P24071 (FCAR_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Immunoglobulin alpha Fc receptor
Short name=IgA Fc receptor

Alternative name(s):
CD_antigen=CD89

Gene names

Name:	FCAR
Synonyms:	CD89

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	287 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production.
Subunit structure	Associates with the Fc epsilon RI gamma 2 receptor inducing tyrosine phosphorylation of gamma 2. Ref.10
Subcellular location	Isoform A.1: Cell membrane; Single-pass type I membrane protein. Isoform A.2: Cell membrane; Single-pass type I membrane protein. Isoform A.3: Cell membrane; Single-pass type I membrane protein. Isoform B: Secreted. Isoform B-delta-S2: Secreted.
Tissue specificity	Isoform A.1, isoform A.2 and isoform A.3 are differentially expressed between blood and mucosal myeloid cells. Isoform A.1, isoform A.2 and isoform A.3 are expressed in monocytes. Isoform A.1 and isoform A.2 are expressed in alveolar macrophages; however only one isoform is expressed at alveolar macrophages surfaces. Ref.3 Ref.5
Sequence similarities	Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

Ontologies

Keywords
Cellular component	Cell membrane Membrane Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Immunoglobulin domain Repeat Signal Transmembrane Transmembrane helix
Ligand	IgA-binding protein
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	immune response Traceable author statement PubMed 10835685. Source: ProtInc
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 11 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform A.1 (identifier: P24071-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform A.2 (identifier: P24071-2)

The sequence of this isoform differs from the canonical sequence as follows:
     195-216: Missing.

Isoform A.3 (identifier: P24071-3)

Also known as: RLA2;

The sequence of this isoform differs from the canonical sequence as follows:
     121-216: Missing.

Isoform B (identifier: P24071-4)

The sequence of this isoform differs from the canonical sequence as follows:
     217-287: DSIHQDYTTQ...TFARTPSVCK → GRYRPVQPCVWVGCPGPCHRAGI

Isoform B-delta-S2 (identifier: P24071-5)

The sequence of this isoform differs from the canonical sequence as follows:
     12-23: Missing.
     217-287: DSIHQDYTTQ...TFARTPSVCK → GRYRPVQPCVWVGCPGPCHRAGI

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform U02 (identifier: P24071-6)

The sequence of this isoform differs from the canonical sequence as follows:
     24-24: G → GRYISEHFWCRSLGCNPVNDASAQRPG
     195-216: Missing.

Isoform L10 (identifier: P24071-7)

The sequence of this isoform differs from the canonical sequence as follows:
     12-23: Missing.
     24-120: Missing.

Isoform U09 (identifier: P24071-8)

The sequence of this isoform differs from the canonical sequence as follows:
     12-23: Missing.
     193-287: CYGWYNRSPY...TFARTPSVCK → LHPPRLHDAELDPHGRGRTGPRGSLGHTG

Isoform U10 (identifier: P24071-9)

The sequence of this isoform differs from the canonical sequence as follows:
     12-23: Missing.
     115-210: Missing.

Isoform U11 (identifier: P24071-10)

The sequence of this isoform differs from the canonical sequence as follows:
     12-23: Missing.

Isoform U13 (identifier: P24071-11)

The sequence of this isoform differs from the canonical sequence as follows:
     12-23: Missing.
     195-216: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 21

21

Potential

Chain

22 – 287

266

Immunoglobulin alpha Fc receptor

PRO_0000015138

Regions

Topological domain

22 – 227

206

Extracellular Potential

Transmembrane

228 – 246

19

Helical; Potential

Topological domain

247 – 287

41

Cytoplasmic Potential

Domain

42 – 107

66

Ig-like C2-type 1

Domain

139 – 200

62

Ig-like C2-type 2

Amino acid modifications

Glycosylation

65

1

N-linked (GlcNAc...) Potential

Glycosylation

79

1

N-linked (GlcNAc...) Potential

Glycosylation

141

1

N-linked (GlcNAc...) Potential

Glycosylation

177

1

N-linked (GlcNAc...) Potential

Glycosylation

186

1

N-linked (GlcNAc...) Potential

Glycosylation

198

1

N-linked (GlcNAc...) Potential

Disulfide bond

49 ↔ 100

Ref.12

Disulfide bond

146 ↔ 193

Ref.12

Natural variations

Alternative sequence

12 – 23

12

Missing in isoform B-delta-S2, isoform L10, isoform U09, isoform U10, isoform U11 and isoform U13.

VSP_002632

Alternative sequence

24 – 120

97

Missing in isoform L10.

VSP_043565

Alternative sequence

24

1

G → GRYISEHFWCRSLGCNPVND ASAQRPG in isoform U02.

VSP_002633

Alternative sequence

115 – 210

96

Missing in isoform U10.

VSP_043566

Alternative sequence

121 – 216

96

Missing in isoform A.3.

VSP_002634

Alternative sequence

193 – 287

95

CYGWY…PSVCK → LHPPRLHDAELDPHGRGRTG PRGSLGHTG in isoform U09.

VSP_043567

Alternative sequence

195 – 216

22

Missing in isoform A.2, isoform U02 and isoform U13.

VSP_002635

Alternative sequence

217 – 287

71

DSIHQ…PSVCK → GRYRPVQPCVWVGCPGPCHR AGI in isoform B and isoform B-delta-S2.

VSP_002636

Natural variant

113

1

D → N. Ref.7
Corresponds to variant rs11666735 [ dbSNP | Ensembl ].

VAR_049996

Natural variant

269

1

S → G. Ref.7
Corresponds to variant rs16986050 [ dbSNP | Ensembl ].

VAR_049997

Secondary structure

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287

Helix Strand Turn

Details...

Helix

23 – 25

3

Beta strand

31 – 35

5

Beta strand

37 – 40

4

Beta strand

45 – 49

5

Beta strand

56 – 64

9

Beta strand

67 – 70

4

Beta strand

72 – 74

3

Beta strand

77 – 79

3

Beta strand

84 – 87

4

Helix

92 – 94

3

Beta strand

96 – 104

9

Turn

105 – 107

3

Beta strand

108 – 111

4

Beta strand

115 – 120

6

Beta strand

127 – 132

6

Beta strand

134 – 136

3

Beta strand

143 – 147

5

Beta strand

149 – 151

3

Beta strand

154 – 160

7

Beta strand

168 – 171

4

Beta strand

173 – 179

7

Helix

185 – 187

3

Beta strand

189 – 196

8

Beta strand

198 – 200

3

Beta strand

211 – 215

5

Sequences

	Sequence		Length	Mass (Da)
	Isoform A.1 [UniParc]. Last modified March 1, 1992. Version 1. Checksum: A2CCA68467CD45F7	FASTA	287	32,265
	10 20 30 40 50 60 MDPKQTTLLC LVLCLGQRIQ AQEGDFPMPF ISAKSSPVIP LDGSVKIQCQ AIREAYLTQL 70 80 90 100 110 120 MIIKNSTYRE IGRRLKFWNE TDPEFVIDHM DANKAGRYQC QYRIGHYRFR YSDTLELVVT 130 140 150 160 170 180 GLYGKPFLSA DRGLVLMPGE NISLTCSSAH IPFDRFSLAK EGELSLPQHQ SGEHPANFSL 190 200 210 220 230 240 GPVDLNVSGI YRCYGWYNRS PYLWSFPSNA LELVVTDSIH QDYTTQNLIR MAVAGLVLVA 250 260 270 280 LLAILVENWH SHTALNKEAS ADVAEPSWSQ QMCQPGLTFA RTPSVCK
	Isoform A.2 [UniParc]. Checksum: 81F71B405469B93A	FASTA	265	29,683
	10 20 30 40 50 60 MDPKQTTLLC LVLCLGQRIQ AQEGDFPMPF ISAKSSPVIP LDGSVKIQCQ AIREAYLTQL 70 80 90 100 110 120 MIIKNSTYRE IGRRLKFWNE TDPEFVIDHM DANKAGRYQC QYRIGHYRFR YSDTLELVVT 130 140 150 160 170 180 GLYGKPFLSA DRGLVLMPGE NISLTCSSAH IPFDRFSLAK EGELSLPQHQ SGEHPANFSL 190 200 210 220 230 240 GPVDLNVSGI YRCYDSIHQD YTTQNLIRMA VAGLVLVALL AILVENWHSH TALNKEASAD 250 260 VAEPSWSQQM CQPGLTFART PSVCK
	Isoform A.3 (RLA2) [UniParc]. Checksum: B5B6854F0437AEBE	FASTA	191	21,694
	10 20 30 40 50 60 MDPKQTTLLC LVLCLGQRIQ AQEGDFPMPF ISAKSSPVIP LDGSVKIQCQ AIREAYLTQL 70 80 90 100 110 120 MIIKNSTYRE IGRRLKFWNE TDPEFVIDHM DANKAGRYQC QYRIGHYRFR YSDTLELVVT 130 140 150 160 170 180 DSIHQDYTTQ NLIRMAVAGL VLVALLAILV ENWHSHTALN KEASADVAEP SWSQQMCQPG 190 LTFARTPSVC K
	Isoform B [UniParc]. Checksum: 4B080309BFAB38E5	FASTA	239	26,996
	10 20 30 40 50 60 MDPKQTTLLC LVLCLGQRIQ AQEGDFPMPF ISAKSSPVIP LDGSVKIQCQ AIREAYLTQL 70 80 90 100 110 120 MIIKNSTYRE IGRRLKFWNE TDPEFVIDHM DANKAGRYQC QYRIGHYRFR YSDTLELVVT 130 140 150 160 170 180 GLYGKPFLSA DRGLVLMPGE NISLTCSSAH IPFDRFSLAK EGELSLPQHQ SGEHPANFSL 190 200 210 220 230 GPVDLNVSGI YRCYGWYNRS PYLWSFPSNA LELVVTGRYR PVQPCVWVGC PGPCHRAGI
	Isoform B-delta-S2 [UniParc]. Checksum: 6C8D9A590920EA83	FASTA	227	25,656
	10 20 30 40 50 60 MDPKQTTLLC LGDFPMPFIS AKSSPVIPLD GSVKIQCQAI REAYLTQLMI IKNSTYREIG 70 80 90 100 110 120 RRLKFWNETD PEFVIDHMDA NKAGRYQCQY RIGHYRFRYS DTLELVVTGL YGKPFLSADR 130 140 150 160 170 180 GLVLMPGENI SLTCSSAHIP FDRFSLAKEG ELSLPQHQSG EHPANFSLGP VDLNVSGIYR 190 200 210 220 CYGWYNRSPY LWSFPSNALE LVVTGRYRPV QPCVWVGCPG PCHRAGI
	Isoform U02 [UniParc]. Checksum: 1DF65E4E613DA0C3	FASTA	291	32,629
	10 20 30 40 50 60 MDPKQTTLLC LVLCLGQRIQ AQEGRYISEH FWCRSLGCNP VNDASAQRPG DFPMPFISAK 70 80 90 100 110 120 SSPVIPLDGS VKIQCQAIRE AYLTQLMIIK NSTYREIGRR LKFWNETDPE FVIDHMDANK 130 140 150 160 170 180 AGRYQCQYRI GHYRFRYSDT LELVVTGLYG KPFLSADRGL VLMPGENISL TCSSAHIPFD 190 200 210 220 230 240 RFSLAKEGEL SLPQHQSGEH PANFSLGPVD LNVSGIYRCY DSIHQDYTTQ NLIRMAVAGL 250 260 270 280 290 VLVALLAILV ENWHSHTALN KEASADVAEP SWSQQMCQPG LTFARTPSVC K
	Isoform L10 [UniParc]. Checksum: CD9549BF14EE74DF	FASTA	178	19,593
	10 20 30 40 50 60 MDPKQTTLLC LGLYGKPFLS ADRGLVLMPG ENISLTCSSA HIPFDRFSLA KEGELSLPQH 70 80 90 100 110 120 QSGEHPANFS LGPVDLNVSG IYRCYGWYNR SPYLWSFPSN ALELVVTDSI HQDYTTQNLI 130 140 150 160 170 RMAVAGLVLV ALLAILVENW HSHTALNKEA SADVAEPSWS QQMCQPGLTF ARTPSVCK
	Isoform U09 [UniParc]. Checksum: 0C10F3D72BEC5366	FASTA	209	23,394
	10 20 30 40 50 60 MDPKQTTLLC LGDFPMPFIS AKSSPVIPLD GSVKIQCQAI REAYLTQLMI IKNSTYREIG 70 80 90 100 110 120 RRLKFWNETD PEFVIDHMDA NKAGRYQCQY RIGHYRFRYS DTLELVVTGL YGKPFLSADR 130 140 150 160 170 180 GLVLMPGENI SLTCSSAHIP FDRFSLAKEG ELSLPQHQSG EHPANFSLGP VDLNVSGIYR 190 200 LHPPRLHDAE LDPHGRGRTG PRGSLGHTG
	Isoform U10 [UniParc]. Checksum: D31062C1B384F6BB	FASTA	179	20,354
	10 20 30 40 50 60 MDPKQTTLLC LGDFPMPFIS AKSSPVIPLD GSVKIQCQAI REAYLTQLMI IKNSTYREIG 70 80 90 100 110 120 RRLKFWNETD PEFVIDHMDA NKAGRYQCQY RIGHYRFRYS DTLELVVTDS IHQDYTTQNL 130 140 150 160 170 IRMAVAGLVL VALLAILVEN WHSHTALNKE ASADVAEPSW SQQMCQPGLT FARTPSVCK
	Isoform U11 [UniParc]. Checksum: 47B8C498C56C82A8	FASTA	275	30,925
	10 20 30 40 50 60 MDPKQTTLLC LGDFPMPFIS AKSSPVIPLD GSVKIQCQAI REAYLTQLMI IKNSTYREIG 70 80 90 100 110 120 RRLKFWNETD PEFVIDHMDA NKAGRYQCQY RIGHYRFRYS DTLELVVTGL YGKPFLSADR 130 140 150 160 170 180 GLVLMPGENI SLTCSSAHIP FDRFSLAKEG ELSLPQHQSG EHPANFSLGP VDLNVSGIYR 190 200 210 220 230 240 CYGWYNRSPY LWSFPSNALE LVVTDSIHQD YTTQNLIRMA VAGLVLVALL AILVENWHSH 250 260 270 TALNKEASAD VAEPSWSQQM CQPGLTFART PSVCK
	Isoform U13 [UniParc]. Checksum: 6081B1C3F5BDED61	FASTA	253	28,343
	10 20 30 40 50 60 MDPKQTTLLC LGDFPMPFIS AKSSPVIPLD GSVKIQCQAI REAYLTQLMI IKNSTYREIG 70 80 90 100 110 120 RRLKFWNETD PEFVIDHMDA NKAGRYQCQY RIGHYRFRYS DTLELVVTGL YGKPFLSADR 130 140 150 160 170 180 GLVLMPGENI SLTCSSAHIP FDRFSLAKEG ELSLPQHQSG EHPANFSLGP VDLNVSGIYR 190 200 210 220 230 240 CYDSIHQDYT TQNLIRMAVA GLVLVALLAI LVENWHSHTA LNKEASADVA EPSWSQQMCQ 250 PGLTFARTPS VCK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression cloning of a human Fc receptor for IgA." Maliszewski C.R., March C.J., Schoenborn M.A., Gimpel S., Shen L. J. Exp. Med. 172:1665-1672(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A.1).
[2]	"Structure of the gene for the human myeloid IgA Fc receptor (CD89)." de Wit T.P.M., Morton H.C., Capel P.J.A., van de Winkel J.G.J. J. Immunol. 155:1203-1209(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM A.1). Tissue: Bone marrow.
[3]	"Identification of Fc alpha receptor (CD89) isoforms generated by alternative splicing that are differentially expressed between blood monocytes and alveolar macrophages." Patry C., Sibille Y., Lehuen A., Monteiro R.C. J. Immunol. 156:4442-4448(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A.2 AND A.3), TISSUE SPECIFICITY. Tissue: Alveolar macrophage and Monocyte.
[4]	van Dijk T.B., Morton H.C., Caldenhoven E., Bracke M., Raaijmakers J.A.M., Lammers J.W.J., Koenderman L., Groot R.P. Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE (ISOFORMS B AND B-DELTA-S2).
[5]	"Alternative splicing of the human IgA Fc receptor CD89 in neutrophils and eosinophils." Pleass R.J., Andrews P.D., Kerr M.A., Woof J.M. Biochem. J. 318:771-777(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A.3), TISSUE SPECIFICITY.
[6]	"IgA nephropathy-specific expression of the IgA Fc receptors (CD89) on blood phagocytic cells." Toyabe S., Kuwano Y., Takeda K., Uchiyama M., Abo T. Clin. Exp. Immunol. 110:226-232(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A.2; A.3; L10; U02; U09; U10; U11 AND U13).
[7]	"Episodes of natural selection shaped the interactions of IgA-Fc with FcalphaRI and bacterial decoy proteins." Abi-Rached L., Dorighi K., Norman P.J., Yawata M., Parham P. J. Immunol. 178:7943-7954(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A.1), VARIANTS ASN-113 AND GLY-269.
[8]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A.1). Tissue: Blood.
[10]	"Association of IgA-Fc receptors (Fc alpha R) with Fc epsilon RI gamma 2 subunits in U937 cells. Aggregation induces the tyrosine phosphorylation of gamma 2." Pfefferkorn L.C., Yeaman G.R. J. Immunol. 153:3228-3236(1994) [PubMed] [Europe PMC] [Abstract] Cited for: SUBUNIT.
[11]	"An unappreciated role for RNA surveillance." Hillman R.T., Green R.E., Brenner S.E. Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract] Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
[12]	"Crystal structure of the ectodomain of human FcalphaRI." Ding Y., Xu G., Yang M., Yao M., Gao G.F., Wang L., Zhang W., Rao Z. J. Biol. Chem. 278:27966-27970(2003) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 21-229, DISULFIDE BONDS.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X54150 mRNA. Translation: CAA38089.1.
X87767 , X87768, X87769, X87766, X87765 Genomic DNA. Translation: CAA61039.1.
U43774 mRNA. Translation: AAC50639.1.
U43677 mRNA. Translation: AAC50595.1.
U56236 mRNA. Translation: AAB00566.1.
U56237 mRNA. Translation: AAB00567.1.
S82919 mRNA. Translation: AAD14421.1.
D87853 mRNA. Translation: BAA13471.1.
D87854 mRNA. Translation: BAA13472.1.
D87855 mRNA. Translation: BAA13473.1.
D87856 mRNA. Translation: BAA13474.1.
D87857 mRNA. Translation: BAA13475.1.
D87859 mRNA. Translation: BAA13477.1.
D87861 mRNA. Translation: BAA13479.1.
D87862 mRNA. Translation: BAA13480.1.
DQ075334 mRNA. Translation: AAZ76577.1.
DQ075335 mRNA. Translation: AAZ76578.1.
DQ075336 mRNA. Translation: AAZ76579.1.
DQ075337 mRNA. Translation: AAZ76580.1.
DQ075338 mRNA. Translation: AAZ76581.1.
DQ075339 mRNA. Translation: AAZ76582.1.
AC011501 Genomic DNA. No translation available.
BC027953 mRNA. Translation: AAH27953.1.

IPI

IPI00022065.
IPI00022077.
IPI00027189.
IPI00107479.
IPI00107482.
IPI00163802.
IPI00218024.
IPI00218026.
IPI00218027.
IPI00218029.

PIR

G02630.
JH0332.

RefSeq

NP_001991.1. NM_002000.2.
NP_579803.1. NM_133269.2.
NP_579805.1. NM_133271.2.
NP_579806.1. NM_133272.2.
NP_579807.1. NM_133273.2.
NP_579808.1. NM_133274.2.
NP_579811.1. NM_133277.2.
NP_579812.1. NM_133278.2.
NP_579813.1. NM_133279.2.

UniGene

Hs.659872.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1OVZ	X-ray	3.00	A/B	22-216	[»]
1OW0	X-ray	3.10	C/D	22-216	[»]
1UCT	X-ray	2.10	A	21-229	[»]

DisProt

DP00311.

ProteinModelPortal

P24071.

ModBase

Search...

Protein-protein interaction databases

IntAct

P24071. 2 interactions.

Protein family/group databases

MEROPS

I43.951.

PTM databases

PhosphoSite

P24071.

Polymorphism databases

DMDM

119860.

Proteomic databases

PaxDb

P24071.

PRIDE

P24071.

Protocols and materials databases

DNASU

2204.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000345937; ENSP00000338257; ENSG00000186431.
ENST00000353758; ENSP00000338058; ENSG00000186431.
ENST00000355524; ENSP00000347714; ENSG00000186431.
ENST00000359272; ENSP00000352218; ENSG00000186431.
ENST00000391723; ENSP00000375603; ENSG00000186431.
ENST00000391724; ENSP00000375604; ENSG00000186431.
ENST00000391725; ENSP00000375605; ENSG00000186431.
ENST00000391726; ENSP00000375606; ENSG00000186431.
ENST00000433231; ENSP00000403072; ENSG00000186431.
ENST00000571746; ENSP00000461560; ENSG00000262827.
ENST00000573273; ENSP00000460893; ENSG00000262827.
ENST00000573433; ENSP00000459334; ENSG00000262827.
ENST00000574058; ENSP00000461176; ENSG00000262827.
ENST00000574238; ENSP00000461886; ENSG00000262827.
ENST00000574618; ENSP00000460083; ENSG00000262827.
ENST00000574738; ENSP00000459672; ENSG00000262827.
ENST00000575074; ENSP00000458478; ENSG00000262827.
ENST00000576265; ENSP00000459762; ENSG00000262827.
ENST00000576451; ENSP00000461091; ENSG00000262806.
ENST00000576568; ENSP00000461291; ENSG00000262806.

GeneID

2204.

KEGG

hsa:2204.

UCSC

uc002qhq.3. human.
uc002qhr.1. human.
uc002qhu.1. human.

Organism-specific databases

CTD

2204.

GeneCards

GC19P055386.

HGNC

HGNC:3608. FCAR.

HPA

HPA014050.

MIM

147045. gene.

neXtProt

NX_P24071.

PharmGKB

PA28055.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG41820.

HOGENOM

HOG000234395.

HOVERGEN

HBG004337.

InParanoid

P24071.

KO

K06513.

OMA

NALELVV.

PhylomeDB

P24071.

Gene expression databases

ArrayExpress

P24071.

Bgee

P24071.

CleanEx

HS_FCAR.

Genevestigator

P24071.

GermOnline

ENSG00000186431. Homo sapiens.

Family and domain databases

Gene3D

2.60.40.10. 2 hits.

InterPro

IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]

SMART

SM00409. IG. 2 hits.
[Graphical view]

PROSITE

PS50835. IG_LIKE. False negative.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

FCAR. human.

EvolutionaryTrace

P24071.

GenomeRNAi

2204.

NextBio

8911.

SOURCE

Search...

Entry information

Entry name

FCAR_HUMAN

Accession

Primary (citable) accession number: P24071
Secondary accession number(s): Q13603 , Q13604, Q15727, Q15728, Q1AJL7, Q1AJL8, Q1AJL9, Q53X38, Q53X39, Q92587, Q92588, Q92590, Q92592, Q92593, Q9UEK0

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
Last sequence update:	March 1, 1992
Last modified:	May 1, 2013
This is version 136 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.