Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P24069

- HAD1_PSEUC

UniProt

P24069 - HAD1_PSEUC

Protein

(S)-2-haloacid dehalogenase 1

Gene
N/A
Organism
Pseudomonas sp. (strain CBS-3)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 2 (01 Oct 1993)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the hydrolytic dehalogenation of small (S)-2-haloalkanoic acids to yield the corresponding (R)-2-hydroxyalkanoic acids. Acts on acids of short chain lengths, C2 to C4, with inversion of configuration at C-2.

    Catalytic activityi

    (S)-2-haloacid + H2O = (R)-2-hydroxyacid + halide.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei10 – 101NucleophileBy similarity

    GO - Molecular functioni

    1. (S)-2-haloacid dehalogenase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    (S)-2-haloacid dehalogenase 1 (EC:3.8.1.2)
    Alternative name(s):
    2-haloalkanoic acid dehalogenase I
    DEHCI
    Halocarboxylic acid halidohydrolase I
    L-2-haloacid dehalogenase I
    OrganismiPseudomonas sp. (strain CBS-3)
    Taxonomic identifieri72586 [NCBI]
    Taxonomic lineageiBacteriaProteobacteria

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 227227(S)-2-haloacid dehalogenase 1PRO_0000079160Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP24069.
    SMRiP24069. Positions 1-224.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di1.10.150.240. 1 hit.
    3.40.50.1000. 1 hit.
    InterProiIPR023214. HAD-like_dom.
    IPR006439. HAD-SF_hydro_IA.
    IPR006328. HAD_II.
    IPR023198. PGP_dom2.
    [Graphical view]
    PfamiPF00702. Hydrolase. 1 hit.
    [Graphical view]
    PRINTSiPR00413. HADHALOGNASE.
    SUPFAMiSSF56784. SSF56784. 1 hit.
    TIGRFAMsiTIGR01493. HAD-SF-IA-v2. 1 hit.
    TIGR01509. HAD-SF-IA-v3. 1 hit.
    TIGR01428. HAD_type_II. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P24069-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDPIRACVFD AYGTLLDVNT AVMKHAHDIG GCAEELSSLW RQRQLEYSWT    50
    RTLMGRYADF WQLTTEALDF ALESFGLLER TDLKNRLLDA YHELSAYPDA 100
    VGTLGALKAA GFTTAILSNG NNEMLRGALR AGNLTEALDQ CISVDEIKIY 150
    KPDPRVYQFA CDRLDVRPSE VCFVSSNAWD IGGAGAFGFN TVRINRINKP 200
    QEYSFAPQRH QLSSLSELPQ LLLRLTQ 227
    Length:227
    Mass (Da):25,430
    Last modified:October 1, 1993 - v2
    Checksum:i0D2002A0282C92EE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M62908 Genomic DNA. Translation: AAA63640.1.
    PIRiA38452.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M62908 Genomic DNA. Translation: AAA63640.1 .
    PIRi A38452.

    3D structure databases

    ProteinModelPortali P24069.
    SMRi P24069. Positions 1-224.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.10.150.240. 1 hit.
    3.40.50.1000. 1 hit.
    InterProi IPR023214. HAD-like_dom.
    IPR006439. HAD-SF_hydro_IA.
    IPR006328. HAD_II.
    IPR023198. PGP_dom2.
    [Graphical view ]
    Pfami PF00702. Hydrolase. 1 hit.
    [Graphical view ]
    PRINTSi PR00413. HADHALOGNASE.
    SUPFAMi SSF56784. SSF56784. 1 hit.
    TIGRFAMsi TIGR01493. HAD-SF-IA-v2. 1 hit.
    TIGR01509. HAD-SF-IA-v3. 1 hit.
    TIGR01428. HAD_type_II. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete nucleotide sequences and comparison of the structural genes of two 2-haloalkanoic acid dehalogenases from Pseudomonas sp. strain CBS3."
      Schneider B., Mueller R., Frank R., Lingens F.
      J. Bacteriol. 173:1530-1535(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiHAD1_PSEUC
    AccessioniPrimary (citable) accession number: P24069
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: October 1, 1993
    Last modified: October 1, 2014
    This is version 59 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3