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P24063

- ITAL_MOUSE

UniProt

P24063 - ITAL_MOUSE

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Protein

Integrin alpha-L

Gene

Itgal

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Mice expressing a null mutation of the alpha-L subunit gene demonstrate impaired tumor rejection and impaired leukocytes recruitment.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi466 – 4749Sequence Analysis
Calcium bindingi528 – 5369Sequence Analysis
Calcium bindingi588 – 5969Sequence Analysis

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. activated T cell proliferation Source: MGI
  2. cell surface receptor signaling pathway Source: MGI
  3. integrin-mediated signaling pathway Source: UniProtKB-KW
  4. leukocyte cell-cell adhesion Source: MGI
  5. positive regulation of calcium-mediated signaling Source: MGI
  6. positive regulation of cell-cell adhesion Source: MGI
  7. positive regulation of T cell proliferation Source: MGI
  8. regulation of cell-cell adhesion Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Integrin, Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_202937. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_216309. Integrin cell surface interactions.
REACT_225233. Cell surface interactions at the vascular wall.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-L
Alternative name(s):
CD11 antigen-like family member A
Leukocyte adhesion glycoprotein LFA-1 alpha chain
Short name:
LFA-1A
Leukocyte function-associated molecule 1 alpha chain
Lymphocyte antigen 15
Short name:
Ly-15
CD_antigen: CD11a
Gene namesi
Name:Itgal
Synonyms:Lfa-1, Ly-15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:96606. Itgal.

Subcellular locationi

GO - Cellular componenti

  1. cell-cell junction Source: MGI
  2. external side of plasma membrane Source: MGI
  3. immunological synapse Source: MGI
  4. integrin complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23231 PublicationAdd
BLAST
Chaini24 – 11631140Integrin alpha-LPRO_0000016293Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi70 ↔ 77By similarity
Glycosylationi86 – 861N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi108 ↔ 126By similarity
Disulfide bondi147 ↔ 199By similarity
Glycosylationi185 – 1851N-linked (GlcNAc...)Sequence Analysis
Glycosylationi270 – 2701N-linked (GlcNAc...)Sequence Analysis
Glycosylationi444 – 4441N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi651 ↔ 705By similarity
Glycosylationi668 – 6681N-linked (GlcNAc...)Sequence Analysis
Glycosylationi696 – 6961N-linked (GlcNAc...)Sequence Analysis
Glycosylationi724 – 7241N-linked (GlcNAc...)Sequence Analysis
Glycosylationi728 – 7281N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi767 ↔ 773By similarity
Glycosylationi776 – 7761N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi840 ↔ 856By similarity
Glycosylationi857 – 8571N-linked (GlcNAc...)Sequence Analysis
Glycosylationi880 – 8801N-linked (GlcNAc...)Sequence Analysis
Glycosylationi890 – 8901N-linked (GlcNAc...)Sequence Analysis
Glycosylationi899 – 8991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi927 – 9271N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi993 ↔ 1009By similarity
Disulfide bondi1017 ↔ 1048By similarity
Glycosylationi1056 – 10561N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP24063.
PaxDbiP24063.
PRIDEiP24063.

PTM databases

PhosphoSiteiP24063.

Expressioni

Tissue specificityi

Leukocytes.

Gene expression databases

BgeeiP24063.
CleanExiMM_ITGAL.
ExpressionAtlasiP24063. baseline and differential.
GenevestigatoriP24063.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Alpha-L associates with beta-2.

Protein-protein interaction databases

DIPiDIP-35643N.
IntActiP24063. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP24063.
SMRiP24063. Positions 24-1068, 1078-1154.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 10871064ExtracellularSequence AnalysisAdd
BLAST
Topological domaini1109 – 116355CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1088 – 110821HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati28 – 7952FG-GAP 1Add
BLAST
Repeati80 – 13859FG-GAP 2Add
BLAST
Domaini153 – 325173VWFAPROSITE-ProRule annotationAdd
BLAST
Repeati336 – 38752FG-GAP 3Add
BLAST
Repeati390 – 44354FG-GAP 4Add
BLAST
Repeati444 – 50461FG-GAP 5Add
BLAST
Repeati505 – 56157FG-GAP 6Add
BLAST
Repeati565 – 62561FG-GAP 7Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1111 – 11155GFFKR motif

Domaini

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated
Contains 7 FG-GAP repeats.Curated
Contains 1 VWFA domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG296688.
GeneTreeiENSGT00760000118782.
HOGENOMiHOG000113114.
HOVERGENiHBG006188.
InParanoidiP24063.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01839. FG-GAP. 1 hit.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24063-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSFRIAGPRL LLLGLQLFAK AWSYNLDTRP TQSFLAQAGR HFGYQVLQIE
60 70 80 90 100
DGVVVGAPGE GDNTGGLYHC RTSSEFCQPV SLHGSNHTSK YLGMTLATDA
110 120 130 140 150
AKGSLLACDP GLSRTCDQNT YLSGLCYLFP QSLEGPMLQN RPAYQECMKG
160 170 180 190 200
KVDLVFLFDG SQSLDRKDFE KILEFMKDVM RKLSNTSYQF AAVQFSTDCR
210 220 230 240 250
TEFTFLDYVK QNKNPDVLLG SVQPMFLLTN TFRAINYVVA HVFKEESGAR
260 270 280 290 300
PDATKVLVII TDGEASDKGN ISAAHDITRY IIGIGKHFVS VQKQKTLHIF
310 320 330 340 350
ASEPVEEFVK ILDTFEKLKD LFTDLQRRIY AIEGTNRQDL TSFNMELSSS
360 370 380 390 400
GISADLSKGH AVVGAVGAKD WAGGFLDLRE DLQGATFVGQ EPLTSDVRGG
410 420 430 440 450
YLGYTVAWMT SRSSRPLLAA GAPRYQHVGQ VLLFQAPEAG GRWNQTQKIE
460 470 480 490 500
GTQIGSYFGG ELCSVDLDQD GEAELLLIGA PLFFGEQRGG RVFTYQRRQS
510 520 530 540 550
LFEMVSELQG DPGYPLGRFG AAITALTDIN GDRLTDVAVG APLEEQGAVY
560 570 580 590 600
IFNGKPGGLS PQPSQRIQGA QVFPGIRWFG RSIHGVKDLG GDRLADVVVG
610 620 630 640 650
AEGRVVVLSS RPVVDVVTEL SFSPEEIPVH EVECSYSARE EQKHGVKLKA
660 670 680 690 700
CFRIKPLTPQ FQGRLLANLS YTLQLDGHRM RSRGLFPDGS HELSGNTSIT
710 720 730 740 750
PDKSCLDFHF HFPICIQDLI SPINVSLNFS LLEEEGTPRD QKGRAMQPIL
760 770 780 790 800
RPSIHTVTKE IPFEKNCGED KKCEANLTLS SPARSGPLRL MSSASLAVEW
810 820 830 840 850
TLSNSGEDAY WVRLDLDFPR GLSFRKVEML QPHSRMPVSC EELTEGSSLL
860 870 880 890 900
TKTLKCNVSS PIFKAGQEVS LQVMFNTLLN SSWEDFVELN GTVHCENENS
910 920 930 940 950
SLQEDNSAAT HIPVLYPVNI LTKEQENSTL YISFTPKGPK TQQVQHVYQV
960 970 980 990 1000
RIQPSAYDHN MPTLEALVGV PWPHSEDPIT YTWSVQTDPL VTCHSEDLKR
1010 1020 1030 1040 1050
PSSEAEQPCL PGVQFRCPIV FRREILIQVT GTVELSKEIK ASSTLSLCSS
1060 1070 1080 1090 1100
LSVSFNSSKH FHLYGSKASE AQVLVKVDLI HEKEMLHVYV LSGIGGLVLL
1110 1120 1130 1140 1150
FLIFLALYKV GFFKRNLKEK MEADGGVPNG SPPEDTDPLA VPGEETKDMG
1160
CLEPSGRVTR TKA
Length:1,163
Mass (Da):128,328
Last modified:July 27, 2011 - v2
Checksum:iF19C786C4D33CC0C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti972 – 9721W → R in AAA39426. (PubMed:2051027)Curated
Sequence conflicti978 – 9781P → L in AAA39426. (PubMed:2051027)Curated
Sequence conflicti1023 – 10231R → W in AAA39426. (PubMed:2051027)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M60778 mRNA. Translation: AAA39426.1.
AC133494 Genomic DNA. No translation available.
PIRiI56126.
UniGeneiMm.1618.

Genome annotation databases

EnsembliENSMUST00000170971; ENSMUSP00000131847; ENSMUSG00000030830.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M60778 mRNA. Translation: AAA39426.1 .
AC133494 Genomic DNA. No translation available.
PIRi I56126.
UniGenei Mm.1618.

3D structure databases

ProteinModelPortali P24063.
SMRi P24063. Positions 24-1068, 1078-1154.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-35643N.
IntActi P24063. 1 interaction.

Chemistry

BindingDBi P24063.
ChEMBLi CHEMBL1075188.

PTM databases

PhosphoSitei P24063.

Proteomic databases

MaxQBi P24063.
PaxDbi P24063.
PRIDEi P24063.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000170971 ; ENSMUSP00000131847 ; ENSMUSG00000030830 .

Organism-specific databases

MGIi MGI:96606. Itgal.

Phylogenomic databases

eggNOGi NOG296688.
GeneTreei ENSGT00760000118782.
HOGENOMi HOG000113114.
HOVERGENi HBG006188.
InParanoidi P24063.

Enzyme and pathway databases

Reactomei REACT_202937. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_216309. Integrin cell surface interactions.
REACT_225233. Cell surface interactions at the vascular wall.

Miscellaneous databases

PROi P24063.
SOURCEi Search...

Gene expression databases

Bgeei P24063.
CleanExi MM_ITGAL.
ExpressionAtlasi P24063. baseline and differential.
Genevestigatori P24063.

Family and domain databases

InterProi IPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR002035. VWF_A.
[Graphical view ]
Pfami PF01839. FG-GAP. 1 hit.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view ]
PRINTSi PR01185. INTEGRINA.
SMARTi SM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view ]
SUPFAMi SSF53300. SSF53300. 1 hit.
PROSITEi PS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the murine lymphocyte function-associated molecule-1 alpha-subunit and its expression in COS cells."
    Kaufmann Y., Tseng E., Springer T.A.
    J. Immunol. 147:369-374(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Sequence homology of the LFA-1 and Mac-1 leukocyte adhesion glycoproteins and unexpected relation to leukocyte interferon."
    Springer T.A., Teplow D.B., Dreyer W.J.
    Nature 314:540-542(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 24-42.

Entry informationi

Entry nameiITAL_MOUSE
AccessioniPrimary (citable) accession number: P24063
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3