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P24069

- HAD1_PSEUC

UniProt

P24069 - HAD1_PSEUC

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Protein

(S)-2-haloacid dehalogenase 1

Gene
N/A
Organism
Pseudomonas sp. (strain CBS-3)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the hydrolytic dehalogenation of small (S)-2-haloalkanoic acids to yield the corresponding (R)-2-hydroxyalkanoic acids. Acts on acids of short chain lengths, C2 to C4, with inversion of configuration at C-2.

Catalytic activityi

(S)-2-haloacid + H2O = (R)-2-hydroxyacid + halide.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei10 – 101Nucleophile By similarity

GO - Molecular functioni

  1. (S)-2-haloacid dehalogenase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
(S)-2-haloacid dehalogenase 1 (EC:3.8.1.2)
Alternative name(s):
2-haloalkanoic acid dehalogenase I
DEHCI
Halocarboxylic acid halidohydrolase I
L-2-haloacid dehalogenase I
OrganismiPseudomonas sp. (strain CBS-3)
Taxonomic identifieri72586 [NCBI]
Taxonomic lineageiBacteriaProteobacteria

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 227227(S)-2-haloacid dehalogenase 1PRO_0000079160Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP24069.
SMRiP24069. Positions 1-224.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.150.240. 1 hit.
3.40.50.1000. 1 hit.
InterProiIPR023214. HAD-like_dom.
IPR006439. HAD-SF_hydro_IA.
IPR006328. HAD_II.
IPR023198. PGP_dom2.
[Graphical view]
PfamiPF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00413. HADHALOGNASE.
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01493. HAD-SF-IA-v2. 1 hit.
TIGR01509. HAD-SF-IA-v3. 1 hit.
TIGR01428. HAD_type_II. 1 hit.

Sequencei

Sequence statusi: Complete.

P24069-1 [UniParc]FASTAAdd to Basket

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MDPIRACVFD AYGTLLDVNT AVMKHAHDIG GCAEELSSLW RQRQLEYSWT    50
RTLMGRYADF WQLTTEALDF ALESFGLLER TDLKNRLLDA YHELSAYPDA 100
VGTLGALKAA GFTTAILSNG NNEMLRGALR AGNLTEALDQ CISVDEIKIY 150
KPDPRVYQFA CDRLDVRPSE VCFVSSNAWD IGGAGAFGFN TVRINRINKP 200
QEYSFAPQRH QLSSLSELPQ LLLRLTQ 227
Length:227
Mass (Da):25,430
Last modified:October 1, 1993 - v2
Checksum:i0D2002A0282C92EE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M62908 Genomic DNA. Translation: AAA63640.1.
PIRiA38452.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M62908 Genomic DNA. Translation: AAA63640.1 .
PIRi A38452.

3D structure databases

ProteinModelPortali P24069.
SMRi P24069. Positions 1-224.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.150.240. 1 hit.
3.40.50.1000. 1 hit.
InterProi IPR023214. HAD-like_dom.
IPR006439. HAD-SF_hydro_IA.
IPR006328. HAD_II.
IPR023198. PGP_dom2.
[Graphical view ]
Pfami PF00702. Hydrolase. 1 hit.
[Graphical view ]
PRINTSi PR00413. HADHALOGNASE.
SUPFAMi SSF56784. SSF56784. 1 hit.
TIGRFAMsi TIGR01493. HAD-SF-IA-v2. 1 hit.
TIGR01509. HAD-SF-IA-v3. 1 hit.
TIGR01428. HAD_type_II. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete nucleotide sequences and comparison of the structural genes of two 2-haloalkanoic acid dehalogenases from Pseudomonas sp. strain CBS3."
    Schneider B., Mueller R., Frank R., Lingens F.
    J. Bacteriol. 173:1530-1535(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiHAD1_PSEUC
AccessioniPrimary (citable) accession number: P24069
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: October 1, 1993
Last modified: October 16, 2013
This is version 58 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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