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P24071

- FCAR_HUMAN

UniProt

P24071 - FCAR_HUMAN

Protein

Immunoglobulin alpha Fc receptor

Gene

FCAR

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 148 (01 Oct 2014)
      Sequence version 1 (01 Mar 1992)
      Previous versions | rss
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    Functioni

    Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production.1 Publication

    GO - Biological processi

    1. immune response Source: ProtInc

    Keywords - Molecular functioni

    Receptor

    Keywords - Ligandi

    IgA-binding protein

    Protein family/group databases

    MEROPSiI43.951.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Immunoglobulin alpha Fc receptor
    Short name:
    IgA Fc receptor
    Alternative name(s):
    CD_antigen: CD89
    Gene namesi
    Name:FCAR
    Synonyms:CD89
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:3608. FCAR.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    2. integral component of plasma membrane Source: ProtInc
    3. plasma membrane Source: HPA

    Keywords - Cellular componenti

    Cell membrane, Membrane, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28055.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 287266Immunoglobulin alpha Fc receptorPRO_0000015138Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi49 ↔ 100
    Glycosylationi65 – 651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi79 – 791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi141 – 1411N-linked (GlcNAc...)1 Publication
    Disulfide bondi146 ↔ 193
    Glycosylationi177 – 1771N-linked (GlcNAc...)1 Publication
    Glycosylationi186 – 1861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi198 – 1981N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP24071.
    PRIDEiP24071.

    PTM databases

    PhosphoSiteiP24071.

    Expressioni

    Tissue specificityi

    Isoform A.1, isoform A.2 and isoform A.3 are differentially expressed between blood and mucosal myeloid cells. Isoform A.1, isoform A.2 and isoform A.3 are expressed in monocytes. Isoform A.1 and isoform A.2 are expressed in alveolar macrophages; however only one isoform is expressed at alveolar macrophages surfaces.2 Publications

    Gene expression databases

    ArrayExpressiP24071.
    BgeeiP24071.
    CleanExiHS_FCAR.
    GenevestigatoriP24071.

    Organism-specific databases

    HPAiHPA014050.

    Interactioni

    Subunit structurei

    Associates with the Fc epsilon RI gamma 2 receptor inducing tyrosine phosphorylation of gamma 2.2 Publications

    Protein-protein interaction databases

    BioGridi108498. 3 interactions.
    IntActiP24071. 2 interactions.

    Structurei

    Secondary structure

    1
    287
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi23 – 253
    Beta strandi31 – 355
    Beta strandi37 – 404
    Beta strandi45 – 495
    Beta strandi56 – 649
    Beta strandi67 – 704
    Beta strandi72 – 743
    Beta strandi77 – 793
    Beta strandi84 – 874
    Helixi92 – 943
    Beta strandi96 – 1049
    Turni105 – 1073
    Beta strandi108 – 1114
    Beta strandi115 – 1206
    Beta strandi127 – 1326
    Beta strandi134 – 1363
    Beta strandi143 – 1475
    Beta strandi149 – 1513
    Beta strandi154 – 1607
    Beta strandi168 – 1714
    Beta strandi173 – 1797
    Helixi185 – 1873
    Beta strandi189 – 1968
    Beta strandi198 – 2003
    Beta strandi211 – 2155

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1OVZX-ray3.00A/B22-216[»]
    1OW0X-ray3.10C/D22-216[»]
    1UCTX-ray2.10A21-229[»]
    DisProtiDP00311.
    ProteinModelPortaliP24071.
    SMRiP24071. Positions 27-216.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP24071.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 227206ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini247 – 28741CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei228 – 24619HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini42 – 10766Ig-like C2-type 1Add
    BLAST
    Domaini139 – 20062Ig-like C2-type 2Add
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG41820.
    HOGENOMiHOG000234395.
    HOVERGENiHBG004337.
    InParanoidiP24071.
    KOiK06513.
    OrthoDBiEOG78SQGZ.
    PhylomeDBiP24071.
    TreeFamiTF336644.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    [Graphical view]
    SMARTiSM00409. IG. 2 hits.
    [Graphical view]

    Sequences (11)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 11 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform A.1 (identifier: P24071-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDPKQTTLLC LVLCLGQRIQ AQEGDFPMPF ISAKSSPVIP LDGSVKIQCQ    50
    AIREAYLTQL MIIKNSTYRE IGRRLKFWNE TDPEFVIDHM DANKAGRYQC 100
    QYRIGHYRFR YSDTLELVVT GLYGKPFLSA DRGLVLMPGE NISLTCSSAH 150
    IPFDRFSLAK EGELSLPQHQ SGEHPANFSL GPVDLNVSGI YRCYGWYNRS 200
    PYLWSFPSNA LELVVTDSIH QDYTTQNLIR MAVAGLVLVA LLAILVENWH 250
    SHTALNKEAS ADVAEPSWSQ QMCQPGLTFA RTPSVCK 287
    Length:287
    Mass (Da):32,265
    Last modified:March 1, 1992 - v1
    Checksum:iA2CCA68467CD45F7
    GO
    Isoform A.2 (identifier: P24071-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         195-216: Missing.

    Show »
    Length:265
    Mass (Da):29,683
    Checksum:i81F71B405469B93A
    GO
    Isoform A.3 (identifier: P24071-3) [UniParc]FASTAAdd to Basket

    Also known as: RLA2

    The sequence of this isoform differs from the canonical sequence as follows:
         121-216: Missing.

    Show »
    Length:191
    Mass (Da):21,694
    Checksum:iB5B6854F0437AEBE
    GO
    Isoform B (identifier: P24071-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         217-287: DSIHQDYTTQ...TFARTPSVCK → GRYRPVQPCVWVGCPGPCHRAGI

    Show »
    Length:239
    Mass (Da):26,996
    Checksum:i4B080309BFAB38E5
    GO
    Isoform B-delta-S2 (identifier: P24071-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         12-23: Missing.
         217-287: DSIHQDYTTQ...TFARTPSVCK → GRYRPVQPCVWVGCPGPCHRAGI

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:227
    Mass (Da):25,656
    Checksum:i6C8D9A590920EA83
    GO
    Isoform U02 (identifier: P24071-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         24-24: G → GRYISEHFWCRSLGCNPVNDASAQRPG
         195-216: Missing.

    Show »
    Length:291
    Mass (Da):32,629
    Checksum:i1DF65E4E613DA0C3
    GO
    Isoform L10 (identifier: P24071-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         12-23: Missing.
         24-120: Missing.

    Show »
    Length:178
    Mass (Da):19,593
    Checksum:iCD9549BF14EE74DF
    GO
    Isoform U09 (identifier: P24071-8) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         12-23: Missing.
         193-287: CYGWYNRSPY...TFARTPSVCK → LHPPRLHDAELDPHGRGRTGPRGSLGHTG

    Show »
    Length:209
    Mass (Da):23,394
    Checksum:i0C10F3D72BEC5366
    GO
    Isoform U10 (identifier: P24071-9) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         12-23: Missing.
         115-210: Missing.

    Show »
    Length:179
    Mass (Da):20,354
    Checksum:iD31062C1B384F6BB
    GO
    Isoform U11 (identifier: P24071-10) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         12-23: Missing.

    Show »
    Length:275
    Mass (Da):30,925
    Checksum:i47B8C498C56C82A8
    GO
    Isoform U13 (identifier: P24071-11) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         12-23: Missing.
         195-216: Missing.

    Show »
    Length:253
    Mass (Da):28,343
    Checksum:i6081B1C3F5BDED61
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti113 – 1131D → N.1 Publication
    Corresponds to variant rs11666735 [ dbSNP | Ensembl ].
    VAR_049996
    Natural varianti269 – 2691S → G.1 Publication
    Corresponds to variant rs16986050 [ dbSNP | Ensembl ].
    VAR_049997

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei12 – 2312Missing in isoform B-delta-S2, isoform L10, isoform U09, isoform U10, isoform U11 and isoform U13. 1 PublicationVSP_002632Add
    BLAST
    Alternative sequencei24 – 12097Missing in isoform L10. 1 PublicationVSP_043565Add
    BLAST
    Alternative sequencei24 – 241G → GRYISEHFWCRSLGCNPVND ASAQRPG in isoform U02. 1 PublicationVSP_002633
    Alternative sequencei115 – 21096Missing in isoform U10. 1 PublicationVSP_043566Add
    BLAST
    Alternative sequencei121 – 21696Missing in isoform A.3. 3 PublicationsVSP_002634Add
    BLAST
    Alternative sequencei193 – 28795CYGWY…PSVCK → LHPPRLHDAELDPHGRGRTG PRGSLGHTG in isoform U09. 1 PublicationVSP_043567Add
    BLAST
    Alternative sequencei195 – 21622Missing in isoform A.2, isoform U02 and isoform U13. 2 PublicationsVSP_002635Add
    BLAST
    Alternative sequencei217 – 28771DSIHQ…PSVCK → GRYRPVQPCVWVGCPGPCHR AGI in isoform B and isoform B-delta-S2. CuratedVSP_002636Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X54150 mRNA. Translation: CAA38089.1.
    X87767
    , X87768, X87769, X87766, X87765 Genomic DNA. Translation: CAA61039.1.
    U43774 mRNA. Translation: AAC50639.1.
    U43677 mRNA. Translation: AAC50595.1.
    U56236 mRNA. Translation: AAB00566.1.
    U56237 mRNA. Translation: AAB00567.1.
    S82919 mRNA. Translation: AAD14421.1.
    D87853 mRNA. Translation: BAA13471.1.
    D87854 mRNA. Translation: BAA13472.1.
    D87855 mRNA. Translation: BAA13473.1.
    D87856 mRNA. Translation: BAA13474.1.
    D87857 mRNA. Translation: BAA13475.1.
    D87859 mRNA. Translation: BAA13477.1.
    D87861 mRNA. Translation: BAA13479.1.
    D87862 mRNA. Translation: BAA13480.1.
    DQ075334 mRNA. Translation: AAZ76577.1.
    DQ075335 mRNA. Translation: AAZ76578.1.
    DQ075336 mRNA. Translation: AAZ76579.1.
    DQ075337 mRNA. Translation: AAZ76580.1.
    DQ075338 mRNA. Translation: AAZ76581.1.
    DQ075339 mRNA. Translation: AAZ76582.1.
    AC011501 Genomic DNA. No translation available.
    BC027953 mRNA. Translation: AAH27953.1.
    CCDSiCCDS12907.1. [P24071-1]
    CCDS12908.1. [P24071-3]
    CCDS12909.1. [P24071-10]
    CCDS12910.1. [P24071-7]
    CCDS42622.1. [P24071-2]
    CCDS42623.1. [P24071-11]
    CCDS42624.1. [P24071-9]
    CCDS42625.1. [P24071-8]
    CCDS46180.1. [P24071-4]
    PIRiG02630.
    JH0332.
    RefSeqiNP_001991.1. NM_002000.2. [P24071-1]
    NP_579803.1. NM_133269.2. [P24071-2]
    NP_579805.1. NM_133271.2. [P24071-3]
    NP_579806.1. NM_133272.2. [P24071-10]
    NP_579807.1. NM_133273.2. [P24071-9]
    NP_579808.1. NM_133274.2. [P24071-8]
    NP_579811.1. NM_133277.2. [P24071-7]
    NP_579812.1. NM_133278.2. [P24071-11]
    NP_579813.1. NM_133279.2. [P24071-4]
    UniGeneiHs.659872.

    Genome annotation databases

    EnsembliENST00000345937; ENSP00000338257; ENSG00000186431. [P24071-3]
    ENST00000353758; ENSP00000338058; ENSG00000186431. [P24071-7]
    ENST00000355524; ENSP00000347714; ENSG00000186431. [P24071-1]
    ENST00000359272; ENSP00000352218; ENSG00000186431. [P24071-10]
    ENST00000391723; ENSP00000375603; ENSG00000186431. [P24071-8]
    ENST00000391724; ENSP00000375604; ENSG00000186431. [P24071-11]
    ENST00000391725; ENSP00000375605; ENSG00000186431. [P24071-2]
    ENST00000391726; ENSP00000375606; ENSG00000186431. [P24071-9]
    ENST00000469767; ENSP00000473814; ENSG00000186431. [P24071-4]
    ENST00000488066; ENSP00000474512; ENSG00000186431. [P24071-5]
    GeneIDi2204.
    KEGGihsa:2204.
    UCSCiuc002qhq.3. human. [P24071-4]
    uc002qhr.1. human. [P24071-1]
    uc002qhs.2. human. [P24071-9]
    uc002qht.1. human. [P24071-11]
    uc002qhu.1. human. [P24071-3]
    uc002qhv.1. human. [P24071-2]
    uc002qhw.1. human. [P24071-10]
    uc002qhz.1. human. [P24071-8]
    uc002qia.1. human. [P24071-7]

    Polymorphism databases

    DMDMi119860.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X54150 mRNA. Translation: CAA38089.1 .
    X87767
    , X87768 , X87769 , X87766 , X87765 Genomic DNA. Translation: CAA61039.1 .
    U43774 mRNA. Translation: AAC50639.1 .
    U43677 mRNA. Translation: AAC50595.1 .
    U56236 mRNA. Translation: AAB00566.1 .
    U56237 mRNA. Translation: AAB00567.1 .
    S82919 mRNA. Translation: AAD14421.1 .
    D87853 mRNA. Translation: BAA13471.1 .
    D87854 mRNA. Translation: BAA13472.1 .
    D87855 mRNA. Translation: BAA13473.1 .
    D87856 mRNA. Translation: BAA13474.1 .
    D87857 mRNA. Translation: BAA13475.1 .
    D87859 mRNA. Translation: BAA13477.1 .
    D87861 mRNA. Translation: BAA13479.1 .
    D87862 mRNA. Translation: BAA13480.1 .
    DQ075334 mRNA. Translation: AAZ76577.1 .
    DQ075335 mRNA. Translation: AAZ76578.1 .
    DQ075336 mRNA. Translation: AAZ76579.1 .
    DQ075337 mRNA. Translation: AAZ76580.1 .
    DQ075338 mRNA. Translation: AAZ76581.1 .
    DQ075339 mRNA. Translation: AAZ76582.1 .
    AC011501 Genomic DNA. No translation available.
    BC027953 mRNA. Translation: AAH27953.1 .
    CCDSi CCDS12907.1. [P24071-1 ]
    CCDS12908.1. [P24071-3 ]
    CCDS12909.1. [P24071-10 ]
    CCDS12910.1. [P24071-7 ]
    CCDS42622.1. [P24071-2 ]
    CCDS42623.1. [P24071-11 ]
    CCDS42624.1. [P24071-9 ]
    CCDS42625.1. [P24071-8 ]
    CCDS46180.1. [P24071-4 ]
    PIRi G02630.
    JH0332.
    RefSeqi NP_001991.1. NM_002000.2. [P24071-1 ]
    NP_579803.1. NM_133269.2. [P24071-2 ]
    NP_579805.1. NM_133271.2. [P24071-3 ]
    NP_579806.1. NM_133272.2. [P24071-10 ]
    NP_579807.1. NM_133273.2. [P24071-9 ]
    NP_579808.1. NM_133274.2. [P24071-8 ]
    NP_579811.1. NM_133277.2. [P24071-7 ]
    NP_579812.1. NM_133278.2. [P24071-11 ]
    NP_579813.1. NM_133279.2. [P24071-4 ]
    UniGenei Hs.659872.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1OVZ X-ray 3.00 A/B 22-216 [» ]
    1OW0 X-ray 3.10 C/D 22-216 [» ]
    1UCT X-ray 2.10 A 21-229 [» ]
    DisProti DP00311.
    ProteinModelPortali P24071.
    SMRi P24071. Positions 27-216.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108498. 3 interactions.
    IntActi P24071. 2 interactions.

    Protein family/group databases

    MEROPSi I43.951.

    PTM databases

    PhosphoSitei P24071.

    Polymorphism databases

    DMDMi 119860.

    Proteomic databases

    PaxDbi P24071.
    PRIDEi P24071.

    Protocols and materials databases

    DNASUi 2204.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000345937 ; ENSP00000338257 ; ENSG00000186431 . [P24071-3 ]
    ENST00000353758 ; ENSP00000338058 ; ENSG00000186431 . [P24071-7 ]
    ENST00000355524 ; ENSP00000347714 ; ENSG00000186431 . [P24071-1 ]
    ENST00000359272 ; ENSP00000352218 ; ENSG00000186431 . [P24071-10 ]
    ENST00000391723 ; ENSP00000375603 ; ENSG00000186431 . [P24071-8 ]
    ENST00000391724 ; ENSP00000375604 ; ENSG00000186431 . [P24071-11 ]
    ENST00000391725 ; ENSP00000375605 ; ENSG00000186431 . [P24071-2 ]
    ENST00000391726 ; ENSP00000375606 ; ENSG00000186431 . [P24071-9 ]
    ENST00000469767 ; ENSP00000473814 ; ENSG00000186431 . [P24071-4 ]
    ENST00000488066 ; ENSP00000474512 ; ENSG00000186431 . [P24071-5 ]
    GeneIDi 2204.
    KEGGi hsa:2204.
    UCSCi uc002qhq.3. human. [P24071-4 ]
    uc002qhr.1. human. [P24071-1 ]
    uc002qhs.2. human. [P24071-9 ]
    uc002qht.1. human. [P24071-11 ]
    uc002qhu.1. human. [P24071-3 ]
    uc002qhv.1. human. [P24071-2 ]
    uc002qhw.1. human. [P24071-10 ]
    uc002qhz.1. human. [P24071-8 ]
    uc002qia.1. human. [P24071-7 ]

    Organism-specific databases

    CTDi 2204.
    GeneCardsi GC19P055386.
    HGNCi HGNC:3608. FCAR.
    HPAi HPA014050.
    MIMi 147045. gene.
    neXtProti NX_P24071.
    PharmGKBi PA28055.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG41820.
    HOGENOMi HOG000234395.
    HOVERGENi HBG004337.
    InParanoidi P24071.
    KOi K06513.
    OrthoDBi EOG78SQGZ.
    PhylomeDBi P24071.
    TreeFami TF336644.

    Miscellaneous databases

    ChiTaRSi FCAR. human.
    EvolutionaryTracei P24071.
    GeneWikii FCAR.
    GenomeRNAii 2204.
    NextBioi 8911.
    PROi P24071.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P24071.
    Bgeei P24071.
    CleanExi HS_FCAR.
    Genevestigatori P24071.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    [Graphical view ]
    SMARTi SM00409. IG. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A.1).
    2. "Structure of the gene for the human myeloid IgA Fc receptor (CD89)."
      de Wit T.P.M., Morton H.C., Capel P.J.A., van de Winkel J.G.J.
      J. Immunol. 155:1203-1209(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM A.1).
      Tissue: Bone marrow.
    3. "Identification of Fc alpha receptor (CD89) isoforms generated by alternative splicing that are differentially expressed between blood monocytes and alveolar macrophages."
      Patry C., Sibille Y., Lehuen A., Monteiro R.C.
      J. Immunol. 156:4442-4448(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A.2 AND A.3), TISSUE SPECIFICITY.
      Tissue: Alveolar macrophage and Monocyte.
    4. van Dijk T.B., Morton H.C., Caldenhoven E., Bracke M., Raaijmakers J.A.M., Lammers J.W.J., Koenderman L., Groot R.P.
      Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE (ISOFORMS B AND B-DELTA-S2).
    5. "Alternative splicing of the human IgA Fc receptor CD89 in neutrophils and eosinophils."
      Pleass R.J., Andrews P.D., Kerr M.A., Woof J.M.
      Biochem. J. 318:771-777(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A.3), TISSUE SPECIFICITY.
    6. "IgA nephropathy-specific expression of the IgA Fc receptors (CD89) on blood phagocytic cells."
      Toyabe S., Kuwano Y., Takeda K., Uchiyama M., Abo T.
      Clin. Exp. Immunol. 110:226-232(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A.2; A.3; L10; U02; U09; U10; U11 AND U13).
    7. "Episodes of natural selection shaped the interactions of IgA-Fc with FcalphaRI and bacterial decoy proteins."
      Abi-Rached L., Dorighi K., Norman P.J., Yawata M., Parham P.
      J. Immunol. 178:7943-7954(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A.1), VARIANTS ASN-113 AND GLY-269.
    8. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A.1).
      Tissue: Blood.
    10. "Association of IgA-Fc receptors (Fc alpha R) with Fc epsilon RI gamma 2 subunits in U937 cells. Aggregation induces the tyrosine phosphorylation of gamma 2."
      Pfefferkorn L.C., Yeaman G.R.
      J. Immunol. 153:3228-3236(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT.
    11. Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
    12. "Crystal structure of the ectodomain of human FcalphaRI."
      Ding Y., Xu G., Yang M., Yao M., Gao G.F., Wang L., Zhang W., Rao Z.
      J. Biol. Chem. 278:27966-27970(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 21-229, DISULFIDE BONDS.
    13. "Insights into IgA-mediated immune responses from the crystal structures of human FcalphaRI and its complex with IgA1-Fc."
      Herr A.B., Ballister E.R., Bjorkman P.J.
      Nature 423:614-620(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 22-216 IN COMPLEX WITH IMMUNOGLOBULIN ALPHA, FUNCTION, DISULFIDE BONDS, GLYCOSYLATION AT ASN-141 AND ASN-177.

    Entry informationi

    Entry nameiFCAR_HUMAN
    AccessioniPrimary (citable) accession number: P24071
    Secondary accession number(s): Q13603
    , Q13604, Q15727, Q15728, Q1AJL7, Q1AJL8, Q1AJL9, Q53X38, Q53X39, Q92587, Q92588, Q92590, Q92592, Q92593, Q9UEK0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: March 1, 1992
    Last modified: October 1, 2014
    This is version 148 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3