000614917; ENSP00000479831; ENSG00000275970. [P24071-2]
ENST00000614954; ENSP00000479924; ENSG00000276858. [P24071-9]
ENST00000615040; ENSP00000477656; ENSG00000276858. [P24071-10]
ENST00000615110; ENSP00000484276; ENSG00000274580. [P24071-2]
ENST00000615361; ENSP00000482741; ENSG00000273738. [P24071-9]
ENST00000615703; ENSP00000484868; ENSG00000275136. [P24071-4]
ENST00000615719; ENSP00000482518; ENSG00000275136. [P24071-7]
ENST00000615800; ENSP00000483841; ENSG00000276985. [P24071-4]
ENST00000615829; ENSP00000482623; ENSG00000274580. [P24071-1]
ENST00000615937; ENSP00000478075; ENSG00000274580. [P24071-11]
ENST00000616340; ENSP00000481676; ENSG00000275269. [P24071-10]
ENST00000616878; ENSP00000480970; ENSG00000275136. [P24071-9]
ENST00000616969; ENSP00000479039; ENSG00000275564. [P24071-5]
ENST00000617025; ENSP00000481129; ENSG00000276985. [P24071-3]
ENST00000617609; ENSP00000481394; ENSG00000274580. [P24071-10]
ENST00000617696; ENSP00000482670; ENSG00000274580. [P24071-9]
ENST00000617762; ENSP00000484136; ENSG00000276858. [P24071-5]
ENST00000617766; ENSP00000479230; ENSG00000275269. [P24071-4]
ENST00000617778; ENSP00000480498; ENSG00000273738. [P24071-3]
ENST00000617964; ENSP00000484141; ENSG00000275564. [P24071-7]
ENST00000618271; ENSP00000484741; ENSG00000276985. [P24071-7]
ENST00000618287; ENSP00000481668; ENSG00000275564. [P24071-10]
ENST00000618328; ENSP00000480496; ENSG00000276985. [P24071-10]
ENST00000618658; ENSP00000479688; ENSG00000275970. [P24071-4]
ENST00000618805; ENSP00000481985; ENSG00000275269. [P24071-2]
ENST00000618985; ENSP00000480323; ENSG00000275269. [P24071-5]
ENST00000619073; ENSP00000479360; ENSG00000273738. [P24071-8]
ENST00000619155; ENSP00000480461; ENSG00000275970. [P24071-5]
ENST00000619385; ENSP00000482334; ENSG00000275269. [P24071-1]
ENST00000619414; ENSP00000478163; ENSG00000276858. [P24071-2]
ENST00000619822; ENSP00000483250; ENSG00000275136. [P24071-2]
ENST00000620162; ENSP00000483258; ENSG00000276858. [P24071-11]
ENST00000620179; ENSP00000478315; ENSG00000278415. [P24071-7]
ENST00000620270; ENSP00000482022; ENSG00000276985. [P24071-11]
ENST00000620397; ENSP00000477584; ENSG00000276985. [P24071-5]
ENST00000620801; ENSP00000481195; ENSG00000275970. [P24071-1]
ENST00000620822; ENSP00000483327; ENSG00000275269. [P24071-7]
ENST00000620873; ENSP00000479099; ENSG00000275269. [P24071-11]
ENST00000621004; ENSP00000484816; ENSG00000275970. [P24071-10]
ENST00000621009; ENSP00000482025; ENSG00000275970. [P24071-3]
ENST00000621289; ENSP00000481366; ENSG00000275136. [P24071-5]
ENST00000621417; ENSP00000478634; ENSG00000274580. [P24071-5]
ENST00000621684; ENSP00000479239; ENSG00000276858. [P24071-3]
ENST00000621702; ENSP00000482807; ENSG00000275136. [P24071-1]
ENST00000621755; ENSP00000484906; ENSG00000275970. [P24071-7]
ENST00000621882; ENSP00000484272; ENSG00000274580. [P24071-7]
ENST00000622157; ENSP00000481502; ENSG00000275564. [P24071-1]
ENST00000622470; ENSP00000477673; ENSG00000276858. [P24071-7]
ENST00000622491; ENSP00000477643; ENSG00000274580. [P24071-8]
ENST00000622543; ENSP00000483402; ENSG00000275564. [P24071-3]
ENST00000622646; ENSP00000480406; ENSG00000273738. [P24071-7]
ENST00000622737; ENSP00000479738; ENSG00000273738. [P24071-1]
ENST00000622777; ENSP00000481345; ENSG00000275136. [P24071-10]
ENST00000622883; ENSP00000479880; ENSG00000276858. [P24071-4]
ENST00000622904; ENSP00000480444; ENSG00000275136. [P24071-11]
GeneIDi2204.
KEGGihsa:2204.
UCSCiuc002qhq.3. human. [P24071-4]
uc002qhr.1. human. [P24071-1]
uc002qhs.2. human. [P24071-9]
uc002qht.1. human. [P24071-11]
uc002qhu.1. human. [P24071-3]
uc002qhv.1. human. [P24071-2]
uc002qhw.1. human. [P24071-10]
uc002qhz.1. human. [P24071-8]
uc002qia.1. human. [P24071-7]

Polymorphism databases

DMDMi119860.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54150 mRNA. Translation: CAA38089.1 .
X87767
, X87768 , X87769 , X87766 , X87765 Genomic DNA. Translation: CAA61039.1 .
U43774 mRNA. Translation: AAC50639.1 .
U43677 mRNA. Translation: AAC50595.1 .
U56236 mRNA. Translation: AAB00566.1 .
U56237 mRNA. Translation: AAB00567.1 .
S82919 mRNA. Translation: AAD14421.1 .
D87853 mRNA. Translation: BAA13471.1 .
D87854 mRNA. Translation: BAA13472.1 .
D87855 mRNA. Translation: BAA13473.1 .
D87856 mRNA. Translation: BAA13474.1 .
D87857 mRNA. Translation: BAA13475.1 .
D87859 mRNA. Translation: BAA13477.1 .
D87861 mRNA. Translation: BAA13479.1 .
D87862 mRNA. Translation: BAA13480.1 .
DQ075334 mRNA. Translation: AAZ76577.1 .
DQ075335 mRNA. Translation: AAZ76578.1 .
DQ075336 mRNA. Translation: AAZ76579.1 .
DQ075337 mRNA. Translation: AAZ76580.1 .
DQ075338 mRNA. Translation: AAZ76581.1 .
DQ075339 mRNA. Translation: AAZ76582.1 .
AC011501 Genomic DNA. No translation available.
BC027953 mRNA. Translation: AAH27953.1 .
CCDSi CCDS12907.1. [P24071-1 ]
CCDS12908.1. [P24071-3 ]
CCDS12909.1. [P24071-10 ]
CCDS12910.1. [P24071-7 ]
CCDS42622.1. [P24071-2 ]
CCDS42623.1. [P24071-11 ]
CCDS42624.1. [P24071-9 ]
CCDS42625.1. [P24071-8 ]
CCDS46180.1. [P24071-4 ]
PIRi G02630.
JH0332.
RefSeqi NP_001991.1. NM_002000.2. [P24071-1 ]
NP_579803.1. NM_133269.2. [P24071-2 ]
NP_579805.1. NM_133271.2. [P24071-3 ]
NP_579806.1. NM_133272.2. [P24071-10 ]
NP_579807.1. NM_133273.2. [P24071-9 ]
NP_579808.1. NM_133274.2. [P24071-8 ]
NP_579811.1. NM_133277.2. [P24071-7 ]
NP_579812.1. NM_133278.2. [P24071-11 ]
NP_579813.1. NM_133279.2. [P24071-4 ]
UniGenei Hs.659872.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1OVZ X-ray 3.00 A/B 22-216 [» ]
1OW0 X-ray 3.10 C/D 22-216 [» ]
1UCT X-ray 2.10 A 21-229 [» ]
DisProti DP00311.
ProteinModelPortali P24071.
SMRi P24071. Positions 27-216.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108498. 5 interactions.
IntActi P24071. 2 interactions.

Protein family/group databases

MEROPSi I43.951.

PTM databases

PhosphoSitei P24071.

Polymorphism databases

DMDMi 119860.

Proteomic databases

PaxDbi P24071.
PRIDEi P24071.

Protocols and materials databases

DNASUi 2204.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000345937 ; ENSP00000338257 ; ENSG00000186431 . [P24071-3 ]
ENST00000353758 ; ENSP00000338058 ; ENSG00000186431 . [P24071-7 ]
ENST00000355524 ; ENSP00000347714 ; ENSG00000186431 . [P24071-1 ]
ENST00000359272 ; ENSP00000352218 ; ENSG00000186431 . [P24071-10 ]
ENST00000391723 ; ENSP00000375603 ; ENSG00000186431 . [P24071-8 ]
ENST00000391724 ; ENSP00000375604 ; ENSG00000186431 . [P24071-11 ]
ENST00000391725 ; ENSP00000375605 ; ENSG00000186431 . [P24071-2 ]
ENST00000391726 ; ENSP00000375606 ; ENSG00000186431 . [P24071-9 ]
ENST00000469767 ; ENSP00000473814 ; ENSG00000186431 . [P24071-4 ]
ENST00000488066 ; ENSP00000474512 ; ENSG00000186431 . [P24071-5 ]
ENST00000610340 ; ENSP00000477610 ; ENSG00000275136 . [P24071-8 ]
ENST00000610397 ; ENSP00000480965 ; ENSG00000275269 . [P24071-3 ]
ENST00000610786 ; ENSP00000483121 ; ENSG00000276858 . [P24071-8 ]
ENST00000611018 ; ENSP00000484483 ; ENSG00000275970 . [P24071-11 ]
ENST00000611130 ; ENSP00000484917 ; ENSG00000273738 . [P24071-11 ]
ENST00000611871 ; ENSP00000482976 ; ENSG00000273738 . [P24071-10 ]
ENST00000611943 ; ENSP00000482273 ; ENSG00000275564 . [P24071-2 ]
ENST00000612150 ; ENSP00000478233 ; ENSG00000275136 . [P24071-3 ]
ENST00000612159 ; ENSP00000484662 ; ENSG00000276985 . [P24071-9 ]
ENST00000612505 ; ENSP00000479792 ; ENSG00000276985 . [P24071-8 ]
ENST00000612803 ; ENSP00000478454 ; ENSG00000275970 . [P24071-8 ]
ENST00000612815 ; ENSP00000483503 ; ENSG00000275269 . [P24071-8 ]
ENST00000612836 ; ENSP00000477977 ; ENSG00000278415 .
ENST00000612918 ; ENSP00000482056 ; ENSG00000274580 . [P24071-3 ]
ENST00000613199 ; ENSP00000478465 ; ENSG00000276858 . [P24071-1 ]
ENST00000613201 ; ENSP00000482108 ; ENSG00000274580 . [P24071-4 ]
ENST00000613298 ; ENSP00000482451 ; ENSG00000275269 . [P24071-9 ]
ENST00000613318 ; ENSP00000481560 ; ENSG00000273738 . [P24071-4 ]
ENST00000613663 ; ENSP00000483437 ; ENSG00000275564 . [P24071-4 ]
ENST00000613685 ; ENSP00000481230 ; ENSG00000275564 . [P24071-11 ]
ENST00000614226 ; ENSP00000483099 ; ENSG00000276985 . [P24071-1 ]
ENST00000614298 ; ENSP00000483472 ; ENSG00000275970 . [P24071-9 ]
ENST00000614433 ; ENSP00000480748 ; ENSG00000276985 . [P24071-2 ]
ENST00000614689 ; ENSP00000480013 ; ENSG00000273738 . [P24071-5 ]
ENST00000614893 ; ENSP00000477966 ; ENSG00000273738 . [P24071-2 ]
ENST00000614917 ; ENSP00000479831 ; ENSG00000275970 . [P24071-2 ]
ENST00000614954 ; ENSP00000479924 ; ENSG00000276858 . [P24071-9 ]
ENST00000615040 ; ENSP00000477656 ; ENSG00000276858 . [P24071-10 ]
ENST00000615110 ; ENSP00000484276 ; ENSG00000274580 . [P24071-2 ]
ENST00000615361 ; ENSP00000482741 ; ENSG00000273738 . [P24071-9 ]
ENST00000615703 ; ENSP00000484868 ; ENSG00000275136 . [P24071-4 ]
ENST00000615719 ; ENSP00000482518 ; ENSG00000275136 . [P24071-7 ]
ENST00000615800 ; ENSP00000483841 ; ENSG00000276985 . [P24071-4 ]
ENST00000615829 ; ENSP00000482623 ; ENSG00000274580 . [P24071-1 ]
ENST00000615937 ; ENSP00000478075 ; ENSG00000274580 . [P24071-11 ]
ENST00000616340 ; ENSP00000481676 ; ENSG00000275269 . [P24071-10 ]
ENST00000616878 ; ENSP00000480970 ; ENSG00000275136 . [P24071-9 ]
ENST00000616969 ; ENSP00000479039 ; ENSG00000275564 . [P24071-5 ]
ENST00000617025 ; ENSP00000481129 ; ENSG00000276985 . [P24071-3 ]
ENST00000617609 ; ENSP00000481394 ; ENSG00000274580 . [P24071-10 ]
ENST00000617696 ; ENSP00000482670 ; ENSG00000274580 . [P24071-9 ]
ENST00000617762 ; ENSP00000484136 ; ENSG00000276858 . [P24071-5 ]
ENST00000617766 ; ENSP00000479230 ; ENSG00000275269 . [P24071-4 ]
ENST00000617778 ; ENSP00000480498 ; ENSG00000273738 . [P24071-3 ]
ENST00000617964 ; ENSP00000484141 ; ENSG00000275564 . [P24071-7 ]
ENST00000618271 ; ENSP00000484741 ; ENSG00000276985 . [P24071-7 ]
ENST00000618287 ; ENSP00000481668 ; ENSG00000275564 . [P24071-10 ]
ENST00000618328 ; ENSP00000480496 ; ENSG00000276985 . [P24071-10 ]
ENST00000618658 ; ENSP00000479688 ; ENSG00000275970 . [P24071-4 ]
ENST00000618805 ; ENSP00000481985 ; ENSG00000275269 . [P24071-2 ]
ENST00000618985 ; ENSP00000480323 ; ENSG00000275269 . [P24071-5 ]
ENST00000619073 ; ENSP00000479360 ; ENSG00000273738 . [P24071-8 ]
ENST00000619155 ; ENSP00000480461 ; ENSG00000275970 . [P24071-5 ]
ENST00000619385 ; ENSP00000482334 ; ENSG00000275269 . [P24071-1 ]
ENST00000619414 ; ENSP00000478163 ; ENSG00000276858 . [P24071-2 ]
ENST00000619822 ; ENSP00000483250 ; ENSG00000275136 . [P24071-2 ]
ENST00000620162 ; ENSP00000483258 ; ENSG00000276858 . [P24071-11 ]
ENST00000620179 ; ENSP00000478315 ; ENSG00000278415 . [P24071-7 ]
ENST00000620270 ; ENSP00000482022 ; ENSG00000276985 . [P24071-11 ]
ENST00000620397 ; ENSP00000477584 ; ENSG00000276985 . [P24071-5 ]
ENST00000620801 ; ENSP00000481195 ; ENSG00000275970 . [P24071-1 ]
ENST00000620822 ; ENSP00000483327 ; ENSG00000275269 . [P24071-7 ]
ENST00000620873 ; ENSP00000479099 ; ENSG00000275269 . [P24071-11 ]
ENST00000621004 ; ENSP00000484816 ; ENSG00000275970 . [P24071-10 ]
ENST00000621009 ; ENSP00000482025 ; ENSG00000275970 . [P24071-3 ]
ENST00000621289 ; ENSP00000481366 ; ENSG00000275136 . [P24071-5 ]
ENST00000621417 ; ENSP00000478634 ; ENSG00000274580 . [P24071-5 ]
ENST00000621684 ; ENSP00000479239 ; ENSG00000276858 . [P24071-3 ]
ENST00000621702 ; ENSP00000482807 ; ENSG00000275136 . [P24071-1 ]
ENST00000621755 ; ENSP00000484906 ; ENSG00000275970 . [P24071-7 ]
ENST00000621882 ; ENSP00000484272 ; ENSG00000274580 . [P24071-7 ]
ENST00000622157 ; ENSP00000481502 ; ENSG00000275564 . [P24071-1 ]
ENST00000622470 ; ENSP00000477673 ; ENSG00000276858 . [P24071-7 ]
ENST00000622491 ; ENSP00000477643 ; ENSG00000274580 . [P24071-8 ]
ENST00000622543 ; ENSP00000483402 ; ENSG00000275564 . [P24071-3 ]
ENST00000622646 ; ENSP00000480406 ; ENSG00000273738 . [P24071-7 ]
ENST00000622737 ; ENSP00000479738 ; ENSG00000273738 . [P24071-1 ]
ENST00000622777 ; ENSP00000481345 ; ENSG00000275136 . [P24071-10 ]
ENST00000622883 ; ENSP00000479880 ; ENSG00000276858 . [P24071-4 ]
ENST00000622904 ; ENSP00000480444 ; ENSG00000275136 . [P24071-11 ]
GeneIDi 2204.
KEGGi hsa:2204.
UCSCi uc002qhq.3. human. [P24071-4 ]
uc002qhr.1. human. [P24071-1 ]
uc002qhs.2. human. [P24071-9 ]
uc002qht.1. human. [P24071-11 ]
uc002qhu.1. human. [P24071-3 ]
uc002qhv.1. human. [P24071-2 ]
uc002qhw.1. human. [P24071-10 ]
uc002qhz.1. human. [P24071-8 ]
uc002qia.1. human. [P24071-7 ]

Organism-specific databases

CTDi 2204.
GeneCardsi GC19P055386.
HGNCi HGNC:3608. FCAR.
HPAi HPA014050.
MIMi 147045. gene.
neXtProti NX_P24071.
PharmGKBi PA28055.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG41820.
GeneTreei ENSGT00760000119033.
HOGENOMi HOG000234395.
HOVERGENi HBG004337.
InParanoidi P24071.
KOi K06513.
OrthoDBi EOG78SQGZ.
PhylomeDBi P24071.
TreeFami TF336644.

Miscellaneous databases

ChiTaRSi FCAR. human.
EvolutionaryTracei P24071.
GeneWikii FCAR.
GenomeRNAii 2204.
NextBioi 8911.
PROi P24071.
SOURCEi Search...

Gene expression databases

Bgeei P24071.
CleanExi HS_FCAR.
ExpressionAtlasi P24071. baseline and differential.
Genevestigatori P24071.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view ]
SMARTi SM00409. IG. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A.1).
  2. "Structure of the gene for the human myeloid IgA Fc receptor (CD89)."
    de Wit T.P.M., Morton H.C., Capel P.J.A., van de Winkel J.G.J.
    J. Immunol. 155:1203-1209(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM A.1).
    Tissue: Bone marrow.
  3. "Identification of Fc alpha receptor (CD89) isoforms generated by alternative splicing that are differentially expressed between blood monocytes and alveolar macrophages."
    Patry C., Sibille Y., Lehuen A., Monteiro R.C.
    J. Immunol. 156:4442-4448(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A.2 AND A.3), TISSUE SPECIFICITY.
    Tissue: Alveolar macrophage and Monocyte.
  4. van Dijk T.B., Morton H.C., Caldenhoven E., Bracke M., Raaijmakers J.A.M., Lammers J.W.J., Koenderman L., Groot R.P.
    Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE (ISOFORMS B AND B-DELTA-S2).
  5. "Alternative splicing of the human IgA Fc receptor CD89 in neutrophils and eosinophils."
    Pleass R.J., Andrews P.D., Kerr M.A., Woof J.M.
    Biochem. J. 318:771-777(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A.3), TISSUE SPECIFICITY.
  6. "IgA nephropathy-specific expression of the IgA Fc receptors (CD89) on blood phagocytic cells."
    Toyabe S., Kuwano Y., Takeda K., Uchiyama M., Abo T.
    Clin. Exp. Immunol. 110:226-232(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A.2; A.3; L10; U02; U09; U10; U11 AND U13).
  7. "Episodes of natural selection shaped the interactions of IgA-Fc with FcalphaRI and bacterial decoy proteins."
    Abi-Rached L., Dorighi K., Norman P.J., Yawata M., Parham P.
    J. Immunol. 178:7943-7954(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A.1), VARIANTS ASN-113 AND GLY-269.
  8. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A.1).
    Tissue: Blood.
  10. "Association of IgA-Fc receptors (Fc alpha R) with Fc epsilon RI gamma 2 subunits in U937 cells. Aggregation induces the tyrosine phosphorylation of gamma 2."
    Pfefferkorn L.C., Yeaman G.R.
    J. Immunol. 153:3228-3236(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT.
  11. Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
  12. "Crystal structure of the ectodomain of human FcalphaRI."
    Ding Y., Xu G., Yang M., Yao M., Gao G.F., Wang L., Zhang W., Rao Z.
    J. Biol. Chem. 278:27966-27970(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 21-229, DISULFIDE BONDS.
  13. "Insights into IgA-mediated immune responses from the crystal structures of human FcalphaRI and its complex with IgA1-Fc."
    Herr A.B., Ballister E.R., Bjorkman P.J.
    Nature 423:614-620(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 22-216 IN COMPLEX WITH IMMUNOGLOBULIN ALPHA, FUNCTION, DISULFIDE BONDS, GLYCOSYLATION AT ASN-141 AND ASN-177.

Entry informationi

Entry nameiFCAR_HUMAN
AccessioniPrimary (citable) accession number: P24071
Secondary accession number(s): Q13603
, Q13604, Q15727, Q15728, Q1AJL7, Q1AJL8, Q1AJL9, Q53X38, Q53X39, Q92587, Q92588, Q92590, Q92592, Q92593, Q9UEK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: November 26, 2014
This is version 150 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3