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P24071 (FCAR_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 144. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Immunoglobulin alpha Fc receptor

Short name=IgA Fc receptor
Alternative name(s):
CD_antigen=CD89
Gene names
Name:FCAR
Synonyms:CD89
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length287 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production. Ref.13

Subunit structure

Associates with the Fc epsilon RI gamma 2 receptor inducing tyrosine phosphorylation of gamma 2. Ref.10

Subcellular location

Isoform A.1: Cell membrane; Single-pass type I membrane protein.

Isoform A.2: Cell membrane; Single-pass type I membrane protein.

Isoform A.3: Cell membrane; Single-pass type I membrane protein.

Isoform B: Secreted.

Isoform B-delta-S2: Secreted.

Tissue specificity

Isoform A1, isoform A2 and isoform A3 are differentially expressed between blood and mucosal myeloid cells. Isoform A1, isoform A2 and isoform A3 are expressed in monocytes. Isoform A1 and isoform A2 are expressed in alveolar macrophages; however only one isoform isexpressed at alveolar macrophages surfaces. Ref.3 Ref.5

Sequence similarities

Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

Alternative products

This entry describes 11 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.
Isoform A.1 (identifier: P24071-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform A.2 (identifier: P24071-2)

The sequence of this isoform differs from the canonical sequence as follows:
     195-216: Missing.
Isoform A.3 (identifier: P24071-3)

Also known as: RLA2;

The sequence of this isoform differs from the canonical sequence as follows:
     121-216: Missing.
Isoform B (identifier: P24071-4)

The sequence of this isoform differs from the canonical sequence as follows:
     217-287: DSIHQDYTTQ...TFARTPSVCK → GRYRPVQPCVWVGCPGPCHRAGI
Isoform B-delta-S2 (identifier: P24071-5)

The sequence of this isoform differs from the canonical sequence as follows:
     12-23: Missing.
     217-287: DSIHQDYTTQ...TFARTPSVCK → GRYRPVQPCVWVGCPGPCHRAGI
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Isoform U02 (identifier: P24071-6)

The sequence of this isoform differs from the canonical sequence as follows:
     24-24: G → GRYISEHFWCRSLGCNPVNDASAQRPG
     195-216: Missing.
Isoform L10 (identifier: P24071-7)

The sequence of this isoform differs from the canonical sequence as follows:
     12-23: Missing.
     24-120: Missing.
Isoform U09 (identifier: P24071-8)

The sequence of this isoform differs from the canonical sequence as follows:
     12-23: Missing.
     193-287: CYGWYNRSPY...TFARTPSVCK → LHPPRLHDAELDPHGRGRTGPRGSLGHTG
Isoform U10 (identifier: P24071-9)

The sequence of this isoform differs from the canonical sequence as follows:
     12-23: Missing.
     115-210: Missing.
Isoform U11 (identifier: P24071-10)

The sequence of this isoform differs from the canonical sequence as follows:
     12-23: Missing.
Isoform U13 (identifier: P24071-11)

The sequence of this isoform differs from the canonical sequence as follows:
     12-23: Missing.
     195-216: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 287266Immunoglobulin alpha Fc receptor
PRO_0000015138

Regions

Topological domain22 – 227206Extracellular Potential
Transmembrane228 – 24619Helical; Potential
Topological domain247 – 28741Cytoplasmic Potential
Domain42 – 10766Ig-like C2-type 1
Domain139 – 20062Ig-like C2-type 2

Amino acid modifications

Glycosylation651N-linked (GlcNAc...) Potential
Glycosylation791N-linked (GlcNAc...) Potential
Glycosylation1411N-linked (GlcNAc...) Ref.13
Glycosylation1771N-linked (GlcNAc...) Ref.13
Glycosylation1861N-linked (GlcNAc...) Potential
Glycosylation1981N-linked (GlcNAc...) Potential
Disulfide bond49 ↔ 100 Ref.12 Ref.13
Disulfide bond146 ↔ 193 Ref.12 Ref.13

Natural variations

Alternative sequence12 – 2312Missing in isoform B-delta-S2, isoform L10, isoform U09, isoform U10, isoform U11 and isoform U13.
VSP_002632
Alternative sequence24 – 12097Missing in isoform L10.
VSP_043565
Alternative sequence241G → GRYISEHFWCRSLGCNPVND ASAQRPG in isoform U02.
VSP_002633
Alternative sequence115 – 21096Missing in isoform U10.
VSP_043566
Alternative sequence121 – 21696Missing in isoform A.3.
VSP_002634
Alternative sequence193 – 28795CYGWY…PSVCK → LHPPRLHDAELDPHGRGRTG PRGSLGHTG in isoform U09.
VSP_043567
Alternative sequence195 – 21622Missing in isoform A.2, isoform U02 and isoform U13.
VSP_002635
Alternative sequence217 – 28771DSIHQ…PSVCK → GRYRPVQPCVWVGCPGPCHR AGI in isoform B and isoform B-delta-S2.
VSP_002636
Natural variant1131D → N. Ref.7
Corresponds to variant rs11666735 [ dbSNP | Ensembl ].
VAR_049996
Natural variant2691S → G. Ref.7
Corresponds to variant rs16986050 [ dbSNP | Ensembl ].
VAR_049997

Secondary structure

................................................. 287
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform A.1 [UniParc].

Last modified March 1, 1992. Version 1.
Checksum: A2CCA68467CD45F7

FASTA28732,265
        10         20         30         40         50         60 
MDPKQTTLLC LVLCLGQRIQ AQEGDFPMPF ISAKSSPVIP LDGSVKIQCQ AIREAYLTQL 

        70         80         90        100        110        120 
MIIKNSTYRE IGRRLKFWNE TDPEFVIDHM DANKAGRYQC QYRIGHYRFR YSDTLELVVT 

       130        140        150        160        170        180 
GLYGKPFLSA DRGLVLMPGE NISLTCSSAH IPFDRFSLAK EGELSLPQHQ SGEHPANFSL 

       190        200        210        220        230        240 
GPVDLNVSGI YRCYGWYNRS PYLWSFPSNA LELVVTDSIH QDYTTQNLIR MAVAGLVLVA 

       250        260        270        280 
LLAILVENWH SHTALNKEAS ADVAEPSWSQ QMCQPGLTFA RTPSVCK 

« Hide

Isoform A.2 [UniParc].

Checksum: 81F71B405469B93A
Show »

FASTA26529,683
Isoform A.3 (RLA2) [UniParc].

Checksum: B5B6854F0437AEBE
Show »

FASTA19121,694
Isoform B [UniParc].

Checksum: 4B080309BFAB38E5
Show »

FASTA23926,996
Isoform B-delta-S2 [UniParc].

Checksum: 6C8D9A590920EA83
Show »

FASTA22725,656
Isoform U02 [UniParc].

Checksum: 1DF65E4E613DA0C3
Show »

FASTA29132,629
Isoform L10 [UniParc].

Checksum: CD9549BF14EE74DF
Show »

FASTA17819,593
Isoform U09 [UniParc].

Checksum: 0C10F3D72BEC5366
Show »

FASTA20923,394
Isoform U10 [UniParc].

Checksum: D31062C1B384F6BB
Show »

FASTA17920,354
Isoform U11 [UniParc].

Checksum: 47B8C498C56C82A8
Show »

FASTA27530,925
Isoform U13 [UniParc].

Checksum: 6081B1C3F5BDED61
Show »

FASTA25328,343

References

« Hide 'large scale' references
[1]"Expression cloning of a human Fc receptor for IgA."
Maliszewski C.R., March C.J., Schoenborn M.A., Gimpel S., Shen L.
J. Exp. Med. 172:1665-1672(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A.1).
[2]"Structure of the gene for the human myeloid IgA Fc receptor (CD89)."
de Wit T.P.M., Morton H.C., Capel P.J.A., van de Winkel J.G.J.
J. Immunol. 155:1203-1209(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM A.1).
Tissue: Bone marrow.
[3]"Identification of Fc alpha receptor (CD89) isoforms generated by alternative splicing that are differentially expressed between blood monocytes and alveolar macrophages."
Patry C., Sibille Y., Lehuen A., Monteiro R.C.
J. Immunol. 156:4442-4448(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A.2 AND A.3), TISSUE SPECIFICITY.
Tissue: Alveolar macrophage and Monocyte.
[4]van Dijk T.B., Morton H.C., Caldenhoven E., Bracke M., Raaijmakers J.A.M., Lammers J.W.J., Koenderman L., Groot R.P.
Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE (ISOFORMS B AND B-DELTA-S2).
[5]"Alternative splicing of the human IgA Fc receptor CD89 in neutrophils and eosinophils."
Pleass R.J., Andrews P.D., Kerr M.A., Woof J.M.
Biochem. J. 318:771-777(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A.3), TISSUE SPECIFICITY.
[6]"IgA nephropathy-specific expression of the IgA Fc receptors (CD89) on blood phagocytic cells."
Toyabe S., Kuwano Y., Takeda K., Uchiyama M., Abo T.
Clin. Exp. Immunol. 110:226-232(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A.2; A.3; L10; U02; U09; U10; U11 AND U13).
[7]"Episodes of natural selection shaped the interactions of IgA-Fc with FcalphaRI and bacterial decoy proteins."
Abi-Rached L., Dorighi K., Norman P.J., Yawata M., Parham P.
J. Immunol. 178:7943-7954(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A.1), VARIANTS ASN-113 AND GLY-269.
[8]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A.1).
Tissue: Blood.
[10]"Association of IgA-Fc receptors (Fc alpha R) with Fc epsilon RI gamma 2 subunits in U937 cells. Aggregation induces the tyrosine phosphorylation of gamma 2."
Pfefferkorn L.C., Yeaman G.R.
J. Immunol. 153:3228-3236(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBUNIT.
[11]"An unappreciated role for RNA surveillance."
Hillman R.T., Green R.E., Brenner S.E.
Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
[12]"Crystal structure of the ectodomain of human FcalphaRI."
Ding Y., Xu G., Yang M., Yao M., Gao G.F., Wang L., Zhang W., Rao Z.
J. Biol. Chem. 278:27966-27970(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 21-229, DISULFIDE BONDS.
[13]"Insights into IgA-mediated immune responses from the crystal structures of human FcalphaRI and its complex with IgA1-Fc."
Herr A.B., Ballister E.R., Bjorkman P.J.
Nature 423:614-620(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 22-216 IN COMPLEX WITH IMMUNOGLOBULIN ALPHA, FUNCTION, DISULFIDE BONDS, GLYCOSYLATION AT ASN-141 AND ASN-177.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X54150 mRNA. Translation: CAA38089.1.
X87767 expand/collapse EMBL AC list , X87768, X87769, X87766, X87765 Genomic DNA. Translation: CAA61039.1.
U43774 mRNA. Translation: AAC50639.1.
U43677 mRNA. Translation: AAC50595.1.
U56236 mRNA. Translation: AAB00566.1.
U56237 mRNA. Translation: AAB00567.1.
S82919 mRNA. Translation: AAD14421.1.
D87853 mRNA. Translation: BAA13471.1.
D87854 mRNA. Translation: BAA13472.1.
D87855 mRNA. Translation: BAA13473.1.
D87856 mRNA. Translation: BAA13474.1.
D87857 mRNA. Translation: BAA13475.1.
D87859 mRNA. Translation: BAA13477.1.
D87861 mRNA. Translation: BAA13479.1.
D87862 mRNA. Translation: BAA13480.1.
DQ075334 mRNA. Translation: AAZ76577.1.
DQ075335 mRNA. Translation: AAZ76578.1.
DQ075336 mRNA. Translation: AAZ76579.1.
DQ075337 mRNA. Translation: AAZ76580.1.
DQ075338 mRNA. Translation: AAZ76581.1.
DQ075339 mRNA. Translation: AAZ76582.1.
AC011501 Genomic DNA. No translation available.
BC027953 mRNA. Translation: AAH27953.1.
PIRG02630.
JH0332.
RefSeqNP_001991.1. NM_002000.2.
NP_579803.1. NM_133269.2.
NP_579805.1. NM_133271.2.
NP_579806.1. NM_133272.2.
NP_579807.1. NM_133273.2.
NP_579808.1. NM_133274.2.
NP_579811.1. NM_133277.2.
NP_579812.1. NM_133278.2.
NP_579813.1. NM_133279.2.
UniGeneHs.659872.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1OVZX-ray3.00A/B22-216[»]
1OW0X-ray3.10C/D22-216[»]
1UCTX-ray2.10A21-229[»]
DisProtDP00311.
ProteinModelPortalP24071.
SMRP24071. Positions 27-266.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid108498. 3 interactions.
IntActP24071. 2 interactions.

Protein family/group databases

MEROPSI43.951.

PTM databases

PhosphoSiteP24071.

Polymorphism databases

DMDM119860.

Proteomic databases

PaxDbP24071.
PRIDEP24071.

Protocols and materials databases

DNASU2204.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000345937; ENSP00000338257; ENSG00000186431. [P24071-3]
ENST00000353758; ENSP00000338058; ENSG00000186431. [P24071-7]
ENST00000355524; ENSP00000347714; ENSG00000186431. [P24071-1]
ENST00000359272; ENSP00000352218; ENSG00000186431. [P24071-10]
ENST00000391723; ENSP00000375603; ENSG00000186431. [P24071-8]
ENST00000391724; ENSP00000375604; ENSG00000186431. [P24071-11]
ENST00000391725; ENSP00000375605; ENSG00000186431. [P24071-2]
ENST00000391726; ENSP00000375606; ENSG00000186431. [P24071-9]
ENST00000469767; ENSP00000473814; ENSG00000186431. [P24071-4]
ENST00000488066; ENSP00000474512; ENSG00000186431. [P24071-5]
ENST00000571746; ENSP00000461560; ENSG00000262827. [P24071-9]
ENST00000572089; ENSP00000475034; ENSG00000262827. [P24071-4]
ENST00000573273; ENSP00000460893; ENSG00000262827. [P24071-8]
ENST00000573433; ENSP00000459334; ENSG00000262827. [P24071-2]
ENST00000574058; ENSP00000461176; ENSG00000262827. [P24071-3]
ENST00000574238; ENSP00000461886; ENSG00000262827. [P24071-7]
ENST00000574664; ENSP00000474317; ENSG00000262827. [P24071-5]
ENST00000574738; ENSP00000459672; ENSG00000262827. [P24071-11]
ENST00000575074; ENSP00000458478; ENSG00000262827. [P24071-10]
ENST00000576265; ENSP00000459762; ENSG00000262827. [P24071-1]
ENST00000576451; ENSP00000461091; ENSG00000262806. [P24071-7]
ENST00000576568; ENSP00000461291; ENSG00000262806.
ENST00000603273; ENSP00000474183; ENSG00000271210. [P24071-10]
ENST00000603443; ENSP00000474382; ENSG00000271210. [P24071-7]
ENST00000603446; ENSP00000474502; ENSG00000271210. [P24071-3]
ENST00000604225; ENSP00000474434; ENSG00000271210. [P24071-4]
ENST00000604719; ENSP00000474575; ENSG00000271210. [P24071-5]
ENST00000604959; ENSP00000474894; ENSG00000271210. [P24071-1]
ENST00000605283; ENSP00000474451; ENSG00000271210. [P24071-9]
ENST00000605332; ENSP00000474883; ENSG00000271210. [P24071-2]
ENST00000605765; ENSP00000474767; ENSG00000271210. [P24071-8]
ENST00000605825; ENSP00000474432; ENSG00000271210. [P24071-11]
GeneID2204.
KEGGhsa:2204.
UCSCuc002qhq.3. human. [P24071-4]
uc002qhr.1. human. [P24071-1]
uc002qhs.2. human. [P24071-9]
uc002qht.1. human. [P24071-11]
uc002qhu.1. human. [P24071-3]
uc002qhv.1. human. [P24071-2]
uc002qhw.1. human. [P24071-10]
uc002qhz.1. human. [P24071-8]
uc002qia.1. human. [P24071-7]

Organism-specific databases

CTD2204.
GeneCardsGC19P055386.
HGNCHGNC:3608. FCAR.
HPAHPA014050.
MIM147045. gene.
neXtProtNX_P24071.
PharmGKBPA28055.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG41820.
HOGENOMHOG000234395.
HOVERGENHBG004337.
InParanoidP24071.
KOK06513.
OMAEFIINHM.
OrthoDBEOG78SQGZ.
PhylomeDBP24071.
TreeFamTF336644.

Gene expression databases

ArrayExpressP24071.
BgeeP24071.
CleanExHS_FCAR.
GenevestigatorP24071.

Family and domain databases

Gene3D2.60.40.10. 2 hits.
InterProIPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTSM00409. IG. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSFCAR. human.
EvolutionaryTraceP24071.
GeneWikiFCAR.
GenomeRNAi2204.
NextBio8911.
PROP24071.
SOURCESearch...

Entry information

Entry nameFCAR_HUMAN
AccessionPrimary (citable) accession number: P24071
Secondary accession number(s): Q13603 expand/collapse secondary AC list , Q13604, Q15727, Q15728, Q1AJL7, Q1AJL8, Q1AJL9, Q53X38, Q53X39, Q92587, Q92588, Q92590, Q92592, Q92593, Q9UEK0
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: April 16, 2014
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries