P24071 (FCAR_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Immunoglobulin alpha Fc receptor
Short name=IgA Fc receptor

Alternative name(s):
CD_antigen=CD89

Gene names

Name:	FCAR
Synonyms:	CD89

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	287 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production.
Subunit structure	Associates with the Fc epsilon RI gamma 2 receptor inducing tyrosine phosphorylation of gamma 2. Ref.9
Subcellular location	Isoform A.1: Cell membrane; Single-pass type I membrane protein. Isoform A.2: Cell membrane; Single-pass type I membrane protein. Isoform A.3: Cell membrane; Single-pass type I membrane protein. Isoform B: Secreted. Isoform B-delta-S2: Secreted.
Tissue specificity	Isoform A.1, isoform A.2 and isoform A.3 are differentially expressed between blood and mucosal myeloid cells. Isoform A.1, isoform A.2 and isoform A.3 are expressed in monocytes. Isoform A.1 and isoform A.2 are expressed in alveolar macrophages; however only one isoform is expressed at alveolar macrophages surfaces. Ref.3 Ref.5
Sequence similarities	Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

Ontologies

Keywords
Cellular component	Cell membrane Membrane Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Immunoglobulin domain Repeat Signal Transmembrane Transmembrane helix
Ligand	IgA-binding protein
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein Nitration Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	immune response Traceable author statement. Source: ProtInc
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell integral to plasma membrane Traceable author statement. Source: ProtInc
Molecular function	IgA binding Inferred from electronic annotation. Source: UniProtKB-KW receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform A.1 (identifier: P24071-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform A.2 (identifier: P24071-2)

The sequence of this isoform differs from the canonical sequence as follows:
     195-216: Missing.

Isoform A.3 (identifier: P24071-3)

Also known as: RLA2;

The sequence of this isoform differs from the canonical sequence as follows:
     121-216: Missing.

Isoform B (identifier: P24071-4)

The sequence of this isoform differs from the canonical sequence as follows:
     217-287: DSIHQDYTTQ...TFARTPSVCK → GRYRPVQPCVWVGCPGPCHRAGI

Isoform B-delta-S2 (identifier: P24071-5)

The sequence of this isoform differs from the canonical sequence as follows:
     12-23: Missing.
     217-287: DSIHQDYTTQ...TFARTPSVCK → GRYRPVQPCVWVGCPGPCHRAGI

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform U02 (identifier: P24071-6)

The sequence of this isoform differs from the canonical sequence as follows:
     24-24: G → GRYISEHFWCRSLGCNPVNDASAQRPG
     195-216: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 21

21

Potential

Chain

22 – 287

266

Immunoglobulin alpha Fc receptor

PRO_0000015138

Regions

Topological domain

22 – 227

206

Extracellular Potential

Transmembrane

228 – 246

19

Helical; Potential

Topological domain

247 – 287

41

Cytoplasmic Potential

Domain

42 – 107

66

Ig-like C2-type 1

Domain

139 – 200

62

Ig-like C2-type 2

Amino acid modifications

Modified residue

56

1

Phosphotyrosine Ref.12

Modified residue

223

1

Nitrated tyrosine Ref.10

Glycosylation

65

1

N-linked (GlcNAc...) Potential

Glycosylation

79

1

N-linked (GlcNAc...) Potential

Glycosylation

141

1

N-linked (GlcNAc...) Potential

Glycosylation

177

1

N-linked (GlcNAc...) Potential

Glycosylation

186

1

N-linked (GlcNAc...) Potential

Glycosylation

198

1

N-linked (GlcNAc...) Potential

Disulfide bond

49 ↔ 100

Ref.13

Disulfide bond

146 ↔ 193

Ref.13

Natural variations

Alternative sequence

12 – 23

12

Missing in isoform B-delta-S2.

VSP_002632

Alternative sequence

24

1

G → GRYISEHFWCRSLGCNPVND ASAQRPG in isoform U02.

VSP_002633

Alternative sequence

121 – 216

96

Missing in isoform A.3.

VSP_002634

Alternative sequence

195 – 216

22

Missing in isoform A.2 and isoform U02.

VSP_002635

Alternative sequence

217 – 287

71

DSIHQ…PSVCK → GRYRPVQPCVWVGCPGPCHR AGI in isoform B and isoform B-delta-S2.

VSP_002636

Natural variant

113

1

D → N. Ref.7
Corresponds to variant rs11666735 [ dbSNP | Ensembl ].

VAR_049996

Natural variant

269

1

S → G. Ref.7
Corresponds to variant rs16986050 [ dbSNP | Ensembl ].

VAR_049997

Secondary structure

1

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287

Helix Strand Turn

Details...

Helix

23 – 25

3

Beta strand

31 – 35

5

Beta strand

37 – 40

4

Beta strand

45 – 49

5

Beta strand

56 – 64

9

Beta strand

67 – 70

4

Beta strand

72 – 74

3

Beta strand

84 – 87

4

Helix

92 – 94

3

Beta strand

96 – 104

9

Turn

105 – 107

3

Beta strand

108 – 111

4

Beta strand

115 – 120

6

Beta strand

127 – 132

6

Beta strand

134 – 136

3

Beta strand

143 – 147

5

Beta strand

149 – 151

3

Beta strand

154 – 160

7

Beta strand

168 – 171

4

Beta strand

173 – 179

7

Helix

185 – 187

3

Beta strand

189 – 196

8

Beta strand

211 – 215

5

Sequences

	Sequence		Length	Mass (Da)
	Isoform A.1 [UniParc]. Last modified March 1, 1992. Version 1. Checksum: A2CCA68467CD45F7	FASTA	287	32,265
	10 20 30 40 50 60 MDPKQTTLLC LVLCLGQRIQ AQEGDFPMPF ISAKSSPVIP LDGSVKIQCQ AIREAYLTQL 70 80 90 100 110 120 MIIKNSTYRE IGRRLKFWNE TDPEFVIDHM DANKAGRYQC QYRIGHYRFR YSDTLELVVT 130 140 150 160 170 180 GLYGKPFLSA DRGLVLMPGE NISLTCSSAH IPFDRFSLAK EGELSLPQHQ SGEHPANFSL 190 200 210 220 230 240 GPVDLNVSGI YRCYGWYNRS PYLWSFPSNA LELVVTDSIH QDYTTQNLIR MAVAGLVLVA 250 260 270 280 LLAILVENWH SHTALNKEAS ADVAEPSWSQ QMCQPGLTFA RTPSVCK
	Isoform A.2 [UniParc]. Checksum: 81F71B405469B93A	FASTA	265	29,683
	10 20 30 40 50 60 MDPKQTTLLC LVLCLGQRIQ AQEGDFPMPF ISAKSSPVIP LDGSVKIQCQ AIREAYLTQL 70 80 90 100 110 120 MIIKNSTYRE IGRRLKFWNE TDPEFVIDHM DANKAGRYQC QYRIGHYRFR YSDTLELVVT 130 140 150 160 170 180 GLYGKPFLSA DRGLVLMPGE NISLTCSSAH IPFDRFSLAK EGELSLPQHQ SGEHPANFSL 190 200 210 220 230 240 GPVDLNVSGI YRCYDSIHQD YTTQNLIRMA VAGLVLVALL AILVENWHSH TALNKEASAD 250 260 VAEPSWSQQM CQPGLTFART PSVCK
	Isoform A.3 (RLA2) [UniParc]. Checksum: B5B6854F0437AEBE	FASTA	191	21,694
	10 20 30 40 50 60 MDPKQTTLLC LVLCLGQRIQ AQEGDFPMPF ISAKSSPVIP LDGSVKIQCQ AIREAYLTQL 70 80 90 100 110 120 MIIKNSTYRE IGRRLKFWNE TDPEFVIDHM DANKAGRYQC QYRIGHYRFR YSDTLELVVT 130 140 150 160 170 180 DSIHQDYTTQ NLIRMAVAGL VLVALLAILV ENWHSHTALN KEASADVAEP SWSQQMCQPG 190 LTFARTPSVC K
	Isoform B [UniParc]. Checksum: 4B080309BFAB38E5	FASTA	239	26,996
	10 20 30 40 50 60 MDPKQTTLLC LVLCLGQRIQ AQEGDFPMPF ISAKSSPVIP LDGSVKIQCQ AIREAYLTQL 70 80 90 100 110 120 MIIKNSTYRE IGRRLKFWNE TDPEFVIDHM DANKAGRYQC QYRIGHYRFR YSDTLELVVT 130 140 150 160 170 180 GLYGKPFLSA DRGLVLMPGE NISLTCSSAH IPFDRFSLAK EGELSLPQHQ SGEHPANFSL 190 200 210 220 230 GPVDLNVSGI YRCYGWYNRS PYLWSFPSNA LELVVTGRYR PVQPCVWVGC PGPCHRAGI
	Isoform B-delta-S2 [UniParc]. Checksum: 6C8D9A590920EA83	FASTA	227	25,656
	10 20 30 40 50 60 MDPKQTTLLC LGDFPMPFIS AKSSPVIPLD GSVKIQCQAI REAYLTQLMI IKNSTYREIG 70 80 90 100 110 120 RRLKFWNETD PEFVIDHMDA NKAGRYQCQY RIGHYRFRYS DTLELVVTGL YGKPFLSADR 130 140 150 160 170 180 GLVLMPGENI SLTCSSAHIP FDRFSLAKEG ELSLPQHQSG EHPANFSLGP VDLNVSGIYR 190 200 210 220 CYGWYNRSPY LWSFPSNALE LVVTGRYRPV QPCVWVGCPG PCHRAGI
	Isoform U02 [UniParc]. Checksum: 1DF65E4E613DA0C3	FASTA	291	32,629
	10 20 30 40 50 60 MDPKQTTLLC LVLCLGQRIQ AQEGRYISEH FWCRSLGCNP VNDASAQRPG DFPMPFISAK 70 80 90 100 110 120 SSPVIPLDGS VKIQCQAIRE AYLTQLMIIK NSTYREIGRR LKFWNETDPE FVIDHMDANK 130 140 150 160 170 180 AGRYQCQYRI GHYRFRYSDT LELVVTGLYG KPFLSADRGL VLMPGENISL TCSSAHIPFD 190 200 210 220 230 240 RFSLAKEGEL SLPQHQSGEH PANFSLGPVD LNVSGIYRCY DSIHQDYTTQ NLIRMAVAGL 250 260 270 280 290 VLVALLAILV ENWHSHTALN KEASADVAEP SWSQQMCQPG LTFARTPSVC K

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression cloning of a human Fc receptor for IgA." Maliszewski C.R., March C.J., Schoenborn M.A., Gimpel S., Shen L. J. Exp. Med. 172:1665-1672(1990) [PubMed: 2258698] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A.1).
[2]	"Structure of the gene for the human myeloid IgA Fc receptor (CD89)." de Wit T.P.M., Morton H.C., Capel P.J.A., van de Winkel J.G.J. J. Immunol. 155:1203-1209(1995) [PubMed: 7636188] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM A.1). Tissue: Bone marrow.
[3]	"Identification of Fc alpha receptor (CD89) isoforms generated by alternative splicing that are differentially expressed between blood monocytes and alveolar macrophages." Patry C., Sibille Y., Lehuen A., Monteiro R.C. J. Immunol. 156:4442-4448(1996) [PubMed: 8666819] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A.2 AND A.3), TISSUE SPECIFICITY. Tissue: Alveolar macrophage and Monocyte.
[4]	van Dijk T.B., Morton H.C., Caldenhoven E., Bracke M., Raaijmakers J.A.M., Lammers J.W.J., Koenderman L., Groot R.P. Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE (ISOFORMS B AND B-DELTA-S2).
[5]	"Alternative splicing of the human IgA Fc receptor CD89 in neutrophils and eosinophils." Pleass R.J., Andrews P.D., Kerr M.A., Woof J.M. Biochem. J. 318:771-777(1996) [PubMed: 8836118] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A.3), TISSUE SPECIFICITY.
[6]	"IgA nephropathy-specific expression of the IgA Fc receptors (CD89) on blood phagocytic cells." Toyabe S., Kuwano Y., Takeda K., Uchiyama M., Abo T. Clin. Exp. Immunol. 110:226-232(1997) [PubMed: 9367406] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A.3 AND U02).
[7]	"Episodes of natural selection shaped the interactions of IgA-Fc with FcalphaRI and bacterial decoy proteins." Abi-Rached L., Dorighi K., Norman P.J., Yawata M., Parham P. J. Immunol. 178:7943-7954(2007) [PubMed: 17548632] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A.1), VARIANTS ASN-113 AND GLY-269.
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A.1). Tissue: Blood.
[9]	"Association of IgA-Fc receptors (Fc alpha R) with Fc epsilon RI gamma 2 subunits in U937 cells. Aggregation induces the tyrosine phosphorylation of gamma 2." Pfefferkorn L.C., Yeaman G.R. J. Immunol. 153:3228-3236(1994) [PubMed: 7522255] [Abstract] Cited for: SUBUNIT.
[10]	"The human pituitary nitroproteome: detection of nitrotyrosyl-proteins with two-dimensional Western blotting, and amino acid sequence determination with mass spectrometry." Zhan X., Desiderio D.M. Biochem. Biophys. Res. Commun. 325:1180-1186(2004) [PubMed: 15555551] [Abstract] Cited for: NITRATION [LARGE SCALE ANALYSIS] AT TYR-223, MASS SPECTROMETRY. Tissue: Pituitary.
[11]	"An unappreciated role for RNA surveillance." Hillman R.T., Green R.E., Brenner S.E. Genome Biol. 5:R8.1-R8.16(2004) [PubMed: 14759258] [Abstract] Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
[12]	"Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer." Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L., Mitchell J., Wetzel R., Macneill J., Ren J.M. , Yuan J., Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X., Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J. Cell 131:1190-1203(2007) [PubMed: 18083107] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-56, MASS SPECTROMETRY. Tissue: Lung carcinoma.
[13]	"Crystal structure of the ectodomain of human FcalphaRI." Ding Y., Xu G., Yang M., Yao M., Gao G.F., Wang L., Zhang W., Rao Z. J. Biol. Chem. 278:27966-27970(2003) [PubMed: 12783876] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 21-229, DISULFIDE BONDS.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X54150 mRNA. Translation: CAA38089.1.
X87767 , X87768, X87769, X87766, X87765 Genomic DNA. Translation: CAA61039.1.
U43774 mRNA. Translation: AAC50639.1.
U43677 mRNA. Translation: AAC50595.1.
U56236 mRNA. Translation: AAB00566.1.
U56237 mRNA. Translation: AAB00567.1.
S82919 mRNA. Translation: AAD14421.1.
D87854 mRNA. Translation: BAA13472.1.
D87859 mRNA. Translation: BAA13477.1.
DQ075334 mRNA. Translation: AAZ76577.1.
DQ075335 mRNA. Translation: AAZ76578.1.
DQ075336 mRNA. Translation: AAZ76579.1.
DQ075337 mRNA. Translation: AAZ76580.1.
DQ075338 mRNA. Translation: AAZ76581.1.
DQ075339 mRNA. Translation: AAZ76582.1.
BC027953 mRNA. Translation: AAH27953.1.

IPI

IPI00027189.
IPI00107482.
IPI00218024.
IPI00218026.
IPI00218027.
IPI00218029.

PIR

G02630.
JH0332.

RefSeq

NP_001991.1. NM_002000.2.
NP_579803.1. NM_133269.2.
NP_579805.1. NM_133271.2.
NP_579813.1. NM_133279.2.

UniGene

Hs.659872.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1OVZ	X-ray	3.00	A/B	22-216	[»]
1OW0	X-ray	3.10	C/D	22-216	[»]
1UCT	X-ray	2.10	A	21-229	[»]

ProteinModelPortal

P24071.

SMR

P24071. Positions 27-216.

DisProt

DP00311.

ModBase

Search...

Protein-protein interaction databases

IntAct

P24071. 1 interaction.

STRING

P24071.

Protein family/group databases

MEROPS

I43.951.

PTM databases

PhosphoSite

P24071.

Polymorphism databases

DMDM

119860.

Proteomic databases

PRIDE

P24071.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000355524; ENSP00000347714; ENSG00000186431.

GeneID

2204.

KEGG

hsa:2204.

UCSC

uc002qhq.1. human.
uc002qhr.1. human.

Organism-specific databases

CTD

2204.

GeneCards

GC19P055386.

HGNC

HGNC:3608. FCAR.

HPA

HPA014050.

MIM

147045. gene.

neXtProt

NX_P24071.

PharmGKB

PA28055.

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG17494.

GeneTree

ENSGT00570000078800.

HOVERGEN

HBG004337.

InParanoid

P24071.

OMA

PFDRFSL.

PhylomeDB

P24071.

Gene expression databases

ArrayExpress

P24071.

Bgee

P24071.

CleanEx

HS_FCAR.

Genevestigator

P24071.

GermOnline

ENSG00000186431. Homo sapiens.

Family and domain databases

InterPro

IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]

Gene3D

G3DSA:2.60.40.10. Ig-like_fold. 2 hits.

KO

K06513.

SMART

SM00409. IG. 2 hits.
[Graphical view]

PROSITE

PS50835. IG_LIKE. False negative.
[Graphical view]

ProtoNet

Search...

Other

NextBio

8911.

SOURCE

Search...

Entry information

Entry name

FCAR_HUMAN

Accession

Primary (citable) accession number: P24071
Secondary accession number(s): Q13603 , Q13604, Q15727, Q15728, Q1AJL7, Q1AJL8, Q1AJL9, Q53X38, Q92590

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
Last sequence update:	March 1, 1992
Last modified:	January 25, 2012
This is version 122 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.