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P24063

- ITAL_MOUSE

UniProt

P24063 - ITAL_MOUSE

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Protein
Integrin alpha-L
Gene
Itgal, Lfa-1, Ly-15
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Mice expressing a null mutation of the alpha-L subunit gene demonstrate impaired tumor rejection and impaired leukocytes recruitment.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi466 – 4749 Reviewed prediction
Calcium bindingi528 – 5369 Reviewed prediction
Calcium bindingi588 – 5969 Reviewed prediction

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. activated T cell proliferation Source: MGI
  2. cell surface receptor signaling pathway Source: MGI
  3. integrin-mediated signaling pathway Source: UniProtKB-KW
  4. leukocyte cell-cell adhesion Source: MGI
  5. positive regulation of T cell proliferation Source: MGI
  6. positive regulation of calcium-mediated signaling Source: MGI
  7. positive regulation of cell-cell adhesion Source: MGI
  8. regulation of cell-cell adhesion Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Integrin, Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_202937. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_216309. Integrin cell surface interactions.
REACT_225233. Cell surface interactions at the vascular wall.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-L
Alternative name(s):
CD11 antigen-like family member A
Leukocyte adhesion glycoprotein LFA-1 alpha chain
Short name:
LFA-1A
Leukocyte function-associated molecule 1 alpha chain
Lymphocyte antigen 15
Short name:
Ly-15
CD_antigen: CD11a
Gene namesi
Name:Itgal
Synonyms:Lfa-1, Ly-15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:96606. Itgal.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 10871064Extracellular Reviewed prediction
Add
BLAST
Transmembranei1088 – 110821Helical; Reviewed prediction
Add
BLAST
Topological domaini1109 – 116355Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell-cell junction Source: MGI
  2. external side of plasma membrane Source: MGI
  3. immunological synapse Source: MGI
  4. integrin complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23231 Publication
Add
BLAST
Chaini24 – 11631140Integrin alpha-L
PRO_0000016293Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi70 ↔ 77 By similarity
Glycosylationi86 – 861N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi108 ↔ 126 By similarity
Disulfide bondi147 ↔ 199 By similarity
Glycosylationi185 – 1851N-linked (GlcNAc...) Reviewed prediction
Glycosylationi270 – 2701N-linked (GlcNAc...) Reviewed prediction
Glycosylationi444 – 4441N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi651 ↔ 705 By similarity
Glycosylationi668 – 6681N-linked (GlcNAc...) Reviewed prediction
Glycosylationi696 – 6961N-linked (GlcNAc...) Reviewed prediction
Glycosylationi724 – 7241N-linked (GlcNAc...) Reviewed prediction
Glycosylationi728 – 7281N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi767 ↔ 773 By similarity
Glycosylationi776 – 7761N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi840 ↔ 856 By similarity
Glycosylationi857 – 8571N-linked (GlcNAc...) Reviewed prediction
Glycosylationi880 – 8801N-linked (GlcNAc...) Reviewed prediction
Glycosylationi890 – 8901N-linked (GlcNAc...) Reviewed prediction
Glycosylationi899 – 8991N-linked (GlcNAc...) Reviewed prediction
Glycosylationi927 – 9271N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi993 ↔ 1009 By similarity
Disulfide bondi1017 ↔ 1048 By similarity
Glycosylationi1056 – 10561N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP24063.
PaxDbiP24063.
PRIDEiP24063.

PTM databases

PhosphoSiteiP24063.

Expressioni

Tissue specificityi

Leukocytes.

Gene expression databases

ArrayExpressiP24063.
BgeeiP24063.
CleanExiMM_ITGAL.
GenevestigatoriP24063.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Alpha-L associates with beta-2.

Protein-protein interaction databases

DIPiDIP-35643N.
IntActiP24063. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP24063.
SMRiP24063. Positions 24-1068, 1078-1154.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati28 – 7952FG-GAP 1
Add
BLAST
Repeati80 – 13859FG-GAP 2
Add
BLAST
Domaini153 – 325173VWFA
Add
BLAST
Repeati336 – 38752FG-GAP 3
Add
BLAST
Repeati390 – 44354FG-GAP 4
Add
BLAST
Repeati444 – 50461FG-GAP 5
Add
BLAST
Repeati505 – 56157FG-GAP 6
Add
BLAST
Repeati565 – 62561FG-GAP 7
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1111 – 11155GFFKR motif

Domaini

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Sequence similaritiesi

Contains 7 FG-GAP repeats.
Contains 1 VWFA domain.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG296688.
GeneTreeiENSGT00750000117471.
HOGENOMiHOG000113114.
HOVERGENiHBG006188.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01839. FG-GAP. 1 hit.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24063-1 [UniParc]FASTAAdd to Basket

« Hide

MSFRIAGPRL LLLGLQLFAK AWSYNLDTRP TQSFLAQAGR HFGYQVLQIE     50
DGVVVGAPGE GDNTGGLYHC RTSSEFCQPV SLHGSNHTSK YLGMTLATDA 100
AKGSLLACDP GLSRTCDQNT YLSGLCYLFP QSLEGPMLQN RPAYQECMKG 150
KVDLVFLFDG SQSLDRKDFE KILEFMKDVM RKLSNTSYQF AAVQFSTDCR 200
TEFTFLDYVK QNKNPDVLLG SVQPMFLLTN TFRAINYVVA HVFKEESGAR 250
PDATKVLVII TDGEASDKGN ISAAHDITRY IIGIGKHFVS VQKQKTLHIF 300
ASEPVEEFVK ILDTFEKLKD LFTDLQRRIY AIEGTNRQDL TSFNMELSSS 350
GISADLSKGH AVVGAVGAKD WAGGFLDLRE DLQGATFVGQ EPLTSDVRGG 400
YLGYTVAWMT SRSSRPLLAA GAPRYQHVGQ VLLFQAPEAG GRWNQTQKIE 450
GTQIGSYFGG ELCSVDLDQD GEAELLLIGA PLFFGEQRGG RVFTYQRRQS 500
LFEMVSELQG DPGYPLGRFG AAITALTDIN GDRLTDVAVG APLEEQGAVY 550
IFNGKPGGLS PQPSQRIQGA QVFPGIRWFG RSIHGVKDLG GDRLADVVVG 600
AEGRVVVLSS RPVVDVVTEL SFSPEEIPVH EVECSYSARE EQKHGVKLKA 650
CFRIKPLTPQ FQGRLLANLS YTLQLDGHRM RSRGLFPDGS HELSGNTSIT 700
PDKSCLDFHF HFPICIQDLI SPINVSLNFS LLEEEGTPRD QKGRAMQPIL 750
RPSIHTVTKE IPFEKNCGED KKCEANLTLS SPARSGPLRL MSSASLAVEW 800
TLSNSGEDAY WVRLDLDFPR GLSFRKVEML QPHSRMPVSC EELTEGSSLL 850
TKTLKCNVSS PIFKAGQEVS LQVMFNTLLN SSWEDFVELN GTVHCENENS 900
SLQEDNSAAT HIPVLYPVNI LTKEQENSTL YISFTPKGPK TQQVQHVYQV 950
RIQPSAYDHN MPTLEALVGV PWPHSEDPIT YTWSVQTDPL VTCHSEDLKR 1000
PSSEAEQPCL PGVQFRCPIV FRREILIQVT GTVELSKEIK ASSTLSLCSS 1050
LSVSFNSSKH FHLYGSKASE AQVLVKVDLI HEKEMLHVYV LSGIGGLVLL 1100
FLIFLALYKV GFFKRNLKEK MEADGGVPNG SPPEDTDPLA VPGEETKDMG 1150
CLEPSGRVTR TKA 1163
Length:1,163
Mass (Da):128,328
Last modified:July 27, 2011 - v2
Checksum:iF19C786C4D33CC0C
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti972 – 9721W → R in AAA39426. 1 Publication
Sequence conflicti978 – 9781P → L in AAA39426. 1 Publication
Sequence conflicti1023 – 10231R → W in AAA39426. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M60778 mRNA. Translation: AAA39426.1.
AC133494 Genomic DNA. No translation available.
PIRiI56126.
UniGeneiMm.1618.

Genome annotation databases

EnsembliENSMUST00000170971; ENSMUSP00000131847; ENSMUSG00000030830.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M60778 mRNA. Translation: AAA39426.1 .
AC133494 Genomic DNA. No translation available.
PIRi I56126.
UniGenei Mm.1618.

3D structure databases

ProteinModelPortali P24063.
SMRi P24063. Positions 24-1068, 1078-1154.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-35643N.
IntActi P24063. 1 interaction.

Chemistry

BindingDBi P24063.
ChEMBLi CHEMBL1075188.

PTM databases

PhosphoSitei P24063.

Proteomic databases

MaxQBi P24063.
PaxDbi P24063.
PRIDEi P24063.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000170971 ; ENSMUSP00000131847 ; ENSMUSG00000030830 .

Organism-specific databases

MGIi MGI:96606. Itgal.

Phylogenomic databases

eggNOGi NOG296688.
GeneTreei ENSGT00750000117471.
HOGENOMi HOG000113114.
HOVERGENi HBG006188.

Enzyme and pathway databases

Reactomei REACT_202937. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_216309. Integrin cell surface interactions.
REACT_225233. Cell surface interactions at the vascular wall.

Miscellaneous databases

PROi P24063.
SOURCEi Search...

Gene expression databases

ArrayExpressi P24063.
Bgeei P24063.
CleanExi MM_ITGAL.
Genevestigatori P24063.

Family and domain databases

InterProi IPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR002035. VWF_A.
[Graphical view ]
Pfami PF01839. FG-GAP. 1 hit.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view ]
PRINTSi PR01185. INTEGRINA.
SMARTi SM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view ]
SUPFAMi SSF53300. SSF53300. 1 hit.
PROSITEi PS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the murine lymphocyte function-associated molecule-1 alpha-subunit and its expression in COS cells."
    Kaufmann Y., Tseng E., Springer T.A.
    J. Immunol. 147:369-374(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Sequence homology of the LFA-1 and Mac-1 leukocyte adhesion glycoproteins and unexpected relation to leukocyte interferon."
    Springer T.A., Teplow D.B., Dreyer W.J.
    Nature 314:540-542(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 24-42.

Entry informationi

Entry nameiITAL_MOUSE
AccessioniPrimary (citable) accession number: P24063
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi