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Protein

(S)-2-haloacid dehalogenase 1

Gene
N/A
Organism
Pseudomonas sp. (strain CBS-3)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the hydrolytic dehalogenation of small (S)-2-haloalkanoic acids to yield the corresponding (R)-2-hydroxyalkanoic acids. Acts on acids of short chain lengths, C2 to C4, with inversion of configuration at C-2.

Catalytic activityi

(S)-2-haloacid + H2O = (R)-2-hydroxyacid + halide.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei10NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
(S)-2-haloacid dehalogenase 1 (EC:3.8.1.2)
Alternative name(s):
2-haloalkanoic acid dehalogenase I
DEHCI
Halocarboxylic acid halidohydrolase I
L-2-haloacid dehalogenase I
OrganismiPseudomonas sp. (strain CBS-3)
Taxonomic identifieri72586 [NCBI]
Taxonomic lineageiBacteriaProteobacteria

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000791601 – 227(S)-2-haloacid dehalogenase 1Add BLAST227

Structurei

3D structure databases

ProteinModelPortaliP24069.
SMRiP24069.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

CDDicd02588. HAD_L2-DEX. 1 hit.
Gene3Di1.10.150.240. 1 hit.
3.40.50.1000. 1 hit.
InterProiView protein in InterPro
IPR006328. 2-HAD.
IPR023214. HAD-like_dom.
IPR006439. HAD-SF_hydro_IA.
IPR023198. PGP_dom2.
PRINTSiPR00413. HADHALOGNASE.
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01493. HAD-SF-IA-v2. 1 hit.
TIGR01509. HAD-SF-IA-v3. 1 hit.
TIGR01428. HAD_type_II. 1 hit.

Sequencei

Sequence statusi: Complete.

P24069-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPIRACVFD AYGTLLDVNT AVMKHAHDIG GCAEELSSLW RQRQLEYSWT
60 70 80 90 100
RTLMGRYADF WQLTTEALDF ALESFGLLER TDLKNRLLDA YHELSAYPDA
110 120 130 140 150
VGTLGALKAA GFTTAILSNG NNEMLRGALR AGNLTEALDQ CISVDEIKIY
160 170 180 190 200
KPDPRVYQFA CDRLDVRPSE VCFVSSNAWD IGGAGAFGFN TVRINRINKP
210 220
QEYSFAPQRH QLSSLSELPQ LLLRLTQ
Length:227
Mass (Da):25,430
Last modified:October 1, 1993 - v2
Checksum:i0D2002A0282C92EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62908 Genomic DNA. Translation: AAA63640.1.
PIRiA38452.

Similar proteinsi

Entry informationi

Entry nameiHAD1_PSEUC
AccessioniPrimary (citable) accession number: P24069
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: October 1, 1993
Last modified: August 30, 2017
This is version 66 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families