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P24069 (HAD1_PSEUC) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
(S)-2-haloacid dehalogenase 1

EC=3.8.1.2
Alternative name(s):
2-haloalkanoic acid dehalogenase I
DEHCI
Halocarboxylic acid halidohydrolase I
L-2-haloacid dehalogenase I
OrganismPseudomonas sp. (strain CBS-3)
Taxonomic identifier72586 [NCBI]
Taxonomic lineageBacteriaProteobacteria

Protein attributes

Sequence length227 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the hydrolytic dehalogenation of small (S)-2-haloalkanoic acids to yield the corresponding (R)-2-hydroxyalkanoic acids. Acts on acids of short chain lengths, C2 to C4, with inversion of configuration at C-2.

Catalytic activity

(S)-2-haloacid + H2O = (R)-2-hydroxyacid + halide.

Sequence similarities

Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family.

Ontologies

Keywords
   Molecular functionHydrolase
Gene Ontology (GO)
   Molecular_function(S)-2-haloacid dehalogenase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 227227(S)-2-haloacid dehalogenase 1
PRO_0000079160

Sites

Active site101Nucleophile By similarity

Sequences

Sequence LengthMass (Da)Tools
P24069 [UniParc].

Last modified October 1, 1993. Version 2.
Checksum: 0D2002A0282C92EE

FASTA22725,430
        10         20         30         40         50         60 
MDPIRACVFD AYGTLLDVNT AVMKHAHDIG GCAEELSSLW RQRQLEYSWT RTLMGRYADF 

        70         80         90        100        110        120 
WQLTTEALDF ALESFGLLER TDLKNRLLDA YHELSAYPDA VGTLGALKAA GFTTAILSNG 

       130        140        150        160        170        180 
NNEMLRGALR AGNLTEALDQ CISVDEIKIY KPDPRVYQFA CDRLDVRPSE VCFVSSNAWD 

       190        200        210        220 
IGGAGAFGFN TVRINRINKP QEYSFAPQRH QLSSLSELPQ LLLRLTQ 

« Hide

References

[1]"Complete nucleotide sequences and comparison of the structural genes of two 2-haloalkanoic acid dehalogenases from Pseudomonas sp. strain CBS3."
Schneider B., Mueller R., Frank R., Lingens F.
J. Bacteriol. 173:1530-1535(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M62908 Genomic DNA. Translation: AAA63640.1.
PIRA38452.

3D structure databases

ProteinModelPortalP24069.
SMRP24069. Positions 1-224.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.150.240. 1 hit.
3.40.50.1000. 1 hit.
InterProIPR023214. HAD-like_dom.
IPR006439. HAD-SF_hydro_IA.
IPR006328. HAD_II.
IPR023198. PGP_dom2.
[Graphical view]
PfamPF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSPR00413. HADHALOGNASE.
SUPFAMSSF56784. SSF56784. 1 hit.
TIGRFAMsTIGR01493. HAD-SF-IA-v2. 1 hit.
TIGR01509. HAD-SF-IA-v3. 1 hit.
TIGR01428. HAD_type_II. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHAD1_PSEUC
AccessionPrimary (citable) accession number: P24069
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: October 1, 1993
Last modified: October 16, 2013
This is version 58 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families