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Protein

Immunoglobulin alpha Fc receptor

Gene

FCAR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production.1 Publication

GO - Biological processi

  • immune response Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

IgA-binding protein

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167633-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.

Protein family/group databases

MEROPSiI43.951.

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin alpha Fc receptor
Short name:
IgA Fc receptor
Alternative name(s):
CD_antigen: CD89
Gene namesi
Name:FCAR
Synonyms:CD89
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:3608. FCAR.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 227ExtracellularSequence analysisAdd BLAST206
Transmembranei228 – 246HelicalSequence analysisAdd BLAST19
Topological domaini247 – 287CytoplasmicSequence analysisAdd BLAST41

GO - Cellular componenti

  • extracellular region Source: UniProtKB-SubCell
  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi2204.
OpenTargetsiENSG00000186431.
ENSG00000273738.
ENSG00000274580.
ENSG00000275136.
ENSG00000275269.
ENSG00000275564.
ENSG00000275970.
ENSG00000276858.
ENSG00000276985.
ENSG00000278415.
PharmGKBiPA28055.

Polymorphism and mutation databases

BioMutaiFCAR.
DMDMi119860.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001513822 – 287Immunoglobulin alpha Fc receptorAdd BLAST266

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 100Combined sources2 Publications
Glycosylationi65N-linked (GlcNAc...)Sequence analysis1
Glycosylationi79N-linked (GlcNAc...)Sequence analysis1
Glycosylationi141N-linked (GlcNAc...)1 Publication1
Disulfide bondi146 ↔ 193Combined sources2 Publications
Glycosylationi177N-linked (GlcNAc...)1 Publication1
Glycosylationi186N-linked (GlcNAc...)Sequence analysis1
Glycosylationi198N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP24071.
PeptideAtlasiP24071.
PRIDEiP24071.

PTM databases

iPTMnetiP24071.
PhosphoSitePlusiP24071.

Expressioni

Tissue specificityi

Isoform A.1, isoform A.2 and isoform A.3 are differentially expressed between blood and mucosal myeloid cells. Isoform A.1, isoform A.2 and isoform A.3 are expressed in monocytes. Isoform A.1 and isoform A.2 are expressed in alveolar macrophages; however only one isoform is expressed at alveolar macrophages surfaces.2 Publications

Gene expression databases

BgeeiENSG00000186431.
CleanExiHS_FCAR.
ExpressionAtlasiP24071. baseline and differential.
GenevisibleiP24071. HS.

Organism-specific databases

HPAiHPA014050.

Interactioni

Subunit structurei

Associates with the Fc epsilon RI gamma 2 receptor inducing tyrosine phosphorylation of gamma 2.2 Publications

Protein-protein interaction databases

BioGridi108498. 4 interactors.
IntActiP24071. 2 interactors.
STRINGi9606.ENSP00000347714.

Structurei

Secondary structure

1287
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi23 – 25Combined sources3
Beta strandi31 – 35Combined sources5
Beta strandi37 – 40Combined sources4
Beta strandi45 – 49Combined sources5
Beta strandi56 – 64Combined sources9
Beta strandi67 – 70Combined sources4
Beta strandi72 – 74Combined sources3
Beta strandi77 – 79Combined sources3
Beta strandi84 – 87Combined sources4
Helixi92 – 94Combined sources3
Beta strandi96 – 104Combined sources9
Turni105 – 107Combined sources3
Beta strandi108 – 111Combined sources4
Beta strandi115 – 120Combined sources6
Beta strandi127 – 132Combined sources6
Beta strandi134 – 136Combined sources3
Beta strandi143 – 147Combined sources5
Beta strandi149 – 151Combined sources3
Beta strandi154 – 160Combined sources7
Beta strandi168 – 171Combined sources4
Beta strandi173 – 179Combined sources7
Helixi185 – 187Combined sources3
Beta strandi189 – 196Combined sources8
Beta strandi198 – 200Combined sources3
Beta strandi211 – 215Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OVZX-ray3.00A/B22-216[»]
1OW0X-ray3.10C/D22-216[»]
1UCTX-ray2.10A21-229[»]
DisProtiDP00311.
ProteinModelPortaliP24071.
SMRiP24071.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP24071.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 107Ig-like C2-type 1Add BLAST66
Domaini139 – 200Ig-like C2-type 2Add BLAST62

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IG5T. Eukaryota.
ENOG4111BK0. LUCA.
GeneTreeiENSGT00760000119033.
HOGENOMiHOG000234395.
HOVERGENiHBG004337.
InParanoidiP24071.
KOiK06513.
OMAiSGNYRCY.
OrthoDBiEOG091G0FVY.
PhylomeDBiP24071.
TreeFamiTF336644.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.

Sequences (11)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 11 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform A.1 (identifier: P24071-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDPKQTTLLC LVLCLGQRIQ AQEGDFPMPF ISAKSSPVIP LDGSVKIQCQ
60 70 80 90 100
AIREAYLTQL MIIKNSTYRE IGRRLKFWNE TDPEFVIDHM DANKAGRYQC
110 120 130 140 150
QYRIGHYRFR YSDTLELVVT GLYGKPFLSA DRGLVLMPGE NISLTCSSAH
160 170 180 190 200
IPFDRFSLAK EGELSLPQHQ SGEHPANFSL GPVDLNVSGI YRCYGWYNRS
210 220 230 240 250
PYLWSFPSNA LELVVTDSIH QDYTTQNLIR MAVAGLVLVA LLAILVENWH
260 270 280
SHTALNKEAS ADVAEPSWSQ QMCQPGLTFA RTPSVCK
Length:287
Mass (Da):32,265
Last modified:March 1, 1992 - v1
Checksum:iA2CCA68467CD45F7
GO
Isoform A.2 (identifier: P24071-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     195-216: Missing.

Show »
Length:265
Mass (Da):29,683
Checksum:i81F71B405469B93A
GO
Isoform A.3 (identifier: P24071-3) [UniParc]FASTAAdd to basket
Also known as: RLA2

The sequence of this isoform differs from the canonical sequence as follows:
     121-216: Missing.

Show »
Length:191
Mass (Da):21,694
Checksum:iB5B6854F0437AEBE
GO
Isoform B (identifier: P24071-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     217-287: DSIHQDYTTQ...TFARTPSVCK → GRYRPVQPCVWVGCPGPCHRAGI

Show »
Length:239
Mass (Da):26,996
Checksum:i4B080309BFAB38E5
GO
Isoform B-delta-S2 (identifier: P24071-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-23: Missing.
     217-287: DSIHQDYTTQ...TFARTPSVCK → GRYRPVQPCVWVGCPGPCHRAGI

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:227
Mass (Da):25,656
Checksum:i6C8D9A590920EA83
GO
Isoform U02 (identifier: P24071-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-24: G → GRYISEHFWCRSLGCNPVNDASAQRPG
     195-216: Missing.

Show »
Length:291
Mass (Da):32,629
Checksum:i1DF65E4E613DA0C3
GO
Isoform L10 (identifier: P24071-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-23: Missing.
     24-120: Missing.

Show »
Length:178
Mass (Da):19,593
Checksum:iCD9549BF14EE74DF
GO
Isoform U09 (identifier: P24071-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-23: Missing.
     193-287: CYGWYNRSPY...TFARTPSVCK → LHPPRLHDAELDPHGRGRTGPRGSLGHTG

Show »
Length:209
Mass (Da):23,394
Checksum:i0C10F3D72BEC5366
GO
Isoform U10 (identifier: P24071-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-23: Missing.
     115-210: Missing.

Show »
Length:179
Mass (Da):20,354
Checksum:iD31062C1B384F6BB
GO
Isoform U11 (identifier: P24071-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-23: Missing.

Show »
Length:275
Mass (Da):30,925
Checksum:i47B8C498C56C82A8
GO
Isoform U13 (identifier: P24071-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-23: Missing.
     195-216: Missing.

Show »
Length:253
Mass (Da):28,343
Checksum:i6081B1C3F5BDED61
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049996113D → N.1 PublicationCorresponds to variant rs11666735dbSNPEnsembl.1
Natural variantiVAR_049997269S → G.1 PublicationCorresponds to variant rs16986050dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00263212 – 23Missing in isoform B-delta-S2, isoform L10, isoform U09, isoform U10, isoform U11 and isoform U13. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_04356524 – 120Missing in isoform L10. 1 PublicationAdd BLAST97
Alternative sequenceiVSP_00263324G → GRYISEHFWCRSLGCNPVND ASAQRPG in isoform U02. 1 Publication1
Alternative sequenceiVSP_043566115 – 210Missing in isoform U10. 1 PublicationAdd BLAST96
Alternative sequenceiVSP_002634121 – 216Missing in isoform A.3. 3 PublicationsAdd BLAST96
Alternative sequenceiVSP_043567193 – 287CYGWY…PSVCK → LHPPRLHDAELDPHGRGRTG PRGSLGHTG in isoform U09. 1 PublicationAdd BLAST95
Alternative sequenceiVSP_002635195 – 216Missing in isoform A.2, isoform U02 and isoform U13. 2 PublicationsAdd BLAST22
Alternative sequenceiVSP_002636217 – 287DSIHQ…PSVCK → GRYRPVQPCVWVGCPGPCHR AGI in isoform B and isoform B-delta-S2. CuratedAdd BLAST71

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54150 mRNA. Translation: CAA38089.1.
X87767
, X87768, X87769, X87766, X87765 Genomic DNA. Translation: CAA61039.1.
U43774 mRNA. Translation: AAC50639.1.
U43677 mRNA. Translation: AAC50595.1.
U56236 mRNA. Translation: AAB00566.1.
U56237 mRNA. Translation: AAB00567.1.
S82919 mRNA. Translation: AAD14421.1.
D87853 mRNA. Translation: BAA13471.1.
D87854 mRNA. Translation: BAA13472.1.
D87855 mRNA. Translation: BAA13473.1.
D87856 mRNA. Translation: BAA13474.1.
D87857 mRNA. Translation: BAA13475.1.
D87859 mRNA. Translation: BAA13477.1.
D87861 mRNA. Translation: BAA13479.1.
D87862 mRNA. Translation: BAA13480.1.
DQ075334 mRNA. Translation: AAZ76577.1.
DQ075335 mRNA. Translation: AAZ76578.1.
DQ075336 mRNA. Translation: AAZ76579.1.
DQ075337 mRNA. Translation: AAZ76580.1.
DQ075338 mRNA. Translation: AAZ76581.1.
DQ075339 mRNA. Translation: AAZ76582.1.
AC011501 Genomic DNA. No translation available.
BC027953 mRNA. Translation: AAH27953.1.
CCDSiCCDS12907.1. [P24071-1]
CCDS12908.1. [P24071-3]
CCDS12909.1. [P24071-10]
CCDS12910.1. [P24071-7]
CCDS42622.1. [P24071-2]
CCDS42623.1. [P24071-11]
CCDS42624.1. [P24071-9]
CCDS42625.1. [P24071-8]
PIRiG02630.
JH0332.
RefSeqiNP_001991.1. NM_002000.3. [P24071-1]
NP_579803.1. NM_133269.3. [P24071-2]
NP_579805.1. NM_133271.3. [P24071-3]
NP_579806.1. NM_133272.3. [P24071-10]
NP_579807.1. NM_133273.3. [P24071-9]
NP_579808.1. NM_133274.3. [P24071-8]
NP_579811.1. NM_133277.3. [P24071-7]
NP_579812.1. NM_133278.3. [P24071-11]
UniGeneiHs.659872.

Genome annotation databases

EnsembliENST00000345937; ENSP00000338257; ENSG00000186431. [P24071-3]
ENST00000353758; ENSP00000338058; ENSG00000186431. [P24071-7]
ENST00000355524; ENSP00000347714; ENSG00000186431. [P24071-1]
ENST00000359272; ENSP00000352218; ENSG00000186431. [P24071-10]
ENST00000391723; ENSP00000375603; ENSG00000186431. [P24071-8]
ENST00000391724; ENSP00000375604; ENSG00000186431. [P24071-11]
ENST00000391725; ENSP00000375605; ENSG00000186431. [P24071-2]
ENST00000391726; ENSP00000375606; ENSG00000186431. [P24071-9]
ENST00000469767; ENSP00000473814; ENSG00000186431. [P24071-4]
ENST00000488066; ENSP00000474512; ENSG00000186431. [P24071-5]
ENST00000610340; ENSP00000477610; ENSG00000275136. [P24071-8]
ENST00000610397; ENSP00000480965; ENSG00000275269. [P24071-3]
ENST00000610786; ENSP00000483121; ENSG00000276858. [P24071-8]
ENST00000611018; ENSP00000484483; ENSG00000275970. [P24071-11]
ENST00000611130; ENSP00000484917; ENSG00000273738. [P24071-11]
ENST00000611871; ENSP00000482976; ENSG00000273738. [P24071-10]
ENST00000611943; ENSP00000482273; ENSG00000275564. [P24071-2]
ENST00000612150; ENSP00000478233; ENSG00000275136. [P24071-3]
ENST00000612159; ENSP00000484662; ENSG00000276985. [P24071-9]
ENST00000612505; ENSP00000479792; ENSG00000276985. [P24071-8]
ENST00000612803; ENSP00000478454; ENSG00000275970. [P24071-8]
ENST00000612815; ENSP00000483503; ENSG00000275269. [P24071-8]
ENST00000612918; ENSP00000482056; ENSG00000274580. [P24071-3]
ENST00000613199; ENSP00000478465; ENSG00000276858. [P24071-1]
ENST00000613201; ENSP00000482108; ENSG00000274580. [P24071-4]
ENST00000613298; ENSP00000482451; ENSG00000275269. [P24071-9]
ENST00000613318; ENSP00000481560; ENSG00000273738. [P24071-4]
ENST00000613663; ENSP00000483437; ENSG00000275564. [P24071-4]
ENST00000613685; ENSP00000481230; ENSG00000275564. [P24071-11]
ENST00000614226; ENSP00000483099; ENSG00000276985. [P24071-1]
ENST00000614298; ENSP00000483472; ENSG00000275970. [P24071-9]
ENST00000614433; ENSP00000480748; ENSG00000276985. [P24071-2]
ENST00000614689; ENSP00000480013; ENSG00000273738. [P24071-5]
ENST00000614893; ENSP00000477966; ENSG00000273738. [P24071-2]
ENST00000614917; ENSP00000479831; ENSG00000275970. [P24071-2]
ENST00000614954; ENSP00000479924; ENSG00000276858. [P24071-9]
ENST00000615040; ENSP00000477656; ENSG00000276858. [P24071-10]
ENST00000615110; ENSP00000484276; ENSG00000274580. [P24071-2]
ENST00000615361; ENSP00000482741; ENSG00000273738. [P24071-9]
ENST00000615703; ENSP00000484868; ENSG00000275136. [P24071-4]
ENST00000615719; ENSP00000482518; ENSG00000275136. [P24071-7]
ENST00000615800; ENSP00000483841; ENSG00000276985. [P24071-4]
ENST00000615829; ENSP00000482623; ENSG00000274580. [P24071-1]
ENST00000615937; ENSP00000478075; ENSG00000274580. [P24071-11]
ENST00000616340; ENSP00000481676; ENSG00000275269. [P24071-10]
ENST00000616878; ENSP00000480970; ENSG00000275136. [P24071-9]
ENST00000616969; ENSP00000479039; ENSG00000275564. [P24071-5]
ENST00000617025; ENSP00000481129; ENSG00000276985. [P24071-3]
ENST00000617609; ENSP00000481394; ENSG00000274580. [P24071-10]
ENST00000617696; ENSP00000482670; ENSG00000274580. [P24071-9]
ENST00000617762; ENSP00000484136; ENSG00000276858. [P24071-5]
ENST00000617766; ENSP00000479230; ENSG00000275269. [P24071-4]
ENST00000617778; ENSP00000480498; ENSG00000273738. [P24071-3]
ENST00000617964; ENSP00000484141; ENSG00000275564. [P24071-7]
ENST00000618271; ENSP00000484741; ENSG00000276985. [P24071-7]
ENST00000618287; ENSP00000481668; ENSG00000275564. [P24071-10]
ENST00000618328; ENSP00000480496; ENSG00000276985. [P24071-10]
ENST00000618658; ENSP00000479688; ENSG00000275970. [P24071-4]
ENST00000618805; ENSP00000481985; ENSG00000275269. [P24071-2]
ENST00000618985; ENSP00000480323; ENSG00000275269. [P24071-5]
ENST00000619073; ENSP00000479360; ENSG00000273738. [P24071-8]
ENST00000619155; ENSP00000480461; ENSG00000275970. [P24071-5]
ENST00000619385; ENSP00000482334; ENSG00000275269. [P24071-1]
ENST00000619414; ENSP00000478163; ENSG00000276858. [P24071-2]
ENST00000619822; ENSP00000483250; ENSG00000275136. [P24071-2]
ENST00000620162; ENSP00000483258; ENSG00000276858. [P24071-11]
ENST00000620179; ENSP00000478315; ENSG00000278415. [P24071-7]
ENST00000620270; ENSP00000482022; ENSG00000276985. [P24071-11]
ENST00000620397; ENSP00000477584; ENSG00000276985. [P24071-5]
ENST00000620801; ENSP00000481195; ENSG00000275970. [P24071-1]
ENST00000620822; ENSP00000483327; ENSG00000275269. [P24071-7]
ENST00000620873; ENSP00000479099; ENSG00000275269. [P24071-11]
ENST00000621004; ENSP00000484816; ENSG00000275970. [P24071-10]
ENST00000621009; ENSP00000482025; ENSG00000275970. [P24071-3]
ENST00000621289; ENSP00000481366; ENSG00000275136. [P24071-5]
ENST00000621417; ENSP00000478634; ENSG00000274580. [P24071-5]
ENST00000621684; ENSP00000479239; ENSG00000276858. [P24071-3]
ENST00000621702; ENSP00000482807; ENSG00000275136. [P24071-1]
ENST00000621755; ENSP00000484906; ENSG00000275970. [P24071-7]
ENST00000621882; ENSP00000484272; ENSG00000274580. [P24071-7]
ENST00000622157; ENSP00000481502; ENSG00000275564. [P24071-1]
ENST00000622470; ENSP00000477673; ENSG00000276858. [P24071-7]
ENST00000622491; ENSP00000477643; ENSG00000274580. [P24071-8]
ENST00000622543; ENSP00000483402; ENSG00000275564. [P24071-3]
ENST00000622646; ENSP00000480406; ENSG00000273738. [P24071-7]
ENST00000622737; ENSP00000479738; ENSG00000273738. [P24071-1]
ENST00000622777; ENSP00000481345; ENSG00000275136. [P24071-10]
ENST00000622883; ENSP00000479880; ENSG00000276858. [P24071-4]
ENST00000622904; ENSP00000480444; ENSG00000275136. [P24071-11]
GeneIDi2204.
KEGGihsa:2204.
UCSCiuc002qhq.4. human. [P24071-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54150 mRNA. Translation: CAA38089.1.
X87767
, X87768, X87769, X87766, X87765 Genomic DNA. Translation: CAA61039.1.
U43774 mRNA. Translation: AAC50639.1.
U43677 mRNA. Translation: AAC50595.1.
U56236 mRNA. Translation: AAB00566.1.
U56237 mRNA. Translation: AAB00567.1.
S82919 mRNA. Translation: AAD14421.1.
D87853 mRNA. Translation: BAA13471.1.
D87854 mRNA. Translation: BAA13472.1.
D87855 mRNA. Translation: BAA13473.1.
D87856 mRNA. Translation: BAA13474.1.
D87857 mRNA. Translation: BAA13475.1.
D87859 mRNA. Translation: BAA13477.1.
D87861 mRNA. Translation: BAA13479.1.
D87862 mRNA. Translation: BAA13480.1.
DQ075334 mRNA. Translation: AAZ76577.1.
DQ075335 mRNA. Translation: AAZ76578.1.
DQ075336 mRNA. Translation: AAZ76579.1.
DQ075337 mRNA. Translation: AAZ76580.1.
DQ075338 mRNA. Translation: AAZ76581.1.
DQ075339 mRNA. Translation: AAZ76582.1.
AC011501 Genomic DNA. No translation available.
BC027953 mRNA. Translation: AAH27953.1.
CCDSiCCDS12907.1. [P24071-1]
CCDS12908.1. [P24071-3]
CCDS12909.1. [P24071-10]
CCDS12910.1. [P24071-7]
CCDS42622.1. [P24071-2]
CCDS42623.1. [P24071-11]
CCDS42624.1. [P24071-9]
CCDS42625.1. [P24071-8]
PIRiG02630.
JH0332.
RefSeqiNP_001991.1. NM_002000.3. [P24071-1]
NP_579803.1. NM_133269.3. [P24071-2]
NP_579805.1. NM_133271.3. [P24071-3]
NP_579806.1. NM_133272.3. [P24071-10]
NP_579807.1. NM_133273.3. [P24071-9]
NP_579808.1. NM_133274.3. [P24071-8]
NP_579811.1. NM_133277.3. [P24071-7]
NP_579812.1. NM_133278.3. [P24071-11]
UniGeneiHs.659872.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OVZX-ray3.00A/B22-216[»]
1OW0X-ray3.10C/D22-216[»]
1UCTX-ray2.10A21-229[»]
DisProtiDP00311.
ProteinModelPortaliP24071.
SMRiP24071.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108498. 4 interactors.
IntActiP24071. 2 interactors.
STRINGi9606.ENSP00000347714.

Protein family/group databases

MEROPSiI43.951.

PTM databases

iPTMnetiP24071.
PhosphoSitePlusiP24071.

Polymorphism and mutation databases

BioMutaiFCAR.
DMDMi119860.

Proteomic databases

PaxDbiP24071.
PeptideAtlasiP24071.
PRIDEiP24071.

Protocols and materials databases

DNASUi2204.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000345937; ENSP00000338257; ENSG00000186431. [P24071-3]
ENST00000353758; ENSP00000338058; ENSG00000186431. [P24071-7]
ENST00000355524; ENSP00000347714; ENSG00000186431. [P24071-1]
ENST00000359272; ENSP00000352218; ENSG00000186431. [P24071-10]
ENST00000391723; ENSP00000375603; ENSG00000186431. [P24071-8]
ENST00000391724; ENSP00000375604; ENSG00000186431. [P24071-11]
ENST00000391725; ENSP00000375605; ENSG00000186431. [P24071-2]
ENST00000391726; ENSP00000375606; ENSG00000186431. [P24071-9]
ENST00000469767; ENSP00000473814; ENSG00000186431. [P24071-4]
ENST00000488066; ENSP00000474512; ENSG00000186431. [P24071-5]
ENST00000610340; ENSP00000477610; ENSG00000275136. [P24071-8]
ENST00000610397; ENSP00000480965; ENSG00000275269. [P24071-3]
ENST00000610786; ENSP00000483121; ENSG00000276858. [P24071-8]
ENST00000611018; ENSP00000484483; ENSG00000275970. [P24071-11]
ENST00000611130; ENSP00000484917; ENSG00000273738. [P24071-11]
ENST00000611871; ENSP00000482976; ENSG00000273738. [P24071-10]
ENST00000611943; ENSP00000482273; ENSG00000275564. [P24071-2]
ENST00000612150; ENSP00000478233; ENSG00000275136. [P24071-3]
ENST00000612159; ENSP00000484662; ENSG00000276985. [P24071-9]
ENST00000612505; ENSP00000479792; ENSG00000276985. [P24071-8]
ENST00000612803; ENSP00000478454; ENSG00000275970. [P24071-8]
ENST00000612815; ENSP00000483503; ENSG00000275269. [P24071-8]
ENST00000612918; ENSP00000482056; ENSG00000274580. [P24071-3]
ENST00000613199; ENSP00000478465; ENSG00000276858. [P24071-1]
ENST00000613201; ENSP00000482108; ENSG00000274580. [P24071-4]
ENST00000613298; ENSP00000482451; ENSG00000275269. [P24071-9]
ENST00000613318; ENSP00000481560; ENSG00000273738. [P24071-4]
ENST00000613663; ENSP00000483437; ENSG00000275564. [P24071-4]
ENST00000613685; ENSP00000481230; ENSG00000275564. [P24071-11]
ENST00000614226; ENSP00000483099; ENSG00000276985. [P24071-1]
ENST00000614298; ENSP00000483472; ENSG00000275970. [P24071-9]
ENST00000614433; ENSP00000480748; ENSG00000276985. [P24071-2]
ENST00000614689; ENSP00000480013; ENSG00000273738. [P24071-5]
ENST00000614893; ENSP00000477966; ENSG00000273738. [P24071-2]
ENST00000614917; ENSP00000479831; ENSG00000275970. [P24071-2]
ENST00000614954; ENSP00000479924; ENSG00000276858. [P24071-9]
ENST00000615040; ENSP00000477656; ENSG00000276858. [P24071-10]
ENST00000615110; ENSP00000484276; ENSG00000274580. [P24071-2]
ENST00000615361; ENSP00000482741; ENSG00000273738. [P24071-9]
ENST00000615703; ENSP00000484868; ENSG00000275136. [P24071-4]
ENST00000615719; ENSP00000482518; ENSG00000275136. [P24071-7]
ENST00000615800; ENSP00000483841; ENSG00000276985. [P24071-4]
ENST00000615829; ENSP00000482623; ENSG00000274580. [P24071-1]
ENST00000615937; ENSP00000478075; ENSG00000274580. [P24071-11]
ENST00000616340; ENSP00000481676; ENSG00000275269. [P24071-10]
ENST00000616878; ENSP00000480970; ENSG00000275136. [P24071-9]
ENST00000616969; ENSP00000479039; ENSG00000275564. [P24071-5]
ENST00000617025; ENSP00000481129; ENSG00000276985. [P24071-3]
ENST00000617609; ENSP00000481394; ENSG00000274580. [P24071-10]
ENST00000617696; ENSP00000482670; ENSG00000274580. [P24071-9]
ENST00000617762; ENSP00000484136; ENSG00000276858. [P24071-5]
ENST00000617766; ENSP00000479230; ENSG00000275269. [P24071-4]
ENST00000617778; ENSP00000480498; ENSG00000273738. [P24071-3]
ENST00000617964; ENSP00000484141; ENSG00000275564. [P24071-7]
ENST00000618271; ENSP00000484741; ENSG00000276985. [P24071-7]
ENST00000618287; ENSP00000481668; ENSG00000275564. [P24071-10]
ENST00000618328; ENSP00000480496; ENSG00000276985. [P24071-10]
ENST00000618658; ENSP00000479688; ENSG00000275970. [P24071-4]
ENST00000618805; ENSP00000481985; ENSG00000275269. [P24071-2]
ENST00000618985; ENSP00000480323; ENSG00000275269. [P24071-5]
ENST00000619073; ENSP00000479360; ENSG00000273738. [P24071-8]
ENST00000619155; ENSP00000480461; ENSG00000275970. [P24071-5]
ENST00000619385; ENSP00000482334; ENSG00000275269. [P24071-1]
ENST00000619414; ENSP00000478163; ENSG00000276858. [P24071-2]
ENST00000619822; ENSP00000483250; ENSG00000275136. [P24071-2]
ENST00000620162; ENSP00000483258; ENSG00000276858. [P24071-11]
ENST00000620179; ENSP00000478315; ENSG00000278415. [P24071-7]
ENST00000620270; ENSP00000482022; ENSG00000276985. [P24071-11]
ENST00000620397; ENSP00000477584; ENSG00000276985. [P24071-5]
ENST00000620801; ENSP00000481195; ENSG00000275970. [P24071-1]
ENST00000620822; ENSP00000483327; ENSG00000275269. [P24071-7]
ENST00000620873; ENSP00000479099; ENSG00000275269. [P24071-11]
ENST00000621004; ENSP00000484816; ENSG00000275970. [P24071-10]
ENST00000621009; ENSP00000482025; ENSG00000275970. [P24071-3]
ENST00000621289; ENSP00000481366; ENSG00000275136. [P24071-5]
ENST00000621417; ENSP00000478634; ENSG00000274580. [P24071-5]
ENST00000621684; ENSP00000479239; ENSG00000276858. [P24071-3]
ENST00000621702; ENSP00000482807; ENSG00000275136. [P24071-1]
ENST00000621755; ENSP00000484906; ENSG00000275970. [P24071-7]
ENST00000621882; ENSP00000484272; ENSG00000274580. [P24071-7]
ENST00000622157; ENSP00000481502; ENSG00000275564. [P24071-1]
ENST00000622470; ENSP00000477673; ENSG00000276858. [P24071-7]
ENST00000622491; ENSP00000477643; ENSG00000274580. [P24071-8]
ENST00000622543; ENSP00000483402; ENSG00000275564. [P24071-3]
ENST00000622646; ENSP00000480406; ENSG00000273738. [P24071-7]
ENST00000622737; ENSP00000479738; ENSG00000273738. [P24071-1]
ENST00000622777; ENSP00000481345; ENSG00000275136. [P24071-10]
ENST00000622883; ENSP00000479880; ENSG00000276858. [P24071-4]
ENST00000622904; ENSP00000480444; ENSG00000275136. [P24071-11]
GeneIDi2204.
KEGGihsa:2204.
UCSCiuc002qhq.4. human. [P24071-1]

Organism-specific databases

CTDi2204.
DisGeNETi2204.
GeneCardsiFCAR.
HGNCiHGNC:3608. FCAR.
HPAiHPA014050.
MIMi147045. gene.
neXtProtiNX_P24071.
OpenTargetsiENSG00000186431.
ENSG00000273738.
ENSG00000274580.
ENSG00000275136.
ENSG00000275269.
ENSG00000275564.
ENSG00000275970.
ENSG00000276858.
ENSG00000276985.
ENSG00000278415.
PharmGKBiPA28055.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG5T. Eukaryota.
ENOG4111BK0. LUCA.
GeneTreeiENSGT00760000119033.
HOGENOMiHOG000234395.
HOVERGENiHBG004337.
InParanoidiP24071.
KOiK06513.
OMAiSGNYRCY.
OrthoDBiEOG091G0FVY.
PhylomeDBiP24071.
TreeFamiTF336644.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167633-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.

Miscellaneous databases

ChiTaRSiFCAR. human.
EvolutionaryTraceiP24071.
GeneWikiiFCAR.
GenomeRNAii2204.
PROiP24071.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000186431.
CleanExiHS_FCAR.
ExpressionAtlasiP24071. baseline and differential.
GenevisibleiP24071. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiFCAR_HUMAN
AccessioniPrimary (citable) accession number: P24071
Secondary accession number(s): Q13603
, Q13604, Q15727, Q15728, Q1AJL7, Q1AJL8, Q1AJL9, Q53X38, Q53X39, Q92587, Q92588, Q92590, Q92592, Q92593, Q9UEK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: November 30, 2016
This is version 167 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.